Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway

Nature Communications

Volumn 7, Issue , 2016, Pages

  Cunha Santos, Janete ^a,b   Duarte Neves, Joana ^a,b   Carmona, Vitor ^a,b   Guarente, Leonard ^c   De Almeida, Luís Pereira ^a,b   Cavadas, Cláudia ^a,b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 3; MESSENGER RNA; POLYGLUTAMINE; RESVERATROL; SIRTUIN 1; MUTANT PROTEIN; STILBENE DERIVATIVE;

BRAIN; GENE EXPRESSION; GENE TRANSFER; NERVOUS SYSTEM DISORDER; NEUROLOGY; PATHOLOGY; PROTEIN; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATXN3 GENE; AUTOPHAGY; CAG REPEAT; CALORIC RESTRICTION; CEREBELLUM; CONTROLLED STUDY; GENE; MACHADO JOSEPH DISEASE; MOTOR COORDINATION; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROPATHOLOGY; NONHUMAN; TRANSGENIC MOUSE; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECT; GAIT; GENETICS; INFLAMMATION; METABOLISM; MOTOR ACTIVITY; NERVE CELL; NERVOUS SYSTEM; PATHOLOGY; TUMOR CELL LINE;

MUS;

ANIMALS; ATAXIN-3; AUTOPHAGY; CALORIC RESTRICTION; CELL LINE, TUMOR; CEREBELLUM; DISEASE MODELS, ANIMAL; GAIT; INFLAMMATION; MACHADO-JOSEPH DISEASE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR ACTIVITY; MUTANT PROTEINS; NERVOUS SYSTEM; NEURONS; RNA, MESSENGER; SIRTUIN 1; STILBENES;

EID: 84968928647     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms11445     Document Type: Article

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