A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration

Journal of Neuroscience

Volumn 33, Issue 21, 2013, Pages 8951-8960

  Gräff, Johannes ^a,b   Kahn, Martin ^a   Samiei, Alireza ^a   Gao, Jun ^a   Ota, Kristie T ^a   Rei, Damien ^a,b   Tsai, Li Huei ^a,b,c  

^a The Picower Institute for Learning and Memory   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SIRTUIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN ATROPHY; BRAIN ELECTROPHYSIOLOGY; CALORIC RESTRICTION; COGNITION; CONTROLLED STUDY; ELECTRON MICROSCOPY; GOLGI STAIN; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MEMORY; MOUSE; NERVE CELL PLASTICITY; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; ATROPHY; BRAIN; CALORIC RESTRICTION; CASE-CONTROL STUDIES; COGNITION DISORDERS; CYCLIN-DEPENDENT KINASE 5; DISEASE MODELS, ANIMAL; DOUBLE-BLIND METHOD; EXCITATORY POSTSYNAPTIC POTENTIALS; FEMALE; GREEN FLUORESCENT PROTEINS; IMMUNOPRECIPITATION; LONG-TERM POTENTIATION; MALE; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; PHOSPHOPYRUVATE HYDRATASE; PIPERIDINES; SILVER STAINING; SIRTUIN 1; SYNAPSES; THIAZOLES; TUMOR SUPPRESSOR PROTEIN P53; VITAMIN E;

EID: 84877994005     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5657-12.2013     Document Type: Article

References (46)

1. Araki T, Sasaki Y, Milbrandt J (2004) Increased nuclear NAD biosynthe-sis and SIRT1 activation prevent axonal degeneration. Science 305: 1010-1013.
2. Bishop NA, Guarente L (2007) Genetic links between diet and lifespan: shared mechanisms from yeast to humans. Nat Rev Genet 8:835-844.
3. Bordone L, Guarente L (2005) Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol 6:298-305.
4. Bordone L, Cohen D, Robinson A, Motta MC, van Veen E, Czopik A, Steele AD, Crowe H, Marmor S, Luo J, Gu W, Guarente L (2007) SIRT1trans-genic mice show phenotypes resembling calorie restriction. Aging Cell 6:759-767.
5. Chen D, Guarente L (2007) SIR2: a potential target for calorie restriction mimetics. Trends Mol Med 13:64-71.
6. Chen D, Steele AD, Hutter G, Bruno J, Govindarajan A, Easlon E, Lin SJ, Aguzzi A, Lindquist S, Guarente L (2008) The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration. Exp Gerontol 43: 1086-1093.
7. Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L (2005) SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J Biol Chem 280: 40364-40374.
8. Cheng HL, Mostoslavsky R, Saito S, Manis JP, Gu Y, Patel P, Bronson R, Appella E, Alt FW, Chua KF (2003) Developmental defects and p53 hy-peracetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A 100:10794-10799.
9. Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R (2009) Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325:201-204.
10. Cruz JC, Tseng HC, Goldman JA, Shih H, Tsai LH (2003) Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegenera-tion and neurofibrillary tangles. Neuron 40:471-483.
11. Cruz JC, Kim D, Moy LY, Dobbin MM, Sun X, Bronson RT, Tsai LH (2006) p25/cyclin-dependent kinase 5 induces production and intra-neuronal accumulation of amyloid beta in vivo. J Neurosci 26:10536-10541.
12. Dai H, Kustigian L, Carney D, Case A, Considine T, Hubbard BP, Perni RB, Riera TV, Szczepankiewicz B, Vlasuk GP, Stein RL (2010) SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator. J Biol Chem 285:32695-32703.
13. Donmez G, Wang D, Cohen DE, Guarente L (2010) SIRT1suppressesbeta-amyloidproductionbyactivatingthealpha-secretasegeneADAM10. Cell 142:320-332.
14. Fiala JC, Spacek J, Harris KM (2002) Dendritic spine pathology: cause or consequence of neurological disorders? Brain Res Brain Res Rev 39: 29-54.
15. Fischer A, Sananbenesi F, Pang PT, Lu B, Tsai LH (2005) Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron 48:825-838.
16. Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai LH (2007) Recovery of learning and memory is associated with chromatin remodelling. Nature 447:178-182.
17. Fontana L, Partridge L, Longo VD (2010) Extendinghealthylifespan-from yeast to humans. Science 328:321-326.
18. Fontán-Lozano A, Saéz-Cassanelli JL, Inda MC, de los Santos-Arteaga M, Sierra-Domínguez SA, López-Lluch G, Delgado-García JM, Carrión AM (2007) Caloricrestrictionincreaseslearningconsolidationandfacilitates synaptic plasticity through mechanisms dependent on NR2B subunits of the NMDA receptor. J Neurosci 27:10185-10195.
19. Fontán-LozanoA, Romero-Granados R, Troncoso J, Múnera A, Delgado-García JM, Carrión AM (2008) Histone deacetylase inhibitors improve learning consolidation in young and in KA-induced-neurodegeneration and SAMP-8-mutant mice. Mol Cell Neurosci 39:193-201.
20. Fusco S, Ripoli C, Podda MV, Ranieri SC, Leone L, Toietta G, McBurney MW, Schutz G, Riccio A, Grassi C, Galeotti T, Pani G (2012) A role for neu-ronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction. Proc Natl Acad Sci U S A 109:621-626.
21. Gan L, Mucke L (2008) Paths of convergence: sirtuins in aging and neuro-degeneration. Neuron 58:10-14.
22. Gao J, Wang WY, Mao YW, Gräff J, Guan JS, Pan L, Mak G, Kim D, Su SC, Tsai LH (2010) A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature 466:1105-1109.
23. Guarente L, Picard F (2005) Calorie restriction-the SIR2 connection. Cell 120:473-482.
24. Halagappa VK, Guo Z, Pearson M, Matsuoka Y, Cutler RG, Laferla FM, Mattson MP (2007) Intermittent fasting and caloric restriction amelio-rate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease. Neurobiol Dis 26:212-220.
25. Heyward FD, Walton RG, Carle MS, Coleman MA, Garvey WT, Sweatt JD (2012) Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression. Neu-robiol Learn Mem 98:25-32.
26. Jadiya P, Chatterjee M, Sammi SR, Kaur S, Palit G, Nazir A (2011) Sir-2. 1 modulates 'calorie-restriction-mediated' prevention of neurodegenera-tion in Caenorhabditis elegans: implications for Parkinson's disease. Biochem Biophys Res Commun 413:306-310.
27. Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH (2007) SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J 26: 3169-3179.
28. Kong S, Kim SJ, Sandal B, Lee SM, Gao B, Zhang DD, Fang D (2011) The type III histone deacetylase Sirt1 protein suppresses p300-mediated his-tone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activa-tion. J Biol Chem 286:16967-16975.
29. Lavu S, Boss O, Elliott PJ, Lambert PD (2008) Sirtuins-novel therapeu-tictargetstotreatage-associateddiseases. NatRevDrugDiscov7:841-853.
30. Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W (2001) Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107:137-148.
31. Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, Longo DL, Allison DB, Young JE, Bryant M, Barnard D, Ward WF, Qi W, Ingram DK, de Cabo R (2012) Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 489:318-321.
32. Michán S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, Sinclair DA, Baudry M, de Cabo R, Longo VD (2010) SIRT1 is essentialfornormalcognitivefunctionandsynapticplasticity. JNeurosci 30:9695-9707.
33. Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L (2010) Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron 67:953-966.
34. Mouton PR, Chachich ME, Quigley C, Spangler E, Ingram DK (2009) Ca-loric restriction attenuates amyloid deposition in middle-aged dtg APP/ PS1 mice. Neurosci Lett 464:184-187.
35. Oren M (2003) Decision making by p53: life, death and cancer. Cell Death Differ 10:431-442.
36. Patel NV, Gordon MN, Connor KE, Good RA, Engelman RW, Mason J, Morgan DG, Morgan TE, Finch CE (2005) Caloricrestrictionattenuates Abeta-deposition in Alzheimer transgenic models. Neurobiol Aging 26: 995-1000.
37. Qin W, Chachich M, Lane M, Roth G, Bryant M, de Cabo R, Ottinger MA, Mattison J, Ingram D, Gandy S, Pasinetti GM (2006a) Calorie restric-tion attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus). J Alzheimer's Dis 10:417-422.
38. Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM (2006b) NeuronalSIRT1activationas a novel mechanism underlying the prevention of Alzheimer disease am-yloid neuropathology by calorie restriction. J Biol Chem 281:21745-21754.
39. Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, Tanokura M, Denu JM, Prolla TA (2010) Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restric-tion. Cell 143:802-812.
40. Tang BL (2009) Sirt1's complex roles in neuroprotection. Cell Mol Neuro-biol 29:1093-1103.
41. Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA (2001) hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107:149-159.
42. Wang J, Ho L, Qin W, Rocher AB, Seror I, Humala N, Maniar K, Dolios G, Wang R, Hof PR, Pasinetti GM (2005) Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease. Faseb J 19:659-661.
43. Witte AV, Fobker M, Gellner R, Knecht S, Floel A (2009) Caloricrestriction improvesmemoryinelderlyhumans. ProcNatlAcadSciU S A106:1255-1260.
44. Wu J, Basha MR, Brock B, Cox DP, Cardozo-Pelaez F, McPherson CA, Harry J, Rice DC, Maloney B, Chen D, Lahiri DK, Zawia NH (2008a) Alzhei-mer's disease (AD)-like pathology in aged monkeys after infantile expo-sure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD. J Neurosci 28:3-9.
45. Wu P, Shen Q, Dong S, Xu Z, Tsien JZ, Hu Y (2008b) Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice. Neurobiol Aging 29:1502-1511.
46. Zhang F, Wang S, Gan L, Vosler PS, Gao Y, Zigmond MJ, Chen J (2011) Protective effects and mechanisms of sirtuins in thenervous system. Prog Neurobiol 95:373-395.