Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3)

Human Molecular Genetics

Volumn 22, Issue 3, 2013, Pages 508-518

  Hübener, Jeannette ^a   Weber, Jonasz Jeremiasz ^a   Richter, Claudia ^a   Honold, Lisa ^a   Weiss, Andreas ^c   Murad, Fabronia ^a   Breuer, Peter ^d   Wüllner, Ullrich ^d   Bellstedt, Peter ^a   Paquet Durand, Francois ^b   Takano, Jiro ^e   Saido, Takaomi C ^e   Riess, Olaf ^a   Nguyen, Huu Phuc ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c NOVARTIS PHARMA AG   (Switzerland)

^d UNIVERSITY OF BONN   (Germany)

^e RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 3; CALCIUM; CALPAIN; CALPAIN 2; CALPASTATIN; POLYGLUTAMINE; PROTEINASE;

ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR PATHOLOGY; MOUSE; MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; SENSITIVITY ANALYSIS; SPINOCEREBELLAR ATAXIA TYPE 3; SPINOCEREBELLAR DEGENERATION; WESTERN BLOTTING;

ANIMALS; CALCIUM; CALCIUM-BINDING PROTEINS; CALPAIN; CEREBELLUM; DISEASE MODELS, ANIMAL; GENE DELETION; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; GENOTYPE; GLYCOPROTEINS; HEK293 CELLS; HOMEOSTASIS; HUMANS; IMMUNOHISTOCHEMISTRY; MACHADO-JOSEPH DISEASE; MICE; MICE, KNOCKOUT; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PEPTIDES; PHENOTYPE; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS;

MUS; MUS MUSCULUS;

EID: 84872416147     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/dds449     Document Type: Article

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