Transient receptor potential vanilloid 4 (TRPV4) is downregulated in keratinocytes in human non-melanoma skin cancer

Journal of Investigative Dermatology

Volumn 134, Issue 9, 2014, Pages 2408-2417

  Fusi, Camilla ^a   Materazzi, Serena ^a   Minocci, Daiana ^a   Maio, Vincenza ^a   Oranges, Teresa ^a   Massi, Daniela ^a   Nassini, Romina ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; INTERLEUKIN 8; MESSENGER RNA; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 2; VANILLOID RECEPTOR 3; VANILLOID RECEPTOR 4; IL8 PROTEIN, HUMAN; TRPV4 PROTEIN, HUMAN; VANILLOID RECEPTOR;

ACTINIC KERATOSIS; ARTICLE; AUTOCRINE EFFECT; BASAL CELL CARCINOMA; BOWEN DISEASE; CANCER CELL CULTURE; CYTOKINE RELEASE; DERMATITIS; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; NON MELANOMA SKIN CANCER; PRECANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SKIN CARCINOGENESIS; SKIN DISEASE; SQUAMOUS CELL CARCINOMA; STAINING; ADULT; AGED; CYTOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HEALTH CARE FACILITY; HEK293 CELL LINE; IMMUNOLOGY; KERATOSIS; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; SKIN TUMOR; VERY ELDERLY; CELL STIMULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY;

ADULT; AGED; AGED, 80 AND OVER; AUTOCRINE COMMUNICATION; CARCINOMA, BASAL CELL; CARCINOMA, SQUAMOUS CELL; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; INTERLEUKIN-8; KERATINOCYTES; KERATOSIS; MALE; MIDDLE AGED; PRECANCEROUS CONDITIONS; SKIN NEOPLASMS; TISSUE BANKS; TRPV CATION CHANNELS;

EID: 84906315513     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2014.145     Document Type: Article

References (72)

1. Andersson DA, Gentry C, Moss S, et al. (2008). Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J Neurosci 28:2485-94
2. Atoyan R, Shander D, Botchkareva NV. (2009). Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin. J Invest Dermatol 129:2312-5
3. Axelsson HE, MinDe JK, Sonesson A, et al. (2009). Transient receptor potential vanilloid 1, vanilloid 2 and melastatin 8 immunoreactive nerve fibers in human skin from individuals with and without Norrbottnian congenital insensitivity to pain. Neuroscience 162:1322-32
4. Bachelor MA, Bowden GT. (2004). Ultraviolet A-induced modulation of Bcl-XL by p38 MAPK in human keratinocytes: Post-Transcriptional regulation through the 3-untranslated region. J Biol Chem 279:42658-68
5. Bautista DM, Jordt SE, Nikai T, et al. (2006). TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124:1269-82
6. Becker D, Blase C, Bereiter-Hahn J, et al. (2005). TRPV4 exhibits a functional role in cell-volume regulation. J Cell Sci 118:2435-40
7. Bellono NW, Kammel LG, Zimmerman AL, et al. (2013). UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes. Proc Natl Acad Sci USA 110:2383-8
8. Biro T, Kovacs L. (2009). An "ice-cold" TR(i)P to skin biology: The role of TRPA1 in human epidermal keratinocytes. J Invest Dermatol 129:2096-9
9. BoDe AM, Cho YY, Zheng D, et al. (2009). Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis. Cancer Res 69:905-13
10. Bodo E, Biro T, Telek A, et al. (2005). A hot new twist to hair biology: Involvement of vanilloid receptor-1 (VR1/TRPV1) signaling in human hair growth control. Am J Pathol 166:985-98
11. Boniol M, Autier P, Boyle P, et al. (2012). Cutaneous melanoma attributable to sunbed use: Systematic review and meta-Analysis. BMJ 345:e4757
12. Bowden GT. (2004). Prevention of non-melanoma skin cancer by targeting ultraviolet-B-light signalling. Nat Rev Cancer 4:23-35
13. Caterina MJ, Schumacher MA, Tominaga M, et al. (1997). The capsaicin receptor: A heat-Activated ion channel in the pain pathway. Nature 389:816-24
14. Chen Y, Williams SH, McNulty AL, et al. (2013). Temporomandibular joint pain: A critical role for Trpv4 in the trigeminal ganglion. Pain 154: 1295-304
15. Cheng X, Jin J, Hu L, et al. (2010). TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell 141:331-43
16. Chung MK, Lee H, Caterina MJ. (2003). Warm temperatures activate TRPV4 in mouse 308 keratinocytes. J Biol Chem 278:32037-46
17. Corsini E, Bruccoleri A, Marinovich M, et al. (1995). In vitro mechanism(s) of ultraviolet-induced tumor necrosis factor-Alpha release in a human keratinocyte cell line. Photodermatol Photoimmunol Photomed 11:112-8
18. Countryman NB, Pei Y, Yi Q, et al. (2000). Evidence for involvement of the epidermal platelet-Activating factor receptor in ultraviolet-B- radiationinduced interleukin-8 production. J Invest Dermatol 115:267-72
19. Denda M, Sokabe T, Fukumi-Tominaga T, et al. (2007). Effects of skin surface temperature on epidermal permeability barrier homeostasis. J Invest Dermatol 127:654-9
20. Duncan LM, Deeds J, Cronin FE, et al. (2001). Melastatin expression and prognosis in cutaneous malignant melanoma. J Clin Oncol 19:568-76
21. Earley S, Gonzales AL, Crnich R. (2009). Endothelium-dependent cerebral artery dilation mediated by TRPA1 and Ca2+-Activated K+ channels. Circ Res 104:987-94
22. Earley S, Gonzales AL, Garcia ZI. (2010). A dietary agonist of transient receptor potential cation channel V3 elicits endothelium-dependent vasodilation. Mol Pharmacol 77:612-20
23. Eid SR, Crown ED, Moore EL, et al. (2008). HC-030031, a TRPA1 selective antagonist, attenuates inflammatory-And neuropathy-induced mechanical hypersensitivity. Mol Pain 4:48-57
24. Elamin I, Zecevic RD, Vojvodic D, et al. (2008). Cytokine concentrations in basal cell carcinomas of different histological types and localization. Acta Dermatovenerol Alp Panonica Adriat 17:55-9
25. Everaerts W, Zhen X, Ghosh D, et al. (2010). Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc Natl Acad Sci USA 107:19084-9
26. Fixemer T, Wissenbach U, Flockerzi V, et al. (2003). Expression of the Ca2+selective cation channel TRPV6 in human prostate cancer: A novel prognostic marker for tumor progression. Oncogene 22:7858-61
27. Geppetti P, Holzer P. (1996). Neurogenic Inflammation. CRC Press: Boca Raton, F.L.
28. Hill K, Schaefer M. (2009). Ultraviolet light and photosensitising agents activate TRPA1 via generation of oxidative stress. Cell Calcium 45:155-64
29. Ho WS, Barrett DA, Randall MD (2008) -Entourage- effects of N-palmitoylethanolamide and N-oleoylethanolamiDe on vasorelaxation to anandamide occur through TRPV1 receptors. Br J Pharmacol 155:837-46
30. Jia Y, Wang X, Varty L, et al. (2004). Functional TRPV4 channels are expressed in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 287:L272-8
31. Kalmar A, Wichmann B, Galamb O, et al. (2013). Gene expression analysis of normal and colorectal cancer tissue samples from fresh frozen and matched formalin-fixed, paraffin-embedded (FFPE) specimens after manual and automated RNA isolation. Methods 59:S16-9
32. Krutmann J, Czech W, Parlow F, et al. (1992). Ultraviolet radiation effects on human keratinocyte ICAM-1 expression: UV-induced inhibition of cytokine-induced ICAM-1 mRNA expression is transient, differentially restored for IFN gamma versus TNF alpha, and followed by ICAM-1 induction via a TNF alpha-like pathway. J Invest Dermatol 98:923-8
33. Kupper TS, Chua AO, Flood P, et al. (1987). Interleukin 1 gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation. J Clin Invest 80:430-6
34. Kwa RE, Campana K, Moy RL. (1992). Biology of cutaneous squamous cell carcinoma. J Am Acad Dermatol 26:1-26
35. Lazzeri M, Vannucchi MG, Spinelli M, et al. (2005). Transient receptor potential vanilloid type 1 (TRPV1) expression changes from normal urothelium to transitional cell carcinoma of human bladder. Eur Urol 48:691-8
36. Lee H, Caterina MJ. (2005). TRPV channels as thermosensory receptors in epithelial cells. Pflugers Arch 451:160-7
37. Lehen-kyi V, Raphael M, Prevarskaya N. (2012). The role of the TRPV6 channel in cancer. J Physiol 590:1369-76
38. Liedtke W, Choe Y, Marti-Renom MA, et al. (2000). Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103:525-35
39. Liedtke W, Kim C. (2005). Functionality of the TRPV subfamily of TRP ion channels: Add mechano-TRP and osmo-TRP to the lexicon! Cell Mol Life Sci 62:2985-3001
40. Link TM, Park U, Vonakis BM, et al. (2010). TRPV2 has a pivotal role in macrophage particle binding and phagocytosis. Nat Immunol 11:232-9
41. Liu B, Escalera J, Balakrishna S, et al. (2013). TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis. FASEB J 27: 3549-63
42. Mandadi S, Sokabe T, Shibasaki K, et al. (2009). TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP. Pflugers Arch 458:1093-102
43. Marnett LJ. (2000). Oxyradicals and DNA damage. Carcinogenesis 21:361-70
44. Materazzi S, Nassini R, Andre E, et al. (2008). Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1. Proc Natl Acad Sci USA 105:12045-50
45. Moore C, Cevikbas F, Pasolli HA, et al. (2013). UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling. Proc Natl Acad Sci USA 110:E3225-34
46. Mukhtar H, Elmets CA. (1996). Photocarcinogenesis: Mechanisms, models and human health implications. Photochem Photobiol 63:356-7
47. Mulliken JS, Russak JE, Rigel DS. (2012). The effect of sunscreen on melanoma risk. Dermatol Clin 30:369-76
48. Nassini R, Pedretti P, Moretto N, et al. (2012). Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes nonneurogenic inflammation. PLoS One 7:e42454
49. Nilius B, Owsianik G, Voets T, et al. (2007). Transient receptor potential cation channels in disease. Physiol Rev 87:165-217
50. Nozawa K, Kawabata-Shoda E, Doihara H, et al. (2009). TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells. Proc Natl Acad Sci USA 106:3408-13
51. Oancea E, Vriens J, Brauchi S, et al. (2009). TRPM1 forms ion channels associated with melanin content in melanocytes. Sci Signal 2:ra21
52. Pei Y, Barber LA, Murphy RC, et al. (1998). Activation of the epidermal plateletactivating factor receptor results in cytokine and cyclooxygenase-2 biosynthesis. J Immunol 161:1954-61
53. Pentland AP, Mahoney MG. (1990). Keratinocyte prostaglandin synthesis is enhanced by IL-1. J Invest Dermatol 94:43-6
54. Perrotta RE, Giordano M, Malaguarnera M. (2011). Non-melanoma skin cancers in elderly patients. Crit Rev Oncol Hematol 80:474-80
55. Radtke C, Sinis N, Sauter M, et al. (2011). TRPV channel expression in human skin and possible role in thermally induced cell death. J Burn Care Res 32:150-9
56. Rundhaug JE, Simper MS, Surh I, et al. (2011). The role of the EP receptors for prostaglandin E2 in skin and skin cancer. Cancer Metastasis Rev 30: 465-80
57. Santoni G, Caprodossi S, Farfariello V, et al. (2012). Antioncogenic effects of transient receptor potential vanilloid 1 in the progression of transitional urothelial cancer of human bladder. ISRN Urol 2012: 458238
58. Sawada Y, Hosokawa H, Matsumura K, et al. (2008). Activation of transient receptor potential ankyrin 1 by hydrogen peroxide. Eur J Neurosci 27:1131-42
59. Sokabe T, Fukumi-Tominaga T, Yonemura S, et al. (2010). The TRPV4 channel contributes to intercellular junction formation in keratinocytes. J Biol Chem 285:18749-58
60. Southall MD, Li T, Gharibova LS, et al. (2003). Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes. J Pharmacol Exp Ther 304:217-22
61. Stander S, Moormann C, Schumacher M, et al. (2004). Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Exp Dermatol 13:129-39
62. St John MA, Dohadwala M, Luo J, et al. (2009). Proinflammatory mediators upregulate snail in head and neck squamous cell carcinoma. Clin Cancer Res 15:6018-27
63. Strickland I, Rhodes LE, Flanagan BF, et al. (1997). TNF-Alpha and IL-8 are upregulated in the epidermis of normal human skin after UVB exposure: Correlation with neutrophil accumulation and E-selectin expression. J Invest Dermatol 108:763-8
64. Sulk M, Seeliger S, Aubert J, et al. (2012). Distribution and expression of nonneuronal transient receptor potential (TRPV) ion channels in rosacea. J Invest Dermatol 132:1253-62
65. Takashima A, Bergstresser PR. (1996). Impact of UVB radiation on the epidermal cytokine network. Photochem Photobiol 63:397-400
66. Thorneloe KS, Sulpizio AC, Lin Z, et al. (2008). N-((1S)-1-{[4-((2S)-2- {[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl] carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamiDe (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I. J Pharmacol Exp Ther 326:432-42
67. Tominaga M, Caterina MJ, Malmberg AB, et al. (1998). The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21:531-43
68. Trevisani M, Siemens J, Materazzi S, et al. (2007) 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci USA 104:13519-24
69. Tsavaler L, Shapero MH, Morkowski S, et al. (2001). Trp-p8, a novel prostatespecific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res 61:3760-9
70. Vincek V, Kurimoto I, Medema JP, et al. (1993). Tumor necrosis factor alpha polymorphism correlates with deleterious effects of ultraviolet B light on cutaneous immunity. Cancer Res 53:728-32
71. Wang Z, Yang Y, Yang H, et al. (2011). NF-kappaB feedback control of JNK1 activation modulates TRPV1-induced increases in IL-6 and IL-8 release by human corneal epithelial cells. Mol Vis 17:3137-46
72. Weinstock MA. (1994). Epidemiologic investigation of nonmelanoma skin cancer mortality: The RhoDe Island Follow-Back Study. J Invest Dermatol 102:6S-9S.