TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor

Pain

Volumn 155, Issue 12, 2014, Pages 2662-2672

  Chen, Yong ^a   Kanju, Patrick ^a   Fang, Quan ^a   Lee, Suk Hee ^a   Parekh, Puja K ^a   Lee, Whasil ^a   Moore, Carlene ^a   Brenner, Daniel ^b   Gereau, Robert W ^b   Wang, Fan ^a   Liedtke, Wolfgang ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

ERK; Formalin model; Formalin receptor; Irritant; MEK; Trigeminal ganglion; Trigeminal pain; TRPV4; Whisker pad

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ANALGESIC AGENT; CALCIUM ION; FORMALDEHYDE; GSK 205; HC 067047; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 4; VANILLOID RECEPTOR ANTAGONIST; 1,3 BUTADIENE DERIVATIVE; ENZYME INHIBITOR; FIXATIVE; HC-067047; MORPHOLINE DERIVATIVE; NITRILE; PGP9.5 PROTEIN, MOUSE; PYRROLE DERIVATIVE; TRPV4 PROTEIN, MOUSE; UBIQUITIN THIOLESTERASE; VANILLOID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVATION; EVOKED RESPONSE; INFANT; MALE; MOUSE; NEUROPATHIC PAIN; NONHUMAN; PAIN RECEPTOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SENSORY NERVE CELL; SINGLE DRUG DOSE; TEMPOROMANDIBULAR JOINT DISORDER; TRIGEMINAL NERVE DISEASE; TRIGEMINUS GANGLION; VIBRISSA; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; GENETICS; INNERVATION; KERATINOCYTE; MEMBRANE POTENTIAL; METABOLISM; NERVE CELL; PAIN; PATHOLOGY; TRANSGENIC MOUSE;

ANIMALS; BUTADIENES; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIXATIVES; FORMALDEHYDE; KERATINOCYTES; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MORPHOLINES; NEURONS; NITRILES; PAIN; PYRROLES; TRIGEMINAL GANGLION; TRPV CATION CHANNELS; UBIQUITIN THIOLESTERASE; VIBRISSAE;

EID: 84921780836     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2014.09.033     Document Type: Article

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