TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis

Nature Communications

Volumn 7, Issue , 2016, Pages

  Aizawa, Sayaka ^a   Okamoto, Toru ^a   Sugiyama, Yukari ^a   Kouwaki, Takahisa ^a   Ito, Ayano ^a   Suzuki, Tatsuya ^a   Ono, Chikako ^a   Fukuhara, Takasuke ^a   Yamamoto, Masahiro ^b   Okochi, Masayasu ^a   Hiraga, Nobuhiko ^c   Imamura, Michio ^c   Chayama, Kazuaki ^c   Suzuki, Ryosuke ^d   Shoji, Ikuo ^e   Moriishi, Kohji ^f   Moriya, Kyoji ^g   Koike, Kazuhiko ^g   Matsuura, Yoshiharu ^a  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^d NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^e KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f UNIVERSITY OF YAMANASHI   (Japan)

^g UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CORE PROTEIN; E3 UBIQUITIN LIGASE TRC8; PROTEASOME; SIGNAL PEPTIDASE; SIGNAL PEPTIDE PEPTIDASE; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; ASPARTIC PROTEINASE; NUCLEOCAPSID PROTEIN, HEPATITIS C VIRUS; UBIQUITIN PROTEIN LIGASE;

CELL ORGANELLE; DEGRADATION; ENZYME ACTIVITY; GENE EXPRESSION; HEPATITIS; INHIBITION; PATHOGENICITY; PROTEIN; RODENT; SENSORY SYSTEM; VIRUS;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FATTY LIVER; FEMALE; GENE INACTIVATION; HAPLOINSUFFICIENCY; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; INSULIN RESISTANCE; MALE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEINASE INHIBITION; VIRAL PROPAGATION; VIRUS PARTICLE; VIRUS PATHOGENESIS; VIRUS REPLICATION; ANIMAL; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; HEPACIVIRUS; HOST PATHOGEN INTERACTION; METABOLISM; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

HEPATITIS C VIRUS; MUS MUSCULUS;

ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM STRESS; FATTY LIVER; GENE EXPRESSION REGULATION; HAPLOINSUFFICIENCY; HEPACIVIRUS; HEPATITIS C; HOST-PATHOGEN INTERACTIONS; HUMANS; INSULIN RESISTANCE; MALE; MICE; MICE, TRANSGENIC; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; SIGNAL TRANSDUCTION; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; VIRAL CORE PROTEINS; VIRUS REPLICATION;

EID: 84966326679     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms11379     Document Type: Article

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