메뉴 건너뛰기




Volumn 20, Issue 36, 2014, Pages 12945-12955

Hepatocellular carcinoma in nonalcoholic fatty liver: Role of environmental and genetic factors

Author keywords

Cirrhosis; Fibrogenesis; Genetics; Hepatocellular carcinoma; Liver disease; Nonalcoholic fatty liver disease; Patatin like phospholipase domain containing 3; Single nucleotide polymorphism; Steatosis

Indexed keywords

VERY LOW DENSITY LIPOPROTEIN;

EID: 84927615859     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i36.12945     Document Type: Article
Times cited : (122)

References (120)
  • 1
    • 0033545541 scopus 로고    scopus 로고
    • Rising incidence of hepatocellular carcinoma in the United States
    • PMID: 10072408
    • El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 1999; 340: 745-750 [PMID: 10072408 DOI: 10.1056/NEJM19990311340 1001]
    • (1999) N Engl J Med , vol.340 , pp. 745-750
    • El-Serag, H.B.1    Mason, A.C.2
  • 3
    • 14944385553 scopus 로고    scopus 로고
    • Global cancer statistics, 2002
    • PMID: 15761078
    • Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74-108 [PMID: 15761078 DOI: 10.3322/canjclin.55.2.74]
    • (2005) CA Cancer J Clin , vol.55 , pp. 74-108
    • Parkin, D.M.1    Bray, F.2    Ferlay, J.3    Pisani, P.4
  • 5
    • 24144496018 scopus 로고    scopus 로고
    • Alpha-1-antitrypsin deficiency: A new paradigm for hepatocellular carcinoma in genetic liver disease
    • PMID: 16044402
    • Rudnick DA, Perlmutter DH. Alpha-1-antitrypsin deficiency: a new paradigm for hepatocellular carcinoma in genetic liver disease. Hepatology 2005; 42: 514-521 [PMID: 16044402 DOI: 10.1002/hep.20815]
    • (2005) Hepatology , vol.42 , pp. 514-521
    • Rudnick, D.A.1    Perlmutter, D.H.2
  • 7
    • 84861197159 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace
    • PMID: 22326465
    • Baffy G, Brunt EM, Caldwell SH. Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. J Hepatol 2012; 56: 1384-1391 [PMID: 22326465 DOI: 10.1016/ j.jhep.2011.10.027]
    • (2012) J Hepatol , vol.56 , pp. 1384-1391
    • Baffy, G.1    Brunt, E.M.2    Caldwell, S.H.3
  • 10
    • 33745559765 scopus 로고    scopus 로고
    • The natural history of compensated cirrhosis due to hepatitis C virus: A 17-year cohort study of 214 patients
    • PMID: 16729298
    • Sangiovanni A, Prati GM, Fasani P, Ronchi G, Romeo R, Manini M, Del Ninno E, Morabito A, Colombo M. The natural history of compensated cirrhosis due to hepatitis C virus: A 17-year cohort study of 214 patients. Hepatology 2006; 43: 1303-1310 [PMID: 16729298 DOI: 10.1002/hep.21176]
    • (2006) Hepatology , vol.43 , pp. 1303-1310
    • Sangiovanni, A.1    Prati, G.M.2    Fasani, P.3    Ronchi, G.4    Romeo, R.5    Manini, M.6    Del Ninno, E.7    Morabito, A.8    Colombo, M.9
  • 11
    • 0034881446 scopus 로고    scopus 로고
    • The role of diabetes in hepatocellular carcinoma: A case-control study among United States Veterans
    • PMID: 11513191
    • El-Serag HB, Richardson PA, Everhart JE. The role of diabetes in hepatocellular carcinoma: a case-control study among United States Veterans. Am J Gastroenterol 2001; 96: 2462-2467 [PMID: 11513191 DOI: 10.1111/j.1572-0241.2001.04054.x]
    • (2001) Am J Gastroenterol , vol.96 , pp. 2462-2467
    • El-Serag, H.B.1    Richardson, P.A.2    Everhart, J.E.3
  • 12
    • 12444285909 scopus 로고    scopus 로고
    • Alcohol, tobacco and obesity are synergistic risk factors for hepatocellular carcinoma
    • PMID: 15664247
    • Marrero JA, Fontana RJ, Fu S, Conjeevaram HS, Su GL, Lok AS. Alcohol, tobacco and obesity are synergistic risk factors for hepatocellular carcinoma. J Hepatol 2005; 42: 218-224 [PMID: 15664247 DOI: 10.1016/j.jhep.2004.10.005]
    • (2005) J Hepatol , vol.42 , pp. 218-224
    • Marrero, J.A.1    Fontana, R.J.2    Fu, S.3    Conjeevaram, H.S.4    Su, G.L.5    Lok, A.S.6
  • 14
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    • PMID: 12711737
    • Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003; 348: 1625-1638 [PMID: 12711737 DOI: 10.1056/NEJMoa021423]
    • (2003) N Engl J Med , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 16
    • 84865127217 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms and risk of hepatocellular carcinoma in cirrhosis
    • PMID: 22609306
    • Nahon P, Zucman-Rossi J. Single nucleotide polymorphisms and risk of hepatocellular carcinoma in cirrhosis. J Hepatol 2012; 57: 663-674 [PMID: 22609306 DOI: 10.1016/ j.jhep.2012.02.035]
    • (2012) J Hepatol , vol.57 , pp. 663-674
    • Nahon, P.1    Zucman-Rossi, J.2
  • 19
    • 30044431801 scopus 로고    scopus 로고
    • From fat to inflammation
    • PMID: 16401483
    • Day CP. From fat to inflammation. Gastroenterology 2006; 130: 207-210 [PMID: 16401483 DOI: 10.1053/j.gastro.2005.11.017]
    • Gastroenterology 2006 , vol.130 , pp. 207-210
    • Day, C.P.1
  • 21
    • 84880245463 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease in the United States: The Third National Health and Nutrition Examination Survey, 1988-1994
    • PMID: 23703888
    • Lazo M, Hernaez R, Eberhardt MS, Bonekamp S, Kamel I, Guallar E, Koteish A, Brancati FL, Clark JM. Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1988-1994. Am J Epidemiol 2013; 178: 38-45 [PMID: 23703888 DOI: 10.1093/aje/kws448]
    • (2013) Am J Epidemiol , vol.178 , pp. 38-45
    • Lazo, M.1    Hernaez, R.2    Eberhardt, M.S.3    Bonekamp, S.4    Kamel, I.5    Guallar, E.6    Koteish, A.7    Brancati, F.L.8    Clark, J.M.9
  • 22
    • 84874053088 scopus 로고    scopus 로고
    • The burden of liver disease in Europe: A review of available epidemiological data
    • PMID: 23419824
    • Blachier M, Leleu H, Peck-Radosavljevic M, Valla DC, Roudot-Thoraval F. The burden of liver disease in Europe: a review of available epidemiological data. J Hepatol 2013; 58: 593-608 [PMID: 23419824 DOI: 10.1016/j.jhep.2012.12.005]
    • (2013) J Hepatol , vol.58 , pp. 593-608
    • Blachier, M.1    Leleu, H.2    Peck-Radosavljevic, M.3    Valla, D.C.4    Roudot-Thoraval, F.5
  • 24
    • 73149120271 scopus 로고    scopus 로고
    • Metabolic syndrome and hepatocellular carcinoma: Two growing epidemics with a potential link
    • PMID: 19834957
    • Siegel AB, Zhu AX. Metabolic syndrome and hepatocellular carcinoma: two growing epidemics with a potential link. Cancer 2009; 115: 5651-5661 [PMID: 19834957 DOI: 10.1002/ cncr.24687]
    • (2009) Cancer , vol.115 , pp. 5651-5661
    • Siegel, A.B.1    Zhu, A.X.2
  • 25
    • 0036894480 scopus 로고    scopus 로고
    • NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States
    • PMID: 12447858
    • Marrero JA, Fontana RJ, Su GL, Conjeevaram HS, Emick DM, Lok AS. NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States. Hepatology 2002; 36: 1349-1354 [PMID: 12447858 DOI: 10.1053/jhep.2002.36939]
    • (2002) Hepatology , vol.36 , pp. 1349-1354
    • Marrero, J.A.1    Fontana, R.J.2    Su, G.L.3    Conjeevaram, H.S.4    Emick, D.M.5    Lok, A.S.6
  • 30
    • 77952730428 scopus 로고    scopus 로고
    • The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
    • PMID: 20209604
    • Ascha MS, Hanouneh IA, Lopez R, Tamimi TA, Feldstein AF, Zein NN. The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology 2010; 51: 1972-1978 [PMID: 20209604 DOI: 10.1002/hep.23527]
    • (2010) Hepatology , vol.51 , pp. 1972-1978
    • Ascha, M.S.1    Hanouneh, I.A.2    Lopez, R.3    Tamimi, T.A.4    Feldstein, A.F.5    Zein, N.N.6
  • 31
    • 0842321807 scopus 로고    scopus 로고
    • Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma
    • PMID: 14762783
    • El-Serag HB, Tran T, Everhart JE. Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma. Gastroenterology 2004; 126: 460-468 [PMID: 14762783 DOI: 10.1053/j.gastro.2003.10.065]
    • (2004) Gastroenterology , vol.126 , pp. 460-468
    • El-Serag, H.B.1    Tran, T.2    Everhart, J.E.3
  • 32
    • 77950803622 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis-associated hepatocellular carcinoma: Our case series and literature review
    • PMID: 20333782
    • Takuma Y, Nouso K. Nonalcoholic steatohepatitis-associated hepatocellular carcinoma: our case series and literature review. World J Gastroenterol 2010; 16: 1436-1441 [PMID: 20333782 DOI: 10.3748/wjg.v16.i12.1436]
    • (2010) World J Gastroenterol , vol.16 , pp. 1436-1441
    • Takuma, Y.1    Nouso, K.2
  • 34
    • 0029165057 scopus 로고
    • Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver
    • PMID: 7475591
    • Teli MR, Day CP, Burt AD, Bennett MK, James OF. Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver. Lancet 1995; 346: 987-990 [PMID: 7475591 DOI: 10.1016/S0140-6736(95)91685-7]
    • (1995) Lancet , vol.346 , pp. 987-990
    • Teli, M.R.1    Day, C.P.2    Burt, A.D.3    Bennett, M.K.4    James, O.F.5
  • 35
    • 70349570846 scopus 로고    scopus 로고
    • The immunopathogenesis of alcoholic and nonalcoholic steatohepatitis: Two triggers for one disease?
    • PMID: 19440711
    • Valenti L, Fracanzani AL, Fargion S. The immunopathogenesis of alcoholic and nonalcoholic steatohepatitis: two triggers for one disease? Semin Immunopathol 2009; 31: 359-369 [PMID: 19440711 DOI: 10.1007/s00281-009-0152-9]
    • (2009) Semin Immunopathol , vol.31 , pp. 359-369
    • Valenti, L.1    Fracanzani, A.L.2    Fargion, S.3
  • 36
    • 34250339305 scopus 로고    scopus 로고
    • Hepatic steatosis is associated with increased frequency of hepatocellular carcinoma in patients with hepatitis C-related cirrhosis
    • PMID: 17487861
    • Pekow JR, Bhan AK, Zheng H, Chung RT. Hepatic steatosis is associated with increased frequency of hepatocellular carcinoma in patients with hepatitis C-related cirrhosis. Cancer 2007; 109: 2490-2496 [PMID: 17487861 DOI: 10.1002/ cncr.22701]
    • (2007) Cancer , vol.109 , pp. 2490-2496
    • Pekow, J.R.1    Bhan, A.K.2    Zheng, H.3    Chung, R.T.4
  • 37
    • 34948827036 scopus 로고    scopus 로고
    • Hepatic steatosis as a possible risk factor for the development of hepatocellular carcinoma after eradication of hepatitis C virus with antiviral therapy in patients with chronic hepatitis C
    • PMID: 17876888
    • Tanaka A, Uegaki S, Kurihara H, Aida K, Mikami M, Nagashima I, Shiga J, Takikawa H. Hepatic steatosis as a possible risk factor for the development of hepatocellular carcinoma after eradication of hepatitis C virus with antiviral therapy in patients with chronic hepatitis C. World J Gastroenterol 2007; 13: 5180-5187 [PMID: 17876888]
    • (2007) World J Gastroenterol , vol.13 , pp. 5180-5187
    • Tanaka, A.1    Uegaki, S.2    Kurihara, H.3    Aida, K.4    Mikami, M.5    Nagashima, I.6    Shiga, J.7    Takikawa, H.8
  • 39
    • 78049529652 scopus 로고    scopus 로고
    • Steatohepatitic hepatocellular carcinoma (SH-HCC): A distinctive histological variant of HCC in hepatitis C virusrelated cirrhosis with associated NAFLD/NASH
    • PMID: 20975341
    • Salomao M, Yu WM, Brown RS, Emond JC, Lefkowitch JH. Steatohepatitic hepatocellular carcinoma (SH-HCC): a distinctive histological variant of HCC in hepatitis C virusrelated cirrhosis with associated NAFLD/NASH. Am J Surg Pathol 2010; 34: 1630-1636 [PMID: 20975341 DOI: 10.1097/ PAS.0b013e3181f31caa]
    • (2010) Am J Surg Pathol , vol.34 , pp. 1630-1636
    • Salomao, M.1    Yu, W.M.2    Brown, R.S.3    Emond, J.C.4    Lefkowitch, J.H.5
  • 40
    • 84876951873 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease contributes to hepatocarcinogenesis in non-cirrhotic liver: A clinical and pathological study
    • PMID: 23302015
    • Alexander J, Torbenson M, Wu TT, Yeh MM. Non-alcoholic fatty liver disease contributes to hepatocarcinogenesis in non-cirrhotic liver: a clinical and pathological study. J Gastroenterol Hepatol 2013; 28: 848-854 [PMID: 23302015 DOI: 10.1111/jgh.12116]
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 848-854
    • Alexander, J.1    Torbenson, M.2    Wu, T.T.3    Yeh, M.M.4
  • 42
    • 63349085247 scopus 로고    scopus 로고
    • Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: A pathological analysis
    • PMID: 19115377
    • Paradis V, Zalinski S, Chelbi E, Guedj N, Degos F, Vilgrain V, Bedossa P, Belghiti J. Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis. Hepatology 2009; 49: 851-859 [PMID: 19115377 DOI: 10.1002/hep.22734]
    • (2009) Hepatology , vol.49 , pp. 851-859
    • Paradis, V.1    Zalinski, S.2    Chelbi, E.3    Guedj, N.4    Degos, F.5    Vilgrain, V.6    Bedossa, P.7    Belghiti, J.8
  • 43
    • 34948867745 scopus 로고    scopus 로고
    • Overweight, obesity and risk of liver cancer: A meta-analysis of cohort studies
    • PMID: 17700568
    • Larsson SC, Wolk A. Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies. Br J Cancer 2007; 97: 1005-1008 [PMID: 17700568 DOI: 10.1038/sj.bjc.6603932]
    • (2007) Br J Cancer , vol.97 , pp. 1005-1008
    • Larsson, S.C.1    Wolk, A.2
  • 44
    • 0036138917 scopus 로고    scopus 로고
    • Obesity and its effect on survival in patients undergoing orthotopic liver transplantation in the United States
    • PMID: 11786965
    • Nair S, Verma S, Thuluvath PJ. Obesity and its effect on survival in patients undergoing orthotopic liver transplantation in the United States. Hepatology 2002; 35: 105-109 [PMID: 11786965 DOI: 10.1053/jhep.2002.30318]
    • (2002) Hepatology , vol.35 , pp. 105-109
    • Nair, S.1    Verma, S.2    Thuluvath, P.J.3
  • 45
    • 15544382574 scopus 로고    scopus 로고
    • Diabetes increases the risk of hepatocellular carcinoma in the United States: A population based case control study
    • PMID: 15753540
    • Davila JA, Morgan RO, Shaib Y, McGlynn KA, El-Serag HB. Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study. Gut 2005; 54: 533-539 [PMID: 15753540 DOI: 10.1136/ gut.2004.052167]
    • (2005) Gut , vol.54 , pp. 533-539
    • Davila, J.A.1    Morgan, R.O.2    Shaib, Y.3    McGlynn, K.A.4    El-Serag, H.B.5
  • 46
    • 3543072186 scopus 로고    scopus 로고
    • Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms
    • PMID: 15286738
    • Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 2004; 4: 579-591 [PMID: 15286738 DOI: 10.1038/nrc1408]
    • (2004) Nat Rev Cancer , vol.4 , pp. 579-591
    • Calle, E.E.1    Kaaks, R.2
  • 48
    • 84855432249 scopus 로고    scopus 로고
    • Risk of hepatocellular carcinoma in diabetic patients and risk reduction associated with anti-diabetic therapy: A populationbased cohort study
    • PMID: 22085817
    • Lai SW, Chen PC, Liao KF, Muo CH, Lin CC, Sung FC. Risk of hepatocellular carcinoma in diabetic patients and risk reduction associated with anti-diabetic therapy: a populationbased cohort study. Am J Gastroenterol 2012; 107: 46-52 [PMID: 22085817 DOI: 10.1038/ajg.2011.384]
    • (2012) Am J Gastroenterol , vol.107 , pp. 46-52
    • Lai, S.W.1    Chen, P.C.2    Liao, K.F.3    Muo, C.H.4    Lin, C.C.5    Sung, F.C.6
  • 49
    • 84881171445 scopus 로고    scopus 로고
    • Population-attributable fractions of risk factors for hepatocellular carcinoma in the United States
    • PMID: 23752878
    • Welzel TM, Graubard BI, Quraishi S, Zeuzem S, Davila JA, El-Serag HB, McGlynn KA. Population-attributable fractions of risk factors for hepatocellular carcinoma in the United States. Am J Gastroenterol 2013; 108: 1314-1321 [PMID: 23752878 DOI: 10.1038/ajg.2013.160]
    • (2013) Am J Gastroenterol , vol.108 , pp. 1314-1321
    • Welzel, T.M.1    Graubard, B.I.2    Quraishi, S.3    Zeuzem, S.4    Davila, J.A.5    El-Serag, H.B.6    McGlynn, K.A.7
  • 50
    • 84892942788 scopus 로고    scopus 로고
    • The association between metabolic syndrome and hepatocellular carcinoma: Systemic review and meta-analysis
    • PMID: 24402120
    • Jinjuvadia R, Patel S, Liangpunsakul S. The association between metabolic syndrome and hepatocellular carcinoma: systemic review and meta-analysis. J Clin Gastroenterol 2014; 48: 172-177 [PMID: 24402120 DOI: 10.1097/ MCG.0b013e3182a030c4]
    • (2014) J Clin Gastroenterol , vol.48 , pp. 172-177
    • Jinjuvadia, R.1    Patel, S.2    Liangpunsakul, S.3
  • 51
    • 84984548367 scopus 로고    scopus 로고
    • Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: A follow-up study in Taiwan
    • PMID: 18505690
    • Chen CL, Yang HI, Yang WS, Liu CJ, Chen PJ, You SL, Wang LY, Sun CA, Lu SN, Chen DS, Chen CJ. Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan. Gastroenterology 2008; 135: 111-121 [PMID: 18505690 DOI: 10.1053/ j.gastro.2008.03.073]
    • (2008) Gastroenterology , vol.135 , pp. 111-121
    • Chen, C.L.1    Yang, H.I.2    Yang, W.S.3    Liu, C.J.4    Chen, P.J.5    You, S.L.6    Wang, L.Y.7    Sun, C.A.8    Lu, S.N.9    Chen, D.S.10    Chen, C.J.11
  • 52
    • 77957200500 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease as a risk factor for hepatocellular carcinoma: Mechanisms and implications
    • PMID: 20650925
    • Stickel F, Hellerbrand C. Non-alcoholic fatty liver disease as a risk factor for hepatocellular carcinoma: mechanisms and implications. Gut 2010; 59: 1303-1307 [PMID: 20650925 DOI: 10.1136/gut.2009.199661]
    • (2010) Gut , vol.59 , pp. 1303-1307
    • Stickel, F.1    Hellerbrand, C.2
  • 53
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • PMID: 20141834
    • Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, Osterreicher CH, Takahashi H, Karin M. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010; 140: 197-208 [PMID: 20141834 DOI: 10.1016/j.cell.2009.12.052]
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3    He, G.4    Ali, S.R.5    Holzer, R.G.6    Osterreicher, C.H.7    Takahashi, H.8    Karin, M.9
  • 54
    • 70349238777 scopus 로고    scopus 로고
    • Adipokines in liver diseases
    • PMID: 19585655
    • Marra F, Bertolani C. Adipokines in liver diseases. Hepatology 2009; 50: 957-969 [PMID: 19585655 DOI: 10.1002/hep.23046]
    • (2009) Hepatology , vol.50 , pp. 957-969
    • Marra, F.1    Bertolani, C.2
  • 55
    • 34748912615 scopus 로고    scopus 로고
    • Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
    • PMID: 17882277
    • Menendez JA, Lupu R. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 2007; 7: 763-777 [PMID: 17882277 DOI: 10.1038/nrc2222]
    • (2007) Nat Rev Cancer , vol.7 , pp. 763-777
    • Menendez, J.A.1    Lupu, R.2
  • 56
    • 56949099962 scopus 로고    scopus 로고
    • Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma
    • PMID: 19008011
    • Yamashita T, Honda M, Takatori H, Nishino R, Minato H, Takamura H, Ohta T, Kaneko S. Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma. J Hepatol 2009; 50: 100-110 [PMID: 19008011 DOI: 10.1016/j.jhep.2008.07.036]
    • (2009) J Hepatol , vol.50 , pp. 100-110
    • Yamashita, T.1    Honda, M.2    Takatori, H.3    Nishino, R.4    Minato, H.5    Takamura, H.6    Ohta, T.7    Kaneko, S.8
  • 57
    • 67349210047 scopus 로고    scopus 로고
    • Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN
    • PMID: 19398230
    • Vinciguerra M, Carrozzino F, Peyrou M, Carlone S, Montesano R, Benelli R, Foti M. Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN. J Hepatol 2009; 50: 1132-1141 [PMID: 19398230 DOI: 10.1016/j.jhep.2009.01.027]
    • (2009) J Hepatol , vol.50 , pp. 1132-1141
    • Vinciguerra, M.1    Carrozzino, F.2    Peyrou, M.3    Carlone, S.4    Montesano, R.5    Benelli, R.6    Foti, M.7
  • 58
    • 79959466358 scopus 로고    scopus 로고
    • Minireview: IGF, Insulin, and Cancer
    • PMID: 21540285
    • Gallagher EJ, LeRoith D. Minireview: IGF, Insulin, and Cancer. Endocrinology 2011; 152: 2546-2551 [PMID: 21540285 DOI: 10.1210/en.2011-0231]
    • (2011) Endocrinology , vol.152 , pp. 2546-2551
    • Gallagher, E.J.1    LeRoith, D.2
  • 59
    • 0030866199 scopus 로고    scopus 로고
    • Excess iron induces hepatic oxidative stress and transforming growth factor beta1 in genetic hemochromatosis
    • PMID: 9303489
    • Houglum K, Ramm GA, Crawford DH, Witztum JL, Powell LW, Chojkier M. Excess iron induces hepatic oxidative stress and transforming growth factor beta1 in genetic hemochromatosis. Hepatology 1997; 26: 605-610 [PMID: 9303489 DOI: 10.1002/hep.510260311]
    • (1997) Hepatology , vol.26 , pp. 605-610
    • Houglum, K.1    Ramm, G.A.2    Crawford, D.H.3    Witztum, J.L.4    Powell, L.W.5    Chojkier, M.6
  • 60
    • 84869210296 scopus 로고    scopus 로고
    • Effect of the A736V TMPRSS6 polymorphism on the penetrance and clinical expression of hereditary hemochromatosis
    • PMID: 22885719
    • Valenti L, Fracanzani AL, Rametta R, Fraquelli M, Soverini G, Pelusi S, Dongiovanni P, Conte D, Fargion S. Effect of the A736V TMPRSS6 polymorphism on the penetrance and clinical expression of hereditary hemochromatosis. J Hepatol 2012; 57: 1319-1325 [PMID: 22885719 DOI: 10.1016/ j.jhep.2012.07.041]
    • (2012) J Hepatol , vol.57 , pp. 1319-1325
    • Valenti, L.1    Fracanzani, A.L.2    Rametta, R.3    Fraquelli, M.4    Soverini, G.5    Pelusi, S.6    Dongiovanni, P.7    Conte, D.8    Fargion, S.9
  • 61
    • 28444435827 scopus 로고    scopus 로고
    • Iron in nonhemochromatotic liver disorders
    • PMID: 16315139
    • Alla V, Bonkovsky HL. Iron in nonhemochromatotic liver disorders. Semin Liver Dis 2005; 25: 461-472 [PMID: 16315139 DOI: 10.1055/s-2005-923317]
    • (2005) Semin Liver Dis , vol.25 , pp. 461-472
    • Alla, V.1    Bonkovsky, H.L.2
  • 63
    • 0034891077 scopus 로고    scopus 로고
    • Hyperferritinemia, iron overload, and multiple metabolic alterations identify patients at risk for nonalcoholic steatohepatitis
    • PMID: 11513189
    • Fargion S, Mattioli M, Fracanzani AL, Sampietro M, Tavazzi D, Fociani P, Taioli E, Valenti L, Fiorelli G. Hyperferritinemia, iron overload, and multiple metabolic alterations identify patients at risk for nonalcoholic steatohepatitis. Am J Gastroenterol 2001; 96: 2448-2455 [PMID: 11513189 DOI: 10.1111/j.1572-0241.2001.04052.x]
    • (2001) Am J Gastroenterol , vol.96 , pp. 2448-2455
    • Fargion, S.1    Mattioli, M.2    Fracanzani, A.L.3    Sampietro, M.4    Tavazzi, D.5    Fociani, P.6    Taioli, E.7    Valenti, L.8    Fiorelli, G.9
  • 68
    • 34249098685 scopus 로고    scopus 로고
    • Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: Evidence from a case-control study
    • PMID: 17391316
    • Valenti L, Fracanzani AL, Dongiovanni P, Bugianesi E, Marchesini G, Manzini P, Vanni E, Fargion S. Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study. Am J Gastroenterol 2007; 102: 1251-1258 [PMID: 17391316 DOI: 10.1111/j.1572-0241.2007.01192.x]
    • (2007) Am J Gastroenterol , vol.102 , pp. 1251-1258
    • Valenti, L.1    Fracanzani, A.L.2    Dongiovanni, P.3    Bugianesi, E.4    Marchesini, G.5    Manzini, P.6    Vanni, E.7    Fargion, S.8
  • 69
    • 0028901928 scopus 로고
    • The effects of dietary iron on initiation and promotion in chemical hepatocarcinogenesis
    • PMID: 7843726
    • Stál P, Hultcrantz R, Möller L, Eriksson LC. The effects of dietary iron on initiation and promotion in chemical hepatocarcinogenesis. Hepatology 1995; 21: 521-528 [PMID: 7843726 DOI: 10.1016/0270-9139(95)90115-9]
    • (1995) Hepatology , vol.21 , pp. 521-528
    • Stál, P.1    Hultcrantz, R.2    Möller, L.3    Eriksson, L.C.4
  • 70
    • 0031416758 scopus 로고    scopus 로고
    • Iron promotes DEN initiated GST-P foci in rat liver
    • PMID: 9067562
    • Carthew P, Nolan BM, Smith AG, Edwards RE. Iron promotes DEN initiated GST-P foci in rat liver. Carcinogenesis 1997; 18: 599-603 [PMID: 9067562 DOI: 10.1093/carcin/ 18.3.599]
    • (1997) Carcinogenesis , vol.18 , pp. 599-603
    • Carthew, P.1    Nolan, B.M.2    Smith, A.G.3    Edwards, R.E.4
  • 71
    • 58149280387 scopus 로고    scopus 로고
    • Liver iron excess in patients with hepatocellular carcinoma developed on non-alcoholic steato-hepatitis
    • PMID: 19070395
    • Sorrentino P, D'Angelo S, Ferbo U, Micheli P, Bracigliano A, Vecchione R. Liver iron excess in patients with hepatocellular carcinoma developed on non-alcoholic steato-hepatitis. J Hepatol 2009; 50: 351-357 [PMID: 19070395 DOI: 10.1016/ j.jhep.2008.09.011]
    • (2009) J Hepatol , vol.50 , pp. 351-357
    • Sorrentino, P.1    D'Angelo, S.2    Ferbo, U.3    Micheli, P.4    Bracigliano, A.5    Vecchione, R.6
  • 72
    • 80052940689 scopus 로고    scopus 로고
    • Iron in fatty liver and in the metabolic syndrome: A promising therapeutic target
    • PMID: 21718726
    • Dongiovanni P, Fracanzani AL, Fargion S, Valenti L. Iron in fatty liver and in the metabolic syndrome: a promising therapeutic target. J Hepatol 2011; 55: 920-932 [PMID: 21718726 DOI: 10.1016/j.jhep.2011.05.008]
    • (2011) J Hepatol , vol.55 , pp. 920-932
    • Dongiovanni, P.1    Fracanzani, A.L.2    Fargion, S.3    Valenti, L.4
  • 73
    • 84880198084 scopus 로고    scopus 로고
    • Genetic predisposition in NAFLD and NASH: Impact on severity of liver disease and response to treatment
    • PMID: 23394097
    • Dongiovanni P, Anstee QM, Valenti L. Genetic predisposition in NAFLD and NASH: impact on severity of liver disease and response to treatment. Curr Pharm Des 2013; 19: 5219-5238 [PMID: 23394097 DOI: 10.2174/1381612811319999 0381]
    • (2013) Curr Pharm des , vol.19 , pp. 5219-5238
    • Dongiovanni, P.1    Anstee, Q.M.2    Valenti, L.3
  • 77
    • 84881559322 scopus 로고    scopus 로고
    • PNPLA3 I148M variant and hepatocellular carcinoma: A common genetic variant for a rare disease
    • PMID: 23333103
    • Valenti L, Dongiovanni P, Ginanni Corradini S, Burza MA, Romeo S. PNPLA3 I148M variant and hepatocellular carcinoma: a common genetic variant for a rare disease. Dig Liver Dis 2013; 45: 619-624 [PMID: 23333103 DOI: 10.1016/ j.dld.2012.12.006]
    • (2013) Dig Liver Dis , vol.45 , pp. 619-624
    • Valenti, L.1    Dongiovanni, P.2    Ginanni Corradini, S.3    Burza, M.A.4    Romeo, S.5
  • 81
    • 77949895032 scopus 로고    scopus 로고
    • A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis
    • PMID: 20034933
    • He S, McPhaul C, Li JZ, Garuti R, Kinch L, Grishin NV, Cohen JC, Hobbs HH. A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis. J Biol Chem 2010; 285: 6706-6715 [PMID: 20034933 DOI: 10.1074/jbc.M109.064501]
    • (2010) J Biol Chem , vol.285 , pp. 6706-6715
    • He, S.1    McPhaul, C.2    Li, J.Z.3    Garuti, R.4    Kinch, L.5    Grishin, N.V.6    Cohen, J.C.7    Hobbs, H.H.8
  • 86
    • 79957462315 scopus 로고    scopus 로고
    • Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
    • PMID: 21381068
    • Sookoian S, Pirola CJ. Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. Hepatology 2011; 53: 1883-1894 [PMID: 21381068 DOI: 10.1002/hep.24283]
    • (2011) Hepatology , vol.53 , pp. 1883-1894
    • Sookoian, S.1    Pirola, C.J.2
  • 87
    • 73349111259 scopus 로고    scopus 로고
    • Variant in PNPLA3 is associated with alcoholic liver disease
    • PMID: 19946271
    • Tian C, Stokowski RP, Kershenobich D, Ballinger DG, Hinds DA. Variant in PNPLA3 is associated with alcoholic liver disease. Nat Genet 2010; 42: 21-23 [PMID: 19946271 DOI: 10.1038/ng.488]
    • (2010) Nat Genet , vol.42 , pp. 21-23
    • Tian, C.1    Stokowski, R.P.2    Kershenobich, D.3    Ballinger, D.G.4    Hinds, D.A.5
  • 90
    • 84863108828 scopus 로고    scopus 로고
    • Patatin-like phospholipase domain containing-3 gene I148M polymorphism, steatosis, and liver damage in hereditary hemochromatosis
    • PMID: 22719190
    • Valenti L, Maggioni P, Piperno A, Rametta R, Pelucchi S, Mariani R, Dongiovanni P, Fracanzani AL, Fargion S. Patatin-like phospholipase domain containing-3 gene I148M polymorphism, steatosis, and liver damage in hereditary hemochromatosis. World J Gastroenterol 2012; 18: 2813-2820 [PMID: 22719190 DOI: 10.3748/wjg.v18.i22.2813]
    • (2012) World J Gastroenterol , vol.18 , pp. 2813-2820
    • Valenti, L.1    Maggioni, P.2    Piperno, A.3    Rametta, R.4    Pelucchi, S.5    Mariani, R.6    Dongiovanni, P.7    Fracanzani, A.L.8    Fargion, S.9
  • 92
    • 84859147155 scopus 로고    scopus 로고
    • PNPLA3 (rs738409 C& gt; G) is a common risk variant associated with hepatocellular carcinoma in alcoholic cirrhosis
    • PMID: 22162034
    • Trepo E, Guyot E, Ganne-Carrie N, Degre D, Gustot T, Franchimont D, Sutton A, Nahon P, Moreno C. PNPLA3 (rs738409 C& gt; G) is a common risk variant associated with hepatocellular carcinoma in alcoholic cirrhosis. Hepatology 2012; 55: 1307-1308 [PMID: 22162034 DOI: 10.1002/ hep.25518]
    • (2012) Hepatology , vol.55 , pp. 1307-1308
    • Trepo, E.1    Guyot, E.2    Ganne-Carrie, N.3    Degre, D.4    Gustot, T.5    Franchimont, D.6    Sutton, A.7    Nahon, P.8    Moreno, C.9
  • 93
    • 79955085671 scopus 로고    scopus 로고
    • Patatin-like phospholipase domain containing 3 sequence variant and hepatocellular carcinoma
    • author reply 1777 PMID: 21351112
    • Corradini SG, Burza MA, Molinaro A, Romeo S. Patatin-like phospholipase domain containing 3 sequence variant and hepatocellular carcinoma. Hepatology 2011; 53: 1776; author reply 1777 [PMID: 21351112 DOI: 10.1002/hep.24244]
    • (2011) Hepatology , vol.53 , pp. 1776
    • Corradini, S.G.1    Burza, M.A.2    Molinaro, A.3    Romeo, S.4
  • 99
    • 84902688337 scopus 로고    scopus 로고
    • Carriage of the PNPLA3 rs738409 C & gt; G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma
    • PMID: 24607626
    • Liu YL, Patman GL, Leathart JB, Piguet AC, Burt AD, Dufour JF, Day CP, Daly AK, Reeves HL, Anstee QM. Carriage of the PNPLA3 rs738409 C & gt; G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma. J Hepatol 2014; 61: 75-81 [PMID: 24607626 DOI: 10.1016/j.jhep.2014.02.030]
    • (2014) J Hepatol , vol.61 , pp. 75-81
    • Liu, Y.L.1    Patman, G.L.2    Leathart, J.B.3    Piguet, A.C.4    Burt, A.D.5    Dufour, J.F.6    Day, C.P.7    Daly, A.K.8    Reeves, H.L.9    Anstee, Q.M.10
  • 102
    • 0031772878 scopus 로고    scopus 로고
    • Familial heterozygous hypobetalipoproteinemia, extrahepatic primary malignancy, and hepatocellular carcinoma
    • PMID: 9824140
    • Lonardo A, Tarugi P, Ballarini G, Bagni A. Familial heterozygous hypobetalipoproteinemia, extrahepatic primary malignancy, and hepatocellular carcinoma. Dig Dis Sci 1998; 43: 2489-2492 [PMID: 9824140]
    • (1998) Dig Dis Sci , vol.43 , pp. 2489-2492
    • Lonardo, A.1    Tarugi, P.2    Ballarini, G.3    Bagni, A.4
  • 105
    • 35948992285 scopus 로고    scopus 로고
    • Transcriptional regulation of telomerase activity: Roles of the the Ets transcription factor family
    • PMID: 17986575
    • Dwyer J, Li H, Xu D, Liu JP. Transcriptional regulation of telomerase activity: roles of the the Ets transcription factor family. Ann N Y Acad Sci 2007; 1114: 36-47 [PMID: 17986575 DOI: 10.1196/annals.1396.022]
    • (2007) Ann N Y Acad Sci , vol.1114 , pp. 36-47
    • Dwyer, J.1    Li, H.2    Xu, D.3    Liu, J.P.4
  • 106
    • 84858750992 scopus 로고    scopus 로고
    • Regulation of the human catalytic subunit of telomerase (hTERT)
    • PMID: 22381618
    • Daniel M, Peek GW, Tollefsbol TO. Regulation of the human catalytic subunit of telomerase (hTERT). Gene 2012; 498: 135-146 [PMID: 22381618 DOI: 10.1016/j.gene.2012.01.095]
    • (2012) Gene , vol.498 , pp. 135-146
    • Daniel, M.1    Peek, G.W.2    Tollefsbol, T.O.3
  • 107
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • PMID: 21376230
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674 [PMID: 21376230 DOI: 10.1016/j.cell.2011.02.013]
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 108
    • 79955097706 scopus 로고    scopus 로고
    • Telomerase mutation: A genetic risk factor for cirrhosis
    • PMID: 21425310
    • Chaiteerakij R, Roberts LR. Telomerase mutation: a genetic risk factor for cirrhosis. Hepatology 2011; 53: 1430-1432 [PMID: 21425310 DOI: 10.1002/hep.24304]
    • (2011) Hepatology , vol.53 , pp. 1430-1432
    • Chaiteerakij, R.1    Roberts, L.R.2
  • 111
    • 0034681457 scopus 로고    scopus 로고
    • Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery
    • PMID: 10678830
    • Rudolph KL, Chang S, Millard M, Schreiber-Agus N, DePinho RA. Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery. Science 2000; 287: 1253-1258 [PMID: 10678830 DOI: 10.1126/science.287.5456.1253]
    • (2000) Science , vol.287 , pp. 1253-1258
    • Rudolph, K.L.1    Chang, S.2    Millard, M.3    Schreiber-Agus, N.4    DePinho, R.A.5
  • 114
    • 84872408259 scopus 로고    scopus 로고
    • Liver transplantation for hepatocellular carcinoma in a patient with a novel telomerase mutation and steatosis
    • PMID: 23000435
    • Valenti L, Dongiovanni P, Maggioni M, Motta BM, Rametta R, Milano M, Fargion S, Reggiani P, Fracanzani AL. Liver transplantation for hepatocellular carcinoma in a patient with a novel telomerase mutation and steatosis. J Hepatol 2013; 58: 399-401 [PMID: 23000435 DOI: 10.1016/ j.jhep.2012.09.011]
    • (2013) J Hepatol , vol.58 , pp. 399-401
    • Valenti, L.1    Dongiovanni, P.2    Maggioni, M.3    Motta, B.M.4    Rametta, R.5    Milano, M.6    Fargion, S.7    Reggiani, P.8    Fracanzani, A.L.9
  • 116
    • 72949096792 scopus 로고    scopus 로고
    • Senescence in tumours: Evidence from mice and humans
    • PMID: 20029423
    • Collado M, Serrano M. Senescence in tumours: evidence from mice and humans. Nat Rev Cancer 2010; 10: 51-57 [PMID: 20029423 DOI: 10.1038/nrc2772]
    • (2010) Nat Rev Cancer , vol.10 , pp. 51-57
    • Collado, M.1    Serrano, M.2
  • 117
    • 79954487874 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrogenesis
    • PMID: 21497738
    • Lee UE, Friedman SL. Mechanisms of hepatic fibrogenesis. Best Pract Res Clin Gastroenterol 2011; 25: 195-206 [PMID: 21497738 DOI: 10.1016/j.bpg.2011.02.005]
    • (2011) Best Pract Res Clin Gastroenterol , vol.25 , pp. 195-206
    • Lee, U.E.1    Friedman, S.L.2
  • 119
    • 0037370003 scopus 로고    scopus 로고
    • Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype
    • PMID: 12601363
    • Schnabl B, Purbeck CA, Choi YH, Hagedorn CH, Brenner D. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Hepatology 2003; 37: 653-664 [PMID: 12601363 DOI: 10.1053/jhep.2003.50097]
    • (2003) Hepatology , vol.37 , pp. 653-664
    • Schnabl, B.1    Purbeck, C.A.2    Choi, Y.H.3    Hagedorn, C.H.4    Brenner, D.5
  • 120
    • 84879880646 scopus 로고    scopus 로고
    • Cancer: An acidic link
    • PMID: 23803768
    • Devkota S, Turnbaugh PJ. Cancer: An acidic link. Nature 2013; 499: 37-38 [PMID: 23803768 DOI: 10.1038/nature12404]
    • (2013) Nature , vol.499 , pp. 37-38
    • Devkota, S.1    Turnbaugh, P.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.