Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions

Journal of Medicinal Chemistry

Volumn 59, Issue 7, 2016, Pages 2962-2972

  Murza, Alexandre ^a,d   Sainsily, Xavier ^a,d   Coquerel, David ^a   Côté, Jérôme ^a,d   Marx, Patricia ^a,d   Besserer Offroy, Élie ^a,d   Longpré, Jean Michel ^a,d   Lainé, Jean ^a   Reversade, Bruno ^c   Salvail, Dany ^b   Leduc, Richard ^a,d   Dumaine, Robert ^a   Lesur, Olivier ^a   Auger Messier, Mannix ^a   Sarret, Philippe ^a,d   Marsault, Éric ^a,d  

^a UNIVERSITY OF SHERBROOKE   (Canada)

^b IPS Therapeutique Inc   (Canada)

^c INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

^d UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

APELIN; APELIN 13; APELIN RECEPTOR; BETA ARRESTIN 2; CARDIOVASCULAR AGENT; ELABELA PEPTIDE; ELABELA(19-32); PEPTIDE DERIVATIVE; PROTEIN; UNCLASSIFIED DRUG; APELIN-13 PEPTIDE; APLNR PROTEIN, HUMAN; ELA PEPTIDE, HUMAN; G PROTEIN COUPLED RECEPTOR; PEPTIDE FRAGMENT; PEPTIDE HORMONE; SIGNAL PEPTIDE;

ADULT; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BINDING AFFINITY; BLOOD VESSEL FUNCTION; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; EMBRYO DEVELOPMENT; HEART FUNCTION; HEART HEMODYNAMICS; IN VIVO STUDY; INOTROPISM; INTERNALIZATION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PEPTIDE SYNTHESIS; PHARMACOPHORE; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN STRUCTURE; RAT; RECEPTOR BINDING; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; SYSTOLIC BLOOD PRESSURE; TRANSTHORACIC ECHOCARDIOGRAPHY; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; BLOOD PRESSURE; CHEMISTRY; DRUG EFFECTS; ELECTROCARDIOGRAPHY; HEART; HEART VENTRICLE; HUMAN; METABOLISM; MOLECULAR GENETICS; ORGAN CULTURE TECHNIQUE; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BLOOD PRESSURE; CARDIOVASCULAR AGENTS; ELECTROCARDIOGRAPHY; HEART; HEART VENTRICLES; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MOLECULAR SEQUENCE DATA; ORGAN CULTURE TECHNIQUES; PEPTIDE FRAGMENTS; PEPTIDE HORMONES; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84966309411     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01549     Document Type: Article

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