By interacting with the C-terminal Phe of apelin, Phe255 and Trp259in helix VI of the apelin receptor are critical for internalization

Journal of Biological Chemistry

Volumn 285, Issue 42, 2010, Pages 32627-32637

  Iturrioz, Xavier ^a   Gerbier, Romain ^a,c   Leroux, Vincent ^b   Alvear Perez, Rodrigo ^a   Maigret, Bernard ^b   Llorens Cortes, Catherine ^a  

^a INSERM   (France)

^b CNRS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING POCKETS; BODY FLUID HOMEOSTASIS; CARDIOVASCULAR FUNCTION; G PROTEIN COUPLED RECEPTORS; HYDROPHOBIC CAVITIES; RECEPTOR ACTIVATION; SITE DIRECTED MUTAGENESIS; THREE-DIMENSIONAL MODEL; TRANSMEMBRANE DOMAIN;

ACTIVATION ANALYSIS; BINDING ENERGY; BIOLOGICAL MEMBRANES; BODY FLUIDS; HYDROPHOBICITY; PROTEINS;

THREE DIMENSIONAL;

ALANINE; APELIN; APELIN RECEPTOR; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; PHENYLALANINE; TRYPTOPHAN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HYDROPHOBICITY; INTERNALIZATION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; PROTEIN CONFORMATION; RADIOLIGAND ASSAY; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT FUSION PROTEINS; TRYPTOPHAN;

EID: 77957815249     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.127167     Document Type: Article

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