Evaluation of novel cyclic analogues of apelin

International Journal of Molecular Medicine

Volumn 22, Issue 4, 2008, Pages 547-552

  Hamada, Juri ^a   Kimura, Junko ^a   Ishida, Junji ^a   Kohda, Takeo ^a   Morishita, Setsuo ^a   Ichihara, Shigeyasu ^a   Fukamizu, Akiyoshi ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Apelin; G protein

Indexed keywords

AMINO ACID; APELIN; APELIN DERIVATIVE; CELL SURFACE RECEPTOR; CYCLIC AMP; CYCLIC APELIN 12; CYCLO APELIN 12; CYCLOUREA APELIN 12; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; PERTUSSIS TOXIN; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LINE; CONTROLLED STUDY; CYCLIZATION; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; CELL LINE; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MOLECULAR SEQUENCE DATA; PEPTIDES, CYCLIC; PERTUSSIS TOXIN; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, G-PROTEIN-COUPLED; TIME FACTORS;

EID: 54049088938     PISSN: 11073756     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijmm_00000054     Document Type: Article

References (30)

1. O'Dowd BF, Heiber M, Chan A, et al: A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene 136: 355-360, 1993.
2. Tatemoto K, Hosoya M, Habata Y, et al: Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun 251: 471-476, 1998.
3. Zou MX, Liu HY, Haraguchi Y, Soda Y, Tatemoto K and Hoshino H: Apelin peptides block the entry of human immuno-deficiency virus (HIV). FEBS Lett 473: 15-18, 2000.
4. Lee DK, George SR and O'Dowd BF: Unravelling the roles of the apelin system: prospective therapeutic applications in heart failure and obesity. Trends Pharmacol Sci 27: 190-194, 2006.
5. Japp AG and Newby DE: The apelin-APJ system in heart failure Pathophysiologic relevance and therapeutic potential. Biochem Pharmacol 75: 1882-1892, 2008.
6. Cayabyab M, Hinuma S, Farzan M, et al: Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry. J Virol 74: 11972-11976, 2000.
7. Szokodi I, Tavi P, Foldes G, et al: Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility. Circ Res 91: 434-440, 2002.
8. Berry MF, Pirolli TJ, Jayasankar V, Burdick J, Morine KJ, Gardner TJ and Woo YJ: Apelin has in vivo inotropie effects on normal and failing hearts. Circulation 110: II187-II193,2004.
9. Ishida J, Hashimoto T, Hashimoto Y, et al: Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo. J Biol Chem 279: 26274-26279, 2004.
10. Ashley EA, Powers J, Chen M, et al: The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo. Cardiovase Res 65: 73-82, 2005.
11. Jia YX, Pan CS, Zhang J, et al: Apelin protects myocardial injury induced by isoproterenol in rats. Regul Pept 133: 147-154, 2006.
12. Simpkin JC, Yellon DM, Davidson SM, Lim SY, Wynne AM and Smith CC: Apelin-13 and apelin-36 exhibit direct cardio-protective activity against ischemia reperfusion injury. Basic Res Cardiol 102: 518-528, 2007.
13. Smith CC, Mocanu MM, Bowen J, et al: Temporal changes in myocardial salvage kinases during reperfusion following ischemia: studies involving the cardioprotective adipocytokine apelin. Cardiovasc Drugs Ther 21: 409-414, 2007.
14. Kleinz MJ and Baxter GF: Apelin reduces myocardial reperfusion injury independently of P13K/Akt and P70S6 kinase. Regul Pept 146: 271-277, 2008.
15. Klabunde T and Hessler G: Drug design strategies for targeting G-protein-coupled receptors. Chembiochem 3: 928-944, 2002.
16. Masri B, Lahlou H, Mazarguil H, Knibiehler B and Audigier Y: Apelin (65-77) activates extracellular signal-regulated kinases via a PTX-sensitive G protein. Biochem Biophys Res Commun 290: 539-545, 2002.
17. Masri B, Morin N, Cornu M, Knibiehler B and Audigier Y: Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells. FASEB J 18: 1909-1911, 2004.
18. Hashimoto Y, Ishida J, Yamamoto R, et al: G protein-coupled APJ receptor signaling induces focal adhesion formation and cell motility. Int J Mol Med 16: 787-792, 2005.
19. Medhurst AD, Jennings CA, Robbins MJ, et al: Pharmacological and inummohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem 84: 1162-1172, 2003.
20. Vickers C, Hales P, Kaushik V, et al: Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J Biol Chem 277: 14838-14843, 2002.
21. Fan X, Zhou N, Zhang X, et al: Structural and functional study of the apelin-13 peptide, an endogenous ligand of the HIV-1 coreceptor, APJ. Biochemistry 42: 10163-10168, 2003.
22. Veber DF, Holly FW, Paleveda WJ, et al: Conformationally restricted bicyclic analogs of somatostatin. Proc Natl Acad Sci USA 75: 2636-2640, 1978.
23. Rohrer SP, Birzin ET, Mosley RT, et al: Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science 282: 737-740, 1998.
24. Haramura M, Okamachi A, Tsuzuki K, et al: Design and synthesis of N-terminal cyclic motilin partial peptides: a novel pure motilin antagonist. Chem Pharm Bull (Tokyo) 49: 40-43, 2001.
25. Le HT, Lemaire IB, Gilbert AK, Jolicoeur F and Lemaire S: Bioactive peptidic analogues and cyclostereoisomers of the minimal antinociceptive histogranin fragment-(7-10). J Med Chem 46: 3094-3101, 2003.
26. El Messari S, Iturrioz X, Fassot C, De Mota N, Roesch D and Llorens-Cortes C: Functional dissociation of apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure. J Neurochem 90: 1290-1301, 2004.
27. New DC, Wu K, Kwok AW and Wong YH: G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis. FEBS J 274: 6025-6036, 2007.
28. Rozengurt E: Mitogenic signaling pathways induced by G protein-coupled receptors. J Cell Physiol 213: 589-602, 2007.
29. Tang SY, Xie H, Yuan LQ, et al: Apelin stimulates proliferation and suppresses apoptosis of mouse osteoblastic cell line MC3T3-E1 via JNK and P13-K/Akt signaling pathways. Peptides 28: 708-718, 2007.
30. O'Donnell LA, Agrawal A, Sabnekar P, Dichter MA, Lynch DR and Kolson DL: Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury. J Neurochem 102: 1905-1917, 2007.