Stability and degradation patterns of chemically modified analogs of apelin-13 in plasma and cerebrospinal fluid

Biopolymers - Peptide Science Section

Volumn 102, Issue 4, 2014, Pages 297-303

  Murza, Alexandre ^a,b   Belleville, Karine ^a,b   Longpré, Jean Michel ^a,b   Sarret, Philippe ^a,b   Marsault, Éric ^a,b  

^a UNIVERSITY OF SHERBROOKE   (Canada)

^b UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

Apelin analogs; In vivo degradation; Plasma stability; Proteolytic cleavage; Unnatural amino acids

Indexed keywords

AMINO ACIDS; BRAIN; CEREBROSPINAL FLUID; HYDROLYSIS; PLASMA (HUMAN); RATS; STABILITY;

APELIN ANALOGS; G PROTEIN COUPLED RECEPTORS; IN-VIVO; INTRAVENOUS ADMINISTRATION; KINETICS OF DEGRADATION; PROTEOLYTIC CLEAVAGE; PROTEOLYTIC DEGRADATION; UNNATURAL AMINO ACIDS;

PLASMA STABILITY;

APELIN; G PROTEIN COUPLED RECEPTOR; ISOPROTEIN; LEUCINE; PHENYLALANINE; PROLINE; PROTEINASE; PYROGLUTAMATE 1 APELIN 13; SERINE; UNCLASSIFIED DRUG; APELIN-13 PEPTIDE; POLYGLUTAMIC ACID; SIGNAL PEPTIDE; APELIN 13; PYROGLUTAMIC ACID DERIVATIVE;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; CEREBROSPINAL FLUID LEVEL; CHEMICAL BOND; CHEMICAL MODIFICATION; DEGRADATION KINETICS; HUMAN; HYDROLYSIS; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN STABILITY; RAT; ANIMAL; BLOOD; C57BL MOUSE; CEREBROSPINAL FLUID; CHEMISTRY; HALF LIFE TIME; SPRAGUE DAWLEY RAT; ANIMAL EXPERIMENT; IN VIVO STUDY; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN FOLDING;

ANIMALS; HALF-LIFE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE, INBRED C57BL; POLYGLUTAMIC ACID; PROTEIN STABILITY; PROTEOLYSIS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 84923860697     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.22498     Document Type: Article

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