Elabela-Apelin Receptor Signaling Pathway is Functional in Mammalian Systems

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Wang, Zhi ^a,b   Yu, Daozhan ^a   Wang, Mengqiao ^c   Wang, Qilong ^d   Kouznetsova, Jennifer ^c   Yang, Rongze ^a   Qian, Kun ^a   Wu, Wenjun ^a   Shuldiner, Alan ^a   Sztalryd, Carole ^a   Zou, Minghui ^d   Zheng, Wei ^c   Gong, Da Wei ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APLNR PROTEIN, HUMAN; CALCIUM; CYCLIC AMP; ELA PEPTIDE, HUMAN; G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEPTIDE HORMONE;

ANGIOGENESIS; ANIMAL; BLOOD VESSEL; C57BL MOUSE; CHO CELL LINE; CRICETULUS; ENDOCYTOSIS; GENETICS; HAMSTER; HEK293 CELL LINE; HUMAN; MALE; METABOLISM; MOUSE; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; BLOOD VESSELS; CALCIUM; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; ENDOCYTOSIS; HEK293 CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOVASCULARIZATION, PHYSIOLOGIC; PEPTIDE HORMONES; PHOSPHORYLATION; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84931086893     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep08170     Document Type: Article

References (39)

1. O'Dowd, B. F. et al. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene 136, 355-360 (1993).
2. Tatemoto, K. et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochemical and biophysical research communications 251, 471-476 (1998).
3. Galanth, C., Hus-Citharel, A., Li, B., Llorens-Cortes, C. Apelin in the control of body fluid homeostasis and cardiovascular functions. Curr Pharm Des 18, 789-798 (2012).
4. Chapman, N. A., Dupre, D. J., Rainey, J. K. The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR. Biochemistry and cell biology5Biochimie et biologie cellulaire 92, 431-440 (2014).
5. Hamada, J. et al. Evaluation of novel cyclic analogues of apelin. Int J MolMed 22, 547-552 (2008).
6. D'Aniello, C. et al. G protein-coupled receptor APJ and its ligand apelin act downstream of Cripto to specify embryonic stem cells toward the cardiac lineage through extracellular signal-regulated kinase/p70S6 kinase signaling pathway. Circ Res 105, 231-238 (2009).
7. Medhurst, A. D. et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem 84, 1162-1172 (2003).
8. Tatemoto, K. et al. The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism. Regul Pept 99, 87-92 (2001).
9. Ishida, J. et al. Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo. J Biol Chem 279, 26274-26279 (2004).
10. Chng, S. C., Ho, L., Tian, J., Reversade, B. ELABELA: a hormone essential for heart development signals via the apelin receptor. Dev Cell 27, 672-680 (2013).
11. Pauli, A. et al. Toddler: an embryonic signal that promotes cell movement via Apelin receptors. Science 343, 1248636 (2014).
12. O'Carroll, A. M., Lolait, S. J., Harris, L. E., Pope, G. R. The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis. J Endocrinol 219, R13-35 (2013).
13. Prisco, A. R., Bukowy, J.D., Hoffmann, B. R., Karcher, J. R., Exner, E. C., Greene, A. S. Automated quantification reveals hyperglycemia inhibits endothelial angiogenic function. PloS one 9, e94599 (2014).
14. Zhong, J. C., Yu, X. Y., Huang, Y., Yung, L. M., Lau, C. W., Lin, S. G. Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice. Cardiovasc Res 74, 388-395 (2007).
15. Hosoya, M. et al. Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin. J Biol Chem 275, 21061-21067 (2000).
16. Szokodi, I. et al. Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility. Circ Res 91, 434-440 (2002).
17. Kasai, A. et al. Apelin is a novel angiogenic factor in retinal endothelial cells. Biochemical and biophysical research communications 325, 395-400 (2004).
18. Kalin, R. E., Kretz, M. P., Meyer, A. M., Kispert, A., Heppner, F. L., Brandli, A. W. Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis. Dev Biol 305, 599-614 (2007).
19. Ashley, E. A. et al. The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo. Cardiovasc Res 65, 73-82 (2005).
20. Perjes, A. et al. Apelin increases cardiac contractility via protein kinase Cepsilonand extracellular signal-regulated kinase-dependent mechanisms. PloS one 9, e93473 (2014).
21. Lee, D. K., Saldivia, V. R., Nguyen, T., Cheng, R., George, S. R., O'Dowd B. F. Modification of the terminal residue of apelin-13 antagonizes its hypotensive action. Endocrinology 146, 231-236 (2005).
22. Pisarenko, O. I. et al. Limitation of myocardial infarction by a structural analog of the peptide apelin-12. Dokl Biol Sci 443, 65-67 (2012).
23. Kleinz, M. J., Baxter, G. F. Apelin reduces myocardial reperfusion injury independently of PI3K/Akt and P70S6 kinase. Regul Pept 146, 271-277 (2008).
24. Jia, Y. X. et al. Apelin protects myocardial injury induced by isoproterenol in rats. Regul Pept 133, 147-154 (2006).
25. Zeng, H., He, X., Hou, X., Li, L., Chen, J. X. Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3. Am J Physiol Heart Circ Physiol 306, H585-597 (2014).
26. Li, L., Zeng, H., Hou, X., He, X., Chen, J. X. Myocardial injection of apelinoverexpressing bone marrow cells improves cardiac repair via upregulation of Sirt3 after myocardial infarction. PloS one 8, e71041 (2013).
27. Wang, W. et al. Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues. J Am Heart Assoc 2, e000249 (2013).
28. Maguire, J. J., Kleinz, M. J., Pitkin, S. L., Davenport, A. P. [Pyr1]apelin-13 identified as the predominant apelin isoform in the human heart: vasoactive mechanisms and inotropic action in disease. Hypertension 54, 598-604 (2009).
29. Katugampola, S. D., Maguire, J. J., Matthewson, S. R., Davenport, A. P. [(125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br J Pharmacol 132, 1255-1260 (2001).
30. Kang, Y. et al. Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development. Circ Res 113, 22-31 (2013).
31. Charo, D. N. et al. Endogenous regulation of cardiovascular function by apelin-APJ. Am J Physiol Heart Circ Physiol 297, H1904-1913 (2009).
32. Kuba, K. et al. Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circ Res 101, e32-42 (2007).
33. Scimia, M. C., Blass, B. E., Koch, W. J. Apelin receptor: its responsiveness to stretch mechanisms and its potential for cardiovascular therapy. Expert Rev Cardiovasc Ther 12, 733-741 (2014).
34. Roberts, E. M., Newson, M. J., Pope, G. R., Landgraf, R., Lolait, S. J., O'Carroll, A. M. Abnormal fluid homeostasis in apelin receptor knockoutmice. J Endocrinol 202, 453-462 (2009).
35. Yu, D. et al. Niemann-Pick Disease Type C: Induced Pluripotent Stem Cell-Derived Neuronal Cells for Modeling Neural Disease and Evaluating Drug Efficacy. J Biomol Screen 19, 1164-1173 (2014).
36. Thorsell, A. et al. A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats. J Neurosci 33, 10132-10142 (2013).
37. Rumjahn, S. M., Javed, M. A., Wong, N., Law, W. E., Buxton, I. L. Purinergic regulation of angiogenesis by human breast carcinoma-secreted nucleoside diphosphate kinase. Br J Cancer 97, 1372-1380 (2007).
38. Dong, Y. et al. Activation of protease calpain by oxidized and glycated LDL increases the degradation of endothelial nitric oxide synthase. J Cell Mol Med 13, 2899-2910 (2009).
39. Dong, Y. et al. Activation of AMP-activated protein kinase inhibits oxidized LDLtriggered endoplasmic reticulum stress in vivo. Diabetes 59, 1386-1396 (2010).