Structural features of the apelin receptor N-terminal tail and first transmembrane segment implicated in ligand binding and receptor trafficking

Biochimica et Biophysica Acta - Biomembranes

Volumn 1828, Issue 6, 2013, Pages 1471-1483

  Langelaan, David N ^a   Reddy, Tyler ^a,b   Banks, Aaron W ^a   Dellaire, Graham ^a,c   Dupré, Denis J ^a   Rainey, Jan K ^a,c  

^a DALHOUSIE UNIVERSITY   (Canada)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Apelin receptor; Biomolecular NMR spectroscopy; Divide and conquer; Homology model; Membrane protein structure; Molecular dynamics simulations

Indexed keywords

APELIN RECEPTOR; DODECYLPHOSPHORYLCHOLINE; MITOGEN ACTIVATED PROTEIN KINASE;

AMINO TERMINAL SEQUENCE; ARTICLE; BILAYER MEMBRANE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; EMBRYO; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LIGAND BINDING; MICELLE; MOLECULAR DYNAMICS; MOLECULAR MODEL; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; RESIDUE ANALYSIS; STRUCTURE ANALYSIS; TRANSMEMBRANE DOMAIN; VALIDATION PROCESS;

AMINO ACID SEQUENCE; CELL MEMBRANE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEK293 CELLS; HUMANS; LIGANDS; LIPID BILAYERS; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE LIPIDS; MICELLES; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PHOSPHORYLCHOLINE; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84874934571     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2013.02.005     Document Type: Article

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