C-terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action

Journal of Medicinal Chemistry

Volumn 58, Issue 5, 2015, Pages 2431-2440

  Murza, Alexandre ^a,b   Besserer Offroy, Élie ^a,b   Côté, Jérôme ^a,b   Bérubé, Patrick ^a,b   Longpré, Jean Michel ^a,b   Dumaine, Robert ^a   Lesur, Olivier ^a   Auger Messier, Mannix ^a   Leduc, Richard ^a,b   Sarret, Philippe ^a,b   Marsault, Éric ^a,b  

^a UNIVERSITY OF SHERBROOKE   (Canada)

^b UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; APELIN; APELIN 13 DERIVATIVE; CYCLIC AMP; UNCLASSIFIED DRUG; APELIN-13 PEPTIDE; APLN PROTEIN, RAT; G PROTEIN COUPLED RECEPTOR; LIGAND; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; BLOOD PRESSURE; BLOOD PRESSURE MEASUREMENT; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC50; LIGAND BINDING; MALE; MITSUNOBU REACTION; NONHUMAN; PEPTIDE SYNTHESIS; PROTEIN MODIFICATION; RAT; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; AMINO ACID SUBSTITUTION; ANIMAL; CHEMISTRY; DRUG EFFECTS; HYPOTENSION; METABOLISM; SPRAGUE DAWLEY RAT;

AMINO ACID SUBSTITUTION; ANIMALS; BLOOD PRESSURE; CYCLIC AMP; HYPOTENSION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84924666736     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501916k     Document Type: Article

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