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Volumn 5, Issue 9, 2015, Pages 988-1003

Mass cytometric functional profiling of acute myeloid leukemia defines cell-cycle and immunophenotypic properties that correlate with known responses to therapy

Author keywords

[No Author keywords available]

Indexed keywords

CD135 ANTIGEN; CD34 ANTIGEN; CD38 ANTIGEN; CD99 ANTIGEN; ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER;

EID: 84941754980     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-15-0298     Document Type: Article
Times cited : (89)

References (50)
  • 1
    • 33751267902 scopus 로고    scopus 로고
    • Acute myeloid leukaemia
    • Estey E, Dohner H. Acute myeloid leukaemia. Lancet 2006;368:1894-907.
    • (2006) Lancet , vol.368 , pp. 1894-1907
    • Estey, E.1    Dohner, H.2
  • 2
    • 0032188805 scopus 로고    scopus 로고
    • The importance of diagnostic cytogenetics on outcome in AML: Analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children’s Leukaemia Working Parties
    • Grimwade D, Walker H, Oliver F, Wheatley K, Harrison C, Harrison G, et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children’s Leukaemia Working Parties. Blood 1998;92:2322-33.
    • (1998) Blood , vol.92 , pp. 2322-2333
    • Grimwade, D.1    Walker, H.2    Oliver, F.3    Wheatley, K.4    Harrison, C.5    Harrison, G.6
  • 3
    • 84871774636 scopus 로고    scopus 로고
    • Prognostic significance of the European LeukemiaNet standardized system for reporting cytogenetic and molecular alterations in adults with acute myeloid leukemia
    • Mrózek K, Marcucci G, Nicolet D, Maharry KS, Becker H, Whitman SP, et al. Prognostic significance of the European LeukemiaNet standardized system for reporting cytogenetic and molecular alterations in adults with acute myeloid leukemia. J Clin Oncol 2012;30:4515-23.
    • (2012) J Clin Oncol , vol.30 , pp. 4515-4523
    • Mrózek, K.1    Marcucci, G.2    Nicolet, D.3    Maharry, K.S.4    Becker, H.5    Whitman, S.P.6
  • 4
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997;3:730-7.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 5
    • 34447646569 scopus 로고    scopus 로고
    • Aberrant marker expression patterns on the CD34+CD38stem cell compartment in acute myeloid leukemia allows to distinguish the malignant from the normal stem cell compartment both at diagnosis and in remission
    • van Rhenen A, Moshaver B, Kelder A, Feller N, Nieuwint AW, Zweegman S, et al. Aberrant marker expression patterns on the CD34+CD38stem cell compartment in acute myeloid leukemia allows to distinguish the malignant from the normal stem cell compartment both at diagnosis and in remission. Leukemia 2007;21:1700-7.
    • (2007) Leukemia , vol.21 , pp. 1700-1707
    • Van Rhenen, A.1    Moshaver, B.2    Kelder, A.3    Feller, N.4    Nieuwint, A.W.5    Zweegman, S.6
  • 6
    • 84859854912 scopus 로고    scopus 로고
    • A clinically relevant population of leukemic CD34+CD38- cells in acute myeloid leukemia
    • Gerber JM, Smith BD, Ngwang B, Zhang H, Vala MS, Morsberger L, et al. A clinically relevant population of leukemic CD34+CD38- cells in acute myeloid leukemia. Blood 2012;119:3571-7.
    • (2012) Blood , vol.119 , pp. 3571-3577
    • Gerber, J.M.1    Smith, B.D.2    Ngwang, B.3    Zhang, H.4    Vala, M.S.5    Morsberger, L.6
  • 7
    • 0029840432 scopus 로고    scopus 로고
    • Fluorouracil selectively spares acute myeloid leukemia cells with long-term growth abilities in immunodeficient mice and in culture
    • Terpstra W, Ploemacher RE, Prins A, van Lom K, Pouwels K, Wognum AW, et al. Fluorouracil selectively spares acute myeloid leukemia cells with long-term growth abilities in immunodeficient mice and in culture. Blood 1996;88:1944-50.
    • (1996) Blood , vol.88 , pp. 1944-1950
    • Terpstra, W.1    Ploemacher, R.E.2    Prins, A.3    Van Lom, K.4    Pouwels, K.5    Wognum, A.W.6
  • 8
    • 0037606054 scopus 로고    scopus 로고
    • Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML)
    • Guan Y, Gerhard B, Hogge DE. Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML). Blood 2003;101:3142-9.
    • (2003) Blood , vol.101 , pp. 3142-3149
    • Guan, Y.1    Gerhard, B.2    Hogge, D.E.3
  • 9
    • 35948984135 scopus 로고    scopus 로고
    • Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region
    • Ishikawa F, Yoshida S, Saito Y, Hijikata A, Kitamura H, Tanaka S, et al. Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotech 2007;25:1315-21.
    • (2007) Nat Biotech , vol.25 , pp. 1315-1321
    • Ishikawa, F.1    Yoshida, S.2    Saito, Y.3    Hijikata, A.4    Kitamura, H.5    Tanaka, S.6
  • 10
    • 0032980506 scopus 로고    scopus 로고
    • In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells
    • Cheshier SH, Morrison SJ, Liao X, Weissman IL. In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. Proc Natl Acad Sci U S A 1999;96:3120-5.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3120-3125
    • Cheshier, S.H.1    Morrison, S.J.2    Liao, X.3    Weissman, I.L.4
  • 11
    • 4644288302 scopus 로고    scopus 로고
    • Individual patient data-based meta-analysis of patients aged 16 to 60 years with core binding factor acute myeloid leukemia: A survey of the German acute myeloid leukemia intergroup
    • Schlenk RF, Benner A, Krauter J, Büchner T, Sauerland C, Ehninger G, et al. Individual patient data-based meta-analysis of patients aged 16 to 60 years with core binding factor acute myeloid leukemia: a survey of the German acute myeloid leukemia intergroup. J Clin Oncol 2004;22:3741-50.
    • (2004) J Clin Oncol , vol.22 , pp. 3741-3750
    • Schlenk, R.F.1    Benner, A.2    Krauter, J.3    Büchner, T.4    Sauerland, C.5    Ehninger, G.6
  • 12
    • 79952099282 scopus 로고    scopus 로고
    • Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: Results of the MRC AML15 Trial
    • Burnett AK, Hills RK, Milligan D, Kjeldsen L, Kell J, Russell NH, et al. Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: results of the MRC AML15 Trial. J Clin Oncol 2011;29:369-77.
    • (2011) J Clin Oncol , vol.29 , pp. 369-377
    • Burnett, A.K.1    Hills, R.K.2    Milligan, D.3    Kjeldsen, L.4    Kell, J.5    Russell, N.H.6
  • 13
    • 84910038046 scopus 로고    scopus 로고
    • Prognostic implication of gene mutations on overall survival in the adult acute myeloid leukemia patients receiving or not receiving allogeneic hematopoietic stem cell transplantations
    • Chou S-C, Tang J-L, Hou H-A, Chou W-C, Hu F-C, Chen C-Y, et al. Prognostic implication of gene mutations on overall survival in the adult acute myeloid leukemia patients receiving or not receiving allogeneic hematopoietic stem cell transplantations. Leuk Res 2014;38:1278-84.
    • (2014) Leuk Res , vol.38 , pp. 1278-1284
    • Chou, S.-C.1    Tang, J.-L.2    Hou, H.-A.3    Chou, W.-C.4    Hu, F.-C.5    Chen, C.-Y.6
  • 14
    • 84878372012 scopus 로고    scopus 로고
    • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 2013;368:2059-74.
    • (2013) N Engl J Med , vol.368 , pp. 2059-2074
  • 17
    • 84922574231 scopus 로고    scopus 로고
    • Transient partial permeabilization with saponin enables cellular barcoding prior to surface marker staining
    • Behbehani GK, Thom C, Zunder ER, Finck R, Gaudilliere B, Fragiadakis GK, et al. Transient partial permeabilization with saponin enables cellular barcoding prior to surface marker staining. Cytometry A 2014;85:1011-9.
    • (2014) Cytometry A , vol.85 , pp. 1011-1019
    • Behbehani, G.K.1    Thom, C.2    Zunder, E.R.3    Finck, R.4    Gaudilliere, B.5    Fragiadakis, G.K.6
  • 18
    • 84924234154 scopus 로고    scopus 로고
    • Amir E-aD, Krishnaswamy S, Gonzalez VD, et al. Palladium-based mass tag cell barcoding with a doublet-filtering scheme and single-cell deconvolution algorithm
    • Zunder ER, Finck R, Behbehani GK, Amir E-aD, Krishnaswamy S, Gonzalez VD, et al. Palladium-based mass tag cell barcoding with a doublet-filtering scheme and single-cell deconvolution algorithm. Nat Protocols 2015;10:316-33.
    • (2015) Nat Protocols , vol.10 , pp. 316-333
    • Zunder, E.R.1    Finck, R.2    Behbehani, G.K.3
  • 19
    • 84880280631 scopus 로고    scopus 로고
    • Bendall SC, et al. ViSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia
    • Amir el AD, Davis KL, Tadmor MD, Simonds EF, Levine JH, Bendall SC, et al. viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia. Nat Biotechnol 2013;31:545-52.
    • (2013) Nat Biotechnol , vol.31 , pp. 545-552
    • Amir El, A.D.1    Davis, K.L.2    Tadmor, M.D.3    Simonds, E.F.4    Levine, J.H.5
  • 20
    • 79955750055 scopus 로고    scopus 로고
    • Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum
    • Bendall SC, Simonds EF, Qiu P, Amir el AD, Krutzik PO, Finck R, et al. Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science 2011;332:687-96.
    • (2011) Science , vol.332 , pp. 687-696
    • Bendall, S.C.1    Simonds, E.F.2    Qiu, P.3    Amir El, A.D.4    Krutzik, P.O.5    Finck, R.6
  • 21
    • 84925361935 scopus 로고    scopus 로고
    • Singlecell mass cytometry reveals intracellular survival/proliferative signaling in FLT3-ITD-mutated AML stem/progenitor cells
    • Han L, Qiu P, Zeng Z, Jorgensen JL, Mak DH, Burks JK, et al. Singlecell mass cytometry reveals intracellular survival/proliferative signaling in FLT3-ITD-mutated AML stem/progenitor cells. Cytometry Part A 2015;87:346-56.
    • (2015) Cytometry Part A , vol.87 , pp. 346-356
    • Han, L.1    Qiu, P.2    Zeng, Z.3    Jorgensen, J.L.4    Mak, D.H.5    Burks, J.K.6
  • 23
    • 70449362059 scopus 로고    scopus 로고
    • FLT3-ITD expression levels and their effect on STAT5 in AML with and without NPM mutations
    • Seedhouse CH, Pallis M, Grundy M, Shang S, Russell NH. FLT3-ITD expression levels and their effect on STAT5 in AML with and without NPM mutations. Br J Haematol 2009;147:653-61.
    • (2009) Br J Haematol , vol.147 , pp. 653-661
    • Seedhouse, C.H.1    Pallis, M.2    Grundy, M.3    Shang, S.4    Russell, N.H.5
  • 24
    • 79960946893 scopus 로고    scopus 로고
    • Cell synchronization by inhibitors of DNA replication induces replication stress and DNA damage response: Analysis by flow cytometry
    • Darzynkiewicz Z, Halicka HD, Zhao H, Podhorecka M. Cell synchronization by inhibitors of DNA replication induces replication stress and DNA damage response: analysis by flow cytometry. Methods Mol Biol 2011;761:85-96.
    • (2011) Methods Mol Biol , vol.761 , pp. 85-96
    • Darzynkiewicz, Z.1    Halicka, H.D.2    Zhao, H.3    Podhorecka, M.4
  • 25
    • 84897108505 scopus 로고    scopus 로고
    • Leukapheresis and low-dose chemotherapy do not reduce early mortality in acute myeloid leukemia hyperleukocytosis: A systematic review and meta-analysis
    • Oberoi S, Lehrnbecher T, Phillips B, Hitzler J, Ethier M-C, Beyene J, et al. Leukapheresis and low-dose chemotherapy do not reduce early mortality in acute myeloid leukemia hyperleukocytosis: a systematic review and meta-analysis. Leuk Res 2014;38:460-8.
    • (2014) Leuk Res , vol.38 , pp. 460-468
    • Oberoi, S.1    Lehrnbecher, T.2    Phillips, B.3    Hitzler, J.4    Ethier, M.-C.5    Beyene, J.6
  • 26
    • 84897578401 scopus 로고    scopus 로고
    • Comparing cancer vs normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients
    • Rapin N, Bagger FO, Jendholm J, Mora-Jensen H, Krogh A, Kohlmann A, et al. Comparing cancer vs normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients. Blood 2014;123:894-904.
    • (2014) Blood , vol.123 , pp. 894-904
    • Rapin, N.1    Bagger, F.O.2    Jendholm, J.3    Mora-Jensen, H.4    Krogh, A.5    Kohlmann, A.6
  • 27
    • 28844456971 scopus 로고    scopus 로고
    • Hematopoietic stem cells express multiple myeloid markers: Implications for the origin and targeted therapy of acute myeloid leukemia
    • Taussig DC, Pearce DJ, Simpson C, Rohatiner AZ, Lister TA, Kelly G, et al. Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia. Blood 2005;106:4086-92.
    • (2005) Blood , vol.106 , pp. 4086-4092
    • Taussig, D.C.1    Pearce, D.J.2    Simpson, C.3    Rohatiner, A.Z.4    Lister, T.A.5    Kelly, G.6
  • 28
    • 32544434077 scopus 로고    scopus 로고
    • Immunoreactivity of MIC2 (CD99) and terminal deoxynucleotidyl transferase in bone marrow clot and core specimens of acute myeloid leukemias and myelodysplastic syndromes
    • Kang LC, Dunphy CH. Immunoreactivity of MIC2 (CD99) and terminal deoxynucleotidyl transferase in bone marrow clot and core specimens of acute myeloid leukemias and myelodysplastic syndromes. Arch Pathol Lab Med 2006;130:153-7.
    • (2006) Arch Pathol Lab Med , vol.130 , pp. 153-157
    • Kang, L.C.1    Dunphy, C.H.2
  • 29
    • 20044388101 scopus 로고    scopus 로고
    • Characterization of CEBPA mutations in acute myeloid leukemia: Most patients with CEBPA mutations have biallelic mutations and show a distinct immunophenotype of the leukemic cells
    • Lin LI, Chen CY, Lin DT, Tsay W, Tang JL, Yeh YC, et al. Characterization of CEBPA mutations in acute myeloid leukemia: most patients with CEBPA mutations have biallelic mutations and show a distinct immunophenotype of the leukemic cells. Clin Cancer Res 2005;11:1372-9.
    • (2005) Clin Cancer Res , vol.11 , pp. 1372-1379
    • Lin, L.I.1    Chen, C.Y.2    Lin, D.T.3    Tsay, W.4    Tang, J.L.5    Yeh, Y.C.6
  • 30
    • 0346100567 scopus 로고    scopus 로고
    • Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
    • Cozzio A, Passegué E, Ayton PM, Karsunky H, Cleary ML, Weissman IL. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev 2003;17:3029-35.
    • (2003) Genes Dev , vol.17 , pp. 3029-3035
    • Cozzio, A.1    Passegué, E.2    Ayton, P.M.3    Karsunky, H.4    Cleary, M.L.5    Weissman, I.L.6
  • 31
    • 31544436322 scopus 로고    scopus 로고
    • AML engraftment in the NOD/SCID assay reflects the outcome of AML: Implications for our understanding of the heterogeneity of AML
    • Pearce DJ, Taussig D, Zibara K, Smith L-L, Ridler CM, Preudhomme C, et al. AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML. Blood 2006;107:1166-73.
    • (2006) Blood , vol.107 , pp. 1166-1173
    • Pearce, D.J.1    Taussig, D.2    Zibara, K.3    Smith, L.-L.4    Ridler, C.M.5    Preudhomme, C.6
  • 32
    • 0034011882 scopus 로고    scopus 로고
    • Identification of variables determining the engraftment potential of human acute myeloid leukemia in the immunodeficient NOD/SCID human chimera model
    • Rombouts WJ, Martens AC, Ploemacher RE. Identification of variables determining the engraftment potential of human acute myeloid leukemia in the immunodeficient NOD/SCID human chimera model. Leukemia 2000;14:889-97.
    • (2000) Leukemia , vol.14 , pp. 889-897
    • Rombouts, W.J.1    Martens, A.C.2    Ploemacher, R.E.3
  • 33
    • 10744223652 scopus 로고    scopus 로고
    • Engraftment of acute myeloid leukemia in NOD/SCID Mice is independent of CXCR4 and predicts poor patient survival
    • Monaco G, Konopleva M, Munsell M, Leysath C, Wang R-Y, Jackson CE, et al. Engraftment of acute myeloid leukemia in NOD/SCID Mice is independent of CXCR4 and predicts poor patient survival. Stem Cells 2004;22:188-201.
    • (2004) Stem Cells , vol.22 , pp. 188-201
    • Monaco, G.1    Konopleva, M.2    Munsell, M.3    Leysath, C.4    Wang, R.-Y.5    Jackson, C.E.6
  • 36
    • 78650950098 scopus 로고    scopus 로고
    • Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2R?C-deficient mice
    • Sarry J-E, Murphy K, Perry R, Sanchez PV, Secreto A, Keefer C, et al. Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2R?c-deficient mice. J Clin Invest 2011;121:384-95.
    • (2011) J Clin Invest , vol.121 , pp. 384-395
    • Sarry, J.-E.1    Murphy, K.2    Perry, R.3    Sanchez, P.V.4    Secreto, A.5    Keefer, C.6
  • 37
  • 38
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
    • Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994;367:645-8.
    • (1994) Nature , vol.367 , pp. 645-648
    • Lapidot, T.1    Sirard, C.2    Vormoor, J.3    Murdoch, B.4    Hoang, T.5    Caceres-Cortes, J.6
  • 39
    • 0032402173 scopus 로고    scopus 로고
    • Most acute myeloid leukemia progenitor cells with long-term proliferative ability in vitro and in vivo have the phenotype CD34+/CD71-/HLA-DR-
    • Blair A, Hogge DE, Sutherland HJ. Most acute myeloid leukemia progenitor cells with long-term proliferative ability in vitro and in vivo have the phenotype CD34+/CD71-/HLA-DR-. Blood 1998;92: 4325-35.
    • (1998) Blood , vol.92 , pp. 4325-4335
    • Blair, A.1    Hogge, D.E.2    Sutherland, H.J.3
  • 40
    • 77950451485 scopus 로고    scopus 로고
    • Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fraction
    • Taussig DC, Vargaftig J, Miraki-Moud F, Griessinger E, Sharrock K, Luke T, et al. Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fraction. Blood 2010;115:1976-84.
    • (2010) Blood , vol.115 , pp. 1976-1984
    • Taussig, D.C.1    Vargaftig, J.2    Miraki-Moud, F.3    Griessinger, E.4    Sharrock, K.5    Luke, T.6
  • 41
    • 77957995156 scopus 로고    scopus 로고
    • CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice
    • Martelli MP, Pettirossi V, Thiede C, Bonifacio E, Mezzasoma F, Cecchini D, et al. CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice. Blood 2010;116:3907-22.
    • (2010) Blood , vol.116 , pp. 3907-3922
    • Martelli, M.P.1    Pettirossi, V.2    Thiede, C.3    Bonifacio, E.4    Mezzasoma, F.5    Cecchini, D.6
  • 42
    • 17544388046 scopus 로고    scopus 로고
    • Frequency of prolonged remission duration after high-dose cytarabine intensification in acute myeloid leukemia varies by cytogenetic subtype
    • Bloomfield CD, Lawrence D, Byrd JC, Carroll A, Pettenati MJ, Tantravahi R, et al. Frequency of prolonged remission duration after high-dose cytarabine intensification in acute myeloid leukemia varies by cytogenetic subtype. Cancer Res 1998;58:4173-9.
    • (1998) Cancer Res , vol.58 , pp. 4173-4179
    • Bloomfield, C.D.1    Lawrence, D.2    Byrd, J.C.3    Carroll, A.4    Pettenati, M.J.5    Tantravahi, R.6
  • 43
    • 1642471800 scopus 로고    scopus 로고
    • Mechanisms of apoptosis induction by nucleoside analogs
    • Sampath D, Rao VA, Plunkett W. Mechanisms of apoptosis induction by nucleoside analogs. Oncogene 2003;22:9063-74.
    • (2003) Oncogene , vol.22 , pp. 9063-9074
    • Sampath, D.1    Rao, V.A.2    Plunkett, W.3
  • 44
    • 28544436371 scopus 로고    scopus 로고
    • Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
    • Passegue E, Wagers AJ, Giuriato S, Anderson WC, Weissman IL. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med 2005;202:1599-611.
    • (2005) J Exp Med , vol.202 , pp. 1599-1611
    • Passegue, E.1    Wagers, A.J.2    Giuriato, S.3    Erson, W.C.4    Weissman, I.L.5
  • 45
    • 0026000457 scopus 로고
    • Biological significance of cell cycle kinetics in 128 standard risk newly diagnosed patients with acute myelocytic leukaemia
    • Raza A, Preisler H, Lampkin B, Yousuf N, Tucker C, Peters N, et al. Biological significance of cell cycle kinetics in 128 standard risk newly diagnosed patients with acute myelocytic leukaemia. Br J Haematol 1991;79:33-9.
    • (1991) Br J Haematol , vol.79 , pp. 33-39
    • Raza, A.1    Preisler, H.2    Lampkin, B.3    Yousuf, N.4    Tucker, C.5    Peters, N.6
  • 46
    • 84906222680 scopus 로고    scopus 로고
    • Clinical impact of gene mutations and lesions detected by SNParray karyotyping in acute myeloid leukemia patients in the context of gemtuzumab ozogamicin treatment: Results of the ALFA-0701 trial
    • Renneville A, Abdelali RB, Chevret S, Nibourel O, Cheok M, Pautas C, et al. Clinical impact of gene mutations and lesions detected by SNParray karyotyping in acute myeloid leukemia patients in the context of gemtuzumab ozogamicin treatment: results of the ALFA-0701 trial. Oncotarget 2014;5:916-32.
    • (2014) Oncotarget , vol.5 , pp. 916-932
    • Renneville, A.1    Abdelali, R.B.2    Chevret, S.3    Nibourel, O.4    Cheok, M.5    Pautas, C.6
  • 47
    • 84859911350 scopus 로고    scopus 로고
    • Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): A randomised, open-label, phase 3 study
    • Castaigne S, Pautas C, Terre C, Raffoux E, Bordessoule D, Bastie JN, et al. Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 study. Lancet 2012;379:1508-16.
    • (2012) Lancet , vol.379 , pp. 1508-1516
    • Castaigne, S.1    Pautas, C.2    Terre, C.3    Raffoux, E.4    Bordessoule, D.5    Bastie, J.N.6
  • 48
    • 0346244001 scopus 로고    scopus 로고
    • Intracellular phospho-protein staining techniques for flow cytometry: Monitoring single cell signaling events
    • Krutzik PO, Nolan GP. Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events. Cytometry A 2003;55:61-70.
    • (2003) Cytometry A , vol.55 , pp. 61-70
    • Krutzik, P.O.1    Nolan, G.P.2
  • 49
    • 41549095036 scopus 로고    scopus 로고
    • Development of analytical methods for multiplex bio-assay with inductively coupled plasma mass spectrometry
    • Ornatsky OI, Kinach R, Bandura DR, Lou X, Tanner SD, Baranov VI, et al. Development of analytical methods for multiplex bio-assay with inductively coupled plasma mass spectrometry. J Anal At Spectrom 2008;23:463-9.
    • (2008) J Anal at Spectrom , vol.23 , pp. 463-469
    • Ornatsky, O.I.1    Kinach, R.2    Bandura, D.R.3    Lou, X.4    Tanner, S.D.5    Baranov, V.I.6


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