메뉴 건너뛰기




Volumn 27, Issue 6, 2015, Pages 560-567

Liquid biopsy: Will it be the 'magic tool' for monitoring response of solid tumors to anticancer therapies?

Author keywords

Biomarkers; Cancer; Circulating tumor cells; Circulating tumor DNA; Liquid biopsy

Indexed keywords

BIOLOGICAL MARKER; CIRCULATING TUMOR DNA; DNA; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; ONCOPROTEIN; RAS PROTEIN; TUMOR MARKER;

EID: 84944056882     PISSN: 10408746     EISSN: 1531703X     Source Type: Journal    
DOI: 10.1097/CCO.0000000000000223     Document Type: Review
Times cited : (33)

References (105)
  • 1
    • 84926459432 scopus 로고    scopus 로고
    • Circulating Tumor Cells and Circulating tumor DNA for precision medicine: Dream or reality?
    • Ignatiadis M, Dawson S-J. Circulating Tumor Cells and Circulating tumor DNA for precision medicine: dream or reality? Ann Oncol 2014; 25:2304-2313.
    • (2014) Ann Oncol , vol.25 , pp. 2304-2313
    • Ignatiadis, M.1    Dawson, S.-J.2
  • 2
    • 84896713649 scopus 로고    scopus 로고
    • Molecular analysis of circulating tumour cells: Biology and biomarkers
    • Krebs MG, Metcalf RL, Carter L, et al. Molecular analysis of circulating tumour cells: biology and biomarkers. Nat Rev Clin Oncol 2014; 11:129-144.
    • (2014) Nat Rev Clin Oncol , vol.11 , pp. 129-144
    • Krebs, M.G.1    Metcalf, R.L.2    Carter, L.3
  • 3
    • 84906731563 scopus 로고    scopus 로고
    • Challenges in circulating tumour cell research
    • Alix-Panabieres C, Pantel K. Challenges in circulating tumour cell research. Nat Rev Cancer 2014; 14:623-631.
    • (2014) Nat Rev Cancer , vol.14 , pp. 623-631
    • Alix-Panabieres, C.1    Pantel, K.2
  • 4
    • 84875520648 scopus 로고    scopus 로고
    • Analysis of circulating tumor DNA to monitor metastatic breast cancer
    • Dawson S-J, Tsui DWY, Murtaza M, et al. Analysis of circulating tumor DNA to monitor metastatic breast cancer. N Engl J Med 2013; 368:1199-1209.
    • (2013) N Engl J Med , vol.368 , pp. 1199-1209
    • Dawson, S.-J.1    Tsui, D.W.Y.2    Murtaza, M.3
  • 5
    • 84877579861 scopus 로고    scopus 로고
    • Noninvasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
    • Murtaza M, Dawson SJ, Tsui DW, et al. Noninvasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature 2013; 497:108-112.
    • (2013) Nature , vol.497 , pp. 108-112
    • Murtaza, M.1    Dawson, S.J.2    Tsui, D.W.3
  • 6
    • 84861746437 scopus 로고    scopus 로고
    • Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA
    • Forshew T, Murtaza M, Parkinson C, et al. Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA. Sci Transl Med 2012; 4:136ra168.
    • (2012) Sci Transl Med , vol.4 , pp. 136ra168
    • Forshew, T.1    Murtaza, M.2    Parkinson, C.3
  • 7
    • 84870312106 scopus 로고    scopus 로고
    • Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing
    • Leary RJ, Sausen M, Kinde I, et al. Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing. Sci Transl Med 2012; 4:162ra154.
    • (2012) Sci Transl Med , vol.4 , pp. 162ra154
    • Leary, R.J.1    Sausen, M.2    Kinde, I.3
  • 8
    • 84921758615 scopus 로고    scopus 로고
    • Plasma circulating tumor DNA as an alternative to metastatic biopsies for mutational analysis in breast cancer
    • Rothe F, Laes JF, Lambrechts D, et al. Plasma circulating tumor DNA as an alternative to metastatic biopsies for mutational analysis in breast cancer. Ann Oncol 2014; 25:1959-1965.
    • (2014) Ann Oncol , vol.25 , pp. 1959-1965
    • Rothe, F.1    Laes, J.F.2    Lambrechts, D.3
  • 9
    • 84940993817 scopus 로고    scopus 로고
    • Significance of circulating tumor cells in metastatic triple-negative breast cancer patients within a randomized, phase II trial: TBCRC 019
    • Paoletti C, Li Y, Muniz MC, et al. Significance of circulating tumor cells in metastatic triple-negative breast cancer patients within a randomized, phase II trial: TBCRC 019. Clin Cancer Res 2015; 21:2771-2779.
    • (2015) Clin Cancer Res , vol.21 , pp. 2771-2779
    • Paoletti, C.1    Li, Y.2    Muniz, M.C.3
  • 10
    • 84903289929 scopus 로고    scopus 로고
    • Circulating tumor cells and response to chemotherapy in metastatic breast cancer: SWOG S0500
    • Smerage JB, Barlow WE, Hortobagyi GN, et al. Circulating tumor cells and response to chemotherapy in metastatic breast cancer: SWOG S0500. J Clin Oncol 2014; 32:3483-3489.
    • (2014) J Clin Oncol , vol.32 , pp. 3483-3489
    • Smerage, J.B.1    Barlow, W.E.2    Hortobagyi, G.N.3
  • 11
    • 84897445481 scopus 로고    scopus 로고
    • Clinical validity of circulating tumour cells in patients with metastatic breast cancer: A pooled analysis of individual patient data
    • Bidard F-C, Peeters DJ, Fehm T, et al. Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data. Lancet Oncol 2014; 15:406-414.
    • (2014) Lancet Oncol , vol.15 , pp. 406-414
    • Bidard, F.-C.1    Peeters, D.J.2    Fehm, T.3
  • 12
    • 84905160299 scopus 로고    scopus 로고
    • Circulating tumor cells predict survival in early average-to-high risk breast cancer patients
    • [Epub ahead of print]
    • Rack B, Schindlbeck C, Juckstock J, et al. Circulating tumor cells predict survival in early average-to-high risk breast cancer patients. J Natl Cancer Inst 2014; 106. [Epub ahead of print]. doi: 10.1093/jnci/dju066.
    • (2014) J Natl Cancer Inst , pp. 106
    • Rack, B.1    Schindlbeck, C.2    Juckstock, J.3
  • 13
    • 33846814619 scopus 로고    scopus 로고
    • Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival
    • Hayes DF, Cristofanilli M, Budd GT, et al. Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival. Clin Cancer Res 2006; 12:4218-4224.
    • (2006) Clin Cancer Res , vol.12 , pp. 4218-4224
    • Hayes, D.F.1    Cristofanilli, M.2    Budd, G.T.3
  • 14
    • 84887319901 scopus 로고    scopus 로고
    • Prognostic value of the combination of circulating tumor cells plus KRAS in patients with metastatic colorectal cancer treated with chemotherapy plus bevacizumab
    • Sastre J, Vidaurreta M, Gomez A, et al. Prognostic value of the combination of circulating tumor cells plus KRAS in patients with metastatic colorectal cancer treated with chemotherapy plus bevacizumab. Clin Colorectal Cancer 2013; 12:280-286.
    • (2013) Clin Colorectal Cancer , vol.12 , pp. 280-286
    • Sastre, J.1    Vidaurreta, M.2    Gomez, A.3
  • 15
    • 49249130844 scopus 로고    scopus 로고
    • Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer
    • Cohen SJ, Punt CJ, Iannotti N, et al. Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. J Clin Oncol 2008; 26:3213-3221.
    • (2008) J Clin Oncol , vol.26 , pp. 3213-3221
    • Cohen, S.J.1    Punt, C.J.2    Iannotti, N.3
  • 16
    • 84924710322 scopus 로고    scopus 로고
    • Relationship between circulating tumor cells and tumor response in colorectal cancer patients treated with chemotherapy: A meta-analysis
    • Huang X, Gao P, Song Y, et al. Relationship between circulating tumor cells and tumor response in colorectal cancer patients treated with chemotherapy: a meta-analysis. BMC Cancer 2014; 14: Article ID 976.
    • (2014) BMC Cancer , vol.14
    • Huang, X.1    Gao, P.2    Song, Y.3
  • 17
    • 84921924652 scopus 로고    scopus 로고
    • Importance of circulating tumor cells in newly diagnosed colorectal cancer
    • van Dalum G, Stam GJ, Scholten LF, et al. Importance of circulating tumor cells in newly diagnosed colorectal cancer. Int J Oncol 2015; 46:1361-1368.
    • (2015) Int J Oncol , vol.46 , pp. 1361-1368
    • Van Dalum, G.1    Stam, G.J.2    Scholten, L.F.3
  • 18
    • 84929940304 scopus 로고    scopus 로고
    • Circulating tumor cells count predicts survival in colorectal cancer patients
    • Romiti A, Raffa S, Di Rocco R, et al. Circulating tumor cells count predicts survival in colorectal cancer patients. J Gastrointestin Liver Dis 2014; 23:279-284.
    • (2014) J Gastrointestin Liver Dis , vol.23 , pp. 279-284
    • Romiti, A.1    Raffa, S.2    Di Rocco, R.3
  • 19
    • 84926330778 scopus 로고    scopus 로고
    • Role of circulating tumor cells as prognostic marker in resected stage III colorectal cancer
    • Sotelo MJ, Sastre J, Maestro ML, et al. Role of circulating tumor cells as prognostic marker in resected stage III colorectal cancer. Ann Oncol 2015; 26:535-541.
    • (2015) Ann Oncol , vol.26 , pp. 535-541
    • Sotelo, M.J.1    Sastre, J.2    Maestro, M.L.3
  • 20
    • 84944144002 scopus 로고    scopus 로고
    • Circulating tumor cells are predictive of poor response to chemotherapy in metastatic gastric cancer
    • [Epub ahead of print]
    • Lee SJ, Lee J, Kim ST, et al. Circulating tumor cells are predictive of poor response to chemotherapy in metastatic gastric cancer. Int J Biol Markers 2015; [Epub ahead of print]. doi: 10.5301/jbm.5000151.
    • (2015) Int J Biol Markers
    • Lee, S.J.1    Lee, J.2    Kim, S.T.3
  • 21
    • 84943360065 scopus 로고    scopus 로고
    • Circulating tumor cells as an independent predictor of survival in advanced gastric cancer
    • [Epub ahead of print]
    • Okabe H, Tsunoda S, Hosogi H, et al. Circulating tumor cells as an independent predictor of survival in advanced gastric cancer. Ann Surg Oncol 2015. [Epub ahead of print]. doi 10.1245/s10434-015-4483-6.
    • (2015) Ann Surg Oncol
    • Okabe, H.1    Tsunoda, S.2    Hosogi, H.3
  • 22
    • 84946500750 scopus 로고    scopus 로고
    • Circulating tumor cells as a biomarker for preoperative prognostic staging in patients with esophageal cancer
    • Reeh M, Effenberger KE, Koenig AM, et al. Circulating tumor cells as a biomarker for preoperative prognostic staging in patients with esophageal cancer. Ann Surg 2015; 261:1124-1130.
    • (2015) Ann Surg , vol.261 , pp. 1124-1130
    • Reeh, M.1    Effenberger, K.E.2    Koenig, A.M.3
  • 23
    • 84887083101 scopus 로고    scopus 로고
    • Clinical significance of circulating tumor cells in peripheral blood from patients with gastric cancer
    • Uenosono Y, Arigami T, Kozono T, et al. Clinical significance of circulating tumor cells in peripheral blood from patients with gastric cancer. Cancer 2013; 119:3984-3991.
    • (2013) Cancer , vol.119 , pp. 3984-3991
    • Uenosono, Y.1    Arigami, T.2    Kozono, T.3
  • 24
    • 84881221655 scopus 로고    scopus 로고
    • Circulating tumor cells in locally advanced pancreatic adenocarcinoma: The ancillary CirCe 07 study to the LAP 07 trial
    • Bidard FC, Huguet F, Louvet C, et al. Circulating tumor cells in locally advanced pancreatic adenocarcinoma: the ancillary CirCe 07 study to the LAP 07 trial. Ann Oncol 2013; 24:2057-2061.
    • (2013) Ann Oncol , vol.24 , pp. 2057-2061
    • Bidard, F.C.1    Huguet, F.2    Louvet, C.3
  • 25
    • 84899107449 scopus 로고    scopus 로고
    • Prognostic value of circulating tumor cells in patients with pancreatic cancer: A meta-analysis
    • Han L, Chen W, Zhao Q. Prognostic value of circulating tumor cells in patients with pancreatic cancer: a meta-analysis. Tumour Biol 2014; 35:2473-2480.
    • (2014) Tumour Biol , vol.35 , pp. 2473-2480
    • Han, L.1    Chen, W.2    Zhao, Q.3
  • 26
    • 84906274430 scopus 로고    scopus 로고
    • Prognostic role of circulating tumor cells in patients with pancreatic cancer: A meta-analysis
    • Ma XL, Li YY, Zhang J, et al. Prognostic role of circulating tumor cells in patients with pancreatic cancer: a meta-analysis. Asian Pac J Cancer Prev 2014; 15:6015-6020.
    • (2014) Asian Pac J Cancer Prev , vol.15 , pp. 6015-6020
    • Ma, X.L.1    Li, Y.Y.2    Zhang, J.3
  • 27
    • 84885956968 scopus 로고    scopus 로고
    • Circulating tumor cells in pancreatic cancer patients: Methods of detection and clinical implications
    • Tjensvoll K, Nordgard O, Smaaland R. Circulating tumor cells in pancreatic cancer patients: methods of detection and clinical implications. Int J Cancer 2014; 134:1-8.
    • (2014) Int J Cancer , vol.134 , pp. 1-8
    • Tjensvoll, K.1    Nordgard, O.2    Smaaland, R.3
  • 28
    • 84987958770 scopus 로고    scopus 로고
    • A multicenter pilot study examining the role of circulating tumor cells as a blood-based tumor marker in patients with extensive small-cell lung cancer
    • Huang CH, Wick JA, Sittampalam GS, et al. A multicenter pilot study examining the role of circulating tumor cells as a blood-based tumor marker in patients with extensive small-cell lung cancer. Front Oncol 2014; 4: Article ID 271.
    • (2014) Front Oncol , vol.4
    • Huang, C.H.1    Wick, J.A.2    Sittampalam, G.S.3
  • 29
    • 84896270201 scopus 로고    scopus 로고
    • Circulating tumor cells as a prognostic factor in patients with small cell lung cancer
    • Igawa S, Gohda K, Fukui T, et al. Circulating tumor cells as a prognostic factor in patients with small cell lung cancer. Oncol Lett 2014; 7:1469-1473.
    • (2014) Oncol Lett , vol.7 , pp. 1469-1473
    • Igawa, S.1    Gohda, K.2    Fukui, T.3
  • 30
    • 84922391673 scopus 로고    scopus 로고
    • Circulating tumor cells correlate with recurrence in stage III small-cell lung cancer after systemic chemoradiotherapy and prophylactic cranial irradiation
    • Fu L, Liu F, Fu H, et al. Circulating tumor cells correlate with recurrence in stage III small-cell lung cancer after systemic chemoradiotherapy and prophylactic cranial irradiation. Jpn J Clin Oncol 2014; 44:948-955.
    • (2014) Jpn J Clin Oncol , vol.44 , pp. 948-955
    • Fu, L.1    Liu, F.2    Fu, H.3
  • 31
    • 79955045007 scopus 로고    scopus 로고
    • Evaluation and prognostic significance of circulating tumor cells in patients with nonsmall-cell lung cancer
    • Krebs MG, Sloane R, Priest L, et al. Evaluation and prognostic significance of circulating tumor cells in patients with nonsmall-cell lung cancer. J Clin Oncol 2011; 29:1556-1563.
    • (2011) J Clin Oncol , vol.29 , pp. 1556-1563
    • Krebs, M.G.1    Sloane, R.2    Priest, L.3
  • 32
    • 84892383021 scopus 로고    scopus 로고
    • Prognostic significance of circulating tumor cells in nonsmall-cell lung cancer patients: A meta-analysis
    • Wang J, Wang K, Xu J, et al. Prognostic significance of circulating tumor cells in nonsmall-cell lung cancer patients: a meta-analysis. PLoS One 2013; 8:e78070.
    • (2013) PLoS One , vol.8
    • Wang, J.1    Wang, K.2    Xu, J.3
  • 33
    • 84901951930 scopus 로고    scopus 로고
    • Circulating tumor cell counts are prognostic of overall survival in SWOG S0421: A phase III trial of docetaxel with or without atrasentan for metastatic castration-resistant prostate cancer
    • Goldkorn A, Ely B, Quinn DI, et al. Circulating tumor cell counts are prognostic of overall survival in SWOG S0421: a phase III trial of docetaxel with or without atrasentan for metastatic castration-resistant prostate cancer. J Clin Oncol 2014; 32:1136-1142.
    • (2014) J Clin Oncol , vol.32 , pp. 1136-1142
    • Goldkorn, A.1    Ely, B.2    Quinn, D.I.3
  • 34
    • 84929413050 scopus 로고    scopus 로고
    • Circulating tumor cell biomarker panel as an individual-level surrogate for survival in metastatic castration-resistant prostate cancer
    • Scher HI, Heller G, Molina A, et al. Circulating tumor cell biomarker panel as an individual-level surrogate for survival in metastatic castration-resistant prostate cancer. J Clin Oncol 2015; 33:1348-1355.
    • (2015) J Clin Oncol , vol.33 , pp. 1348-1355
    • Scher, H.I.1    Heller, G.2    Molina, A.3
  • 35
    • 58149165081 scopus 로고    scopus 로고
    • Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer
    • de Bono JS, Scher HI, Montgomery RB, et al. Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer. Clin Cancer Res 2008; 14:6302-6309.
    • (2008) Clin Cancer Res , vol.14 , pp. 6302-6309
    • De Bono, J.S.1    Scher, H.I.2    Montgomery, R.B.3
  • 36
    • 77955491837 scopus 로고    scopus 로고
    • Trabectedin plus pegylated liposomal doxorubicin in recurrent ovarian cancer
    • Monk BJ, Herzog TJ, Kaye SB, et al. Trabectedin plus pegylated liposomal doxorubicin in recurrent ovarian cancer. J Clin Oncol 2010; 28:3107-3114.
    • (2010) J Clin Oncol , vol.28 , pp. 3107-3114
    • Monk, B.J.1    Herzog, T.J.2    Kaye, S.B.3
  • 37
    • 80051548021 scopus 로고    scopus 로고
    • Circulating tumor cells predict progression free survival and overall survival in patients with relapsed/recurrent advanced ovarian cancer
    • Poveda A, Kaye SB, McCormack R, et al. Circulating tumor cells predict progression free survival and overall survival in patients with relapsed/recurrent advanced ovarian cancer. Gynecol Oncol 2011; 122:567-572.
    • (2011) Gynecol Oncol , vol.122 , pp. 567-572
    • Poveda, A.1    Kaye, S.B.2    McCormack, R.3
  • 38
    • 84942157607 scopus 로고    scopus 로고
    • The predictive value of circulating tumor cells in ovarian cancer: A meta analysis
    • [Epub ahead of print]
    • Zeng L, Liang X, Liu Q, et al. The predictive value of circulating tumor cells in ovarian cancer: a meta analysis. Int J Gynecol Cancer 2015. [Epub ahead of print]
    • (2015) Int J Gynecol Cancer
    • Zeng, L.1    Liang, X.2    Liu, Q.3
  • 39
    • 84928395353 scopus 로고    scopus 로고
    • Prognostic value of circulating tumor cells in patients with squamous cell carcinoma of the head and neck: A systematic review and meta-analysis
    • Wang Z, Cui K, Xue Y, et al. Prognostic value of circulating tumor cells in patients with squamous cell carcinoma of the head and neck: a systematic review and meta-analysis. Med Oncol 2015; 32: Article ID 164.
    • (2015) Med Oncol , vol.32
    • Wang, Z.1    Cui, K.2    Xue, Y.3
  • 40
    • 84892933772 scopus 로고    scopus 로고
    • Circulating tumor cells in head and neck cancer: Clinical impact in diagnosis and follow-up
    • Mockelmann N, Laban S, Pantel K, et al. Circulating tumor cells in head and neck cancer: clinical impact in diagnosis and follow-up. Eur Arch Otorhinolaryngol 2014; 271:15-21.
    • (2014) Eur Arch Otorhinolaryngol , vol.271 , pp. 15-21
    • Mockelmann, N.1    Laban, S.2    Pantel, K.3
  • 41
    • 84862806703 scopus 로고    scopus 로고
    • Assessment of prognostic circulating tumor cells in a phase III trial of adjuvant immunotherapy after complete resection of stage IV melanoma
    • Hoshimoto S, Faries MB, Morton DL, et al. Assessment of prognostic circulating tumor cells in a phase III trial of adjuvant immunotherapy after complete resection of stage IV melanoma. Ann Surg 2012; 255:357-362.
    • (2012) Ann Surg , vol.255 , pp. 357-362
    • Hoshimoto, S.1    Faries, M.B.2    Morton, D.L.3
  • 42
    • 84928548312 scopus 로고    scopus 로고
    • Circulating tumor cells as tumor biomarkers in melanoma: Detection methods and clinical relevance
    • Khoja L, Lorigan P, Dive C, et al. Circulating tumor cells as tumor biomarkers in melanoma: detection methods and clinical relevance. Ann Oncol 2014.
    • (2014) Ann Oncol
    • Khoja, L.1    Lorigan, P.2    Dive, C.3
  • 43
    • 84901687402 scopus 로고    scopus 로고
    • International study on inter-reader variability for circulating tumor cells in breast cancer
    • Ignatiadis M, Riethdorf S, Bidard FC, et al. International study on inter-reader variability for circulating tumor cells in breast cancer. Breast Cancer Res 2014; 16:R43.
    • (2014) Breast Cancer Res , vol.16 , pp. R43
    • Ignatiadis, M.1    Riethdorf, S.2    Bidard, F.C.3
  • 44
    • 84941954718 scopus 로고    scopus 로고
    • Development of circulating tumor cell-endocrine therapy index in patients with hormone receptor positive breast cancer
    • Paoletti C, Muniz MC, Thomas DG, et al. Development of circulating tumor cell-endocrine therapy index in patients with hormone receptor positive breast cancer. Clin Cancer Res 2015; 21:2487-2498.
    • (2015) Clin Cancer Res , vol.21 , pp. 2487-2498
    • Paoletti, C.1    Muniz, M.C.2    Thomas, D.G.3
  • 45
    • 84907342688 scopus 로고    scopus 로고
    • Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis
    • Aceto N, Bardia A, Miyamoto DT, et al. Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis. Cell 2014; 158:1110-1122.
    • (2014) Cell , vol.158 , pp. 1110-1122
    • Aceto, N.1    Bardia, A.2    Miyamoto, D.T.3
  • 46
    • 84895802375 scopus 로고    scopus 로고
    • Circulating giant macrophages as a potential biomarker of solid tumors
    • Adams DL, Martin SS, Alpaugh RK, et al. Circulating giant macrophages as a potential biomarker of solid tumors. Proc Natl Acad Sci 2014; 111:3514-3519.
    • (2014) Proc Natl Acad Sci , vol.111 , pp. 3514-3519
    • Adams, D.L.1    Martin, S.S.2    Alpaugh, R.K.3
  • 47
    • 84907057471 scopus 로고    scopus 로고
    • AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer
    • Antonarakis ES, Lu C, Wang H, et al. AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer. N Engl J Med 2014; 371:1028-1038.
    • (2014) N Engl J Med , vol.371 , pp. 1028-1038
    • Antonarakis, E.S.1    Lu, C.2    Wang, H.3
  • 48
    • 84902705681 scopus 로고    scopus 로고
    • Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer reveals heterogeneity, discordance, and mutation persistence in cultured disseminated tumor cells from bone marrow
    • Deng G, Krishnakumar S, Powell AA, et al. Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer reveals heterogeneity, discordance, and mutation persistence in cultured disseminated tumor cells from bone marrow. BMC Cancer 2014; 14: Article ID 456.
    • (2014) BMC Cancer , vol.14
    • Deng, G.1    Krishnakumar, S.2    Powell, A.A.3
  • 49
    • 84908084150 scopus 로고    scopus 로고
    • TP53 mutations detected in circulating tumor cells present in the blood of metastatic triple negative breast cancer patients
    • Fernandez SV, Bingham C, Fittipaldi P, et al. TP53 mutations detected in circulating tumor cells present in the blood of metastatic triple negative breast cancer patients. Breast Cancer Res 2014; 16: Article ID 445.
    • (2014) Breast Cancer Res , vol.16
    • Fernandez, S.V.1    Bingham, C.2    Fittipaldi, P.3
  • 50
    • 84916898794 scopus 로고    scopus 로고
    • PIK3CA mutational status in circulating tumor cells can change during disease recurrence or progression in patients with breast cancer
    • Markou A, Farkona S, Schiza C, et al. PIK3CA mutational status in circulating tumor cells can change during disease recurrence or progression in patients with breast cancer. Clin Cancer Res 2014; 20:5823-5834.
    • (2014) Clin Cancer Res , vol.20 , pp. 5823-5834
    • Markou, A.1    Farkona, S.2    Schiza, C.3
  • 51
    • 84910671460 scopus 로고    scopus 로고
    • Molecular profiling of single circulating tumor cells with diagnostic intention
    • Polzer B, Medoro G, Pasch S, et al. Molecular profiling of single circulating tumor cells with diagnostic intention. EMBO Mol Med 2014; 6:1371-1386.
    • (2014) EMBO Mol Med , vol.6 , pp. 1371-1386
    • Polzer, B.1    Medoro, G.2    Pasch, S.3
  • 52
    • 84926419351 scopus 로고    scopus 로고
    • Heterogeneity of PIK3CA mutational status at the single cell level in circulating tumor cells from metastatic breast cancer patients
    • Pestrin M, Salvianti F, Galardi F, et al. Heterogeneity of PIK3CA mutational status at the single cell level in circulating tumor cells from metastatic breast cancer patients. Mol Oncol 2015; 9:749-757.
    • (2015) Mol Oncol , vol.9 , pp. 749-757
    • Pestrin, M.1    Salvianti, F.2    Galardi, F.3
  • 53
    • 84930616776 scopus 로고    scopus 로고
    • Mutational analysis of circulating tumor cells from colorectal cancer patients and correlation with primary tumor tissue
    • Lyberopoulou A, Aravantinos G, Efstathopoulos EP, et al. Mutational analysis of circulating tumor cells from colorectal cancer patients and correlation with primary tumor tissue. PLoS One 2015; 10:e0123902.
    • (2015) PLoS One , vol.10
    • Lyberopoulou, A.1    Aravantinos, G.2    Efstathopoulos, E.P.3
  • 54
    • 84926420107 scopus 로고    scopus 로고
    • Noninvasive sensitive detection of KRAS and BRAF mutation in circulating tumor cells of colorectal cancer patients
    • Mohamed Suhaimi NA, Foong YM, Lee DY, et al. Noninvasive sensitive detection of KRAS and BRAF mutation in circulating tumor cells of colorectal cancer patients. Mol Oncol 2015; 9:850-860.
    • (2015) Mol Oncol , vol.9 , pp. 850-860
    • Mohamed Suhaimi, N.A.1    Foong, Y.M.2    Lee, D.Y.3
  • 55
    • 84921821089 scopus 로고    scopus 로고
    • ERCC1-positive circulating tumor cells in the blood of ovarian cancer patients as a predictive biomarker for platinum resistance
    • Kuhlmann JD, Wimberger P, Bankfalvi A, et al. ERCC1-positive circulating tumor cells in the blood of ovarian cancer patients as a predictive biomarker for platinum resistance. Clin Chem 2014; 60:1282-1289.
    • (2014) Clin Chem , vol.60 , pp. 1282-1289
    • Kuhlmann, J.D.1    Wimberger, P.2    Bankfalvi, A.3
  • 56
    • 84943654057 scopus 로고    scopus 로고
    • High level of chromosomal instability in circulating tumor cells of ROS1-rearranged nonsmall-cell lung cancer
    • Pailler E, Auger N, Lindsay CR, et al. High level of chromosomal instability in circulating tumor cells of ROS1-rearranged nonsmall-cell lung cancer. Ann Oncol 2015; 26:1408-1415.
    • (2015) Ann Oncol , vol.26 , pp. 1408-1415
    • Pailler, E.1    Auger, N.2    Lindsay, C.R.3
  • 57
    • 84900333051 scopus 로고    scopus 로고
    • Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer
    • Lohr JG, Adalsteinsson VA, Cibulskis K, et al. Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer. Nat Biotechnol 2014; 32:479-484.
    • (2014) Nat Biotechnol , vol.32 , pp. 479-484
    • Lohr, J.G.1    Adalsteinsson, V.A.2    Cibulskis, K.3
  • 58
    • 84904121066 scopus 로고    scopus 로고
    • Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility
    • Yu M, Bardia A, Aceto N, et al. Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility. Science 2014; 345:216-220.
    • (2014) Science , vol.345 , pp. 216-220
    • Yu, M.1    Bardia, A.2    Aceto, N.3
  • 59
    • 84928698890 scopus 로고    scopus 로고
    • Establishment and characterization of a cell line from human circulating colon cancer cells
    • Cayrefourcq L, Mazard T, Joosse S, et al. Establishment and characterization of a cell line from human circulating colon cancer cells. Cancer Res 2015; 75:892-901.
    • (2015) Cancer Res , vol.75 , pp. 892-901
    • Cayrefourcq, L.1    Mazard, T.2    Joosse, S.3
  • 60
    • 84905819148 scopus 로고    scopus 로고
    • Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer
    • Hodgkinson CL, Morrow CJ, Li Y, et al. Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer. Nat Med 2014; 20:897-903.
    • (2014) Nat Med , vol.20 , pp. 897-903
    • Hodgkinson, C.L.1    Morrow, C.J.2    Li, Y.3
  • 61
    • 84895449750 scopus 로고    scopus 로고
    • Microfluidic, marker-free isolation of circulating tumor cells from blood samples
    • Karabacak NM, Spuhler PS, Fachin F, et al. Microfluidic, marker-free isolation of circulating tumor cells from blood samples. Nat Protoc 2014; 9:694-710.
    • (2014) Nat Protoc , vol.9 , pp. 694-710
    • Karabacak, N.M.1    Spuhler, P.S.2    Fachin, F.3
  • 62
    • 84906238686 scopus 로고    scopus 로고
    • Clonal evolution in breast cancer revealed by single nucleus genome sequencing
    • Wang Y, Waters J, Leung ML, et al. Clonal evolution in breast cancer revealed by single nucleus genome sequencing. Nature 2014; 512:155-160.
    • (2014) Nature , vol.512 , pp. 155-160
    • Wang, Y.1    Waters, J.2    Leung, M.L.3
  • 63
    • 84931052979 scopus 로고    scopus 로고
    • Gene expression profiles of circulating tumor cells versus primary tumors in metastatic breast cancer
    • Onstenk W, Sieuwerts AM, Weekhout M, et al. Gene expression profiles of circulating tumor cells versus primary tumors in metastatic breast cancer. Cancer Lett 2015; 362:36-44.
    • (2015) Cancer Lett , vol.362 , pp. 36-44
    • Onstenk, W.1    Sieuwerts, A.M.2    Weekhout, M.3
  • 64
    • 80052436485 scopus 로고    scopus 로고
    • High fragmentation characterizes tumour-derived circulating DNA
    • Mouliere F, Robert B, Arnau Peyrotte E, et al. High fragmentation characterizes tumour-derived circulating DNA. PLoS One 2011; 6:e23418.
    • (2011) PLoS One , vol.6
    • Mouliere, F.1    Robert, B.2    Arnau Peyrotte, E.3
  • 65
    • 84896371874 scopus 로고    scopus 로고
    • Detection of circulating tumor DNA in early-and late-stage human malignancies
    • Bettegowda C, Sausen M, Leary RJ, et al. Detection of circulating tumor DNA in early-and late-stage human malignancies. Sci Transl Med 2014; 6:224ra224.
    • (2014) Sci Transl Med , vol.6 , pp. 224ra224
    • Bettegowda, C.1    Sausen, M.2    Leary, R.J.3
  • 66
    • 84903218109 scopus 로고    scopus 로고
    • An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
    • Newman AM, Bratman SV, To J, et al. An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nat Med 2014; 20:548-554.
    • (2014) Nat Med , vol.20 , pp. 548-554
    • Newman, A.M.1    Bratman, S.V.2    To, J.3
  • 67
    • 84921939213 scopus 로고    scopus 로고
    • Monitoring gastric cancer progression with circulating tumour DNA
    • Hamakawa T, Kukita Y, Kurokawa Y, et al. Monitoring gastric cancer progression with circulating tumour DNA. Br J Cancer 2015; 112:352-356.
    • (2015) Br J Cancer , vol.112 , pp. 352-356
    • Hamakawa, T.1    Kukita, Y.2    Kurokawa, Y.3
  • 68
    • 84923066128 scopus 로고    scopus 로고
    • Mutation profiling of tumor DNA from plasma and tumor tissue of colorectal cancer patients with a novel, highsensitivity multiplexed mutation detection platform
    • Kidess E, Heirich K, Wiggin M, et al. Mutation profiling of tumor DNA from plasma and tumor tissue of colorectal cancer patients with a novel, highsensitivity multiplexed mutation detection platform. Oncotarget 2015; 6:2549-2561.
    • (2015) Oncotarget , vol.6 , pp. 2549-2561
    • Kidess, E.1    Heirich, K.2    Wiggin, M.3
  • 69
    • 84930038230 scopus 로고    scopus 로고
    • Analysis of circulating tumour DNA to monitor disease burden following colorectal cancer surgery
    • [Epub ahead of print]
    • Reinert T, Scholer LV, Thomsen R, et al. Analysis of circulating tumour DNA to monitor disease burden following colorectal cancer surgery. Gut 2015. [Epub ahead of print]. doi: 10.1136/gutjnl-2014-308859.
    • (2015) Gut
    • Reinert, T.1    Scholer, L.V.2    Thomsen, R.3
  • 70
    • 84925451599 scopus 로고    scopus 로고
    • Tracking tumor-specific mutations in circulating-free DNA to predict early relapse after treatment of primary breast cancer
    • abstr 511 Available at
    • Turner NC, Garcia-Murillas I, Schiavon G, et al. Tracking tumor-specific mutations in circulating-free DNA to predict early relapse after treatment of primary breast cancer. J Clin Oncol 2014; 32 (suppl; abstr 511) Available at: http://meetinglibrary.asco.org/content/134201-144.
    • (2014) J Clin Oncol , vol.32
    • Turner, N.C.1    Garcia-Murillas, I.2    Schiavon, G.3
  • 71
    • 84938414305 scopus 로고    scopus 로고
    • Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease
    • Olsson E, Winter C, George A, et al. Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease. EMBO Mol Med 2015. doi: 10.15252/emmm.201404913.
    • (2015) EMBO Mol Med
    • Olsson, E.1    Winter, C.2    George, A.3
  • 72
    • 84923164411 scopus 로고    scopus 로고
    • Circulating tumor DNA and circulating tumor cells in metastatic triple negative breast cancer patients
    • Madic J, Kiialainen A, Bidard FC, et al. Circulating tumor DNA and circulating tumor cells in metastatic triple negative breast cancer patients. Int J Cancer 2015; 136:2158-2165.
    • (2015) Int J Cancer , vol.136 , pp. 2158-2165
    • Madic, J.1    Kiialainen, A.2    Bidard, F.C.3
  • 73
    • 84923174088 scopus 로고    scopus 로고
    • High levels of cell-free circulating nucleic acids in pancreatic cancer are associated with vascular encasement, metastasis and poor survival
    • Singh N, Gupta S, Pandey RM, et al. High levels of cell-free circulating nucleic acids in pancreatic cancer are associated with vascular encasement, metastasis and poor survival. Cancer Invest 2015; 33:78-85.
    • (2015) Cancer Invest , vol.33 , pp. 78-85
    • Singh, N.1    Gupta, S.2    Pandey, R.M.3
  • 74
    • 84908877379 scopus 로고    scopus 로고
    • Cell-free DNA in healthy individuals, noncancerous disease and strong prognostic value in colorectal cancer
    • Spindler K-LG, Appelt AL, Pallisgaard N, et al. Cell-free DNA in healthy individuals, noncancerous disease and strong prognostic value in colorectal cancer. Int J Cancer 2014; 135:2984-2991.
    • (2014) Int J Cancer , vol.135 , pp. 2984-2991
    • Spindler, K.-L.G.1    Appelt, A.L.2    Pallisgaard, N.3
  • 75
    • 84924283696 scopus 로고    scopus 로고
    • Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib
    • Wong AL, Lim JS, Sinha A, et al. Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib. J Transl Med 2015; 13: Article ID 57.
    • (2015) J Transl Med , vol.13
    • Wong, A.L.1    Lim, J.S.2    Sinha, A.3
  • 76
    • 84900410805 scopus 로고    scopus 로고
    • Personalized ovarian cancer disease surveillance and detection of candidate therapeutic drug target in circulating tumor DNA
    • Martignetti JA, Camacho-Vanegas O, Priedigkeit N, et al. Personalized ovarian cancer disease surveillance and detection of candidate therapeutic drug target in circulating tumor DNA. Neoplasia 2014; 16:97-103.
    • (2014) Neoplasia , vol.16 , pp. 97-103
    • Martignetti, J.A.1    Camacho-Vanegas, O.2    Priedigkeit, N.3
  • 77
    • 84941630950 scopus 로고    scopus 로고
    • Circulating Tumor DNA as an Early Marker of Therapeutic Response in Patients with Metastatic Colorectal Cancer
    • Tie J, Kinde I, Wang Y, et al. Circulating Tumor DNA as an Early Marker of Therapeutic Response in Patients with Metastatic Colorectal Cancer. Ann Oncol 2015; 26:1715-1722.
    • (2015) Ann Oncol , vol.26 , pp. 1715-1722
    • Tie, J.1    Kinde, I.2    Wang, Y.3
  • 78
    • 84941885181 scopus 로고    scopus 로고
    • Short report:Monitoring ESR1 mutations by circulating tumor DNA in aromatase inhibitor resistant metastatic breast cancer
    • Sefrioui D, Perdrix A, Sarafan-Vasseur N, et al. Short report:Monitoring ESR1 mutations by circulating tumor DNA in aromatase inhibitor resistant metastatic breast cancer. Int J Cancer 2015. doi: 10.1002/ijc.29612.
    • (2015) Int J Cancer
    • Sefrioui, D.1    Perdrix, A.2    Sarafan-Vasseur, N.3
  • 79
    • 84931855006 scopus 로고    scopus 로고
    • Noninvasive detection of activating estrogen receptor 1 (ESR1) mutations in estrogen receptor-positive metastatic breast cancer
    • Guttery DS, Page K, Hills A, et al. Noninvasive detection of activating estrogen receptor 1 (ESR1) mutations in estrogen receptor-positive metastatic breast cancer. Clin Chem 2015; 61:974-982.
    • (2015) Clin Chem , vol.61 , pp. 974-982
    • Guttery, D.S.1    Page, K.2    Hills, A.3
  • 80
    • 84925460062 scopus 로고    scopus 로고
    • PIK3CA mutations in serum DNA are predictive of recurrence in primary breast cancer patients
    • Oshiro C, Kagara N, Naoi Y, et al. PIK3CA mutations in serum DNA are predictive of recurrence in primary breast cancer patients. Breast Cancer Res Treat 2015; 150:299-307.
    • (2015) Breast Cancer Res Treat , vol.150 , pp. 299-307
    • Oshiro, C.1    Kagara, N.2    Naoi, Y.3
  • 81
    • 84900992934 scopus 로고    scopus 로고
    • Detection of cancer DNA in plasma of patients with early-stage breast cancer
    • Beaver JA, Jelovac D, Balukrishna S, et al. Detection of cancer DNA in plasma of patients with early-stage breast cancer. Clin Cancer Res 2014; 20:2643-2650.
    • (2014) Clin Cancer Res , vol.20 , pp. 2643-2650
    • Beaver, J.A.1    Jelovac, D.2    Balukrishna, S.3
  • 82
    • 84898476658 scopus 로고    scopus 로고
    • Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA
    • Thierry AR, Mouliere F, El Messaoudi S, et al. Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA. Nat Med 2014; 20:430-435.
    • (2014) Nat Med , vol.20 , pp. 430-435
    • Thierry, A.R.1    Mouliere, F.2    El Messaoudi, S.3
  • 83
    • 84936748494 scopus 로고    scopus 로고
    • Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients
    • Siravegna G, Mussolin B, Buscarino M, et al. Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients. Nat Med 2015; 21:795-801.
    • (2015) Nat Med , vol.21 , pp. 795-801
    • Siravegna, G.1    Mussolin, B.2    Buscarino, M.3
  • 84
    • 84926431987 scopus 로고    scopus 로고
    • Characterizing the patterns of clonal selection in circulating tumor DNA from patients with colorectal cancer refractory to anti-EGFR treatment
    • Morelli MP, Overman MJ, Dasari A, et al. Characterizing the patterns of clonal selection in circulating tumor DNA from patients with colorectal cancer refractory to anti-EGFR treatment. Ann Oncol 2015; 26:731-736.
    • (2015) Ann Oncol , vol.26 , pp. 731-736
    • Morelli, M.P.1    Overman, M.J.2    Dasari, A.3
  • 85
    • 84931364786 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutation mediates cross-resistance to panitumumab and cetuximab in gastrointestinal cancer
    • Braig F, Marz M, Schieferdecker A, et al. Epidermal growth factor receptor mutation mediates cross-resistance to panitumumab and cetuximab in gastrointestinal cancer. Oncotarget 2015; 6:12035-12047.
    • (2015) Oncotarget , vol.6 , pp. 12035-12047
    • Braig, F.1    Marz, M.2    Schieferdecker, A.3
  • 86
    • 84931259623 scopus 로고    scopus 로고
    • Prognostic role of APC and RASSF1A promoter methylation status in cell free circulating DNA of operable gastric cancer patients
    • Balgkouranidou I, Matthaios D, Karayiannakis A, et al. Prognostic role of APC and RASSF1A promoter methylation status in cell free circulating DNA of operable gastric cancer patients. Mutation Res 2015; 778:46-51.
    • (2015) Mutation Res , vol.778 , pp. 46-51
    • Balgkouranidou, I.1    Matthaios, D.2    Karayiannakis, A.3
  • 87
    • 84942111942 scopus 로고    scopus 로고
    • HER2 amplification detected in the circulating DNA of patients with gastric cancer: A retrospective pilot study
    • Shoda K, Masuda K, Ichikawa D, et al. HER2 amplification detected in the circulating DNA of patients with gastric cancer: a retrospective pilot study. Gastric Cancer 2014; doi 10.1007/s10120-014-0432-5.
    • (2014) Gastric Cancer
    • Shoda, K.1    Masuda, K.2    Ichikawa, D.3
  • 88
    • 84931061208 scopus 로고    scopus 로고
    • Detection of K-ras gene mutation by liquid biopsy in patients with pancreatic cancer
    • Kinugasa H, Nouso K, Miyahara K, et al. Detection of K-ras gene mutation by liquid biopsy in patients with pancreatic cancer. Cancer 2015; 121:2271-2280.
    • (2015) Cancer , vol.121 , pp. 2271-2280
    • Kinugasa, H.1    Nouso, K.2    Miyahara, K.3
  • 89
    • 84938399710 scopus 로고    scopus 로고
    • Detection and dynamic changes of EGFR mutations from circulating tumor DNA as a predictor of survival outcomes in NSCLC patients treated with first-line intercalated erlotinib and chemotherapy
    • Mok T, Wu YL, Lee JS, et al. Detection and dynamic changes of EGFR mutations from circulating tumor DNA as a predictor of survival outcomes in NSCLC patients treated with first-line intercalated erlotinib and chemotherapy. Clin Cancer Res 2015; 21:3196-1203.
    • (2015) Clin Cancer Res , vol.21 , pp. 3196-3203
    • Mok, T.1    Wu, Y.L.2    Lee, J.S.3
  • 90
    • 84921032852 scopus 로고    scopus 로고
    • Circulating tumor DNA is effective for the detection of EGFR mutation in non-small cell lung cancer: A meta-analysis
    • Qiu M, Wang J, Xu Y, et al. Circulating tumor DNA is effective for the detection of EGFR mutation in non-small cell lung cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev 2015; 24:206-212.
    • (2015) Cancer Epidemiol Biomarkers Prev , vol.24 , pp. 206-212
    • Qiu, M.1    Wang, J.2    Xu, Y.3
  • 91
    • 84937414146 scopus 로고    scopus 로고
    • Heterogeneity underlies the emergence of EGFRT790 wild-type clones following treatment of T790Mpositive cancers with a third-generation EGFR inhibitor
    • Piotrowska Z, Niederst MJ, Karlovich CA, et al. Heterogeneity underlies the emergence of EGFRT790 wild-type clones following treatment of T790Mpositive cancers with a third-generation EGFR inhibitor. Cancer Discov 2015; 5:713-722.
    • (2015) Cancer Discov , vol.5 , pp. 713-722
    • Piotrowska, Z.1    Niederst, M.J.2    Karlovich, C.A.3
  • 92
    • 84931051590 scopus 로고    scopus 로고
    • Quantification of concentration and assessment of EGFR mutation in circulating DNA
    • Mazurek A, Pierzyna M, Giglok M, et al. Quantification of concentration and assessment of EGFR mutation in circulating DNA. Cancer Biomark 2015.
    • (2015) Cancer Biomark
    • Mazurek, A.1    Pierzyna, M.2    Giglok, M.3
  • 93
    • 84906250256 scopus 로고    scopus 로고
    • Gefitinib treatment in EGFR mutated caucasian NSCLC: Circulating-free tumor DNA as a surrogate for determination of EGFR status
    • Douillard JY, Ostoros G, Cobo M, et al. Gefitinib treatment in EGFR mutated caucasian NSCLC: circulating-free tumor DNA as a surrogate for determination of EGFR status. J Thorac Oncol 2014; 9:1345-1353.
    • (2014) J Thorac Oncol , vol.9 , pp. 1345-1353
    • Douillard, J.Y.1    Ostoros, G.2    Cobo, M.3
  • 94
    • 84908548256 scopus 로고    scopus 로고
    • Methylated Glutathione S-transferase 1 (mGSTP1) is a potential plasma free DNA epigenetic marker of prognosis and response to chemotherapy in castrate-resistant prostate cancer
    • Mahon KL, Qu W, Devaney J, et al. Methylated Glutathione S-transferase 1 (mGSTP1) is a potential plasma free DNA epigenetic marker of prognosis and response to chemotherapy in castrate-resistant prostate cancer. Br J Cancer 2014; 111:1802-1809.
    • (2014) Br J Cancer , vol.111 , pp. 1802-1809
    • Mahon, K.L.1    Qu, W.2    Devaney, J.3
  • 95
    • 84934985499 scopus 로고    scopus 로고
    • Monitoring response to therapy in melanoma by quantifying circulating tumour DNA with droplet digital PCR for BRAF and NRAS mutations
    • Chang-Hao Tsao S, Weiss J, Hudson C, et al. Monitoring response to therapy in melanoma by quantifying circulating tumour DNA with droplet digital PCR for BRAF and NRAS mutations. Sci Rep 2015; 5: Article ID 11198.
    • (2015) Sci Rep , vol.5
    • Chang-Hao Tsao, S.1    Weiss, J.2    Hudson, C.3
  • 96
    • 84920520594 scopus 로고    scopus 로고
    • Quantitative cellfree circulating BRAFV600E mutation analysis by use of droplet digital PCR in the follow-up of patients with melanoma being treated with BRAF inhibitors
    • Sanmamed MF, Fernandez-Landazuri S, Rodriguez C, et al. Quantitative cellfree circulating BRAFV600E mutation analysis by use of droplet digital PCR in the follow-up of patients with melanoma being treated with BRAF inhibitors. Clin Chem 2015; 61:297-304.
    • (2015) Clin Chem , vol.61 , pp. 297-304
    • Sanmamed, M.F.1    Fernandez-Landazuri, S.2    Rodriguez, C.3
  • 97
    • 84941642630 scopus 로고    scopus 로고
    • Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer
    • Barault L, Amatu A, Bleeker FE, et al. Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer. Ann Oncol 2015. doi: 10.1093/annonc/mdv272.
    • (2015) Ann Oncol
    • Barault, L.1    Amatu, A.2    Bleeker, F.E.3
  • 98
    • 84949091659 scopus 로고    scopus 로고
    • Detection of KIT and PDGFRA mutations in the plasma of patients with gastrointestinal stromal tumor
    • Kang G, Bae BN, Sohn BS, et al. Detection of KIT and PDGFRA mutations in the plasma of patients with gastrointestinal stromal tumor. Target Oncol 2015. doi: 10.1007/s11523-015-0361-1.
    • (2015) Target Oncol
    • Kang, G.1    Bae, B.N.2    Sohn, B.S.3
  • 99
    • 84984918388 scopus 로고    scopus 로고
    • Detection of tumor ALK status in neuroblastoma patients using peripheral blood
    • Combaret V, Iacono I, Bellini A, et al. Detection of tumor ALK status in neuroblastoma patients using peripheral blood. Cancer Med 2015; 4:540-550.
    • (2015) Cancer Med , vol.4 , pp. 540-550
    • Combaret, V.1    Iacono, I.2    Bellini, A.3
  • 100
    • 84923059431 scopus 로고    scopus 로고
    • Diagnostic value of circulating free DNA for the detection of EGFR mutation status in NSCLC: A systematic review and metaanalysis
    • Luo J, Shen L, Zheng D. Diagnostic value of circulating free DNA for the detection of EGFR mutation status in NSCLC: a systematic review and metaanalysis. Sci Rep 2014; 4: Article ID 6269.
    • (2014) Sci Rep , vol.4
    • Luo, J.1    Shen, L.2    Zheng, D.3
  • 101
    • 84919471556 scopus 로고    scopus 로고
    • Insufficiency of peripheral blood as a substitute tissue for detecting EGFR mutations in lung cancer: A meta-analysis
    • Li Z, Zhang Y, Bao W, et al. Insufficiency of peripheral blood as a substitute tissue for detecting EGFR mutations in lung cancer: a meta-analysis. Target Oncol 2014; 9:381-388.
    • (2014) Target Oncol , vol.9 , pp. 381-388
    • Li, Z.1    Zhang, Y.2    Bao, W.3
  • 102
    • 84965092386 scopus 로고    scopus 로고
    • ASsociation of EGFR l858r mutation in circulating free DNA with survival in the eurtac trial
    • Karachaliou N, Mayo-de las Casas C, Queralt C, et al. ASsociation of egfr l858r mutation in circulating free dna with survival in the eurtac trial. J Am Med Assoc Oncol 2015; 1:149-157.
    • (2015) J Am Med Assoc Oncol , vol.1 , pp. 149-157
    • Karachaliou, N.1    Mayo-De Las Casas, C.2    Queralt, C.3
  • 103
    • 84906245875 scopus 로고    scopus 로고
    • Changes in mutational status during third-line treatment for metastatic colorectal cancer-results of consecutive measurement of cell free DNA, KRAS and BRAF in the plasma
    • Spindler KL, Pallisgaard N, Andersen RF, et al. Changes in mutational status during third-line treatment for metastatic colorectal cancer-results of consecutive measurement of cell free DNA, KRAS and BRAF in the plasma. Int J Cancer 2014; 135:2215-2222.
    • (2014) Int J Cancer , vol.135 , pp. 2215-2222
    • Spindler, K.L.1    Pallisgaard, N.2    Andersen, R.F.3
  • 104
    • 84926416450 scopus 로고    scopus 로고
    • Circulating tumor DNA as a noninvasive substitute to metastasis biopsy for tumor genotyping and personalized medicine in a prospective trial across all tumor types
    • Lebofsky R, Decraene C, Bernard V, et al. Circulating tumor DNA as a noninvasive substitute to metastasis biopsy for tumor genotyping and personalized medicine in a prospective trial across all tumor types. Mol Oncol 2015; 9:783-790.
    • (2015) Mol Oncol , vol.9 , pp. 783-790
    • Lebofsky, R.1    Decraene, C.2    Bernard, V.3
  • 105
    • 84906890825 scopus 로고    scopus 로고
    • Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: A proof-of-principle
    • De Mattos-Arruda L, Weigelt B, Cortes J, et al. Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle. Ann Oncol 2014; 25:1729-1735.
    • (2014) Ann Oncol , vol.25 , pp. 1729-1735
    • De Mattos-Arruda, L.1    Weigelt, B.2    Cortes, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.