-
1
-
-
84856529558
-
Making personalized cancer medicine a reality: Challenges and opportunities in the development of biomarkers and companion diagnostics
-
Parkinson DR, Johnson BE, Sledge GW. Making personalized cancer medicine a reality: challenges and opportunities in the development of biomarkers and companion diagnostics. Clin Cancer Res 2012;18:619-24.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 619-624
-
-
Parkinson, D.R.1
Johnson, B.E.2
Sledge, G.W.3
-
2
-
-
84901199614
-
Molecular profiling and the reclassification of cancer: Divide and conquer
-
Munoz J, Swanton C, Kurzrock R. Molecular profiling and the reclassification of cancer: divide and conquer. Am Soc Clin Oncol Educ Book 2013;2013:127-34.
-
(2013)
Am Soc Clin Oncol Educ Book
, vol.2013
, pp. 127-134
-
-
Munoz, J.1
Swanton, C.2
Kurzrock, R.3
-
3
-
-
84908460595
-
Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
-
Hoadley KA, Yau C, Wolf DM, Cherniack AD, Tamborero D, Ng S, et al. Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. Cell 2014;158:929-44.
-
(2014)
Cell
, vol.158
, pp. 929-944
-
-
Hoadley, K.A.1
Yau, C.2
Wolf, D.M.3
Cherniack, A.D.4
Tamborero, D.5
Ng, S.6
-
4
-
-
0037103424
-
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
-
Demetri GD, Von Mehren M, Blanke CD, Van Den Abbeele AD, Eisenberg B, Roberts PJ, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002;347:472-80.
-
(2002)
N Engl J Med
, vol.347
, pp. 472-480
-
-
Demetri, G.D.1
Von Mehren, M.2
Blanke, C.D.3
Van Den Abbeele, A.D.4
Eisenberg, B.5
Roberts, P.J.6
-
5
-
-
42949128595
-
Major response to imatinib mesylate in KIT-mutated melanoma
-
Hodi FS, Friedlander P, Corless CL, Heinrich MC, MacRae S, Kruse A, et al. Major response to imatinib mesylate in KIT-mutated melanoma. J Clin Oncol 2008;26:2046-51.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2046-2051
-
-
Hodi, F.S.1
Friedlander, P.2
Corless, C.L.3
Heinrich, M.C.4
MacRae, S.5
Kruse, A.6
-
6
-
-
84871968444
-
PIK3CA mutation H1047R is associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early-phase clinical trials
-
Janku F, Wheler JJ, Naing A, Falchook GS, Hong DS, Stepanek VM, et al. PIK3CA mutation H1047R is associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early-phase clinical trials. Cancer Res 2013;73:276-84.
-
(2013)
Cancer Res
, vol.73
, pp. 276-284
-
-
Janku, F.1
Wheler, J.J.2
Naing, A.3
Falchook, G.S.4
Hong, D.S.5
Stepanek, V.M.6
-
7
-
-
84895906492
-
Assessing PIK3CA and PTEN in early-phase trials with PI3K/AKT/mTOR inhibitors
-
Janku F, Hong DS, Fu S, Piha-Paul SA, Naing A, Falchook GS, et al. Assessing PIK3CA and PTEN in early-phase trials with PI3K/AKT/mTOR inhibitors. Cell Rep 2014;6:377-87.
-
(2014)
Cell Rep
, vol.6
, pp. 377-387
-
-
Janku, F.1
Hong, D.S.2
Fu, S.3
Piha-Paul, S.A.4
Naing, A.5
Falchook, G.S.6
-
8
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011;364:2507-16.
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
Haanen, J.B.4
Ascierto, P.5
Larkin, J.6
-
9
-
-
84865620351
-
KRAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo
-
Hofmann I, Weiss A, Elain G, Schwaederle M, Sterker D, Romanet V, et al. KRAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo. PLoS One 2012;7:e44146.
-
(2012)
PLoS One
, vol.7
, pp. e44146
-
-
Hofmann, I.1
Weiss, A.2
Elain, G.3
Schwaederle, M.4
Sterker, D.5
Romanet, V.6
-
10
-
-
31144453233
-
BRAF mutation predicts sensitivity to MEK inhibition
-
Solit DB, Garraway LA, Pratilas CA, Sawai A, Getz G, Basso A, et al. BRAF mutation predicts sensitivity to MEK inhibition. Nature 2006;439:358-62.
-
(2006)
Nature
, vol.439
, pp. 358-362
-
-
Solit, D.B.1
Garraway, L.A.2
Pratilas, C.A.3
Sawai, A.4
Getz, G.5
Basso, A.6
-
11
-
-
84871396050
-
It's about time: Lessons for solid tumors from chronic myelogenous leukemia therapy
-
Westin JR, Kurzrock R. It's about time: lessons for solid tumors from chronic myelogenous leukemia therapy. Mol Cancer Ther 2012;11:2549-55.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 2549-2555
-
-
Westin, J.R.1
Kurzrock, R.2
-
12
-
-
33845444046
-
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
-
Druker BJ, Guilhot F, O'Brien SG, Gathmann I, Kantarjian H, Gattermann N, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006;355:2408-17.
-
(2006)
N Engl J Med
, vol.355
, pp. 2408-2417
-
-
Druker, B.J.1
Guilhot, F.2
O'Brien, S.G.3
Gathmann, I.4
Kantarjian, H.5
Gattermann, N.6
-
13
-
-
0037186915
-
Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
-
Kantarjian H, Sawyers C, Hochhaus A, Guilhot F, Schiffer C, Gambacorti-Passerini C, et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med 2002;346:645-52.
-
(2002)
N Engl J Med
, vol.346
, pp. 645-652
-
-
Kantarjian, H.1
Sawyers, C.2
Hochhaus, A.3
Guilhot, F.4
Schiffer, C.5
Gambacorti-Passerini, C.6
-
14
-
-
84869223443
-
Personalized medicine in a phase I clinical trials program: The MD Anderson Cancer Center initiative
-
Tsimberidou A-M, Iskander NG, Hong DS, Wheler JJ, Falchook GS, Fu S, et al. Personalized medicine in a phase I clinical trials program: the MD Anderson Cancer Center initiative. Clin Cancer Res 2012;18:6373-83.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 6373-6383
-
-
Tsimberidou, A.-M.1
Iskander, N.G.2
Hong, D.S.3
Wheler, J.J.4
Falchook, G.S.5
Fu, S.6
-
15
-
-
84869209150
-
Outcomes of phase II clinical trials with single-agent therapies in advanced/metastatic non-small cell lung cancer published between 2000 and 2009
-
Janku F, Berry DA, Gong J, Parsons HA, Stewart DJ, Kurzrock R. Outcomes of phase II clinical trials with single-agent therapies in advanced/metastatic non-small cell lung cancer published between 2000 and 2009. Clin Cancer Res 2012;18:6356-63.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 6356-6363
-
-
Janku, F.1
Berry, D.A.2
Gong, J.3
Parsons, H.A.4
Stewart, D.J.5
Kurzrock, R.6
-
16
-
-
84880321253
-
P53 mutations in advanced cancers: Clinical characteristics, outcomes, and correlation between progression-free survival and bevacizumab-containing therapy
-
Said R, Hong DS, Warneke CL, Lee JJ, Wheler JJ, Janku F, et al. P53 mutations in advanced cancers: clinical characteristics, outcomes, and correlation between progression-free survival and bevacizumab-containing therapy. Oncotarget 2013;4:705-14.
-
(2013)
Oncotarget
, vol.4
, pp. 705-714
-
-
Said, R.1
Hong, D.S.2
Warneke, C.L.3
Lee, J.J.4
Wheler, J.J.5
Janku, F.6
-
17
-
-
84901936604
-
Enabling a genetically informed approach to cancer medicine: A retrospective evaluation of the impact of comprehensive tumor profiling using a targeted next-generation sequencing panel
-
Johnson DB, Dahlman KH, Knol J, Gilbert J, Puzanov I, Means-Powell J, et al. Enabling a genetically informed approach to cancer medicine: a retrospective evaluation of the impact of comprehensive tumor profiling using a targeted next-generation sequencing panel. Oncologist 2014;9:616-22.
-
(2014)
Oncologist
, vol.9
, pp. 616-622
-
-
Johnson, D.B.1
Dahlman, K.H.2
Knol, J.3
Gilbert, J.4
Puzanov, I.5
Means-Powell, J.6
-
18
-
-
84901918076
-
Molecular tumor board: The University of California San Diego Moores Cancer Center Experience
-
Schwaederle M, Parker BA, Schwab RB, Fanta PT, Boles SG, Daniels GA, et al. Molecular tumor board: The University of California San Diego Moores Cancer Center Experience. Oncologist 2014;18:631-6.
-
(2014)
Oncologist
, vol.18
, pp. 631-636
-
-
Schwaederle, M.1
Parker, B.A.2
Schwab, R.B.3
Fanta, P.T.4
Boles, S.G.5
Daniels, G.A.6
-
19
-
-
52049089936
-
Phase II, open-label study evaluating the activity of imatinib in treating life-threatening malignancies known to be associated with imatinib-sensitive tyrosine kinases
-
Heinrich MC, Joensuu H, Demetri GD, Corless CL, Apperley J, Fletcher JA, et al. Phase II, open-label study evaluating the activity of imatinib in treating life-threatening malignancies known to be associated with imatinib-sensitive tyrosine kinases. Clin Cancer Res 2008;14:2717-25.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 2717-2725
-
-
Heinrich, M.C.1
Joensuu, H.2
Demetri, G.D.3
Corless, C.L.4
Apperley, J.5
Fletcher, J.A.6
-
21
-
-
84901217741
-
Unique molecular signatures as a hallmark of patients with metastatic breast cancer: Implications for current treatment paradigms
-
Wheler JJ, Parker BA, Lee JJ, Atkins JT, Janku F, Tsimberidou AM, et al. Unique molecular signatures as a hallmark of patients with metastatic breast cancer: implications for current treatment paradigms. Oncotarget 2014;5:2349-54.
-
(2014)
Oncotarget
, vol.5
, pp. 2349-2354
-
-
Wheler, J.J.1
Parker, B.A.2
Lee, J.J.3
Atkins, J.T.4
Janku, F.5
Tsimberidou, A.M.6
-
22
-
-
84942117421
-
A framework for genomic biomarker actionability and its use in clinical decision making
-
Vidwans SJ, Turski ML, Janku F, Garrido-Laguna I, Munoz J, Schwab R, et al. A framework for genomic biomarker actionability and its use in clinical decision making. Oncoscience 2014;1:614-23.
-
(2014)
Oncoscience
, vol.1
, pp. 614-623
-
-
Vidwans, S.J.1
Turski, M.L.2
Janku, F.3
Garrido-Laguna, I.4
Munoz, J.5
Schwab, R.6
|