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Volumn 7, Issue , 2016, Pages

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; GREEN FLUORESCENT PROTEIN;

EID: 84966283572     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms11499     Document Type: Article
Times cited : (450)

References (62)
  • 2
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • Block, M. L., Zecca, L. & Hong, J. S. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 8, 57-69 (2007).
    • (2007) Nat. Rev. Neurosci , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.S.3
  • 3
    • 34248392684 scopus 로고    scopus 로고
    • Microglial activation and its implications in the brain diseases
    • Dheen, S. T., Kaur, C. & Ling, E. A. Microglial activation and its implications in the brain diseases. Curr. Med. Chem. 14, 1189-1197 (2007).
    • (2007) Curr. Med. Chem. , vol.14 , pp. 1189-1197
    • Dheen, S.T.1    Kaur, C.2    Ling, E.A.3
  • 4
    • 79960141471 scopus 로고    scopus 로고
    • The immunology of stroke: From mechanisms to translation
    • Iadecola, C. & Anrather, J. The immunology of stroke: from mechanisms to translation. Nat. Med. 17, 796-808 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 796-808
    • Iadecola, C.1    Anrather, J.2
  • 5
    • 77953620336 scopus 로고    scopus 로고
    • Inflammation and brain injury: Acute cerebral ischaemia, peripheral and central inflammation
    • Denes, A., Thornton, P., Rothwell, N. J. & Allan, S. M. Inflammation and brain injury: acute cerebral ischaemia, peripheral and central inflammation. Brain Behav. Immun. 24, 708-723 (2010).
    • (2010) Brain Behav. Immun. , vol.24 , pp. 708-723
    • Denes, A.1    Thornton, P.2    Rothwell, N.J.3    Allan, S.M.4
  • 6
    • 84899418705 scopus 로고    scopus 로고
    • Microglia and brain macrophages in the molecular age: From origin to neuropsychiatric disease
    • Prinz, M. & Priller, J. Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease. Nat. Rev. Neurosci. 15, 300-312 (2014).
    • (2014) Nat. Rev. Neurosci. , vol.15 , pp. 300-312
    • Prinz, M.1    Priller, J.2
  • 7
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn, A., Kirchhoff, F. & Helmchen, F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308, 1314-1318 (2005).
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 8
    • 22244464662 scopus 로고    scopus 로고
    • ATP mediates rapid microglial response to local brain injury in vivo
    • Davalos, D. et al. ATP mediates rapid microglial response to local brain injury in vivo. Nat. Neurosci. 8, 752-758 (2005).
    • (2005) Nat. Neurosci. , vol.8 , pp. 752-758
    • Davalos, D.1
  • 9
    • 84938089621 scopus 로고    scopus 로고
    • Perivascular microglia promote blood vessel disintegration in the ischaemic penumbra
    • Jolivel, V. et al. Perivascular microglia promote blood vessel disintegration in the ischaemic penumbra. Acta Neuropathol. 129, 279-295 (2015).
    • (2015) Acta Neuropathol. , vol.129 , pp. 279-295
    • Jolivel, V.1
  • 10
    • 48549087008 scopus 로고    scopus 로고
    • In vivo calcium imaging reveals functional rewiring of single somatosensory neurons after stroke
    • Winship, I. R. & Murphy, T. H. In vivo calcium imaging reveals functional rewiring of single somatosensory neurons after stroke. J. Neurosci. 28, 6592-6606 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 6592-6606
    • Winship, I.R.1    Murphy, T.H.2
  • 11
    • 65249157852 scopus 로고    scopus 로고
    • Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischaemic terminals
    • Wake, H., Moorhouse, A. J., Jinno, S., Kohsaka, S. & Nabekura, J. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischaemic terminals. J. Neurosci. 29, 3974-3980 (2009).
    • (2009) J. Neurosci. , vol.29 , pp. 3974-3980
    • Wake, H.1    Moorhouse, A.J.2    Jinno, S.3    Kohsaka, S.4    Nabekura, J.5
  • 12
    • 84922575495 scopus 로고    scopus 로고
    • Modulation of microglial process convergence toward neuronal dendrites by extracellular calcium
    • Eyo, U. B. et al. Modulation of microglial process convergence toward neuronal dendrites by extracellular calcium. J. Neurosci. 35, 2417-2422 (2015).
    • (2015) J. Neurosci. , vol.35 , pp. 2417-2422
    • Eyo, U.B.1
  • 13
    • 84868094724 scopus 로고    scopus 로고
    • Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain
    • Kaindl, A. M. et al. Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain. Ann. Neurol. 72, 536-549 (2012).
    • (2012) Ann. Neurol. , vol.72 , pp. 536-549
    • Kaindl, A.M.1
  • 14
    • 84887854565 scopus 로고    scopus 로고
    • Glutamate excitotoxicity in the cerebellum mediated by IL-1beta
    • Mohebiany, A. N. & Schneider, R. Glutamate excitotoxicity in the cerebellum mediated by IL-1beta. J. Neurosci. 33, 18353-18355 (2013).
    • (2013) J. Neurosci. , vol.33 , pp. 18353-18355
    • Mohebiany, A.N.1    Schneider, R.2
  • 15
    • 30644480429 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha but not interleukin 1 beta mediates neuroprotection in response to acute nitric oxide excitotoxicity
    • Turrin, N. P. & Rivest, S. Tumor necrosis factor alpha but not interleukin 1 beta mediates neuroprotection in response to acute nitric oxide excitotoxicity. J. Neurosci. 26, 143-151 (2006).
    • (2006) J. Neurosci. , vol.26 , pp. 143-151
    • Turrin, N.P.1    Rivest, S.2
  • 16
    • 84856349219 scopus 로고    scopus 로고
    • Neuroprotective function for ramified microglia in hippocampal excitotoxicity
    • Vinet, J. et al. Neuroprotective function for ramified microglia in hippocampal excitotoxicity. J. Neuroinflammation 9, 27 (2012).
    • (2012) J. Neuroinflammation , vol.9 , pp. 27
    • Vinet, J.1
  • 17
    • 84930267757 scopus 로고    scopus 로고
    • The stroke-migraine depolarization continuum
    • Dreier, J. P. & Reiffurth, C. The stroke-migraine depolarization continuum. Neuron 86, 902-922 (2015).
    • (2015) Neuron , vol.86 , pp. 902-922
    • Dreier, J.P.1    Reiffurth, C.2
  • 18
    • 79953757268 scopus 로고    scopus 로고
    • The role of spreading depression, spreading depolarization and spreading ischaemia in neurological disease
    • Dreier, J. P. The role of spreading depression, spreading depolarization and spreading ischaemia in neurological disease. Nat. Med. 17, 439-447 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 439-447
    • Dreier, J.P.1
  • 19
    • 84856697460 scopus 로고    scopus 로고
    • Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex
    • Dreier, J. P. et al. Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex. Brain 135, 259-275 (2012).
    • (2012) Brain , vol.135 , pp. 259-275
    • Dreier, J.P.1
  • 20
    • 84926138697 scopus 로고    scopus 로고
    • Spreading depolarizations mediate excitotoxicity in the development of acute cortical lesions
    • Hinzman, J. M., DiNapoli, V. A., Mahoney, E. J., Gerhardt, G. A. & Hartings, J. A. Spreading depolarizations mediate excitotoxicity in the development of acute cortical lesions. Exp. Neurol. 267, 243-253 (2015).
    • (2015) Exp. Neurol. , vol.267 , pp. 243-253
    • Hinzman, J.M.1    DiNapoli, V.A.2    Mahoney, E.J.3    Gerhardt, G.A.4    Hartings, J.A.5
  • 21
    • 78149360132 scopus 로고    scopus 로고
    • Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    • Ginhoux, F. et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330, 841-845 (2010).
    • (2010) Science , vol.330 , pp. 841-845
    • Ginhoux, F.1
  • 22
    • 84875892857 scopus 로고    scopus 로고
    • Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
    • Kierdorf, K. et al. Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat. Neurosci. 16, 273-280 (2013).
    • (2013) Nat. Neurosci. , vol.16 , pp. 273-280
    • Kierdorf, K.1
  • 23
    • 80055051144 scopus 로고    scopus 로고
    • Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits
    • Erblich, B., Zhu, L., Etgen, A. M., Dobrenis, K. & Pollard, J. W. Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits. PLoS ONE 6, e26317 (2011).
    • (2011) PLoS ONE , vol.6
    • Erblich, B.1    Zhu, L.2    Etgen, A.M.3    Dobrenis, K.4    Pollard, J.W.5
  • 24
    • 84898676953 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 receptor signalling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain
    • Elmore, M. R. et al. Colony-stimulating factor 1 receptor signalling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain. Neuron 82, 380-397 (2014).
    • (2014) Neuron , vol.82 , pp. 380-397
    • Elmore, M.R.1
  • 25
    • 84876486923 scopus 로고    scopus 로고
    • CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice
    • Fumagalli, S., Perego, C., Ortolano, F. & De Simoni, M. G. CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice. Glia 61, 827-842 (2013).
    • (2013) Glia , vol.61 , pp. 827-842
    • Fumagalli, S.1    Perego, C.2    Ortolano, F.3    De Simoni, M.G.4
  • 26
    • 84895422067 scopus 로고    scopus 로고
    • Microglia induce motor neuron death via the classical NF-kappaB pathway in amyotrophic lateral sclerosis
    • Frakes, A. E. et al. Microglia induce motor neuron death via the classical NF-kappaB pathway in amyotrophic lateral sclerosis. Neuron 81, 1009-1023 (2014).
    • (2014) Neuron , vol.81 , pp. 1009-1023
    • Frakes, A.E.1
  • 27
    • 84886434703 scopus 로고    scopus 로고
    • Phagocytosis executes delayed neuronal death after focal brain ischemia
    • Neher, J. J. et al. Phagocytosis executes delayed neuronal death after focal brain ischemia. Proc. Natl Acad. Sci. USA 110, E4098-E4107 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. E4098-E4107
    • Neher, J.J.1
  • 28
    • 80052561392 scopus 로고    scopus 로고
    • Microglial cells contribute to endogenous brain defenses after acute neonatal focal stroke
    • Faustino, J. V. et al. Microglial cells contribute to endogenous brain defenses after acute neonatal focal stroke. J. Neurosci. 31, 12992-13001 (2011).
    • (2011) J. Neurosci. , vol.31 , pp. 12992-13001
    • Faustino, J.V.1
  • 29
    • 44949248404 scopus 로고    scopus 로고
    • Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: A new mechanism of CNS immune privilege
    • Neumann, J. et al. Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: a new mechanism of CNS immune privilege. J. Neurosci. 28, 5965-5975 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 5965-5975
    • Neumann, J.1
  • 30
    • 84886953273 scopus 로고    scopus 로고
    • A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation
    • Goldmann, T. et al. A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation. Nat. Neurosci. 16, 1618-1626 (2013).
    • (2013) Nat. Neurosci. , vol.16 , pp. 1618-1626
    • Goldmann, T.1
  • 31
    • 84937738858 scopus 로고    scopus 로고
    • Genetic cell ablation reveals clusters of local self-renewing microglia in the mammalian central nervous system
    • Bruttger, J. et al. Genetic cell ablation reveals clusters of local self-renewing microglia in the mammalian central nervous system. Immunity 43, 92-106 (2015).
    • (2015) Immunity , vol.43 , pp. 92-106
    • Bruttger, J.1
  • 32
    • 84936869193 scopus 로고    scopus 로고
    • Elimination of microglia improves functional outcomes following extensive neuronal loss in the hippocampus
    • Rice, R. A. et al. Elimination of microglia improves functional outcomes following extensive neuronal loss in the hippocampus. J. Neurosci. 35, 9977-9989 (2015).
    • (2015) J. Neurosci. , vol.35 , pp. 9977-9989
    • Rice, R.A.1
  • 33
    • 84872149088 scopus 로고    scopus 로고
    • A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion
    • Morrison, H. W. & Filosa, J. A. A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion. J. Neuroinflammation 10, 4 (2013).
    • (2013) J. Neuroinflammation , vol.10 , pp. 4
    • Morrison, H.W.1    Filosa, J.A.2
  • 34
    • 38549103252 scopus 로고    scopus 로고
    • Direct, live imaging of cortical spreading depression and anoxic depolarisation using a fluorescent, voltage-sensitive dye
    • Farkas, E., Pratt, R., Sengpiel, F. & Obrenovitch, T. P. Direct, live imaging of cortical spreading depression and anoxic depolarisation using a fluorescent, voltage-sensitive dye. J. Cereb. Blood Flow Metab. 28, 251-262 (2008).
    • (2008) J. Cereb. Blood Flow Metab. , vol.28 , pp. 251-262
    • Farkas, E.1    Pratt, R.2    Sengpiel, F.3    Obrenovitch, T.P.4
  • 35
    • 80055019036 scopus 로고    scopus 로고
    • Blood-brain barrier breakdown in acute and chronic cerebrovascular disease
    • Yang, Y. & Rosenberg, G. A. Blood-brain barrier breakdown in acute and chronic cerebrovascular disease. Stroke 42, 3323-3328 (2011).
    • (2011) Stroke , vol.42 , pp. 3323-3328
    • Yang, Y.1    Rosenberg, G.A.2
  • 36
    • 84897859634 scopus 로고    scopus 로고
    • Microglial phagocytosis of live neurons
    • Brown, G. C. & Neher, J. J. Microglial phagocytosis of live neurons. Nat. Rev. Neurosci. 15, 209-216 (2014).
    • (2014) Nat. Rev. Neurosci. , vol.15 , pp. 209-216
    • Brown, G.C.1    Neher, J.J.2
  • 37
    • 0042190147 scopus 로고    scopus 로고
    • Microglial activation precedes and predominates over macrophage infiltration in transient focal cerebral ischemia: A study in green fluorescent protein transgenic bone marrow chimeric mice
    • Schilling, M. et al. Microglial activation precedes and predominates over macrophage infiltration in transient focal cerebral ischemia: a study in green fluorescent protein transgenic bone marrow chimeric mice. Exp. Neurol. 183, 25-33 (2003).
    • (2003) Exp. Neurol. , vol.183 , pp. 25-33
    • Schilling, M.1
  • 38
    • 84880004655 scopus 로고    scopus 로고
    • Central and haematopoietic interleukin-1 both contribute to ischaemic brain injury in mice
    • Denes, A. et al. Central and haematopoietic interleukin-1 both contribute to ischaemic brain injury in mice. Dis. Model. Mech. 6, 1043-1048 (2013).
    • (2013) Dis. Model. Mech. , vol.6 , pp. 1043-1048
    • Denes, A.1
  • 39
    • 84894574217 scopus 로고    scopus 로고
    • Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor
    • Parkhurst, C. N. et al. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell 155, 1596-1609 (2013).
    • (2013) Cell , vol.155 , pp. 1596-1609
    • Parkhurst, C.N.1
  • 40
    • 20044376483 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis repressed by microglial paralysis
    • Heppner, F. L. et al. Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat. Med. 11, 146-152 (2005).
    • (2005) Nat. Med. , vol.11 , pp. 146-152
    • Heppner, F.L.1
  • 41
    • 0035693680 scopus 로고    scopus 로고
    • Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death
    • Sattler, R. & Tymianski, M. Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death. Mol. Neurobiol. 24, 107-129 (2001).
    • (2001) Mol. Neurobiol. , vol.24 , pp. 107-129
    • Sattler, R.1    Tymianski, M.2
  • 42
    • 39549116502 scopus 로고    scopus 로고
    • Two-photon imaging of stroke onset in vivo reveals that NMDA-receptor independent ischemic depolarization is the major cause of rapid reversible damage to dendrites and spines
    • Murphy, T. H., Li, P., Betts, K. & Liu, R. Two-photon imaging of stroke onset in vivo reveals that NMDA-receptor independent ischemic depolarization is the major cause of rapid reversible damage to dendrites and spines. J. Neurosci. 28, 1756-1772 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 1756-1772
    • Murphy, T.H.1    Li, P.2    Betts, K.3    Liu, R.4
  • 43
    • 84871712919 scopus 로고    scopus 로고
    • The smallest stroke: Occlusion of one penetrating vessel leads to infarction and a cognitive deficit
    • Shih, A. Y. et al. The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit. Nat. Neurosci. 16, 55-63 (2013).
    • (2013) Nat. Neurosci. , vol.16 , pp. 55-63
    • Shih, A.Y.1
  • 44
    • 84900799748 scopus 로고    scopus 로고
    • Spreading depression requires microglia and is decreased by their M2a polarization from environmental enrichment
    • Pusic, K. M., Pusic, A. D., Kemme, J. & Kraig, R. P. Spreading depression requires microglia and is decreased by their M2a polarization from environmental enrichment. Glia 62, 1176-1194 (2014).
    • (2014) Glia , vol.62 , pp. 1176-1194
    • Pusic, K.M.1    Pusic, A.D.2    Kemme, J.3    Kraig, R.P.4
  • 45
    • 33846565429 scopus 로고    scopus 로고
    • Ca2+ signals and neuronal death in brain ischemia
    • Bano, D. & Nicotera, P. Ca2+ signals and neuronal death in brain ischemia. Stroke 38, 674-676 (2007).
    • (2007) Stroke , vol.38 , pp. 674-676
    • Bano, D.1    Nicotera, P.2
  • 46
    • 84971221416 scopus 로고    scopus 로고
    • Excitotoxicity and stroke: Identifying novel targets for neuroprotection
    • Lai, T. W., Zhang, S. & Wang, Y. T. Excitotoxicity and stroke: identifying novel targets for neuroprotection. Prog. Neurobiol. 115, 157-188 (2014).
    • (2014) Prog. Neurobiol. , vol.115 , pp. 157-188
    • Lai, T.W.1    Zhang, S.2    Wang, Y.T.3
  • 47
    • 28044456070 scopus 로고    scopus 로고
    • The effects of anesthetics on brain activity and cognitive function
    • Heinke, W. & Koelsch, S. The effects of anesthetics on brain activity and cognitive function. Curr. Opin. Anaesthesiol. 18, 625-631 (2005).
    • (2005) Curr. Opin. Anaesthesiol. , vol.18 , pp. 625-631
    • Heinke, W.1    Koelsch, S.2
  • 48
    • 84874539371 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival
    • Luo, J. et al. Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival. J. Exp. Med. 210, 157-172 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 157-172
    • Luo, J.1
  • 49
    • 33847785649 scopus 로고    scopus 로고
    • Selective ablation of proliferating microglial cells exacerbates ischaemic injury in the brain
    • Lalancette-Hebert, M., Gowing, G., Simard, A., Weng, Y. C. & Kriz, J. Selective ablation of proliferating microglial cells exacerbates ischaemic injury in the brain. J. Neurosci. 27, 2596-2605 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 2596-2605
    • Lalancette-Hebert, M.1    Gowing, G.2    Simard, A.3    Weng, Y.C.4    Kriz, J.5
  • 50
    • 84870832562 scopus 로고    scopus 로고
    • Reciprocal regulation between resting microglial dynamics and neuronal activity in vivo
    • Li, Y., Du, X. F., Liu, C. S., Wen, Z. L. & Du, J. L. Reciprocal regulation between resting microglial dynamics and neuronal activity in vivo. Dev. Cell 23, 1189-1202 (2012).
    • (2012) Dev. Cell , vol.23 , pp. 1189-1202
    • Li, Y.1    Du, X.F.2    Liu, C.S.3    Wen, Z.L.4    Du, J.L.5
  • 51
    • 84902144244 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha: A link between neuroinflammation and excitotoxicity
    • Olmos, G. & Llado, J. Tumor necrosis factor alpha: a link between neuroinflammation and excitotoxicity. Mediators Inflamm. 2014, 861231 (2014).
    • (2014) Mediators Inflamm. , vol.2014
    • Olmos, G.1    Llado, J.2
  • 52
    • 84856209632 scopus 로고    scopus 로고
    • Neuroprotection by interleukin-6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in ischemic stroke
    • Jung, J. E., Kim, G. S. & Chan, P. H. Neuroprotection by interleukin-6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in ischemic stroke. Stroke 42, 3574-3579 (2011).
    • (2011) Stroke , vol.42 , pp. 3574-3579
    • Jung, J.E.1    Kim, G.S.2    Chan, P.H.3
  • 53
  • 54
    • 84880427381 scopus 로고    scopus 로고
    • Ultrasensitive fluorescent proteins for imaging neuronal activity
    • Chen, T. W. et al. Ultrasensitive fluorescent proteins for imaging neuronal activity. Nature 499, 295-300 (2013).
    • (2013) Nature , vol.499 , pp. 295-300
    • Chen, T.W.1
  • 55
    • 84856447940 scopus 로고    scopus 로고
    • Fast two-photon in vivo imaging with three-dimensional random-access scanning in large tissue volumes
    • Katona, G. et al. Fast two-photon in vivo imaging with three-dimensional random-access scanning in large tissue volumes. Nat. Methods 9, 201-208 (2012).
    • (2012) Nat. Methods , vol.9 , pp. 201-208
    • Katona, G.1
  • 56
    • 84901068493 scopus 로고    scopus 로고
    • Dendritic spikes induce ripples in parvalbumin interneurons during hippocampal sharp waves
    • Chiovini, B. et al. Dendritic spikes induce ripples in parvalbumin interneurons during hippocampal sharp waves. Neuron 82, 908-924 (2014).
    • (2014) Neuron , vol.82 , pp. 908-924
    • Chiovini, B.1
  • 57
    • 77955170921 scopus 로고    scopus 로고
    • Rapid determination of particle velocity from space-time images using the Radon transform
    • Drew, P. J., Blinder, P., Cauwenberghs, G., Shih, A. Y. & Kleinfeld, D. Rapid determination of particle velocity from space-time images using the Radon transform. J. Comput. Neurosci. 29, 5-11 (2010).
    • (2010) J. Comput. Neurosci. , vol.29 , pp. 5-11
    • Drew, P.J.1    Blinder, P.2    Cauwenberghs, G.3    Shih, A.Y.4    Kleinfeld, D.5
  • 58
    • 77955346640 scopus 로고    scopus 로고
    • Chronic systemic infection exacerbates ischemic brain damage via a CCL5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice
    • Denes, A., Humphreys, N., Lane, T. E., Grencis, R. & Rothwell, N. Chronic systemic infection exacerbates ischemic brain damage via a CCL5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice. J. Neurosci. 30, 10086-10095 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 10086-10095
    • Denes, A.1    Humphreys, N.2    Lane, T.E.3    Grencis, R.4    Rothwell, N.5
  • 59
    • 78649927344 scopus 로고    scopus 로고
    • Superresolution imaging of chemical synapses in the brain
    • Dani, A., Huang, B., Bergan, J., Dulac, C. & Zhuang, X. Superresolution imaging of chemical synapses in the brain. Neuron 68, 843-856 (2010).
    • (2010) Neuron , vol.68 , pp. 843-856
    • Dani, A.1    Huang, B.2    Bergan, J.3    Dulac, C.4    Zhuang, X.5
  • 60
    • 84926213695 scopus 로고    scopus 로고
    • Cell-specific STORM super-resolution imaging reveals nanoscale organization of cannabinoid signaling
    • Dudok, B. et al. Cell-specific STORM super-resolution imaging reveals nanoscale organization of cannabinoid signaling. Nat. Neurosci. 18, 75-86 (2015).
    • (2015) Nat. Neurosci. , vol.18 , pp. 75-86
    • Dudok, B.1
  • 61
    • 84988566258 scopus 로고    scopus 로고
    • Correlated confocal and super-resolution imaging by VividSTORM
    • Barna, L. et al. Correlated confocal and super-resolution imaging by VividSTORM. Nat. Protoc. 11, 163-183 (2016).
    • (2016) Nat. Protoc. , vol.11 , pp. 163-183
    • Barna, L.1
  • 62
    • 84902256480 scopus 로고    scopus 로고
    • Streptococcus pneumoniae worsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ibalpha
    • Denes, A. et al. Streptococcus pneumoniae worsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ibalpha. Ann. Neurol. 75, 670-683 (2014).
    • (2014) Ann. Neurol. , vol.75 , pp. 670-683
    • Denes, A.1


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