-
1
-
-
36448994709
-
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
-
DOI 10.1038/nn2014, PII NN2014
-
Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W. and Rossi, F. M. (2007). Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat. Neurosci. 10, 1538-1543. (Pubitemid 350175883)
-
(2007)
Nature Neuroscience
, vol.10
, Issue.12
, pp. 1538-1543
-
-
Ajami, B.1
Bennett, J.L.2
Krieger, C.3
Tetzlaff, W.4
Rossi, F.M.V.5
-
2
-
-
23444441962
-
Interleukin-1 and neuronal injury
-
DOI 10.1038/nri1664
-
Allan, S. M., Tyrrell, P. J. and Rothwell, N. J. (2005). Interleukin-1 and neuronal injury. Nat. Rev. Immunol. 5, 629-640. (Pubitemid 41113194)
-
(2005)
Nature Reviews Immunology
, vol.5
, Issue.8
, pp. 629-640
-
-
Allan, S.M.1
Tyrrell, P.J.2
Rothwell, N.J.3
-
3
-
-
29944432812
-
Permanent partial phenotypic correction and tolerance in a mouse model of hemophilia B by stem cell gene delivery of human factor IX
-
DOI 10.1038/sj.gt.3302638, PII 3302638
-
Bigger, B. W., Siapati, E. K., Mistry, A., Waddington, S. N., Nivsarkar, M. S., Jacobs, L., Perrett, R., Holder, M. V., Ridler, C., Kemball-Cook, G. et al. (2006). Permanent partial phenotypic correction and tolerance in a mouse model of hemophilia B by stem cell gene delivery of human factor IX. Gene Ther. 13, 117-126. (Pubitemid 43039904)
-
(2006)
Gene Therapy
, vol.13
, Issue.2
, pp. 117-126
-
-
Bigger, B.W.1
Siapati, E.K.2
Mistry, A.3
Waddington, S.N.4
Nivsarkar, M.S.5
Jacobs, L.6
Perrett, R.7
Holder, M.V.8
Ridler, C.9
Kemball-Cook, G.10
Ali, R.R.11
Forbes, S.J.12
Coutelle, C.13
Wright, N.14
Alison, M.15
Thrasher, A.J.16
Bonnet, D.17
Themis, M.18
-
4
-
-
56849129516
-
Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice
-
Clausen, B. H., Lambertsen, K. L., Babcock, A. A., Holm, T. H., Dagnaes-Hansen, F. and Finsen, B. (2008). Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice. J. Neuroinflammation 5, 46.
-
(2008)
J. Neuroinflammation
, vol.5
, pp. 46
-
-
Clausen, B.H.1
Lambertsen, K.L.2
Babcock, A.A.3
Holm, T.H.4
Dagnaes-Hansen, F.5
Finsen, B.6
-
5
-
-
79959969839
-
Neutralization of interleukin-1β reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice
-
Clausen, F., Hånell, A., Israelsson, C., Hedin, J., Ebendal, T., Mir, A. K., Gram, H. and Marklund, N. (2011). Neutralization of interleukin-1β reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice. Eur. J. Neurosci. 34, 110-123.
-
(2011)
Eur. J. Neurosci.
, vol.34
, pp. 110-123
-
-
Clausen, F.1
Hånell, A.2
Israelsson, C.3
Hedin, J.4
Ebendal, T.5
Mir, A.K.6
Gram, H.7
Marklund, N.8
-
6
-
-
0032978333
-
The progression and topographic distribution of interleukin-1beta expression after permanent middle cerebral artery occlusion in the rat
-
Davies, C. A., Loddick, S. A., Toulmond, S., Stroemer, R. P., Hunt, J. and Rothwell, N. J. (1999). The progression and topographic distribution of interleukin-1beta expression after permanent middle cerebral artery occlusion in the rat. J. Cereb. Blood Flow Metab. 19, 87-98. (Pubitemid 29283584)
-
(1999)
Journal of Cerebral Blood Flow and Metabolism
, vol.19
, Issue.1
, pp. 87-98
-
-
Davies, C.A.1
Loddick, S.A.2
Toulmond, S.3
Paul, S.R.4
Hunt, J.5
Rothwell, N.J.6
-
7
-
-
77953620336
-
Inflammation and brain injury: Acute cerebral ischaemia, peripheral and central inflammation
-
Denes, A., Thornton, P., Rothwell, N. J. and Allan, S. M. (2010a). Inflammation and brain injury: acute cerebral ischaemia, peripheral and central inflammation. Brain Behav. Immun. 24, 708-723.
-
(2010)
Brain Behav. Immun.
, vol.24
, pp. 708-723
-
-
Denes, A.1
Thornton, P.2
Rothwell, N.J.3
Allan, S.M.4
-
8
-
-
77955346640
-
Chronic systemic infection exacerbates ischemic brain damage via a CCL5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice
-
Dénes, A., Humphreys, N., Lane, T. E., Grencis, R. and Rothwell, N. (2010b). Chronic systemic infection exacerbates ischemic brain damage via a CCL5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice. J. Neurosci. 30, 10086-10095.
-
(2010)
J. Neurosci.
, vol.30
, pp. 10086-10095
-
-
Dénes, A.1
Humphreys, N.2
Lane, T.E.3
Grencis, R.4
Rothwell, N.5
-
9
-
-
81355139185
-
Interleukin-1 and stroke: Biomarker, harbinger of damage, and therapeutic target
-
Denes, A., Pinteaux, E., Rothwell, N. J. and Allan, S. M. (2011a). Interleukin-1 and stroke: biomarker, harbinger of damage, and therapeutic target. Cerebrovasc. Dis. 32, 517-527.
-
(2011)
Cerebrovasc. Dis.
, vol.32
, pp. 517-527
-
-
Denes, A.1
Pinteaux, E.2
Rothwell, N.J.3
Allan, S.M.4
-
10
-
-
79953284058
-
Experimental stroke-induced changes in the bone marrow reveal complex regulation of leukocyte responses
-
Denes, A., McColl, B. W., Leow-Dyke, S. F., Chapman, K. Z., Humphreys, N. E., Grencis, R. K., Allan, S. M. and Rothwell, N. J. (2011b). Experimental stroke-induced changes in the bone marrow reveal complex regulation of leukocyte responses. J. Cereb. Blood Flow Metab. 31, 1036-1050.
-
(2011)
J. Cereb. Blood Flow Metab.
, vol.31
, pp. 1036-1050
-
-
Denes, A.1
McColl, B.W.2
Leow-Dyke, S.F.3
Chapman, K.Z.4
Humphreys, N.E.5
Grencis, R.K.6
Allan, S.M.7
Rothwell, N.J.8
-
11
-
-
79953813107
-
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
-
Dinarello, C. A. (2011). Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 117, 3720-3732.
-
(2011)
Blood
, vol.117
, pp. 3720-3732
-
-
Dinarello, C.A.1
-
12
-
-
79551687466
-
Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: Results of a dose-ranging study
-
Galea, J., Ogungbenro, K., Hulme, S., Greenhalgh, A., Aarons, L., Scarth, S., Hutchinson, P., Grainger, S., King, A., Hopkins, S. J. et al. (2011). Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: results of a dose-ranging study. J. Cereb. Blood Flow Metab. 31, 439-447.
-
(2011)
J. Cereb. Blood Flow Metab.
, vol.31
, pp. 439-447
-
-
Galea, J.1
Ogungbenro, K.2
Hulme, S.3
Greenhalgh, A.4
Aarons, L.5
Scarth, S.6
Hutchinson, P.7
Grainger, S.8
King, A.9
Hopkins, S.J.10
-
13
-
-
77950932320
-
Rapid brain penetration of interleukin-1 receptor antagonist in rat cerebral ischaemia: Pharmacokinetics, distribution, protection
-
Greenhalgh, A. D., Galea, J., Dénes, A., Tyrrell, P. J. and Rothwell, N. J. (2010). Rapid brain penetration of interleukin-1 receptor antagonist in rat cerebral ischaemia: pharmacokinetics, distribution, protection. Br. J. Pharmacol. 160, 153-159.
-
(2010)
Br. J. Pharmacol.
, vol.160
, pp. 153-159
-
-
Greenhalgh, A.D.1
Galea, J.2
Dénes, A.3
Tyrrell, P.J.4
Rothwell, N.J.5
-
14
-
-
0036849018
-
Microglia as a source and target of cytokines
-
Hanisch, U. K. (2002). Microglia as a source and target of cytokines. Glia 40, 140-155.
-
(2002)
Glia
, vol.40
, pp. 140-155
-
-
Hanisch, U.K.1
-
15
-
-
84865989120
-
Inflammatory cytokines in experimental and human stroke
-
Lambertsen, K. L., Biber, K. and Finsen, B. (2012). Inflammatory cytokines in experimental and human stroke. J. Cereb. Blood Flow Metab. 32, 1677-1698.
-
(2012)
J. Cereb. Blood Flow Metab.
, vol.32
, pp. 1677-1698
-
-
Lambertsen, K.L.1
Biber, K.2
Finsen, B.3
-
16
-
-
84855184162
-
Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues
-
Luheshi, N. M., Kovács, K. J., Lopez-Castejon, G., Brough, D. and Denes, A. (2011). Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues. J. Neuroinflammation 8, 186.
-
(2011)
J. Neuroinflammation
, vol.8
, pp. 186
-
-
Luheshi, N.M.1
Kovács, K.J.2
Lopez-Castejon, G.3
Brough, D.4
Denes, A.5
-
17
-
-
36448955070
-
+ monocytes only under defined host conditions
-
DOI 10.1038/nn2015, PII NN2015
-
Mildner, A., Schmidt, H., Nitsche, M., Merkler, D., Hanisch, U. K., Mack, M., Heikenwalder, M., Brück, W., Priller, J. and Prinz, M. (2007). Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions. Nat. Neurosci. 10, 1544-1553. (Pubitemid 350175884)
-
(2007)
Nature Neuroscience
, vol.10
, Issue.12
, pp. 1544-1553
-
-
Mildner, A.1
Schmidt, H.2
Nitsche, M.3
Merkler, D.4
Hanisch, U.-K.5
Mack, M.6
Heikenwalder, M.7
Bruck, W.8
Priller, J.9
Prinz, M.10
-
18
-
-
0030904130
-
'Green mice' as a source of ubiquitous green cells
-
DOI 10.1016/S0014-5793(97)00313-X, PII S001457939700313X
-
Okabe, M., Ikawa, M., Kominami, K., Nakanishi, T. and Nishimune, Y. (1997). 'Green mice' as a source of ubiquitous green cells. FEBS Lett. 407, 313-319. (Pubitemid 27199450)
-
(1997)
FEBS Letters
, vol.407
, Issue.3
, pp. 313-319
-
-
Okabe, M.1
Ikawa, M.2
Kominami, K.3
Nakanishi, T.4
Nishimune, Y.5
-
19
-
-
84859717206
-
Innate immunity in the central nervous system
-
Ransohoff, R. M. and Brown, M. A. (2012). Innate immunity in the central nervous system. J. Clin. Invest. 122, 1164-1171.
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 1164-1171
-
-
Ransohoff, R.M.1
Brown, M.A.2
-
20
-
-
0026656192
-
Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat
-
Relton, J. K. and Rothwell, N. J. (1992). Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat. Brain Res. Bull. 29, 243-246.
-
(1992)
Brain Res. Bull.
, vol.29
, pp. 243-246
-
-
Relton, J.K.1
Rothwell, N.J.2
-
21
-
-
80355146868
-
Monocyte recruitment during infection and inflammation
-
Shi, C. and Pamer, E. G. (2011). Monocyte recruitment during infection and inflammation. Nat. Rev. Immunol. 11, 762-774.
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 762-774
-
-
Shi, C.1
Pamer, E.G.2
-
22
-
-
77951735539
-
Platelet interleukin-1alpha drives cerebrovascular inflammation
-
Thornton, P., McColl, B. W., Greenhalgh, A., Denes, A., Allan, S. M. and Rothwell, N. J. (2010). Platelet interleukin-1alpha drives cerebrovascular inflammation. Blood 115, 3632-3639.
-
(2010)
Blood
, vol.115
, pp. 3632-3639
-
-
Thornton, P.1
McColl, B.W.2
Greenhalgh, A.3
Denes, A.4
Allan, S.M.5
Rothwell, N.J.6
-
23
-
-
84878584836
-
Busulfan conditioning enhances engraftment of hematopoietic donor-derived cells in the brain compared with irradiation
-
Wilkinson, F. L., Sergijenko, A., Langford-Smith, K. J., Malinowska, M., Wynn, R. F. and Bigger, B. W. (2013). Busulfan conditioning enhances engraftment of hematopoietic donor-derived cells in the brain compared with irradiation. Mol. Ther. 21, 868-876.
-
(2013)
Mol. Ther.
, vol.21
, pp. 868-876
-
-
Wilkinson, F.L.1
Sergijenko, A.2
Langford-Smith, K.J.3
Malinowska, M.4
Wynn, R.F.5
Bigger, B.W.6
-
24
-
-
0028958354
-
Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats
-
discussion 681
-
Yamasaki, Y., Matsuura, N., Shozuhara, H., Onodera, H., Itoyama, Y. and Kogure, K. (1995). Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats. Stroke 26, 676-680, discussion 681.
-
(1995)
Stroke
, vol.26
, pp. 676-680
-
-
Yamasaki, Y.1
Matsuura, N.2
Shozuhara, H.3
Onodera, H.4
Itoyama, Y.5
Kogure, K.6
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