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Volumn 129, Issue 2, 2015, Pages 279-295

Perivascular microglia promote blood vessel disintegration in the ischemic penumbra

Author keywords

Blood brain barrier; Endothelial cell; Ischemic stroke; Microglia; Middle cerebral artery occlusion

Indexed keywords

PLASMA PROTEIN; CHEMOKINE RECEPTOR; CX3CR1 PROTEIN, MOUSE; GREEN FLUORESCENT PROTEIN;

EID: 84938089621     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-014-1372-1     Document Type: Article
Times cited : (198)

References (70)
  • 2
    • 33947363967 scopus 로고    scopus 로고
    • The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease
    • COI: 1:CAS:528:DC%2BD2sXjsVyqsr4%3D, PID: 17339406
    • Adams RA, Bauer J, Flick MJ et al (2007) The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. J Exp Med 204:571–582
    • (2007) J Exp Med , vol.204 , pp. 571-582
    • Adams, R.A.1    Bauer, J.2    Flick, M.J.3
  • 3
    • 84858254017 scopus 로고    scopus 로고
    • PDGF receptor beta signaling in pericytes following ischemic brain injury
    • COI: 1:CAS:528:DC%2BC38Xjs1Kmtbs%3D, PID: 22272762
    • Arimura K, Ago T, Kamouchi M et al (2012) PDGF receptor beta signaling in pericytes following ischemic brain injury. Curr Neurovasc Res 9:1–9
    • (2012) Curr Neurovasc Res , vol.9 , pp. 1-9
    • Arimura, K.1    Ago, T.2    Kamouchi, M.3
  • 4
    • 0035478029 scopus 로고    scopus 로고
    • Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia
    • COI: 1:STN:280:DC%2BD3MritFGluw%3D%3D, PID: 11567062
    • Asahi M, Wang X, Mori T et al (2001) Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci 21:7724–7732
    • (2001) J Neurosci , vol.21 , pp. 7724-7732
    • Asahi, M.1    Wang, X.2    Mori, T.3
  • 5
    • 0017623724 scopus 로고
    • Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia
    • COI: 1:CAS:528:DyaE2sXoslakug%3D%3D, PID: 13521
    • Astrup J, Symon L, Branston NM, Lassen NA (1977) Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia. Stroke 8:51–57
    • (1977) Stroke , vol.8 , pp. 51-57
    • Astrup, J.1    Symon, L.2    Branston, N.M.3    Lassen, N.A.4
  • 6
    • 0030580410 scopus 로고    scopus 로고
    • Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats
    • COI: 1:CAS:528:DyaK28Xms1ejsL8%3D, PID: 8955928
    • Belayev L, Busto R, Zhao W, Ginsberg MD (1996) Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats. Brain Res 739:88–96
    • (1996) Brain Res , vol.739 , pp. 88-96
    • Belayev, L.1    Busto, R.2    Zhao, W.3    Ginsberg, M.D.4
  • 7
    • 68549085490 scopus 로고    scopus 로고
    • Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way
    • COI: 1:CAS:528:DC%2BD1MXms12gtLk%3D, PID: 19483738
    • Carmeliet P, De Smet F, Loges S, Mazzone M (2009) Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way. Nat Rev Clin Oncol 6:315–326
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 315-326
    • Carmeliet, P.1    De Smet, F.2    Loges, S.3    Mazzone, M.4
  • 8
    • 84874586343 scopus 로고    scopus 로고
    • Microglia regulate the number of neural precursor cells in the developing cerebral cortex
    • COI: 1:CAS:528:DC%2BC3sXhtl2jsLrL, PID: 23467340
    • Cunningham CL, Martinez-Cerdeno V, Noctor SC (2013) Microglia regulate the number of neural precursor cells in the developing cerebral cortex. J Neurosci 33:4216–4233
    • (2013) J Neurosci , vol.33 , pp. 4216-4233
    • Cunningham, C.L.1    Martinez-Cerdeno, V.2    Noctor, S.C.3
  • 9
    • 22244464662 scopus 로고    scopus 로고
    • ATP mediates rapid microglial response to local brain injury in vivo
    • COI: 1:CAS:528:DC%2BD2MXksVeit7Y%3D, PID: 15895084
    • Davalos D, Grutzendler J, Yang G et al (2005) ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 8:752–758
    • (2005) Nat Neurosci , vol.8 , pp. 752-758
    • Davalos, D.1    Grutzendler, J.2    Yang, G.3
  • 10
    • 84870815173 scopus 로고    scopus 로고
    • Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation
    • PID: 23187627
    • Davalos D, Ryu JK, Merlini M et al (2012) Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nat Commun 3:1227
    • (2012) Nat Commun , vol.3 , pp. 1227
    • Davalos, D.1    Ryu, J.K.2    Merlini, M.3
  • 11
    • 33846591479 scopus 로고    scopus 로고
    • Microglial activation and matrix protease generation during focal cerebral ischemia
    • PID: 17261708
    • del Zoppo GJ, Milner R, Mabuchi T et al (2007) Microglial activation and matrix protease generation during focal cerebral ischemia. Stroke 38:646–651
    • (2007) Stroke , vol.38 , pp. 646-651
    • del Zoppo, G.J.1    Milner, R.2    Mabuchi, T.3
  • 12
    • 52549109505 scopus 로고    scopus 로고
    • Role of CX3CR1 (fractalkine receptor) in brain damage and inflammation induced by focal cerebral ischemia in mouse
    • COI: 1:CAS:528:DC%2BD1cXhtFGhsLzI, PID: 18575457
    • Denes A, Ferenczi S, Halasz J, Kornyei Z, Kovacs KJ (2008) Role of CX3CR1 (fractalkine receptor) in brain damage and inflammation induced by focal cerebral ischemia in mouse. J Cereb Blood Flow Metab 28:1707–1721
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1707-1721
    • Denes, A.1    Ferenczi, S.2    Halasz, J.3    Kornyei, Z.4    Kovacs, K.J.5
  • 13
    • 52549109505 scopus 로고    scopus 로고
    • Role of CX3CR1 (fractalkine receptor) in brain damage and inflammation induced by focal cerebral ischemia in mouse
    • COI: 1:CAS:528:DC%2BD1cXhtFGhsLzI, PID: 18575457
    • Denes A, Ferenczi S, Halasz J, Kornyei Z, Kovacs KJ (2008) Role of CX3CR1 (fractalkine receptor) in brain damage and inflammation induced by focal cerebral ischemia in mouse. J Cereb Blood Flow Metab 28:1707–1721
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1707-1721
    • Denes, A.1    Ferenczi, S.2    Halasz, J.3    Kornyei, Z.4    Kovacs, K.J.5
  • 14
    • 84877124637 scopus 로고    scopus 로고
    • The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury
    • PID: 23269317
    • Enzmann G, Mysiorek C, Gorina R et al (2013) The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury. Acta Neuropathol 125:395–412
    • (2013) Acta Neuropathol , vol.125 , pp. 395-412
    • Enzmann, G.1    Mysiorek, C.2    Gorina, R.3
  • 15
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • COI: 1:CAS:528:DC%2BD3sXktFOnur4%3D, PID: 12778165
    • Ferrara N, Gerber HP, LeCouter J (2003) The biology of VEGF and its receptors. Nat Med 9:669–676
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 16
    • 1542316096 scopus 로고    scopus 로고
    • Blood-brain barrier permeability and monocyte infiltration in experimental allergic encephalomyelitis: a quantitative MRI study
    • COI: 1:STN:280:DC%2BD2c7gtVSluw%3D%3D, PID: 14691063
    • Floris S, Blezer EL, Schreibelt G et al (2004) Blood-brain barrier permeability and monocyte infiltration in experimental allergic encephalomyelitis: a quantitative MRI study. Brain 127:616–627
    • (2004) Brain , vol.127 , pp. 616-627
    • Floris, S.1    Blezer, E.L.2    Schreibelt, G.3
  • 17
    • 0029814808 scopus 로고    scopus 로고
    • Spontaneous neurological recovery after stroke and the fate of the ischemic penumbra
    • COI: 1:STN:280:DyaK28zmvFKlsQ%3D%3D, PID: 8773603
    • Furlan M, Marchal G, Viader F, Derlon JM, Baron JC (1996) Spontaneous neurological recovery after stroke and the fate of the ischemic penumbra. Ann Neurol 40:216–226
    • (1996) Ann Neurol , vol.40 , pp. 216-226
    • Furlan, M.1    Marchal, G.2    Viader, F.3    Derlon, J.M.4    Baron, J.C.5
  • 18
    • 65549130913 scopus 로고    scopus 로고
    • Temporal and spatial dynamics of cerebral immune cell accumulation in stroke
    • PID: 19265055
    • Gelderblom M, Leypoldt F, Steinbach K et al (2009) Temporal and spatial dynamics of cerebral immune cell accumulation in stroke. Stroke 40:1849–1857
    • (2009) Stroke , vol.40 , pp. 1849-1857
    • Gelderblom, M.1    Leypoldt, F.2    Steinbach, K.3
  • 19
    • 84883196455 scopus 로고    scopus 로고
    • Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices
    • PID: 23404620
    • Girard S, Brough D, Lopez-Castejon G, Giles J, Rothwell NJ, Allan SM (2013) Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices. Glia 61:813–824
    • (2013) Glia , vol.61 , pp. 813-824
    • Girard, S.1    Brough, D.2    Lopez-Castejon, G.3    Giles, J.4    Rothwell, N.J.5    Allan, S.M.6
  • 20
    • 0033848141 scopus 로고    scopus 로고
    • Ischemic penumbra: evidence from functional imaging in man
    • COI: 1:STN:280:DC%2BD3cvksVCktw%3D%3D, PID: 10994849
    • Heiss WD (2000) Ischemic penumbra: evidence from functional imaging in man. J Cereb Blood Flow Metab 20:1276–1293
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 1276-1293
    • Heiss, W.D.1
  • 21
    • 84866561480 scopus 로고    scopus 로고
    • The ischemic penumbra: how does tissue injury evolve?
    • PID: 22994218
    • Heiss WD (2012) The ischemic penumbra: how does tissue injury evolve? Ann N Y Acad Sci 1268:26–34
    • (2012) Ann N Y Acad Sci , vol.1268 , pp. 26-34
    • Heiss, W.D.1
  • 22
    • 79960141471 scopus 로고    scopus 로고
    • The immunology of stroke: from mechanisms to translation
    • COI: 1:CAS:528:DC%2BC3MXos1Srsrw%3D, PID: 21738161
    • Iadecola C, Anrather J (2011) The immunology of stroke: from mechanisms to translation. Nat Med 17:796–808
    • (2011) Nat Med , vol.17 , pp. 796-808
    • Iadecola, C.1    Anrather, J.2
  • 23
    • 77952513645 scopus 로고    scopus 로고
    • Inflammatory mechanisms in ischemic stroke: role of inflammatory cells
    • COI: 1:CAS:528:DC%2BC3cXmvVCht74%3D, PID: 20130219
    • Jin R, Yang G, Li G (2010) Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol 87:779–789
    • (2010) J Leukoc Biol , vol.87 , pp. 779-789
    • Jin, R.1    Yang, G.2    Li, G.3
  • 24
    • 0348141856 scopus 로고    scopus 로고
    • Neutrophil infiltration increases matrix metalloproteinase-9 in the ischemic brain after occlusion/reperfusion of the middle cerebral artery in rats
    • COI: 1:CAS:528:DC%2BD3sXps1GqtLc%3D, PID: 14663338
    • Justicia C, Panes J, Sole S et al (2003) Neutrophil infiltration increases matrix metalloproteinase-9 in the ischemic brain after occlusion/reperfusion of the middle cerebral artery in rats. J Cereb Blood Flow Metab 23:1430–1440
    • (2003) J Cereb Blood Flow Metab , vol.23 , pp. 1430-1440
    • Justicia, C.1    Panes, J.2    Sole, S.3
  • 25
    • 84878848681 scopus 로고    scopus 로고
    • Polymorphonuclear neutrophil infiltration into ischemic infarctions: myth or truth?
    • PID: 23417713
    • Kalimo H, del Zoppo GJ, Paetau A, Lindsberg PJ (2013) Polymorphonuclear neutrophil infiltration into ischemic infarctions: myth or truth? Acta Neuropathol 125:313–316
    • (2013) Acta Neuropathol , vol.125 , pp. 313-316
    • Kalimo, H.1    del Zoppo, G.J.2    Paetau, A.3    Lindsberg, P.J.4
  • 26
    • 84872903768 scopus 로고    scopus 로고
    • Quantitating the subtleties of microglial morphology with fractal analysis
    • PID: 23386810
    • Karperien A, Ahammer H, Jelinek HF (2013) Quantitating the subtleties of microglial morphology with fractal analysis. Front Cell Neurosci 7:3
    • (2013) Front Cell Neurosci , vol.7 , pp. 3
    • Karperien, A.1    Ahammer, H.2    Jelinek, H.F.3
  • 27
    • 0027971574 scopus 로고
    • Energy metabolism, ion homeostasis, and cell damage in the brain
    • COI: 1:CAS:528:DyaK2cXmtVWqtL8%3D, PID: 7698500
    • Katsura K, Kristian T, Siesjo BK (1994) Energy metabolism, ion homeostasis, and cell damage in the brain. Biochem Soc Trans 22:991–996
    • (1994) Biochem Soc Trans , vol.22 , pp. 991-996
    • Katsura, K.1    Kristian, T.2    Siesjo, B.K.3
  • 28
    • 1642504310 scopus 로고    scopus 로고
    • Intracerebroventricular injection of microglia protects against focal brain ischemia
    • COI: 1:CAS:528:DC%2BD2cXhvVCgt70%3D, PID: 14978360
    • Kitamura Y, Takata K, Inden M et al (2004) Intracerebroventricular injection of microglia protects against focal brain ischemia. J Pharmacol Sci 94:203–206
    • (2004) J Pharmacol Sci , vol.94 , pp. 203-206
    • Kitamura, Y.1    Takata, K.2    Inden, M.3
  • 29
    • 15744362925 scopus 로고    scopus 로고
    • Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia
    • COI: 1:CAS:528:DC%2BD2MXhvFKltrk%3D, PID: 15684564
    • Kitamura Y, Yanagisawa D, Inden M et al (2005) Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia. J Pharmacol Sci 97:289–293
    • (2005) J Pharmacol Sci , vol.97 , pp. 289-293
    • Kitamura, Y.1    Yanagisawa, D.2    Inden, M.3
  • 30
    • 84899967644 scopus 로고    scopus 로고
    • Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke
    • COI: 1:CAS:528:DC%2BC2cXmsVCht7w%3D, PID: 24746419
    • Knowland D, Arac A, Sekiguchi KJ et al (2014) Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke. Neuron 82:603–617
    • (2014) Neuron , vol.82 , pp. 603-617
    • Knowland, D.1    Arac, A.2    Sekiguchi, K.J.3
  • 31
    • 84879602682 scopus 로고    scopus 로고
    • Siglec-h on activated microglia for recognition and engulfment of glioma cells
    • PID: 23633299
    • Kopatz J, Beutner C, Welle K et al (2013) Siglec-h on activated microglia for recognition and engulfment of glioma cells. Glia 61:1122–1133
    • (2013) Glia , vol.61 , pp. 1122-1133
    • Kopatz, J.1    Beutner, C.2    Welle, K.3
  • 32
    • 84891833039 scopus 로고    scopus 로고
    • Stroke-induced brain parenchymal injury drives blood-brain barrier early leakage kinetics: a combined in vivo/in vitro study
    • PID: 24084699
    • Kuntz M, Mysiorek C, Petrault O et al (2014) Stroke-induced brain parenchymal injury drives blood-brain barrier early leakage kinetics: a combined in vivo/in vitro study. J Cereb Blood Flow Metab 34:95–107
    • (2014) J Cereb Blood Flow Metab , vol.34 , pp. 95-107
    • Kuntz, M.1    Mysiorek, C.2    Petrault, O.3
  • 33
    • 0022410974 scopus 로고
    • The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion
    • COI: 1:STN:280:DyaL28%2FntlejsQ%3D%3D, PID: 3907257
    • Kuroiwa T, Ting P, Martinez H, Klatzo I (1985) The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion. Acta Neuropathol 68:122–129
    • (1985) Acta Neuropathol , vol.68 , pp. 122-129
    • Kuroiwa, T.1    Ting, P.2    Martinez, H.3    Klatzo, I.4
  • 34
    • 3042546942 scopus 로고    scopus 로고
    • Doxycycline suppresses cerebral matrix metalloproteinase-9 and angiogenesis induced by focal hyperstimulation of vascular endothelial growth factor in a mouse model
    • COI: 1:CAS:528:DC%2BD2cXltVOjurw%3D, PID: 15166398
    • Lee CZ, Xu B, Hashimoto T, McCulloch CE, Yang G-Y, Young WL (2004) Doxycycline suppresses cerebral matrix metalloproteinase-9 and angiogenesis induced by focal hyperstimulation of vascular endothelial growth factor in a mouse model. Stroke 35:1715–1719
    • (2004) Stroke , vol.35 , pp. 1715-1719
    • Lee, C.Z.1    Xu, B.2    Hashimoto, T.3    McCulloch, C.E.4    Yang, G.-Y.5    Young, W.L.6
  • 35
    • 84893515578 scopus 로고    scopus 로고
    • Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke
    • PID: 24154617
    • Li T, Pang S, Yu Y, Wu X, Guo J, Zhang S (2013) Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke. Brain 136:3578–3588
    • (2013) Brain , vol.136 , pp. 3578-3588
    • Li, T.1    Pang, S.2    Yu, Y.3    Wu, X.4    Guo, J.5    Zhang, S.6
  • 36
    • 1842664163 scopus 로고    scopus 로고
    • Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of gender
    • PID: 15081592
    • Li X, Blizzard KK, Zeng Z, DeVries AC, Hurn PD, McCullough LD (2004) Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of gender. Exp Neurol 187:94–104
    • (2004) Exp Neurol , vol.187 , pp. 94-104
    • Li, X.1    Blizzard, K.K.2    Zeng, Z.3    DeVries, A.C.4    Hurn, P.D.5    McCullough, L.D.6
  • 37
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • COI: 1:CAS:528:DC%2BD38XhtFelt7s%3D, PID: 11846609
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402–408
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 38
    • 60449094498 scopus 로고    scopus 로고
    • Heart disease and stroke statistics–2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • PID: 19171871
    • Lloyd-Jones D, Adams R, Carnethon M et al (2009) Heart disease and stroke statistics–2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 119:480–486
    • (2009) Circulation , vol.119 , pp. 480-486
    • Lloyd-Jones, D.1    Adams, R.2    Carnethon, M.3
  • 39
    • 43249116466 scopus 로고    scopus 로고
    • A new penumbra: transitioning from injury into repair after stroke
    • COI: 1:CAS:528:DC%2BD1cXlsFCmsr0%3D, PID: 18463660
    • Lo EH (2008) A new penumbra: transitioning from injury into repair after stroke. Nat Med 14:497–500
    • (2008) Nat Med , vol.14 , pp. 497-500
    • Lo, E.H.1
  • 40
    • 84984763363 scopus 로고    scopus 로고
    • Mechanisms, challenges and opportunities in stroke
    • COI: 1:CAS:528:DC%2BD3sXjtlalsbg%3D, PID: 12728267
    • Lo EH, Dalkara T, Moskowitz MA (2003) Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci 4:399–415
    • (2003) Nat Rev Neurosci , vol.4 , pp. 399-415
    • Lo, E.H.1    Dalkara, T.2    Moskowitz, M.A.3
  • 41
    • 77953992774 scopus 로고    scopus 로고
    • Microglial involvement in neuroplastic changes following focal brain ischemia in rats
    • PID: 19956568
    • Madinier A, Bertrand N, Mossiat C et al (2009) Microglial involvement in neuroplastic changes following focal brain ischemia in rats. PLoS One 4:e8101
    • (2009) PLoS One , vol.4 , pp. e8101
    • Madinier, A.1    Bertrand, N.2    Mossiat, C.3
  • 42
    • 0033902012 scopus 로고    scopus 로고
    • Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia
    • COI: 1:CAS:528:DC%2BD3cXitVeqsr8%3D, PID: 10702412
    • Marti HJ, Bernaudin M, Bellail A et al (2000) Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. Am J Pathol 156:965–976
    • (2000) Am J Pathol , vol.156 , pp. 965-976
    • Marti, H.J.1    Bernaudin, M.2    Bellail, A.3
  • 43
    • 0028335125 scopus 로고
    • The early events of oxygen and glucose deprivation: setting the scene for neuronal death?
    • COI: 1:CAS:528:DyaK2cXltVGhu7Y%3D, PID: 7521086
    • Martin RL, Lloyd HG, Cowan AI (1994) The early events of oxygen and glucose deprivation: setting the scene for neuronal death? Trends Neurosci 17:251–257
    • (1994) Trends Neurosci , vol.17 , pp. 251-257
    • Martin, R.L.1    Lloyd, H.G.2    Cowan, A.I.3
  • 44
    • 80052791226 scopus 로고    scopus 로고
    • Capillary blood flow around microglial somata determines dynamics of microglial processes in ischemic conditions
    • PID: 21800362
    • Masuda T, Croom D, Hida H, Kirov SA (2011) Capillary blood flow around microglial somata determines dynamics of microglial processes in ischemic conditions. Glia 59:1744–1753
    • (2011) Glia , vol.59 , pp. 1744-1753
    • Masuda, T.1    Croom, D.2    Hida, H.3    Kirov, S.A.4
  • 45
    • 84891145231 scopus 로고    scopus 로고
    • Cerebral ischaemia and matrix metalloproteinase-9 modulate the angiogenic function of early and late outgrowth endothelial progenitor cells
    • COI: 1:CAS:528:DC%2BC2cXosVKl, PID: 23945132
    • Morancho A, Hernández-Guillamon M, Boada C et al (2013) Cerebral ischaemia and matrix metalloproteinase-9 modulate the angiogenic function of early and late outgrowth endothelial progenitor cells. J Cell Mol Med 17:1543–1553
    • (2013) J Cell Mol Med , vol.17 , pp. 1543-1553
    • Morancho, A.1    Hernández-Guillamon, M.2    Boada, C.3
  • 46
    • 77955487488 scopus 로고    scopus 로고
    • The science of stroke: mechanisms in search of treatments
    • COI: 1:CAS:528:DC%2BC3cXpsVCgtLc%3D, PID: 20670828
    • Moskowitz MA, Lo EH, Iadecola C (2010) The science of stroke: mechanisms in search of treatments. Neuron 67:181–198
    • (2010) Neuron , vol.67 , pp. 181-198
    • Moskowitz, M.A.1    Lo, E.H.2    Iadecola, C.3
  • 47
    • 78651106773 scopus 로고    scopus 로고
    • Review: molecular pathogenesis of blood-brain barrier breakdown in acute brain injury
    • COI: 1:CAS:528:DC%2BC3MXhvV2rt7Y%3D, PID: 20946242
    • Nag S, Kapadia A, Stewart DJ (2011) Review: molecular pathogenesis of blood-brain barrier breakdown in acute brain injury. Neuropathol Appl Neurobiol 37:3–23
    • (2011) Neuropathol Appl Neurobiol , vol.37 , pp. 3-23
    • Nag, S.1    Kapadia, A.2    Stewart, D.J.3
  • 48
    • 60149098421 scopus 로고    scopus 로고
    • Debris clearance by microglia: an essential link between degeneration and regeneration
    • COI: 1:STN:280:DC%2BD1M7jtVeltA%3D%3D, PID: 18567623
    • Neumann H, Kotter MR, Franklin RJ (2009) Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 132:288–295
    • (2009) Brain , vol.132 , pp. 288-295
    • Neumann, H.1    Kotter, M.R.2    Franklin, R.J.3
  • 50
    • 84879435496 scopus 로고    scopus 로고
    • EGFL7 ligates alphavbeta3 integrin to enhance vessel formation
    • COI: 1:CAS:528:DC%2BC3sXmsFehtbw%3D, PID: 23386126
    • Nikolic I, Stankovic ND, Bicker F et al (2013) EGFL7 ligates alphavbeta3 integrin to enhance vessel formation. Blood 121:3041–3050
    • (2013) Blood , vol.121 , pp. 3041-3050
    • Nikolic, I.1    Stankovic, N.D.2    Bicker, F.3
  • 51
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • COI: 1:CAS:528:DC%2BD2MXks1Ciuro%3D, PID: 15831717
    • Nimmerjahn A, Kirchhoff F, Helmchen F (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308:1314–1318
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 52
    • 84876417600 scopus 로고    scopus 로고
    • Neurovascular protection by targeting early blood-brain barrier disruption with neurotrophic factors after ischemia-reperfusion in rats
    • COI: 1:CAS:528:DC%2BC3sXltFCgs7c%3D, PID: 23299242
    • Pillai DR, Shanbhag NC, Dittmar MS, Bogdahn U, Schlachetzki F (2013) Neurovascular protection by targeting early blood-brain barrier disruption with neurotrophic factors after ischemia-reperfusion in rats. J Cereb Blood Flow Metab 33:557–566
    • (2013) J Cereb Blood Flow Metab , vol.33 , pp. 557-566
    • Pillai, D.R.1    Shanbhag, N.C.2    Dittmar, M.S.3    Bogdahn, U.4    Schlachetzki, F.5
  • 53
    • 0032989129 scopus 로고    scopus 로고
    • Cell type specific upregulation of vascular endothelial growth factor in an MCA-occlusion model of cerebral infarct
    • COI: 1:STN:280:DyaK1MzgtFaqsA%3D%3D, PID: 10374756
    • Plate KH, Beck H, Danner S, Allegrini PR, Wiessner C (1999) Cell type specific upregulation of vascular endothelial growth factor in an MCA-occlusion model of cerebral infarct. J Neuropathol Exp Neurol 58:654–666
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 654-666
    • Plate, K.H.1    Beck, H.2    Danner, S.3    Allegrini, P.R.4    Wiessner, C.5
  • 54
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: role of the HIF system
    • COI: 1:CAS:528:DC%2BD3sXktFOnur8%3D, PID: 12778166
    • Pugh CW, Ratcliffe PJ (2003) Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 9:677–684
    • (2003) Nat Med , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 55
    • 0017237180 scopus 로고
    • Chemotaxis for human monocytes by fibrinogen-derived peptides
    • COI: 1:CAS:528:DyaE28XhslyisLs%3D, PID: 1259932
    • Richardson DL, Pepper DS, Kay AB (1976) Chemotaxis for human monocytes by fibrinogen-derived peptides. Br J Haematol 32:507–513
    • (1976) Br J Haematol , vol.32 , pp. 507-513
    • Richardson, D.L.1    Pepper, D.S.2    Kay, A.B.3
  • 56
    • 33745117279 scopus 로고    scopus 로고
    • Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke
    • COI: 1:CAS:528:DC%2BD28Xksl2isL8%3D, PID: 16690896
    • Rosell A, Ortega-Aznar A, Alvarez-Sabín J et al (2006) Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke. Stroke 37:1399–1406
    • (2006) Stroke , vol.37 , pp. 1399-1406
    • Rosell, A.1    Ortega-Aznar, A.2    Alvarez-Sabín, J.3
  • 57
    • 34848828298 scopus 로고    scopus 로고
    • Iron oxide particle-enhanced MRI suggests variability of brain inflammation at early stages after ischemic stroke
    • PID: 17717318
    • Saleh A, Schroeter M, Ringelstein A et al (2007) Iron oxide particle-enhanced MRI suggests variability of brain inflammation at early stages after ischemic stroke. Stroke 38:2733–2737
    • (2007) Stroke , vol.38 , pp. 2733-2737
    • Saleh, A.1    Schroeter, M.2    Ringelstein, A.3
  • 58
    • 53749096762 scopus 로고    scopus 로고
    • Blood-brain barrier tight junction permeability and ischemic stroke
    • COI: 1:CAS:528:DC%2BD1cXht1Kns7nI, PID: 18790057
    • Sandoval KE, Witt KA (2008) Blood-brain barrier tight junction permeability and ischemic stroke. Neurobiol Dis 32:200–219
    • (2008) Neurobiol Dis , vol.32 , pp. 200-219
    • Sandoval, K.E.1    Witt, K.A.2
  • 59
    • 27744561356 scopus 로고    scopus 로고
    • Predominant phagocytic activity of resident microglia over hematogenous macrophages following transient focal cerebral ischemia: an investigation using green fluorescent protein transgenic bone marrow chimeric mice
    • COI: 1:CAS:528:DC%2BD2MXht1Wju7rF, PID: 16153641
    • Schilling M, Besselmann M, Muller M, Strecker JK, Ringelstein EB, Kiefer R (2005) Predominant phagocytic activity of resident microglia over hematogenous macrophages following transient focal cerebral ischemia: an investigation using green fluorescent protein transgenic bone marrow chimeric mice. Exp Neurol 196:290–297
    • (2005) Exp Neurol , vol.196 , pp. 290-297
    • Schilling, M.1    Besselmann, M.2    Muller, M.3    Strecker, J.K.4    Ringelstein, E.B.5    Kiefer, R.6
  • 60
    • 67650074913 scopus 로고    scopus 로고
    • Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal
    • COI: 1:CAS:528:DC%2BD1MXnvF2rs7o%3D, PID: 19503073
    • Schmidt MHH, Bicker F, Nikolic I et al (2009) Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal. Nat Cell Biol 11:873–880
    • (2009) Nat Cell Biol , vol.11 , pp. 873-880
    • Schmidt, M.H.H.1    Bicker, F.2    Nikolic, I.3
  • 61
    • 84872893030 scopus 로고    scopus 로고
    • Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis
    • COI: 1:CAS:528:DC%2BC3sXht1ajtbfL, PID: 23386811
    • Sierra A, Abiega O, Shahraz A, Neumann H (2013) Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis. Front Cell Neurosci 7:6
    • (2013) Front Cell Neurosci , vol.7 , pp. 6
    • Sierra, A.1    Abiega, O.2    Shahraz, A.3    Neumann, H.4
  • 62
    • 77957328867 scopus 로고    scopus 로고
    • Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis
    • COI: 1:CAS:528:DC%2BC3cXht1ClsLfE, PID: 20887954
    • Sierra A, Encinas JM, Deudero JJ et al (2010) Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Cell Stem Cell 7:483–495
    • (2010) Cell Stem Cell , vol.7 , pp. 483-495
    • Sierra, A.1    Encinas, J.M.2    Deudero, J.J.3
  • 63
    • 0035101188 scopus 로고    scopus 로고
    • Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices
    • COI: 1:STN:280:DC%2BD3M3lvFOgsQ%3D%3D, PID: 11241743
    • Stence N, Waite M, Dailey ME (2001) Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices. Glia 33:256–266
    • (2001) Glia , vol.33 , pp. 256-266
    • Stence, N.1    Waite, M.2    Dailey, M.E.3
  • 64
    • 77954669022 scopus 로고    scopus 로고
    • Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching
    • COI: 1:CAS:528:DC%2BC3cXos1Kqsbc%3D, PID: 20154215
    • Strasser GA, Kaminker JS, Tessier-Lavigne M (2010) Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching. Blood 115:5102–5110
    • (2010) Blood , vol.115 , pp. 5102-5110
    • Strasser, G.A.1    Kaminker, J.S.2    Tessier-Lavigne, M.3
  • 65
    • 4644288370 scopus 로고    scopus 로고
    • Superoxide production at phagosomal cup/phagosome through beta I protein kinase C during Fc gamma R-mediated phagocytosis in microglia
    • COI: 1:CAS:528:DC%2BD2cXnslWmtL8%3D, PID: 15383592
    • Ueyama T, Lennartz MR, Noda Y et al (2004) Superoxide production at phagosomal cup/phagosome through beta I protein kinase C during Fc gamma R-mediated phagocytosis in microglia. J Immunol 173:4582–4589
    • (2004) J Immunol , vol.173 , pp. 4582-4589
    • Ueyama, T.1    Lennartz, M.R.2    Noda, Y.3
  • 66
    • 77954233247 scopus 로고    scopus 로고
    • VEGF promotes angiogenesis and functional recovery in stroke rats
    • COI: 1:CAS:528:DC%2BC3cXivFaqsrw%3D, PID: 20590386
    • Yang JP, Liu HJ, Liu XF (2010) VEGF promotes angiogenesis and functional recovery in stroke rats. J Invest Surg 23:149–155
    • (2010) J Invest Surg , vol.23 , pp. 149-155
    • Yang, J.P.1    Liu, H.J.2    Liu, X.F.3
  • 67
    • 33645799230 scopus 로고    scopus 로고
    • Microglia potentiate damage to blood-brain barrier constituents: improvement by minocycline in vivo and in vitro
    • PID: 16497985
    • Yenari MA, Xu L, Tang XN, Qiao Y, Giffard RG (2006) Microglia potentiate damage to blood-brain barrier constituents: improvement by minocycline in vivo and in vitro. Stroke 37:1087–1093
    • (2006) Stroke , vol.37 , pp. 1087-1093
    • Yenari, M.A.1    Xu, L.2    Tang, X.N.3    Qiao, Y.4    Giffard, R.G.5
  • 68
    • 78649953975 scopus 로고    scopus 로고
    • Biomarkers of endothelial cell activation serve as potential surrogate markers for drug-induced vascular injury
    • COI: 1:CAS:528:DC%2BC3cXhtlCrtLvI, PID: 20716788
    • Zhang J, Defelice AF, Hanig JP, Colatsky T (2010) Biomarkers of endothelial cell activation serve as potential surrogate markers for drug-induced vascular injury. Toxicol Pathol 38:856–871
    • (2010) Toxicol Pathol , vol.38 , pp. 856-871
    • Zhang, J.1    Defelice, A.F.2    Hanig, J.P.3    Colatsky, T.4
  • 69
    • 0033797255 scopus 로고    scopus 로고
    • VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain
    • COI: 1:CAS:528:DC%2BD3cXntVyiu7o%3D, PID: 11018070
    • Zhang ZG, Zhang L, Jiang Q et al (2000) VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest 106:829–838
    • (2000) J Clin Invest , vol.106 , pp. 829-838
    • Zhang, Z.G.1    Zhang, L.2    Jiang, Q.3
  • 70
    • 70349652273 scopus 로고    scopus 로고
    • Bovine serum albumin promotes IL-1beta and TNF-alpha secretion by N9 microglial cells
    • PID: 19696964
    • Zhao TZ, Xia YZ, Li L et al (2009) Bovine serum albumin promotes IL-1beta and TNF-alpha secretion by N9 microglial cells. Neurol Sci 30:379–383
    • (2009) Neurol Sci , vol.30 , pp. 379-383
    • Zhao, T.Z.1    Xia, Y.Z.2    Li, L.3


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