-
1
-
-
0034611678
-
Towards a molecular understanding of adaptive thermogenesis
-
Lowell, B. B., and Spiegelman, B. M. (2000) Towards a molecular understanding of adaptive thermogenesis. Nature 404, 652-660.
-
(2000)
Nature
, vol.404
, pp. 652-660
-
-
Lowell, B.B.1
Spiegelman, B.M.2
-
2
-
-
77953169046
-
Cellular bioenergetics as a target for obesity therapy
-
Tseng, Y. H., Cypess, A. M., and Kahn, C. R. (2010) Cellular bioenergetics as a target for obesity therapy. Nat. Rev. Drug Discov. 9, 465-482.
-
(2010)
Nat. Rev. Drug Discov
, vol.9
, pp. 465-482
-
-
Tseng, Y.H.1
Cypess, A.M.2
Kahn, C.R.3
-
3
-
-
0037315245
-
Uptake in supraclavicular area fat (U.S.A.-fat): Description on 18F-FDG PET/CT
-
Cohade, C., Osman, M., Pannu, H. K., and Wahl, R. L. (2003) Uptake in supraclavicular area fat ("U.S.A.-Fat"): description on 18F-FDG PET/CT. J. Nucl. Med. 44, 170-176.
-
(2003)
J. Nucl. Med.
, vol.44
, pp. 170-176
-
-
Cohade, C.1
Osman, M.2
Pannu, H.K.3
Wahl, R.L.4
-
4
-
-
77950221998
-
Human brown adipose tissue
-
Enerbäck, S. (2010) Human brown adipose tissue. Cell metabolism 11, 248-252.
-
(2010)
Cell Metabolism
, vol.11
, pp. 248-252
-
-
Enerbäck, S.1
-
5
-
-
79960480409
-
The implication of brown adipose tissue for humans
-
Ravussin, E., and Galgani, J. E. (2011) The implication of brown adipose tissue for humans. Annu. Rev. Nutr. 31, 33-47.
-
(2011)
Annu. Rev. Nutr.
, vol.31
, pp. 33-47
-
-
Ravussin, E.1
Galgani, J.E.2
-
6
-
-
64349105205
-
Identification and importance of brown adipose tissue in adult humans
-
Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y. H., Doria, A., Kolodny, G. M., and Kahn, C. R. (2009) Identification and importance of brown adipose tissue in adult humans. N. Engl. J. Med. 360, 1509-1517.
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 1509-1517
-
-
Cypess, A.M.1
Lehman, S.2
Williams, G.3
Tal, I.4
Rodman, D.5
Goldfine, A.B.6
Kuo, F.C.7
Palmer, E.L.8
Tseng, Y.H.9
Doria, A.10
Kolodny, G.M.11
Kahn, C.R.12
-
7
-
-
34547631960
-
Unexpected evidence for active brown adipose tissue in adult humans
-
Nedergaard, J., Bengtsson, T., and Cannon, B. (2007) Unexpected evidence for active brown adipose tissue in adult humans. Am. J. Physiol. Endocrinol. Metab. 293, E444-E452.
-
(2007)
Am. J. Physiol. Endocrinol. Metab
, vol.293
, pp. E444-E452
-
-
Nedergaard, J.1
Bengtsson, T.2
Cannon, B.3
-
8
-
-
67650242165
-
High incidence of metabolically active brown adipose tissue in healthy adult humans: Effects of cold exposure and adiposity
-
Saito, M., Okamatsu-Ogura, Y., Matsushita, M., Watanabe, K., Yoneshiro, T., Nio-Kobayashi, J., Iwanaga, T., Miyagawa, M., Kameya, T., Nakada, K., Kawai, Y., and Tsujisaki, M. (2009) High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 58, 1526-1531.
-
(2009)
Diabetes
, vol.58
, pp. 1526-1531
-
-
Saito, M.1
Okamatsu-Ogura, Y.2
Matsushita, M.3
Watanabe, K.4
Yoneshiro, T.5
Nio-Kobayashi, J.6
Iwanaga, T.7
Miyagawa, M.8
Kameya, T.9
Nakada, K.10
Kawai, Y.11
Tsujisaki, M.12
-
9
-
-
64349095231
-
Cold-activated brown adipose tissue in healthy men
-
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., and Teule, G. J. (2009) Cold-activated brown adipose tissue in healthy men. N. Engl. J. Med. 360, 1500-1508.
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 1500-1508
-
-
Van Marken Lichtenbelt, W.D.1
Vanhommerig, J.W.2
Smulders, N.M.3
Drossaerts, J.M.4
Kemerink, G.J.5
Bouvy, N.D.6
Schrauwen, P.7
Teule, G.J.8
-
10
-
-
64349123664
-
Functional brown adipose tissue in healthy adults
-
Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N. J., Enerbäck, S., and Nuutila, P. (2009) Functional brown adipose tissue in healthy adults. N. Engl. J. Med. 360, 1518-1525.
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 1518-1525
-
-
Virtanen, K.A.1
Lidell, M.E.2
Orava, J.3
Heglind, M.4
Westergren, R.5
Niemi, T.6
Taittonen, M.7
Laine, J.8
Savisto, N.J.9
Enerbäck, S.10
Nuutila, P.11
-
11
-
-
70349334680
-
The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
-
Zingaretti, M. C., Crosta, F., Vitali, A., Guerrieri, M., Frontini, A., Cannon, B., Nedergaard, J., and Cinti, S. (2009) The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J. 23, 3113-3120.
-
(2009)
FASEB J
, vol.23
, pp. 3113-3120
-
-
Zingaretti, M.C.1
Crosta, F.2
Vitali, A.3
Guerrieri, M.4
Frontini, A.5
Cannon, B.6
Nedergaard, J.7
Cinti, S.8
-
12
-
-
0028884511
-
Causes of differences in respiration rate of hepatocytes from mammals of different body mass
-
Porter, R. K., and Brand, M. D. (1995) Causes of differences in respiration rate of hepatocytes from mammals of different body mass. Am. J. Physiol. 269, R1213-1R224.
-
(1995)
Am. J. Physiol.
, vol.269
, pp. R1213-1R224
-
-
Porter, R.K.1
Brand, M.D.2
-
13
-
-
0032953969
-
Contribution of mitochondrial proton leak to respiration rate in working skeletal muscle and liver and to SMR
-
Rolfe, D. F., Newman, J. M., Buckingham, J. A., Clark, M. G., and Brand, M. D. (1999) Contribution of mitochondrial proton leak to respiration rate in working skeletal muscle and liver and to SMR. Am. J. Physiol. 276, C692-C699.
-
(1999)
Am. J. Physiol.
, vol.276
, pp. C692-C699
-
-
Rolfe, D.F.1
Newman, J.M.2
Buckingham, J.A.3
Clark, M.G.4
Brand, M.D.5
-
14
-
-
0020693920
-
Luxuskonsumption, diet-induced thermogenesis and brown fat: The case in favour
-
Rothwell, N. J., and Stock, M. J. (1983) Luxuskonsumption, diet-induced thermogenesis and brown fat: The case in favour. Clin. Sci. 64, 19-23.
-
(1983)
Clin. Sci.
, vol.64
, pp. 19-23
-
-
Rothwell, N.J.1
Stock, M.J.2
-
15
-
-
58749091645
-
Ucp1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
-
Feldmann, H. M., Golozoubova, V., Cannon, B., and Nedergaard, J. (2009) UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 9, 203-209.
-
(2009)
Cell Metab.
, vol.9
, pp. 203-209
-
-
Feldmann, H.M.1
Golozoubova, V.2
Cannon, B.3
Nedergaard, J.4
-
16
-
-
0028865142
-
Expression of the mitochondrial uncoupling protein gene from the ap2 gene promoter prevents genetic obesity
-
Kopecky, J., Clarke, G., Enerbäck, S., Spiegelman, B., and Kozak, L. P. (1995) Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J. Clin. Invest. 96, 2914-2923.
-
(1995)
J. Clin. Invest.
, vol.96
, pp. 2914-2923
-
-
Kopecky, J.1
Clarke, G.2
Enerbäck, S.3
Spiegelman, B.4
Kozak, L.P.5
-
17
-
-
0033787068
-
Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
-
Li, B., Nolte, L. A., Ju, J. S., Han, D. H., Coleman, T., Holloszy, J. O., and Semenkovich, C. F. (2000) Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice. Nat. Med. 6, 1115-1120.
-
(2000)
Nat. Med.
, vol.6
, pp. 1115-1120
-
-
Li, B.1
Nolte, L.A.2
Ju, J.S.3
Han, D.H.4
Coleman, T.5
Holloszy, J.O.6
Semenkovich, C.F.7
-
18
-
-
77952623888
-
The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation
-
Barbatelli, G., Murano, I., Madsen, L., Hao, Q., Jimenez, M., Kristiansen, K., Giacobino, J. P., De Matteis, R., and Cinti, S. (2010) The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation. Am. J. Physiol. Endocrinol. Metab. 298, E1244-E1253.
-
(2010)
Am. J. Physiol. Endocrinol. Metab.
, vol.298
, pp. E1244-E1253
-
-
Barbatelli, G.1
Murano, I.2
Madsen, L.3
Hao, Q.4
Jimenez, M.5
Kristiansen, K.6
Giacobino, J.P.7
De Matteis, R.8
Cinti, S.9
-
19
-
-
85027909934
-
Adipose tissue browning and metabolic health
-
Bartelt, A., and Heeren, J. (2014) Adipose tissue browning and metabolic health. Nat. Rev. Endocrinol. 10, 24-36.
-
(2014)
Nat. Rev. Endocrinol
, vol.10
, pp. 24-36
-
-
Bartelt, A.1
Heeren, J.2
-
20
-
-
84874377962
-
The genetics of brown adipocyte induction in white fat depots
-
Kozak, L. P. (2011) The genetics of brown adipocyte induction in white fat depots. Front. Endocrinol. 2, 64.
-
(2011)
Front. Endocrinol.
, vol.2
, pp. 64
-
-
Kozak, L.P.1
-
21
-
-
77950226740
-
Chronic peroxisome proliferator-activated receptor gamma (PPARγ) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, ucp1-containing adipocytes molecularly distinct from classic brown adipocytes
-
Petrovic, N., Walden, T. B., Shabalina, I. G., Timmons, J. A., Cannon, B., and Nedergaard, J. (2010) Chronic peroxisome proliferator-activated receptor gamma (PPARγ) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J. Biol. Chem. 285, 7153-7164.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 7153-7164
-
-
Petrovic, N.1
Walden, T.B.2
Shabalina, I.G.3
Timmons, J.A.4
Cannon, B.5
Nedergaard, J.6
-
22
-
-
77649275112
-
Role of Nrf1 in antioxidant response element-mediated gene expression and beyond
-
Biswas, M., and Chan, J. Y. (2010) Role of Nrf1 in antioxidant response element-mediated gene expression and beyond. Toxicol. Appl. Pharmacol. 244, 16-20.
-
(2010)
Toxicol. Appl. Pharmacol
, vol.244
, pp. 16-20
-
-
Biswas, M.1
Chan, J.Y.2
-
23
-
-
0033525730
-
Molecular cloning and functional characterization of a new cap 'n' collar family transcription factor NRF3
-
Kobayashi, A., Ito, E., Toki, T., Kogame, K., Takahashi, S., Igarashi, K., Hayashi, N., and Yamamoto, M. (1999) Molecular cloning and functional characterization of a new Cap 'n' collar family transcription factor Nrf3. J. Biol. Chem. 274, 6443-6452.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 6443-6452
-
-
Kobayashi, A.1
Ito, E.2
Toki, T.3
Kogame, K.4
Takahashi, S.5
Igarashi, K.6
Hayashi, N.7
Yamamoto, M.8
-
24
-
-
7244253081
-
NRF2-keap1 defines a physiologically important stress response mechanism
-
Motohashi, H., and Yamamoto, M. (2004) NRF2-Keap1 defines a physiologically important stress response mechanism. Trends Mol. Med. 10, 549-557.
-
(2004)
Trends Mol. Med
, vol.10
, pp. 549-557
-
-
Motohashi, H.1
Yamamoto, M.2
-
25
-
-
12444257799
-
Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of NRF2 in response to electrophiles
-
Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., O'Connor, T., and Yamamoto, M. (2003) Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of NRF2 in response to electrophiles. Genes Cells 8, 379-391.
-
(2003)
Genes Cells
, vol.8
, pp. 379-391
-
-
Itoh, K.1
Wakabayashi, N.2
Katoh, Y.3
Ishii, T.4
O'Connor, T.5
Yamamoto, M.6
-
26
-
-
1242296811
-
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the keap1 sensor modified by inducers
-
Wakabayashi, N., Dinkova-Kostova, A. T., Holtzclaw, W. D., Kang, M. I., Kobayashi, A., Yamamoto, M., Kensler, T. W., and Talalay, P. (2004) Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proc. Natl. Acad. Sci. U.S.A. 101, 2040-2045.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 2040-2045
-
-
Wakabayashi, N.1
Dinkova-Kostova, A.T.2
Holtzclaw, W.D.3
Kang, M.I.4
Kobayashi, A.5
Yamamoto, M.6
Kensler, T.W.7
Talalay, P.8
-
27
-
-
33644501791
-
Activation of the NRF2-ARE signaling pathway: A promising strategy in cancer prevention
-
Giudice, A., and Montella, M. (2006) Activation of the NRF2-ARE signaling pathway: A promising strategy in cancer prevention. Bioessays 28, 169-181.
-
(2006)
Bioessays
, vol.28
, pp. 169-181
-
-
Giudice, A.1
Montella, M.2
-
28
-
-
0037424262
-
Modulation of gene expression by cancer chemopreventive dithiolethiones through the keap1-NRF2 pathway. Identification of novel gene clusters for cell survival
-
Kwak, M. K., Wakabayashi, N., Itoh, K., Motohashi, H., Yamamoto, M., and Kensler, T. W. (2003) Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-NRF2 pathway. Identification of novel gene clusters for cell survival. J. Biol. Chem. 278, 8135-8145.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 8135-8145
-
-
Kwak, M.K.1
Wakabayashi, N.2
Itoh, K.3
Motohashi, H.4
Yamamoto, M.5
Kensler, T.W.6
-
29
-
-
0037763721
-
Regulatory mechanisms controlling gene expression mediated by the antioxidant response element
-
Nguyen, T., Sherratt, P. J., and Pickett, C. B. (2003) Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu. Rev. Pharmacol. Toxicol. 43, 233-260.
-
(2003)
Annu. Rev. Pharmacol. Toxicol
, vol.43
, pp. 233-260
-
-
Nguyen, T.1
Sherratt, P.J.2
Pickett, C.B.3
-
30
-
-
47849083585
-
NRF2 signaling: An adaptive response pathway for protection against environmental toxic insults
-
Osburn, W. O., and Kensler, T. W. (2008) NRF2 signaling: An adaptive response pathway for protection against environmental toxic insults. Mutat. Res. 659, 31-39.
-
(2008)
Mutat. Res
, vol.659
, pp. 31-39
-
-
Osburn, W.O.1
Kensler, T.W.2
-
31
-
-
33748052967
-
NRF2-keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
-
Kobayashi, M., and Yamamoto, M. (2006) NRF2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv. Enzyme Regul. 46, 113-140.
-
(2006)
Adv. Enzyme Regul
, vol.46
, pp. 113-140
-
-
Kobayashi, M.1
Yamamoto, M.2
-
32
-
-
84884864669
-
The aryl hydrocarbon receptor interacts with nuclear factor erythroid 2-related factor 2 to mediate induction of NAD(p)h:quinoneoxidoreductase 1 by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin
-
Wang, L., He, X., Szklarz, G. D., Bi, Y., Rojanasakul, Y., and Ma, Q. (2013) The aryl hydrocarbon receptor interacts with nuclear factor erythroid 2-related factor 2 to mediate induction of NAD(P)H:quinoneoxidoreductase 1 by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. Arch. Biochem. Biophys. 537, 31-38.
-
(2013)
Arch. Biochem. Biophys.
, vol.537
, pp. 31-38
-
-
Wang, L.1
He, X.2
Szklarz, G.D.3
Bi, Y.4
Rojanasakul, Y.5
Ma, Q.6
-
33
-
-
65049089113
-
Regulation of glutathione synthesis
-
Lu, S. C. (2009) Regulation of glutathione synthesis. Mol. Aspects Med. 30, 42-59.
-
(2009)
Mol. Aspects Med
, vol.30
, pp. 42-59
-
-
Lu, S.C.1
-
34
-
-
0035836698
-
An important function of NRF2 in combating oxidative stress: Detoxification of acetaminophen
-
Chan, K., Han, X. D., and Kan, Y. W. (2001) An important function of NRF2 in combating oxidative stress: detoxification of acetaminophen. Proc. Natl. Acad. Sci. U.S.A. 98, 4611-4616.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 4611-4616
-
-
Chan, K.1
Han, X.D.2
Kan, Y.W.3
-
35
-
-
49049106335
-
Activation of NRF2 in defense against cadmium-induced oxidative stress
-
He, X., Chen, M. G., and Ma, Q. (2008) Activation of NRF2 in defense against cadmium-induced oxidative stress. Chem. Res. Toxicol. 21, 1375-1383.
-
(2008)
Chem. Res. Toxicol
, vol.21
, pp. 1375-1383
-
-
He, X.1
Chen, M.G.2
Ma, Q.3
-
36
-
-
34447581166
-
Protection against chromium (VI)-induced oxidative stress and apoptosis by NRF2. Recruiting NRF2 into the nucleus and disrupting the nuclear NRF2/keap1 association
-
He, X., Lin, G. X., Chen, M. G., Zhang, J. X., and Ma, Q. (2007) Protection against chromium (VI)-induced oxidative stress and apoptosis by NRF2. Recruiting NRF2 into the nucleus and disrupting the nuclear NRF2/Keap1 association. Toxicol. Sci. 98, 298-309.
-
(2007)
Toxicol. Sci
, vol.98
, pp. 298-309
-
-
He, X.1
Lin, G.X.2
Chen, M.G.3
Zhang, J.X.4
Ma, Q.5
-
37
-
-
33744729373
-
Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor NRF2
-
Ma, Q., Battelli, L., and Hubbs, A. F. (2006) Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor NRF2. Am. J. Pathol. 168, 1960-1974.
-
(2006)
Am. J. Pathol
, vol.168
, pp. 1960-1974
-
-
Ma, Q.1
Battelli, L.2
Hubbs, A.F.3
-
38
-
-
0035853157
-
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in NRF2 transcription factor-deficient mice
-
Ramos-Gomez, M., Kwak, M. K., Dolan, P. M., Itoh, K., Yamamoto, M., Talalay, P., and Kensler, T. W. (2001) Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in NRF2 transcription factor-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 98, 3410-3415.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 3410-3415
-
-
Ramos-Gomez, M.1
Kwak, M.K.2
Dolan, P.M.3
Itoh, K.4
Yamamoto, M.5
Talalay, P.6
Kensler, T.W.7
-
39
-
-
21744445077
-
NRF2, a multi-organ protector?
-
Lee, J. M., Li, J., Johnson, D. A., Stein, T. D., Kraft, A. D., Calkins, M. J., Jakel, R. J., and Johnson, J. A. (2005) NRF2, a multi-organ protector? FASEB J. 19, 1061-1066.
-
(2005)
FASEB J
, vol.19
, pp. 1061-1066
-
-
Lee, J.M.1
Li, J.2
Johnson, D.A.3
Stein, T.D.4
Kraft, A.D.5
Calkins, M.J.6
Jakel, R.J.7
Johnson, J.A.8
-
40
-
-
84855453637
-
Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of ccaat/enhancer-binding protein β during adipogenesis
-
Hou, Y., Xue, P., Bai, Y., Liu, D., Woods, C. G., Yarborough, K., Fu, J., Zhang, Q., Sun, G., Collins, S., Chan, J. Y., Yamamoto, M., Andersen, M. E., and Pi, J. (2012) Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis. Free Radic. Biol. Med. 52, 462-472.
-
(2012)
Free Radic. Biol. Med
, vol.52
, pp. 462-472
-
-
Hou, Y.1
Xue, P.2
Bai, Y.3
Liu, D.4
Woods, C.G.5
Yarborough, K.6
Fu, J.7
Zhang, Q.8
Sun, G.9
Collins, S.10
Chan, J.Y.11
Yamamoto, M.12
Andersen, M.E.13
Pi, J.14
-
41
-
-
77950553993
-
Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity
-
Pi, J., Leung, L., Xue, P., Wang, W., Hou, Y., Liu, D., Yehuda-Shnaidman, E., Lee, C., Lau, J., Kurtz, T. W., and Chan, J. Y. (2010) Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity. J. Biol. Chem. 285, 9292-9300.
-
(2010)
J. Biol. Chem
, vol.285
, pp. 9292-9300
-
-
Pi, J.1
Leung, L.2
Xue, P.3
Wang, W.4
Hou, Y.5
Liu, D.6
Yehuda-Shnaidman, E.7
Lee, C.8
Lau, J.9
Kurtz, T.W.10
Chan, J.Y.11
-
42
-
-
0030451213
-
NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
-
Chan, K., Lu, R., Chang, J. C., and Kan, Y. W. (1996) NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc. Natl. Acad. Sci. U.S.A. 93, 13943-13948.
-
(1996)
Proc. Natl. Acad. Sci. U.S.A
, vol.93
, pp. 13943-13948
-
-
Chan, K.1
Lu, R.2
Chang, J.C.3
Kan, Y.W.4
-
43
-
-
84899155583
-
A method for assessing mitochondrial bioenergetics in whole white adipose tissues
-
Dunham-Snary, K. J., Sandel, M. W., Westbrook, D. G., and Ballinger, S. W. (2014) A method for assessing mitochondrial bioenergetics in whole white adipose tissues. Redox Biol. 2, 656-660.
-
(2014)
Redox Biol
, vol.2
, pp. 656-660
-
-
Dunham-Snary, K.J.1
Sandel, M.W.2
Westbrook, D.G.3
Ballinger, S.W.4
-
44
-
-
57749174647
-
Biosensor plates detect mitochondrial physiological regulators and mutations in vivo
-
Rolo, A. P., Palmeira, C. M., and Cortopassi, G. A. (2009) Biosensor plates detect mitochondrial physiological regulators and mutations in vivo. Anal. Biochem. 385, 176-178.
-
(2009)
Anal. Biochem.
, vol.385
, pp. 176-178
-
-
Rolo, A.P.1
Palmeira, C.M.2
Cortopassi, G.A.3
-
45
-
-
39949085437
-
Nonequilibrium thermodynamics of thiol/disulfide redox systems: A perspective on redox systems biology
-
Kemp, M., Go, Y. M., and Jones, D. P. (2008) Nonequilibrium thermodynamics of thiol/disulfide redox systems: A perspective on redox systems biology. Free Radic. Biol. Med. 44, 921-937.
-
(2008)
Free Radic. Biol. Med.
, vol.44
, pp. 921-937
-
-
Kemp, M.1
Go, Y.M.2
Jones, D.P.3
-
46
-
-
84901684204
-
Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species
-
Ro, S. H., Nam, M., Jang, I., Park, H. W., Park, H., Semple, I. A., Kim, M., Kim, J. S., Park, H., Einat, P., Damari, G., Golikov, M., Feinstein, E., and Lee, J. H. (2014) Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species. Proc. Natl. Acad. Sci. U.S.A. 111, 7849-7854.
-
(2014)
Proc. Natl. Acad. Sci. U.S.A.
, vol.111
, pp. 7849-7854
-
-
Ro, S.H.1
Nam, M.2
Jang, I.3
Park, H.W.4
Park, H.5
Semple, I.A.6
Kim, M.7
Kim, J.S.8
Park, H.9
Einat, P.10
Damari, G.11
Golikov, M.12
Feinstein, E.13
Lee, J.H.14
-
47
-
-
84855743089
-
Lipid metabolism and body composition in GCLM(-/-) mice
-
Kendig, E. L., Chen, Y., Krishan, M., Johansson, E., Schneider, S. N., Genter, M. B., Nebert, D. W., and Shertzer, H. G. (2011) Lipid metabolism and body composition in Gclm(-/-) mice. Toxicol. Appl. Pharmacol. 257, 338-348.
-
(2011)
Toxicol. Appl. Pharmacol.
, vol.257
, pp. 338-348
-
-
Kendig, E.L.1
Chen, Y.2
Krishan, M.3
Johansson, E.4
Schneider, S.N.5
Genter, M.B.6
Nebert, D.W.7
Shertzer, H.G.8
-
48
-
-
70349512259
-
Reactive oxygen species enhance insulin sensitivity
-
Loh, K., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B. J., Skiba, B., Ooms, L. M., Stepto, N., Wu, B., Mitchell, C. A., Tonks, N. K., Watt, M. J., et al. (2009) Reactive oxygen species enhance insulin sensitivity. Cell Metab. 10, 260-272.
-
(2009)
Cell Metab.
, vol.10
, pp. 260-272
-
-
Loh, K.1
Deng, H.2
Fukushima, A.3
Cai, X.4
Boivin, B.5
Galic, S.6
Bruce, C.7
Shields, B.J.8
Skiba, B.9
Ooms, L.M.10
Stepto, N.11
Wu, B.12
Mitchell, C.A.13
Tonks, N.K.14
Watt, M.J.15
-
49
-
-
2942667688
-
Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase
-
McClung, J. P., Roneker, C. A., Mu, W., Lisk, D. J., Langlais, P., Liu, F., and Lei, X. G. (2004) Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase. Proc. Natl. Acad. Sci. U.S.A. 101, 8852-8857.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A
, vol.101
, pp. 8852-8857
-
-
McClung, J.P.1
Roneker, C.A.2
Mu, W.3
Lisk, D.J.4
Langlais, P.5
Liu, F.6
Lei, X.G.7
-
50
-
-
84867777934
-
Redox regulation by nuclear factor erythroid 2-related factor 2: Gatekeeping for the basal and diabetes-induced expression of thioredoxin-interacting protein
-
He, X., and Ma, Q. (2012) Redox regulation by nuclear factor erythroid 2-related factor 2: gatekeeping for the basal and diabetes-induced expression of thioredoxin-interacting protein. Mol. Pharmacol. 82, 887-897.
-
(2012)
Mol. Pharmacol
, vol.82
, pp. 887-897
-
-
He, X.1
Ma, Q.2
-
51
-
-
77953196716
-
Deletion of the -γ arrestin protein txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity
-
Chutkow, W. A., Birkenfeld, A. L., Brown, J. D., Lee, H. Y., Frederick, D. W., Yoshioka, J., Patwari, P., Kursawe, R., Cushman, S. W., Plutzky, J., Shulman, G. I., Samuel, V. T., and Lee, R. T. (2010) Deletion of the -γ arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity. Diabetes 59, 1424-1434.
-
(2010)
Diabetes
, vol.59
, pp. 1424-1434
-
-
Chutkow, W.A.1
Birkenfeld, A.L.2
Brown, J.D.3
Lee, H.Y.4
Frederick, D.W.5
Yoshioka, J.6
Patwari, P.7
Kursawe, R.8
Cushman, S.W.9
Plutzky, J.10
Shulman, G.I.11
Samuel, V.T.12
Lee, R.T.13
-
52
-
-
0030988140
-
Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression
-
Boss, O., Samec, S., Paoloni-Giacobino, A., Rossier, C., Dulloo, A., Seydoux, J., Muzzin, P., and Giacobino, J. P. (1997) Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett. 408, 39-42.
-
(1997)
FEBS Lett
, vol.408
, pp. 39-42
-
-
Boss, O.1
Samec, S.2
Paoloni-Giacobino, A.3
Rossier, C.4
Dulloo, A.5
Seydoux, J.6
Muzzin, P.7
Giacobino, J.P.8
-
53
-
-
0031019249
-
Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
-
Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champigny, O., Levi- Meyrueis, C., Bouillaud, F., Seldin, M. F., Surwit, R. S., Ricquier, D., and Warden, C. H. (1997) Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia. Nat. Genet. 15, 269-272.
-
(1997)
Nat. Genet
, vol.15
, pp. 269-272
-
-
Fleury, C.1
Neverova, M.2
Collins, S.3
Raimbault, S.4
Champigny, O.5
Levi- Meyrueis, C.6
Bouillaud, F.7
Seldin, M.F.8
Surwit, R.S.9
Ricquier, D.10
Warden, C.H.11
-
54
-
-
0006877856
-
Mice over expressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
-
Clapham, J. C., Arch, J. R., Chapman, H., Haynes, A., Lister, C., Moore, G. B., Piercy, V., Carter, S. A., Lehner, I., Smith, S. A., Beeley, L. J., Godden, R. J., Herrity, N., Skehel, M., Changani, K. K., et al. (2000) Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Nature 406, 415-418.
-
(2000)
Nature
, vol.406
, pp. 415-418
-
-
Clapham, J.C.1
Arch, J.R.2
Chapman, H.3
Haynes, A.4
Lister, C.5
Moore, G.B.6
Piercy, V.7
Carter, S.A.8
Lehner, I.9
Smith, S.A.10
Beeley, L.J.11
Godden, R.J.12
Herrity, N.13
Skehel, M.14
Changani, K.K.15
-
55
-
-
84964798610
-
Uncoupling protein-2 (ucp2) gene expression in subcutaneous and omental adipose tissue of Asian Indians: Relationship to adiponectin and parameters of metabolic syndrome
-
Mahadik, S. R., Lele, R. D., Saranath, D., Seth, A., and Parikh, V. (2012) Uncoupling protein-2 (UCP2) gene expression in subcutaneous and omental adipose tissue of Asian Indians: relationship to adiponectin and parameters of metabolic syndrome. Adipocyte 1, 101-107.
-
(2012)
Adipocyte
, vol.1
, pp. 101-107
-
-
Mahadik, S.R.1
Lele, R.D.2
Saranath, D.3
Seth, A.4
Parikh, V.5
-
56
-
-
84879054362
-
The role of uncoupling protein 2 and 3 genes polymorphism and energy expenditure in obese Indonesian children
-
Mexitalia, M., Yamauchi, T., Utari, A., Sjarif, D. R., Subagio, H. W., Soemantri, A., and Ishida, T. (2013) The role of uncoupling protein 2 and 3 genes polymorphism and energy expenditure in obese Indonesian children. J. Pediatr. Endocrinol. Metab. 26, 441-447.
-
(2013)
J. Pediatr. Endocrinol. Metab
, vol.26
, pp. 441-447
-
-
Mexitalia, M.1
Yamauchi, T.2
Utari, A.3
Sjarif, D.R.4
Subagio, H.W.5
Soemantri, A.6
Ishida, T.7
-
57
-
-
84875684855
-
Ucp2-866g/a, ala55val and ucp3-55c/t polymorphisms in association with obesity susceptibility: A meta-analysis study
-
Qian, L., Xu, K., Xu, X., Gu, R., Liu, X., Shan, S., and Yang, T. (2013) UCP2-866G/A, Ala55Val and UCP3-55C/T polymorphisms in association with obesity susceptibility: A meta-analysis study. PLoS One 8, e58939.
-
(2013)
PLoS One
, vol.8
, pp. e58939
-
-
Qian, L.1
Xu, K.2
Xu, X.3
Gu, R.4
Liu, X.5
Shan, S.6
Yang, T.7
-
58
-
-
84878003949
-
The transcription factor NRF2 promotes survival by enhancing the expression of uncoupling protein 3 under conditions of oxidative stress
-
Anedda, A., López-Bernardo, E., Acosta-Iborra, B., Saadeh Suleiman, M., Landázuri, M. O., and Cadenas, S. (2013) The transcription factor NRF2 promotes survival by enhancing the expression of uncoupling protein 3 under conditions of oxidative stress. Free Radic. Biol. Med. 61, 395-407.
-
(2013)
Free Radic. Biol. Med
, vol.61
, pp. 395-407
-
-
Anedda, A.1
López-Bernardo, E.2
Acosta-Iborra, B.3
Saadeh Suleiman, M.4
Landázuri, M.O.5
Cadenas, S.6
-
59
-
-
84878057587
-
Pgc-1γ is required for exercise- And exercise training-induced ucp1 up-regulation in mouse white adipose tissue
-
Ringholm, S., Grunnet Knudsen, J., Leick, L., Lundgaard, A., Munk Nielsen, M., and Pilegaard, H. (2013) PGC-1- is required for exercise γ and exercise training-induced UCP1 up-regulation in mouse white adipose tissue. PLoS One 8, e64123.
-
(2013)
PLoS One
, vol.8
, pp. e64123
-
-
Ringholm, S.1
Grunnet Knudsen, J.2
Leick, L.3
Lundgaard, A.4
Munk Nielsen, M.5
Pilegaard, H.6
-
60
-
-
27144476457
-
Rip140-targeted repression of gene expression in adipocytes
-
Christian, M., Kiskinis, E., Debevec, D., Leonardsson, G., White, R., and Parker, M. G. (2005) RIP140-targeted repression of gene expression in adipocytes. Mol. Cell. Biol. 25, 9383-9391.
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 9383-9391
-
-
Christian, M.1
Kiskinis, E.2
Debevec, D.3
Leonardsson, G.4
White, R.5
Parker, M.G.6
-
61
-
-
2942532305
-
Nuclear receptor corepressor RIP140 regulates fat accumulation
-
Leonardsson, G., Steel, J. H., Christian, M., Pocock, V., Milligan, S., Bell, J., So, P. W., Medina-Gomez, G., Vidal-Puig, A., White, R., and Parker, M. G. (2004) Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc. Natl. Acad. Sci. U.S.A. 101, 8437-8442.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A
, vol.101
, pp. 8437-8442
-
-
Leonardsson, G.1
Steel, J.H.2
Christian, M.3
Pocock, V.4
Milligan, S.5
Bell, J.6
So, P.W.7
Medina-Gomez, G.8
Vidal-Puig, A.9
White, R.10
Parker, M.G.11
-
62
-
-
41149117092
-
Liver X receptor γ is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype
-
Wang, H., Zhang, Y., Yehuda-Shnaidman, E., Medvedev, A. V., Kumar, N., Daniel, K. W., Robidoux, J., Czech, M. P., Mangelsdorf, D. J., and Collins, S. (2008) Liver X receptor γ is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype. Mol. Cell. Biol. 28, 2187-2200.
-
(2008)
Mol. Cell. Biol
, vol.28
, pp. 2187-2200
-
-
Wang, H.1
Zhang, Y.2
Yehuda-Shnaidman, E.3
Medvedev, A.V.4
Kumar, N.5
Daniel, K.W.6
Robidoux, J.7
Czech, M.P.8
Mangelsdorf, D.J.9
Collins, S.10
-
63
-
-
18244379331
-
Superoxide activates mitochondrial uncoupling proteins
-
Echtay, K. S., Roussel, D., St-Pierre, J., Jekabsons, M. B., Cadenas, S., Stuart, J. A., Harper, J. A., Roebuck, S. J., Morrison, A., Pickering, S., Clapham, J. C., and Brand, M. D. (2002) Superoxide activates mitochondrial uncoupling proteins. Nature 415, 96-99.
-
(2002)
Nature
, vol.415
, pp. 96-99
-
-
Echtay, K.S.1
Roussel, D.2
St-Pierre, J.3
Jekabsons, M.B.4
Cadenas, S.5
Stuart, J.A.6
Harper, J.A.7
Roebuck, S.J.8
Morrison, A.9
Pickering, S.10
Clapham, J.C.11
Brand, M.D.12
-
64
-
-
79953210362
-
Regulation of PGC-1-gamma; nodal regulator of mitochondrial biogenesis
-
Fernandez-Marcos, P. J., and Auwerx, J. (2011) Regulation of PGC-1-gamma;, a nodal regulator of mitochondrial biogenesis. Am. J. Clin. Nutr. 93, 884S-890S.
-
(2011)
Am. J. Clin. Nutr
, vol.93
, pp. 884S-890S
-
-
Fernandez-Marcos, P.J.1
Auwerx, J.2
-
65
-
-
47149115165
-
Increased oxidative stress precedes the onset of high-fat dietinduced insulin resistance and obesity
-
Matsuzawa-Nagata, N., Takamura, T., Ando, H., Nakamura, S., Kurita, S., Misu, H., Ota, T., Yokoyama, M., Honda, M., Miyamoto, K., and Kaneko, S. (2008) Increased oxidative stress precedes the onset of high-fat dietinduced insulin resistance and obesity. Metabolism 57, 1071-1077.
-
(2008)
Metabolism
, vol.57
, pp. 1071-1077
-
-
Matsuzawa-Nagata, N.1
Takamura, T.2
Ando, H.3
Nakamura, S.4
Kurita, S.5
Misu, H.6
Ota, T.7
Yokoyama, M.8
Honda, M.9
Miyamoto, K.10
Kaneko, S.11
-
66
-
-
33749999530
-
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
-
St-Pierre, J., Drori, S., Uldry, M., Silvaggi, J. M., Rhee, J., Jäger, S., Handschin, C., Zheng, K., Lin, J., Yang, W., Simon, D. K., Bachoo, R., and Spiegelman, B. M. (2006) Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 127, 397-408.
-
(2006)
Cell
, vol.127
, pp. 397-408
-
-
St-Pierre, J.1
Drori, S.2
Uldry, M.3
Silvaggi, J.M.4
Rhee, J.5
Jäger, S.6
Handschin, C.7
Zheng, K.8
Lin, J.9
Yang, W.10
Simon, D.K.11
Bachoo, R.12
Spiegelman, B.M.13
-
67
-
-
0033538473
-
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
-
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., and Spiegelman, B. M. (1999) Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98, 115-124.
-
(1999)
Cell
, vol.98
, pp. 115-124
-
-
Wu, Z.1
Puigserver, P.2
Andersson, U.3
Zhang, C.4
Adelmant, G.5
Mootha, V.6
Troy, A.7
Cinti, S.8
Lowell, B.9
Scarpulla, R.C.10
Spiegelman, B.M.11
-
68
-
-
84896710569
-
Functional thermogenic beige adipogenesis is inducible in human neck fat
-
Lee, P., Werner, C. D., Kebebew, E., and Celi, F. S. (2013) Functional thermogenic beige adipogenesis is inducible in human neck fat. Int. J. Obes. 38, 170-176.
-
(2013)
Int. J. Obes
, vol.38
, pp. 170-176
-
-
Lee, P.1
Werner, C.D.2
Kebebew, E.3
Celi, F.S.4
-
69
-
-
84878523414
-
Pharmacological strategies for targeting bat thermogenesis
-
Whittle, A., Relat-Pardo, J., and Vidal-Puig, A. (2013) Pharmacological strategies for targeting BAT thermogenesis. Trends Pharmacol. Sci. 34, 347-355.
-
(2013)
Trends Pharmacol. Sci.
, vol.34
, pp. 347-355
-
-
Whittle, A.1
Relat-Pardo, J.2
Vidal-Puig, A.3
-
70
-
-
84885959413
-
Brown adipose tissue: Research milestones of a potential player in human energy balance and obesity
-
Zafrir, B. (2013) Brown adipose tissue: research milestones of a potential player in human energy balance and obesity. Horm. Metab. Res. 45, 774-785.
-
(2013)
Horm. Metab. Res
, vol.45
, pp. 774-785
-
-
Zafrir, B.1
-
71
-
-
84865781554
-
Beige differentiation of adipose depots in mice lacking prolactin receptor protects against high-fat-diet-induced obesity
-
Auffret, J., Viengchareun, S., Carré, N., Denis, R. G., Magnan, C., Marie, P. Y., Muscat, A., Fève, B., Lombès, M., and Binart, N. (2012) Beige differentiation of adipose depots in mice lacking prolactin receptor protects against high-fat-diet-induced obesity. FASEB J. 26, 3728-3737.
-
(2012)
FASEB J
, vol.26
, pp. 3728-3737
-
-
Auffret, J.1
Viengchareun, S.2
Carré, N.3
Denis, R.G.4
Magnan, C.5
Marie, P.Y.6
Muscat, A.7
Fève, B.8
Lombès, M.9
Binart, N.10
-
72
-
-
69449097633
-
The protein kinase ikke regulates energy balance in obese mice
-
Chiang, S. H., Bazuine, M., Lumeng, C. N., Geletka, L. M., Mowers, J., White, N. M., Ma, J. T., Zhou, J., Qi, N., Westcott, D., Delproposto, J. B., Blackwell, T. S., Yull, F. E., and Saltiel, A. R. (2009) The protein kinase IKKe regulates energy balance in obese mice. Cell 138, 961-975.
-
(2009)
Cell
, vol.138
, pp. 961-975
-
-
Chiang, S.H.1
Bazuine, M.2
Lumeng, C.N.3
Geletka, L.M.4
Mowers, J.5
White, N.M.6
Ma, J.T.7
Zhou, J.8
Qi, N.9
Westcott, D.10
Delproposto, J.B.11
Blackwell, T.S.12
Yull, F.E.13
Saltiel, A.R.14
-
73
-
-
84863012022
-
FGF21 regulates PGC-1γ and browning of white adipose tissues in adaptive thermogenesis
-
Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., and Spiegelman, B. M. (2012) FGF21 regulates PGC-1γ and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 26, 271-281.
-
(2012)
Genes Dev
, vol.26
, pp. 271-281
-
-
Fisher, F.M.1
Kleiner, S.2
Douris, N.3
Fox, E.C.4
Mepani, R.J.5
Verdeguer, F.6
Wu, J.7
Kharitonenkov, A.8
Flier, J.S.9
Maratos-Flier, E.10
Spiegelman, B.M.11
-
74
-
-
77952970098
-
Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes
-
Vegiopoulos, A., Müller-Decker, K., Strzoda, D., Schmitt, I., Chichelnitskiy, E., Ostertag, A., Berriel Diaz, M., Rozman, J., Hrabe de Angelis, M., Nüsing, R. M., Meyer, C. W., Wahli, W., Klingenspor, M., and Herzig, S. (2010) Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science 328, 1158-1161.
-
(2010)
Science
, vol.328
, pp. 1158-1161
-
-
Vegiopoulos, A.1
Müller-Decker, K.2
Strzoda, D.3
Schmitt, I.4
Chichelnitskiy, E.5
Ostertag, A.6
Berriel Diaz, M.7
Rozman, J.8
Hrabe De Angelis, M.9
Nüsing, R.M.10
Meyer, C.W.11
Wahli, W.12
Klingenspor, M.13
Herzig, S.14
-
75
-
-
20444435873
-
Fgf-21 as a novel metabolic regulator
-
Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., Gromada, J., Brozinick, J. T., Hawkins, E. D., Wroblewski, V. J., Li, D. S., et al. (2005) FGF-21 as a novel metabolic regulator. J. Clin. Invest. 115, 1627-1635.
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 1627-1635
-
-
Kharitonenkov, A.1
Shiyanova, T.L.2
Koester, A.3
Ford, A.M.4
Micanovic, R.5
Galbreath, E.J.6
Sandusky, G.E.7
Hammond, L.J.8
Moyers, J.S.9
Owens, R.A.10
Gromada, J.11
Brozinick, J.T.12
Hawkins, E.D.13
Wroblewski, V.J.14
Li, D.S.15
-
76
-
-
80053389113
-
NRF2 represses FGF21 during long-term high-fat diet-induced obesity in mice
-
Chartoumpekis, D. V., Ziros, P. G., Psyrogiannis, A. I., Papavassiliou, A. G., Kyriazopoulou, V. E., Sykiotis, G. P., and Habeos, I. G. (2011) NRF2 represses FGF21 during long-term high-fat diet-induced obesity in mice. Diabetes 60, 2465-2473.
-
(2011)
Diabetes
, vol.60
, pp. 2465-2473
-
-
Chartoumpekis, D.V.1
Ziros, P.G.2
Psyrogiannis, A.I.3
Papavassiliou, A.G.4
Kyriazopoulou, V.E.5
Sykiotis, G.P.6
Habeos, I.G.7
-
77
-
-
84884761856
-
Coordinate functional regulation between microsomal prostaglandin e synthase-1 (mpges-1) and peroxisome proliferator-activated receptor - (PPARγ) in the conversion of white-to-brown adipocytes
-
García-Alonso, V., López-Vicario, C., Titos, E., Morán-Salvador, E., González-Périz, A., Rius, B., Párrizas, M., Werz, O., Arroyo, V., and Clària, J. (2013) Coordinate functional regulation between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor - (PPARPPARγ) in the conversion of white-to-brown adipocytes. J. Biol. Chem. 288, 28230-28242.
-
(2013)
J. Biol. Chem
, vol.288
, pp. 28230-28242
-
-
García-Alonso, V.1
López-Vicario, C.2
Titos, E.3
Morán-Salvador, E.4
González-Périz, A.5
Rius, B.6
Párrizas, M.7
Werz, O.8
Arroyo, V.9
Clària, J.10
-
78
-
-
20944439189
-
Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance
-
Jones, J. R., Barrick, C., Kim, K. A., Lindner, J., Blondeau, B., Fujimoto, Y., Shiota, M., Kesterson, R. A., Kahn, B. B., and Magnuson, M. A. (2005) Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc. Natl. Acad. Sci. U.S.A. 102, 6207-6212.
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 6207-6212
-
-
Jones, J.R.1
Barrick, C.2
Kim, K.A.3
Lindner, J.4
Blondeau, B.5
Fujimoto, Y.6
Shiota, M.7
Kesterson, R.A.8
Kahn, B.B.9
Magnuson, M.A.10
-
79
-
-
84880682182
-
The keap1-NRF2 system prevents onset of diabetes mellitus
-
Uruno, A., Furusawa, Y., Yagishita, Y., Fukutomi, T., Muramatsu, H., Negishi, T., Sugawara, A., Kensler, T. W., and Yamamoto, M. (2013) The Keap1-NRF2 system prevents onset of diabetes mellitus. Mol. Cell. Biol. 33, 2996-3010.
-
(2013)
Mol. Cell. Biol.
, vol.33
, pp. 2996-3010
-
-
Uruno, A.1
Furusawa, Y.2
Yagishita, Y.3
Fukutomi, T.4
Muramatsu, H.5
Negishi, T.6
Sugawara, A.7
Kensler, T.W.8
Yamamoto, M.9
-
80
-
-
84870361939
-
Enhanced NRF2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice
-
Xu, J., Kulkarni, S. R., Donepudi, A. C., More, V. R., and Slitt, A. L. (2012) Enhanced NRF2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice. Diabetes 61, 3208-3218.
-
(2012)
Diabetes
, vol.61
, pp. 3208-3218
-
-
Xu, J.1
Kulkarni, S.R.2
Donepudi, A.C.3
More, V.R.4
Slitt, A.L.5
-
81
-
-
84873336694
-
Adipose deficiency of NRF2 in ob/ob mice results in severe metabolic syndrome
-
Xue, P., Hou, Y., Chen, Y., Yang, B., Fu, J., Zheng, H., Yarborough, K., Woods, C. G., Liu, D., Yamamoto, M., Zhang, Q., Andersen, M. E., and Pi, J. (2013) Adipose deficiency of NRF2 in ob/ob mice results in severe metabolic syndrome. Diabetes 62, 845-854.
-
(2013)
Diabetes
, vol.62
, pp. 845-854
-
-
Xue, P.1
Hou, Y.2
Chen, Y.3
Yang, B.4
Fu, J.5
Zheng, H.6
Yarborough, K.7
Woods, C.G.8
Liu, D.9
Yamamoto, M.10
Zhang, Q.11
Andersen, M.E.12
Pi, J.13
-
82
-
-
84877046011
-
Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding
-
More, V. R., Xu, J., Shimpi, P. C., Belgrave, C., Luyendyk, J. P., Yamamoto, M., and Slitt, A. L. (2013) Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding. Free Radic. Biol. Med. 61, 85-94.
-
(2013)
Free Radic. Biol. Med
, vol.61
, pp. 85-94
-
-
More, V.R.1
Xu, J.2
Shimpi, P.C.3
Belgrave, C.4
Luyendyk, J.P.5
Yamamoto, M.6
Slitt, A.L.7
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