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Volumn 291, Issue 14, 2016, Pages 7754-7766

Increased energy expenditure, ucp1 expression, and resistance to diet-induced obesity in mice lacking nuclear factor-erythroid-2-related transcription factor-2 (nrf2)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELL CULTURE; FIBROBLASTS; GENES; GLUCOSE OXIDASE; GLUCOSE SENSORS; MAMMALS; MANGANESE; NUTRITION; OXIDATIVE STRESS; OXYGEN; TISSUE; TRANSCRIPTION; TRANSCRIPTION FACTORS;

EID: 84964868442     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.673756     Document Type: Article
Times cited : (62)

References (82)
  • 1
    • 0034611678 scopus 로고    scopus 로고
    • Towards a molecular understanding of adaptive thermogenesis
    • Lowell, B. B., and Spiegelman, B. M. (2000) Towards a molecular understanding of adaptive thermogenesis. Nature 404, 652-660.
    • (2000) Nature , vol.404 , pp. 652-660
    • Lowell, B.B.1    Spiegelman, B.M.2
  • 2
    • 77953169046 scopus 로고    scopus 로고
    • Cellular bioenergetics as a target for obesity therapy
    • Tseng, Y. H., Cypess, A. M., and Kahn, C. R. (2010) Cellular bioenergetics as a target for obesity therapy. Nat. Rev. Drug Discov. 9, 465-482.
    • (2010) Nat. Rev. Drug Discov , vol.9 , pp. 465-482
    • Tseng, Y.H.1    Cypess, A.M.2    Kahn, C.R.3
  • 3
    • 0037315245 scopus 로고    scopus 로고
    • Uptake in supraclavicular area fat (U.S.A.-fat): Description on 18F-FDG PET/CT
    • Cohade, C., Osman, M., Pannu, H. K., and Wahl, R. L. (2003) Uptake in supraclavicular area fat ("U.S.A.-Fat"): description on 18F-FDG PET/CT. J. Nucl. Med. 44, 170-176.
    • (2003) J. Nucl. Med. , vol.44 , pp. 170-176
    • Cohade, C.1    Osman, M.2    Pannu, H.K.3    Wahl, R.L.4
  • 4
    • 77950221998 scopus 로고    scopus 로고
    • Human brown adipose tissue
    • Enerbäck, S. (2010) Human brown adipose tissue. Cell metabolism 11, 248-252.
    • (2010) Cell Metabolism , vol.11 , pp. 248-252
    • Enerbäck, S.1
  • 5
    • 79960480409 scopus 로고    scopus 로고
    • The implication of brown adipose tissue for humans
    • Ravussin, E., and Galgani, J. E. (2011) The implication of brown adipose tissue for humans. Annu. Rev. Nutr. 31, 33-47.
    • (2011) Annu. Rev. Nutr. , vol.31 , pp. 33-47
    • Ravussin, E.1    Galgani, J.E.2
  • 7
    • 34547631960 scopus 로고    scopus 로고
    • Unexpected evidence for active brown adipose tissue in adult humans
    • Nedergaard, J., Bengtsson, T., and Cannon, B. (2007) Unexpected evidence for active brown adipose tissue in adult humans. Am. J. Physiol. Endocrinol. Metab. 293, E444-E452.
    • (2007) Am. J. Physiol. Endocrinol. Metab , vol.293 , pp. E444-E452
    • Nedergaard, J.1    Bengtsson, T.2    Cannon, B.3
  • 11
    • 70349334680 scopus 로고    scopus 로고
    • The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
    • Zingaretti, M. C., Crosta, F., Vitali, A., Guerrieri, M., Frontini, A., Cannon, B., Nedergaard, J., and Cinti, S. (2009) The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J. 23, 3113-3120.
    • (2009) FASEB J , vol.23 , pp. 3113-3120
    • Zingaretti, M.C.1    Crosta, F.2    Vitali, A.3    Guerrieri, M.4    Frontini, A.5    Cannon, B.6    Nedergaard, J.7    Cinti, S.8
  • 12
    • 0028884511 scopus 로고
    • Causes of differences in respiration rate of hepatocytes from mammals of different body mass
    • Porter, R. K., and Brand, M. D. (1995) Causes of differences in respiration rate of hepatocytes from mammals of different body mass. Am. J. Physiol. 269, R1213-1R224.
    • (1995) Am. J. Physiol. , vol.269 , pp. R1213-1R224
    • Porter, R.K.1    Brand, M.D.2
  • 13
    • 0032953969 scopus 로고    scopus 로고
    • Contribution of mitochondrial proton leak to respiration rate in working skeletal muscle and liver and to SMR
    • Rolfe, D. F., Newman, J. M., Buckingham, J. A., Clark, M. G., and Brand, M. D. (1999) Contribution of mitochondrial proton leak to respiration rate in working skeletal muscle and liver and to SMR. Am. J. Physiol. 276, C692-C699.
    • (1999) Am. J. Physiol. , vol.276 , pp. C692-C699
    • Rolfe, D.F.1    Newman, J.M.2    Buckingham, J.A.3    Clark, M.G.4    Brand, M.D.5
  • 14
    • 0020693920 scopus 로고
    • Luxuskonsumption, diet-induced thermogenesis and brown fat: The case in favour
    • Rothwell, N. J., and Stock, M. J. (1983) Luxuskonsumption, diet-induced thermogenesis and brown fat: The case in favour. Clin. Sci. 64, 19-23.
    • (1983) Clin. Sci. , vol.64 , pp. 19-23
    • Rothwell, N.J.1    Stock, M.J.2
  • 15
    • 58749091645 scopus 로고    scopus 로고
    • Ucp1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
    • Feldmann, H. M., Golozoubova, V., Cannon, B., and Nedergaard, J. (2009) UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 9, 203-209.
    • (2009) Cell Metab. , vol.9 , pp. 203-209
    • Feldmann, H.M.1    Golozoubova, V.2    Cannon, B.3    Nedergaard, J.4
  • 16
    • 0028865142 scopus 로고
    • Expression of the mitochondrial uncoupling protein gene from the ap2 gene promoter prevents genetic obesity
    • Kopecky, J., Clarke, G., Enerbäck, S., Spiegelman, B., and Kozak, L. P. (1995) Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J. Clin. Invest. 96, 2914-2923.
    • (1995) J. Clin. Invest. , vol.96 , pp. 2914-2923
    • Kopecky, J.1    Clarke, G.2    Enerbäck, S.3    Spiegelman, B.4    Kozak, L.P.5
  • 17
    • 0033787068 scopus 로고    scopus 로고
    • Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
    • Li, B., Nolte, L. A., Ju, J. S., Han, D. H., Coleman, T., Holloszy, J. O., and Semenkovich, C. F. (2000) Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice. Nat. Med. 6, 1115-1120.
    • (2000) Nat. Med. , vol.6 , pp. 1115-1120
    • Li, B.1    Nolte, L.A.2    Ju, J.S.3    Han, D.H.4    Coleman, T.5    Holloszy, J.O.6    Semenkovich, C.F.7
  • 19
    • 85027909934 scopus 로고    scopus 로고
    • Adipose tissue browning and metabolic health
    • Bartelt, A., and Heeren, J. (2014) Adipose tissue browning and metabolic health. Nat. Rev. Endocrinol. 10, 24-36.
    • (2014) Nat. Rev. Endocrinol , vol.10 , pp. 24-36
    • Bartelt, A.1    Heeren, J.2
  • 20
    • 84874377962 scopus 로고    scopus 로고
    • The genetics of brown adipocyte induction in white fat depots
    • Kozak, L. P. (2011) The genetics of brown adipocyte induction in white fat depots. Front. Endocrinol. 2, 64.
    • (2011) Front. Endocrinol. , vol.2 , pp. 64
    • Kozak, L.P.1
  • 21
    • 77950226740 scopus 로고    scopus 로고
    • Chronic peroxisome proliferator-activated receptor gamma (PPARγ) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, ucp1-containing adipocytes molecularly distinct from classic brown adipocytes
    • Petrovic, N., Walden, T. B., Shabalina, I. G., Timmons, J. A., Cannon, B., and Nedergaard, J. (2010) Chronic peroxisome proliferator-activated receptor gamma (PPARγ) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J. Biol. Chem. 285, 7153-7164.
    • (2010) J. Biol. Chem. , vol.285 , pp. 7153-7164
    • Petrovic, N.1    Walden, T.B.2    Shabalina, I.G.3    Timmons, J.A.4    Cannon, B.5    Nedergaard, J.6
  • 22
    • 77649275112 scopus 로고    scopus 로고
    • Role of Nrf1 in antioxidant response element-mediated gene expression and beyond
    • Biswas, M., and Chan, J. Y. (2010) Role of Nrf1 in antioxidant response element-mediated gene expression and beyond. Toxicol. Appl. Pharmacol. 244, 16-20.
    • (2010) Toxicol. Appl. Pharmacol , vol.244 , pp. 16-20
    • Biswas, M.1    Chan, J.Y.2
  • 23
    • 0033525730 scopus 로고    scopus 로고
    • Molecular cloning and functional characterization of a new cap 'n' collar family transcription factor NRF3
    • Kobayashi, A., Ito, E., Toki, T., Kogame, K., Takahashi, S., Igarashi, K., Hayashi, N., and Yamamoto, M. (1999) Molecular cloning and functional characterization of a new Cap 'n' collar family transcription factor Nrf3. J. Biol. Chem. 274, 6443-6452.
    • (1999) J. Biol. Chem. , vol.274 , pp. 6443-6452
    • Kobayashi, A.1    Ito, E.2    Toki, T.3    Kogame, K.4    Takahashi, S.5    Igarashi, K.6    Hayashi, N.7    Yamamoto, M.8
  • 24
    • 7244253081 scopus 로고    scopus 로고
    • NRF2-keap1 defines a physiologically important stress response mechanism
    • Motohashi, H., and Yamamoto, M. (2004) NRF2-Keap1 defines a physiologically important stress response mechanism. Trends Mol. Med. 10, 549-557.
    • (2004) Trends Mol. Med , vol.10 , pp. 549-557
    • Motohashi, H.1    Yamamoto, M.2
  • 25
    • 12444257799 scopus 로고    scopus 로고
    • Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of NRF2 in response to electrophiles
    • Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., O'Connor, T., and Yamamoto, M. (2003) Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of NRF2 in response to electrophiles. Genes Cells 8, 379-391.
    • (2003) Genes Cells , vol.8 , pp. 379-391
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    O'Connor, T.5    Yamamoto, M.6
  • 27
    • 33644501791 scopus 로고    scopus 로고
    • Activation of the NRF2-ARE signaling pathway: A promising strategy in cancer prevention
    • Giudice, A., and Montella, M. (2006) Activation of the NRF2-ARE signaling pathway: A promising strategy in cancer prevention. Bioessays 28, 169-181.
    • (2006) Bioessays , vol.28 , pp. 169-181
    • Giudice, A.1    Montella, M.2
  • 28
    • 0037424262 scopus 로고    scopus 로고
    • Modulation of gene expression by cancer chemopreventive dithiolethiones through the keap1-NRF2 pathway. Identification of novel gene clusters for cell survival
    • Kwak, M. K., Wakabayashi, N., Itoh, K., Motohashi, H., Yamamoto, M., and Kensler, T. W. (2003) Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-NRF2 pathway. Identification of novel gene clusters for cell survival. J. Biol. Chem. 278, 8135-8145.
    • (2003) J. Biol. Chem , vol.278 , pp. 8135-8145
    • Kwak, M.K.1    Wakabayashi, N.2    Itoh, K.3    Motohashi, H.4    Yamamoto, M.5    Kensler, T.W.6
  • 29
    • 0037763721 scopus 로고    scopus 로고
    • Regulatory mechanisms controlling gene expression mediated by the antioxidant response element
    • Nguyen, T., Sherratt, P. J., and Pickett, C. B. (2003) Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu. Rev. Pharmacol. Toxicol. 43, 233-260.
    • (2003) Annu. Rev. Pharmacol. Toxicol , vol.43 , pp. 233-260
    • Nguyen, T.1    Sherratt, P.J.2    Pickett, C.B.3
  • 30
    • 47849083585 scopus 로고    scopus 로고
    • NRF2 signaling: An adaptive response pathway for protection against environmental toxic insults
    • Osburn, W. O., and Kensler, T. W. (2008) NRF2 signaling: An adaptive response pathway for protection against environmental toxic insults. Mutat. Res. 659, 31-39.
    • (2008) Mutat. Res , vol.659 , pp. 31-39
    • Osburn, W.O.1    Kensler, T.W.2
  • 31
    • 33748052967 scopus 로고    scopus 로고
    • NRF2-keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
    • Kobayashi, M., and Yamamoto, M. (2006) NRF2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv. Enzyme Regul. 46, 113-140.
    • (2006) Adv. Enzyme Regul , vol.46 , pp. 113-140
    • Kobayashi, M.1    Yamamoto, M.2
  • 32
    • 84884864669 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor interacts with nuclear factor erythroid 2-related factor 2 to mediate induction of NAD(p)h:quinoneoxidoreductase 1 by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin
    • Wang, L., He, X., Szklarz, G. D., Bi, Y., Rojanasakul, Y., and Ma, Q. (2013) The aryl hydrocarbon receptor interacts with nuclear factor erythroid 2-related factor 2 to mediate induction of NAD(P)H:quinoneoxidoreductase 1 by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. Arch. Biochem. Biophys. 537, 31-38.
    • (2013) Arch. Biochem. Biophys. , vol.537 , pp. 31-38
    • Wang, L.1    He, X.2    Szklarz, G.D.3    Bi, Y.4    Rojanasakul, Y.5    Ma, Q.6
  • 33
    • 65049089113 scopus 로고    scopus 로고
    • Regulation of glutathione synthesis
    • Lu, S. C. (2009) Regulation of glutathione synthesis. Mol. Aspects Med. 30, 42-59.
    • (2009) Mol. Aspects Med , vol.30 , pp. 42-59
    • Lu, S.C.1
  • 34
    • 0035836698 scopus 로고    scopus 로고
    • An important function of NRF2 in combating oxidative stress: Detoxification of acetaminophen
    • Chan, K., Han, X. D., and Kan, Y. W. (2001) An important function of NRF2 in combating oxidative stress: detoxification of acetaminophen. Proc. Natl. Acad. Sci. U.S.A. 98, 4611-4616.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 4611-4616
    • Chan, K.1    Han, X.D.2    Kan, Y.W.3
  • 35
    • 49049106335 scopus 로고    scopus 로고
    • Activation of NRF2 in defense against cadmium-induced oxidative stress
    • He, X., Chen, M. G., and Ma, Q. (2008) Activation of NRF2 in defense against cadmium-induced oxidative stress. Chem. Res. Toxicol. 21, 1375-1383.
    • (2008) Chem. Res. Toxicol , vol.21 , pp. 1375-1383
    • He, X.1    Chen, M.G.2    Ma, Q.3
  • 36
    • 34447581166 scopus 로고    scopus 로고
    • Protection against chromium (VI)-induced oxidative stress and apoptosis by NRF2. Recruiting NRF2 into the nucleus and disrupting the nuclear NRF2/keap1 association
    • He, X., Lin, G. X., Chen, M. G., Zhang, J. X., and Ma, Q. (2007) Protection against chromium (VI)-induced oxidative stress and apoptosis by NRF2. Recruiting NRF2 into the nucleus and disrupting the nuclear NRF2/Keap1 association. Toxicol. Sci. 98, 298-309.
    • (2007) Toxicol. Sci , vol.98 , pp. 298-309
    • He, X.1    Lin, G.X.2    Chen, M.G.3    Zhang, J.X.4    Ma, Q.5
  • 37
    • 33744729373 scopus 로고    scopus 로고
    • Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor NRF2
    • Ma, Q., Battelli, L., and Hubbs, A. F. (2006) Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor NRF2. Am. J. Pathol. 168, 1960-1974.
    • (2006) Am. J. Pathol , vol.168 , pp. 1960-1974
    • Ma, Q.1    Battelli, L.2    Hubbs, A.F.3
  • 38
    • 0035853157 scopus 로고    scopus 로고
    • Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in NRF2 transcription factor-deficient mice
    • Ramos-Gomez, M., Kwak, M. K., Dolan, P. M., Itoh, K., Yamamoto, M., Talalay, P., and Kensler, T. W. (2001) Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in NRF2 transcription factor-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 98, 3410-3415.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 3410-3415
    • Ramos-Gomez, M.1    Kwak, M.K.2    Dolan, P.M.3    Itoh, K.4    Yamamoto, M.5    Talalay, P.6    Kensler, T.W.7
  • 41
    • 77950553993 scopus 로고    scopus 로고
    • Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity
    • Pi, J., Leung, L., Xue, P., Wang, W., Hou, Y., Liu, D., Yehuda-Shnaidman, E., Lee, C., Lau, J., Kurtz, T. W., and Chan, J. Y. (2010) Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity. J. Biol. Chem. 285, 9292-9300.
    • (2010) J. Biol. Chem , vol.285 , pp. 9292-9300
    • Pi, J.1    Leung, L.2    Xue, P.3    Wang, W.4    Hou, Y.5    Liu, D.6    Yehuda-Shnaidman, E.7    Lee, C.8    Lau, J.9    Kurtz, T.W.10    Chan, J.Y.11
  • 42
    • 0030451213 scopus 로고    scopus 로고
    • NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
    • Chan, K., Lu, R., Chang, J. C., and Kan, Y. W. (1996) NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc. Natl. Acad. Sci. U.S.A. 93, 13943-13948.
    • (1996) Proc. Natl. Acad. Sci. U.S.A , vol.93 , pp. 13943-13948
    • Chan, K.1    Lu, R.2    Chang, J.C.3    Kan, Y.W.4
  • 43
    • 84899155583 scopus 로고    scopus 로고
    • A method for assessing mitochondrial bioenergetics in whole white adipose tissues
    • Dunham-Snary, K. J., Sandel, M. W., Westbrook, D. G., and Ballinger, S. W. (2014) A method for assessing mitochondrial bioenergetics in whole white adipose tissues. Redox Biol. 2, 656-660.
    • (2014) Redox Biol , vol.2 , pp. 656-660
    • Dunham-Snary, K.J.1    Sandel, M.W.2    Westbrook, D.G.3    Ballinger, S.W.4
  • 44
    • 57749174647 scopus 로고    scopus 로고
    • Biosensor plates detect mitochondrial physiological regulators and mutations in vivo
    • Rolo, A. P., Palmeira, C. M., and Cortopassi, G. A. (2009) Biosensor plates detect mitochondrial physiological regulators and mutations in vivo. Anal. Biochem. 385, 176-178.
    • (2009) Anal. Biochem. , vol.385 , pp. 176-178
    • Rolo, A.P.1    Palmeira, C.M.2    Cortopassi, G.A.3
  • 45
    • 39949085437 scopus 로고    scopus 로고
    • Nonequilibrium thermodynamics of thiol/disulfide redox systems: A perspective on redox systems biology
    • Kemp, M., Go, Y. M., and Jones, D. P. (2008) Nonequilibrium thermodynamics of thiol/disulfide redox systems: A perspective on redox systems biology. Free Radic. Biol. Med. 44, 921-937.
    • (2008) Free Radic. Biol. Med. , vol.44 , pp. 921-937
    • Kemp, M.1    Go, Y.M.2    Jones, D.P.3
  • 49
    • 2942667688 scopus 로고    scopus 로고
    • Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase
    • McClung, J. P., Roneker, C. A., Mu, W., Lisk, D. J., Langlais, P., Liu, F., and Lei, X. G. (2004) Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase. Proc. Natl. Acad. Sci. U.S.A. 101, 8852-8857.
    • (2004) Proc. Natl. Acad. Sci. U.S.A , vol.101 , pp. 8852-8857
    • McClung, J.P.1    Roneker, C.A.2    Mu, W.3    Lisk, D.J.4    Langlais, P.5    Liu, F.6    Lei, X.G.7
  • 50
    • 84867777934 scopus 로고    scopus 로고
    • Redox regulation by nuclear factor erythroid 2-related factor 2: Gatekeeping for the basal and diabetes-induced expression of thioredoxin-interacting protein
    • He, X., and Ma, Q. (2012) Redox regulation by nuclear factor erythroid 2-related factor 2: gatekeeping for the basal and diabetes-induced expression of thioredoxin-interacting protein. Mol. Pharmacol. 82, 887-897.
    • (2012) Mol. Pharmacol , vol.82 , pp. 887-897
    • He, X.1    Ma, Q.2
  • 55
    • 84964798610 scopus 로고    scopus 로고
    • Uncoupling protein-2 (ucp2) gene expression in subcutaneous and omental adipose tissue of Asian Indians: Relationship to adiponectin and parameters of metabolic syndrome
    • Mahadik, S. R., Lele, R. D., Saranath, D., Seth, A., and Parikh, V. (2012) Uncoupling protein-2 (UCP2) gene expression in subcutaneous and omental adipose tissue of Asian Indians: relationship to adiponectin and parameters of metabolic syndrome. Adipocyte 1, 101-107.
    • (2012) Adipocyte , vol.1 , pp. 101-107
    • Mahadik, S.R.1    Lele, R.D.2    Saranath, D.3    Seth, A.4    Parikh, V.5
  • 57
    • 84875684855 scopus 로고    scopus 로고
    • Ucp2-866g/a, ala55val and ucp3-55c/t polymorphisms in association with obesity susceptibility: A meta-analysis study
    • Qian, L., Xu, K., Xu, X., Gu, R., Liu, X., Shan, S., and Yang, T. (2013) UCP2-866G/A, Ala55Val and UCP3-55C/T polymorphisms in association with obesity susceptibility: A meta-analysis study. PLoS One 8, e58939.
    • (2013) PLoS One , vol.8 , pp. e58939
    • Qian, L.1    Xu, K.2    Xu, X.3    Gu, R.4    Liu, X.5    Shan, S.6    Yang, T.7
  • 58
    • 84878003949 scopus 로고    scopus 로고
    • The transcription factor NRF2 promotes survival by enhancing the expression of uncoupling protein 3 under conditions of oxidative stress
    • Anedda, A., López-Bernardo, E., Acosta-Iborra, B., Saadeh Suleiman, M., Landázuri, M. O., and Cadenas, S. (2013) The transcription factor NRF2 promotes survival by enhancing the expression of uncoupling protein 3 under conditions of oxidative stress. Free Radic. Biol. Med. 61, 395-407.
    • (2013) Free Radic. Biol. Med , vol.61 , pp. 395-407
    • Anedda, A.1    López-Bernardo, E.2    Acosta-Iborra, B.3    Saadeh Suleiman, M.4    Landázuri, M.O.5    Cadenas, S.6
  • 59
    • 84878057587 scopus 로고    scopus 로고
    • Pgc-1γ is required for exercise- And exercise training-induced ucp1 up-regulation in mouse white adipose tissue
    • Ringholm, S., Grunnet Knudsen, J., Leick, L., Lundgaard, A., Munk Nielsen, M., and Pilegaard, H. (2013) PGC-1- is required for exercise γ and exercise training-induced UCP1 up-regulation in mouse white adipose tissue. PLoS One 8, e64123.
    • (2013) PLoS One , vol.8 , pp. e64123
    • Ringholm, S.1    Grunnet Knudsen, J.2    Leick, L.3    Lundgaard, A.4    Munk Nielsen, M.5    Pilegaard, H.6
  • 64
    • 79953210362 scopus 로고    scopus 로고
    • Regulation of PGC-1-gamma; nodal regulator of mitochondrial biogenesis
    • Fernandez-Marcos, P. J., and Auwerx, J. (2011) Regulation of PGC-1-gamma;, a nodal regulator of mitochondrial biogenesis. Am. J. Clin. Nutr. 93, 884S-890S.
    • (2011) Am. J. Clin. Nutr , vol.93 , pp. 884S-890S
    • Fernandez-Marcos, P.J.1    Auwerx, J.2
  • 68
    • 84896710569 scopus 로고    scopus 로고
    • Functional thermogenic beige adipogenesis is inducible in human neck fat
    • Lee, P., Werner, C. D., Kebebew, E., and Celi, F. S. (2013) Functional thermogenic beige adipogenesis is inducible in human neck fat. Int. J. Obes. 38, 170-176.
    • (2013) Int. J. Obes , vol.38 , pp. 170-176
    • Lee, P.1    Werner, C.D.2    Kebebew, E.3    Celi, F.S.4
  • 69
    • 84878523414 scopus 로고    scopus 로고
    • Pharmacological strategies for targeting bat thermogenesis
    • Whittle, A., Relat-Pardo, J., and Vidal-Puig, A. (2013) Pharmacological strategies for targeting BAT thermogenesis. Trends Pharmacol. Sci. 34, 347-355.
    • (2013) Trends Pharmacol. Sci. , vol.34 , pp. 347-355
    • Whittle, A.1    Relat-Pardo, J.2    Vidal-Puig, A.3
  • 70
    • 84885959413 scopus 로고    scopus 로고
    • Brown adipose tissue: Research milestones of a potential player in human energy balance and obesity
    • Zafrir, B. (2013) Brown adipose tissue: research milestones of a potential player in human energy balance and obesity. Horm. Metab. Res. 45, 774-785.
    • (2013) Horm. Metab. Res , vol.45 , pp. 774-785
    • Zafrir, B.1
  • 71
  • 77
    • 84884761856 scopus 로고    scopus 로고
    • Coordinate functional regulation between microsomal prostaglandin e synthase-1 (mpges-1) and peroxisome proliferator-activated receptor - (PPARγ) in the conversion of white-to-brown adipocytes
    • García-Alonso, V., López-Vicario, C., Titos, E., Morán-Salvador, E., González-Périz, A., Rius, B., Párrizas, M., Werz, O., Arroyo, V., and Clària, J. (2013) Coordinate functional regulation between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor - (PPARPPARγ) in the conversion of white-to-brown adipocytes. J. Biol. Chem. 288, 28230-28242.
    • (2013) J. Biol. Chem , vol.288 , pp. 28230-28242
    • García-Alonso, V.1    López-Vicario, C.2    Titos, E.3    Morán-Salvador, E.4    González-Périz, A.5    Rius, B.6    Párrizas, M.7    Werz, O.8    Arroyo, V.9    Clària, J.10
  • 80
    • 84870361939 scopus 로고    scopus 로고
    • Enhanced NRF2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice
    • Xu, J., Kulkarni, S. R., Donepudi, A. C., More, V. R., and Slitt, A. L. (2012) Enhanced NRF2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice. Diabetes 61, 3208-3218.
    • (2012) Diabetes , vol.61 , pp. 3208-3218
    • Xu, J.1    Kulkarni, S.R.2    Donepudi, A.C.3    More, V.R.4    Slitt, A.L.5


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