Role of Nrf1 in antioxidant response element-mediated gene expression and beyond

Toxicology and Applied Pharmacology

Volumn 244, Issue 1, 2010, Pages 16-20

  Biswas, Madhurima ^a   Chan, Jefferson Y ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antioxidant; bZIP factor; Nrf1; Nrf2; Oxidative stress

Indexed keywords

BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA;

ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; BINDING SITE; CATALYSIS; DNA BINDING; GENE TARGETING; OXIDATIVE STRESS; PHENOTYPE; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REVIEW; SEQUENCE HOMOLOGY;

ANIMALS; ANTIOXIDANTS; BINDING SITES; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 1; NUCLEAR RESPIRATORY FACTOR 1; OXIDATIVE STRESS; PROTEIN CONFORMATION; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

MUS;

EID: 77649275112     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.07.034     Document Type: Review

References (31)

1. Berg D.T., Gupta A., Richardson M.A., O'Brien L.A., Calnek D., and Grinnell B.W. Negative regulation of inducible nitric-oxide synthase expression mediated through transforming growth factor-beta-dependent modulation of transcription factor TCF11. J. Biol. Chem. 282 (2007) 36837-36844
2. Chan J.Y., Han X.L., and Kan Y.W. Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 11371-11375
3. Chan J.Y., Han X.L., and Kan Y.W. Isolation of cDNA encoding the human NF-E2 protein. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 11366-11370
4. Chan J.Y., Cheung M.C., Moi P., Chan K., and Kan Y.W. Chromosomal localization of the human NF-E2 family of bZIP transcription factors by fluorescence in situ hybridization. Hum. Genet. 95 (1995) 265-269
5. Chan J.Y., Kwong M., Lu R., Chang J., Wang B., Yen T.S., and Kan Y.W. Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice. EMBO J. 17 (1998) 1779-1787
6. Chen L., Kwong M., Lu R., Ginzinger D., Lee C., Leung L., and Chan J.Y. Nrf1 is critical for redox balance and survival of liver cells during development. Mol. Cell. Biol. 23 (2003) 4673-4686
7. Hertel M., Braun S., Durka S., Alzheimer C., and Werner S. Upregulation and activation of the Nrf-1 transcription factor in the lesioned hippocampus. Eur. J. Neurosci. 15 (2002) 1707-1711
8. Itoh K., Igarashi K., Hayashi N., Nishizawa M., and Yamamoto M. Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins. Mol. Cell. Biol. 15 (1995) 4184-4193
9. Johnsen O., Skammelsrud N., Luna L., Nishizawa M., Prydz H., and Kolsto A.B. Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1. Nucleic Acids Res. 24 (1996) 4289-4297
10. Johnsen O., Murphy P., Prydz H., and Kolsto A.B. Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription. Nucleic Acids Res. 26 (1998) 512-520
11. Kobayashi A., Ito E., Toki T., Kogame K., Takahashi S., Igarashi K., Hayashi N., and Yamamoto M. Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. J. Biol. Chem. 274 (1999) 6443-6452
12. Kwong M., Kan Y.W., and Chan J.Y. The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts. J. Biol. Chem. 274 (1999) 37491-37498
13. Lee T.D., Yang H., Whang J., and Lu S.C. Cloning and characterization of the human glutathione synthetase 5′-flanking region. Biochem. J. 390 (2005) 521-528
14. Leung L., Kwong M., Hou S., Lee C., and Chan J.Y. Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress. J. Biol. Chem. 278 (2003) 48021-48029
15. Luna L., Johnsen O., Skartlien A.H., Pedeutour F., Turc-Carel C., Prydz H., and Kolsto A.B. Molecular cloning of a putative novel human bZIP transcription factor on chromosome 17q22. Genomics 22 (1994) 553-562
16. Luna L., Skammelsrud N., Johnsen O., Abel K.J., Weber B.L., Prydz H., and Kolsto A.B. Structural organization and mapping of the human TCF11 gene. Genomics 27 (1995) 237-244
17. Marini M.G., Chan K., Casula L., Kan Y.W., Cao A., and Moi P. hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2. J. Biol. Chem. 272 (1997) 16490-16497
18. McKie J., Johnstone K., Mattei M.G., and Scambler P. Cloning and mapping of murine Nfe2l1. Genomics 25 (1995) 716-719
19. Murphy P., and Kolsto A. Expression of the bZIP transcription factor TCF11 and its potential dimerization partners during development. Mech. Dev. 97 (2000) 141-148
20. Myhrstad M.C., Husberg C., Murphy P., Nordstrom O., Blomhoff R., Moskaug J.O., and Kolsto A.B. TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter. Biochim. Biophys. Acta 1517 (2001) 212-219
21. Narayanan K., Ramachandran A., Peterson M.C., Hao J., Kolsto A.B., Friedman A.D., and George A. The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiation. J. Biol. Chem. 279 (2004) 45423-45432
22. Newman J.R., and Keating A.E. Comprehensive identification of human bZIP interactions with coiled-coil arrays. Science 300 (2003) 2097-2101
23. Ohtsuji M., Katsuoka F., Kobayashi A., Aburatani H., Hayes J.D., and Yamamoto M. Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes. J. Biol. Chem. 283 (2008) 33554-33562
24. Wang W., and Chan J.Y. Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function. J. Biol. Chem. 281 (2006) 19676-19687
25. Wang W., Kwok A.M., and Chan J.Y. The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription. J. Biol. Chem. 282 (2007) 24670-24678
26. Wu G., Fang Y.Z., Yang S., Lupton J.R., and Turner N.D. Glutathione metabolism and its implications for health. J. Nutr. 134 (2004) 489-492
27. Xing W., Singgih A., Kapoor A., Alarcon C.M., Baylink D.J., and Mohan S. Nuclear factor-E2-related factor-1 mediates ascorbic acid induction of osterix expression via interaction with antioxidant-responsive element in bone cells. J. Biol. Chem. 282 (2007) 22052-22061
28. Xu Z., Chen L., Leung L., Yen T.S., Lee C., and Chan J.Y. Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 4120-4125
29. Zhang Y., Crouch D.H., Yamamoto M., and Hayes J.D. Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum. Biochem. J. 399 (2006) 373-385
30. Zhang Y., Lucocq J.M., Yamamoto M., and Hayes J.D. The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation. Biochem. J. 408 (2007) 161-172
31. Zhang Y., Lucocq J.M., and Hayes J.D. The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors. Biochem. J. 418 (2009) 293-310