메뉴 건너뛰기




Volumn 6, Issue 4, 2016, Pages

Recent advances in dynamic m6A RNA Modification

Author keywords

M6A; Methylation; MRNA

Indexed keywords

ADENOSINE; LONG UNTRANSLATED RNA; MESSENGER RNA; RNA;

EID: 84964727206     PISSN: None     EISSN: 20462441     Source Type: Journal    
DOI: 10.1098/rsob.16.0003     Document Type: Review
Times cited : (264)

References (97)
  • 1
    • 84888838351 scopus 로고    scopus 로고
    • Primate transcript and protein expression levels evolve under compensatory selection pressures
    • Khan Z, Ford MJ, Cusanovich DA, Mitrano A, Pritchard JK, Gilad Y. 2013 Primate transcript and protein expression levels evolve under compensatory selection pressures. Science 342, 1100-1104. (doi:10.1126/science.1242379).
    • (2013) Science , vol.342 , pp. 1100-1104
    • Khan, Z.1    Ford, M.J.2    Cusanovich, D.A.3    Mitrano, A.4    Pritchard, J.K.5    Gilad, Y.6
  • 4
    • 84875692043 scopus 로고    scopus 로고
    • MODOMICS: A database of RNA modification pathways-2013 update
    • Machnicka MA et al. 2013 MODOMICS: A database of RNA modification pathways-2013 update. Nucleic Acids Res. 41, D262-D267. (doi:10.1093/nar/gks1007).
    • (2013) Nucleic Acids Res , vol.41 , pp. D262-D267
    • Machnicka, M.A.1
  • 5
    • 0016285746 scopus 로고
    • Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells
    • Desrosiers R, Friderici K, Rottman F. 1974 Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc. Natl Acad. Sci. USA 71, 3971-3975. (doi:10.1073/pnas.71.10.3971).
    • (1974) Proc. Natl Acad. Sci. USA , vol.71 , pp. 3971-3975
    • Desrosiers, R.1    Friderici, K.2    Rottman, F.3
  • 7
    • 0016793057 scopus 로고
    • Modified nucleosides and bizarre 50- Termini in mouse myeloma mRNA
    • Adams JM, Cory S. 1975 Modified nucleosides and bizarre 50- Termini in mouse myeloma mRNA. Nature 255, 28-33. (doi:10.1038/255028a0).
    • (1975) Nature , vol.255 , pp. 28-33
    • Adams, J.M.1    Cory, S.2
  • 8
    • 0016770156 scopus 로고
    • Methylated nucleotides block 50 terminus of HeLa cell messenger RNA
    • Wei CM, Gershowitz A, Moss B. 1975 Methylated nucleotides block 50 terminus of HeLa cell messenger RNA. Cell 4, 379-386. (doi:10.1016/0092-8674(75)90158-0).
    • (1975) Cell , vol.4 , pp. 379-386
    • Wei, C.M.1    Gershowitz, A.2    Moss, B.3
  • 9
    • 0016432834 scopus 로고
    • Methylated nucleotides block 50- Terminus of vaccinia virus messenger RNA
    • Wei CM, Moss B. 1975 Methylated nucleotides block 50- Terminus of vaccinia virus messenger RNA. Proc. Natl Acad. Sci. USA 72, 318-322. (doi:10.1073/pnas.72.1.318).
    • (1975) Proc. Natl Acad. Sci. USA , vol.72 , pp. 318-322
    • Wei, C.M.1    Moss, B.2
  • 10
    • 0017177599 scopus 로고
    • Influenza viral mRNA contains internal N6-methyladenosine and 50- Terminal 7-methylguanosine in cap structures
    • Krug RM, Morgan MA, Shatkin AJ. 1976 Influenza viral mRNA contains internal N6-methyladenosine and 50- Terminal 7-methylguanosine in cap structures. J. Virol. 20, 45-53.
    • (1976) J. Virol , vol.20 , pp. 45-53
    • Krug, R.M.1    Morgan, M.A.2    Shatkin, A.J.3
  • 12
    • 79955768436 scopus 로고    scopus 로고
    • Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells
    • doi:10.1038/nbt.1861
    • Rabani M et al. 2011 Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells. Nat. Biotechnol. 29, 436-442. (doi:10.1038/nbt.1861).
    • (2011) Nat. Biotechnol , vol.29 , pp. 436-442
    • Rabani, M.1
  • 14
    • 81355146483 scopus 로고    scopus 로고
    • N6-methyladenosine in nuclear RNA is a major substrate of the obesity- Associated FTO
    • Jia G et al. 2011 N6-methyladenosine in nuclear RNA is a major substrate of the obesity- Associated FTO. Nat. Chem. Biol. 7, 885-887. (doi:10.1038/nchembio.687).
    • (2011) Nat. Chem. Biol. , vol.7 , pp. 885-887
    • Jia, G.1
  • 15
    • 84860779086 scopus 로고    scopus 로고
    • Topology of the human and mouse m6A RNA methylomes revealed by m6Aseq
    • Dominissini D et al. 2012 Topology of the human and mouse m6A RNA methylomes revealed by m6Aseq. Nature 485, 201-206. (doi:10.1038/nature11112).
    • (2012) Nature , vol.485 , pp. 201-206
    • Dominissini, D.1
  • 16
    • 84862649489 scopus 로고    scopus 로고
    • Comprehensive analysis of mRNA methylation reveals enrichment in 30 UTRs and near stop codons
    • Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR. 2012 Comprehensive analysis of mRNA methylation reveals enrichment in 30 UTRs and near stop codons. Cell 149, 1635-1646. (doi:10.1016/j.cell.2012.05.003).
    • (2012) Cell , vol.149 , pp. 1635-1646
    • Meyer, K.D.1    Saletore, Y.2    Zumbo, P.3    Elemento, O.4    Mason, C.E.5    Jaffrey, S.R.6
  • 17
    • 84920273757 scopus 로고    scopus 로고
    • FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
    • Zhao X et al. 2014 FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Cell Res. 24, 1403-1419. (doi:10.1038/cr.2014.151).
    • (2014) Cell Res , vol.24 , pp. 1403-1419
    • Zhao, X.1
  • 18
    • 84922342926 scopus 로고    scopus 로고
    • Stem cells. M6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation
    • Geula S et al. 2015 Stem cells. m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation. Science 347, 1002-1006. (doi:10.1126/science.1261417).
    • (2015) Science , vol.347 , pp. 1002-1006
    • Geula, S.1
  • 19
    • 84919836468 scopus 로고    scopus 로고
    • RNA epigenetics
    • Liu N, Pan T. 2015 RNA epigenetics. Transl. Res. 165, 28-35. (doi:10.1016/j.trsl.2014.04.003).
    • (2015) Transl. Res , vol.165 , pp. 28-35
    • Liu, N.1    Pan, T.2
  • 20
    • 84903829672 scopus 로고    scopus 로고
    • Dynamic RNA modifications in disease
    • Klungland A, Dahl JA. 2014 Dynamic RNA modifications in disease. Curr. Opin. Genet. Dev. 26, 47-52. (doi:10.1016/j.gde.2014.05.006).
    • (2014) Curr. Opin. Genet. Dev , vol.26 , pp. 47-52
    • Klungland, A.1    Dahl, J.A.2
  • 21
    • 84904412679 scopus 로고    scopus 로고
    • Role of RNA methyltransferases in tissue renewal and pathology
    • Blanco S, Frye M. 2014 Role of RNA methyltransferases in tissue renewal and pathology. Curr. Opin. Cell Biol. 31, 1-7. (doi:10.1016/j.ceb. 2014.06.006).
    • (2014) Curr. Opin. Cell Biol , vol.31 , pp. 1-7
    • Blanco, S.1    Frye, M.2
  • 22
    • 67649875640 scopus 로고    scopus 로고
    • Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations
    • Boissel S et al. 2009 Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. Am. J. Hum. Genet. 85, 106-111. (doi:10.1016/j. ajhg.2009.06.002).
    • (2009) Am. J. Hum. Genet , vol.85 , pp. 106-111
    • Boissel, S.1
  • 23
    • 0015582818 scopus 로고
    • Mitochondrial protein synthesis: RNA with the properties of Eukaryotic messenger RNA
    • Perlman S, Abelson HT, Penman S. 1973 Mitochondrial protein synthesis: RNA with the properties of Eukaryotic messenger RNA. Proc. Natl Acad. Sci. USA 70, 350-353. (doi:10.1073/pnas.70.2.350).
    • (1973) Proc. Natl Acad. Sci. USA , vol.70 , pp. 350-353
    • Perlman, S.1    Abelson, H.T.2    Penman, S.3
  • 24
    • 41549094036 scopus 로고    scopus 로고
    • Polyadenylation in mammalian mitochondria: Insights from recent studies
    • Nagaike T, Suzuki T, Ueda T. 2008 Polyadenylation in mammalian mitochondria: insights from recent studies. Biochim. Biophys. Acta 1779, 266-269. (doi:10.1016/j.bbagrm.2008.02.001).
    • (2008) Biochim. Biophys. Acta , vol.1779 , pp. 266-269
    • Nagaike, T.1    Suzuki, T.2    Ueda, T.3
  • 25
    • 33745116597 scopus 로고    scopus 로고
    • Polyadenylation of ribosomal RNA in human cells
    • Slomovic S. 2006 Polyadenylation of ribosomal RNA in human cells. Nucleic Acids Res. 34, 2966-2975. (doi:10.1093/nar/gkl357).
    • (2006) Nucleic Acids Res , vol.34 , pp. 2966-2975
    • Slomovic, S.1
  • 26
    • 84919457819 scopus 로고    scopus 로고
    • M6A RNA modification controls cell fate transition in mammalian embryonic stem cells
    • Batista PJ et al. 2014 m6A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell 15, 707-719. (doi:10.1016/j.stem.2014.09.019).
    • (2014) Cell Stem Cell , vol.15 , pp. 707-719
    • Batista, P.J.1
  • 27
    • 84924283323 scopus 로고    scopus 로고
    • M6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency
    • Chen T et al. 2015 m6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency. Cell Stem Cell 16, 289-301. (doi:10.1016/j.stem.2015.01.016).
    • (2015) Cell Stem Cell , vol.16 , pp. 289-301
    • Chen, T.1
  • 28
    • 84922607221 scopus 로고    scopus 로고
    • Unique features of the m6A methylome in Arabidopsis thaliana
    • Luo GZ et al. 2014 Unique features of the m6A methylome in Arabidopsis thaliana. Nat. Commun. 5, 5630. (doi:10.1038/ncomms6630).
    • (2014) Nat. Commun , vol.5 , pp. 5630
    • Luo, G.Z.1
  • 29
    • 84861997955 scopus 로고    scopus 로고
    • The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts
    • Baltz AG et al. 2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46, 674-690. (doi:10.1016/j. molcel.2012.05.021).
    • (2012) Mol. Cell , vol.46 , pp. 674-690
    • Baltz, A.G.1
  • 30
    • 84921472110 scopus 로고    scopus 로고
    • Global analysis of the RNAprotein interaction and RNA secondary structure landscapes of the Arabidopsis nucleus
    • Gosai SJ et al. 2015 Global analysis of the RNAprotein interaction and RNA secondary structure landscapes of the Arabidopsis nucleus. Mol. Cell 57, 376-388. (doi:10.1016/j.molcel.2014.12.004).
    • (2015) Mol. Cell , vol.57 , pp. 376-388
    • Gosai, S.J.1
  • 31
    • 84861121932 scopus 로고    scopus 로고
    • Global analysis of RNA secondary structure in two metazoans
    • Li F et al. 2012 Global analysis of RNA secondary structure in two metazoans. Cell Rep. 1, 69-82. (doi:10.1016/j.celrep.2011.10.002).
    • (2012) Cell Rep , vol.1 , pp. 69-82
    • Li, F.1
  • 32
    • 0042161864 scopus 로고    scopus 로고
    • The thermodynamic stability of RNA duplexes and hairpins containing N6- Alkyladenosines and 2-methylthio-N6- Alkyladenosines
    • Kierzek E, Kierzek R. 2003 The thermodynamic stability of RNA duplexes and hairpins containing N6- Alkyladenosines and 2-methylthio-N6- Alkyladenosines. Nucleic Acids Res. 31, 4472-4480. (doi:10.1093/nar/gkg633).
    • (2003) Nucleic Acids Res , vol.31 , pp. 4472-4480
    • Kierzek, E.1    Kierzek, R.2
  • 33
    • 84890107723 scopus 로고    scopus 로고
    • High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis
    • 2155
    • Schwartz S et al. 2013 High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell 155, 1409-1421. (doi:10.1016/j.cell.2013.10.047).
    • (2013) Cell , pp. 1409-1421
    • Schwartz, S.1
  • 34
    • 84924072927 scopus 로고    scopus 로고
    • N6-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions
    • Liu N, Dai Q, Zheng G, He C, Parisien M, Pan T. 2015 N6-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. Nature 518, 560-564. (doi:10.1038/nature14234).
    • (2015) Nature , vol.518 , pp. 560-564
    • Liu, N.1    Dai, Q.2    Zheng, G.3    He, C.4    Parisien, M.5    Pan, T.6
  • 35
    • 0017350708 scopus 로고
    • Sequence specificity of internal methylation in B77 avian sarcoma virus RNA subunits
    • Dimock K, Stoltzfus CM. 1977 Sequence specificity of internal methylation in B77 avian sarcoma virus RNA subunits. Biochemistry 16, 471-478. (doi:10. 1021/bi00622a021).
    • (1977) Biochemistry , vol.16 , pp. 471-478
    • Dimock, K.1    Stoltzfus, C.M.2
  • 36
    • 0018657266 scopus 로고
    • Identification and mapping of N6-methyladenosine containing sequences in simian virus 40 RNA
    • Canaani D, Kahana C, Lavi S, Groner Y. 1979 Identification and mapping of N6-methyladenosine containing sequences in simian virus 40 RNA. Nucleic Acids Res. 6, 2879-2899. (doi:10.1093/nar/6.8.2879).
    • (1979) Nucleic Acids Res , vol.6 , pp. 2879-2899
    • Canaani, D.1    Kahana, C.2    Lavi, S.3    Groner, Y.4
  • 37
    • 0017296194 scopus 로고
    • 50-Terminal and internal methylated nucleotide sequences in HeLa cell mRNA
    • Wei CM, Gershowitz A, Moss B. 1976 50-Terminal and internal methylated nucleotide sequences in HeLa cell mRNA. Biochemistry 15, 397-401. (doi:10.1021/bi00647a024).
    • (1976) Biochemistry , vol.15 , pp. 397-401
    • Wei, C.M.1    Gershowitz, A.2    Moss, B.3
  • 38
    • 0017367836 scopus 로고
    • Nucleotide sequences at the N6-methyladenosine sites of HeLa cell messenger ribonucleic acid
    • Wei CM, Moss B. 1977 Nucleotide sequences at the N6-methyladenosine sites of HeLa cell messenger ribonucleic acid. Biochemistry 16, 1672-1676. (doi:10.1021/bi00627a023).
    • (1977) Biochemistry , vol.16 , pp. 1672-1676
    • Wei, C.M.1    Moss, B.2
  • 39
    • 0017708804 scopus 로고
    • Comparison of methylated sequences in messenger RNA and heterogeneous nuclear RNA from mouse L cells
    • Schibler U, Kelley DE, Perry RP. 1977 Comparison of methylated sequences in messenger RNA and heterogeneous nuclear RNA from mouse L cells. J. Mol. Biol. 115, 695-714. (doi:10.1016/0022- 2836(77)90110-3).
    • (1977) J. Mol. Biol , vol.115 , pp. 695-714
    • Schibler, U.1    Kelley, D.E.2    Perry, R.P.3
  • 41
    • 84943570207 scopus 로고    scopus 로고
    • A majority of m6A residues are in the last exons, allowing the potential for 30 UTR regulation
    • Ke S et al. 2015 A majority of m6A residues are in the last exons, allowing the potential for 30 UTR regulation. Genes Dev. 29, 2037-2053. (doi:10. 1101/gad.269415.115).
    • (2015) Genes Dev , vol.29 , pp. 2037-2053
    • Ke, S.1
  • 42
    • 84921512407 scopus 로고    scopus 로고
    • High-resolution N6- methyladenosine (m6A) map using photocrosslinking- Assisted m6A sequencing
    • Chen K et al. 2015 High-resolution N6- methyladenosine (m6A) map using photocrosslinking- Assisted m6A sequencing. Angew. Chem. Int. Ed. Engl. 54, 1587-1590. (doi:10.1002/anie. 201410647).
    • (2015) Angew. Chem. Int. Ed. Engl , vol.54 , pp. 1587-1590
    • Chen, K.1
  • 43
    • 0024259949 scopus 로고
    • An in vitro system for accurate methylation of internal adenosine residues in messenger RNA
    • Narayan P, Rottman FM. 1988 An in vitro system for accurate methylation of internal adenosine residues in messenger RNA. Science 242, 1159-1162. (doi:10.1126/science.3187541).
    • (1988) Science , vol.242 , pp. 1159-1162
    • Narayan, P.1    Rottman, F.M.2
  • 44
    • 0028242885 scopus 로고
    • Characterization and partial purification of mRNA N6- Adenosine methyltransferase from HeLa cell nuclei. Internal mRNA methylation requires a multisubunit complex
    • 704
    • Bokar JA et al. 1994 Characterization and partial purification of mRNA N6- Adenosine methyltransferase from HeLa cell nuclei. Internal mRNA methylation requires a multisubunit complex. J. Biol. Chem. 269, 17 697-17 704.
    • (1994) J. Biol. Chem , vol.269 , Issue.17 , pp. 697-717
    • Bokar, J.A.1
  • 45
    • 0030712151 scopus 로고    scopus 로고
    • Purification and cDNA cloning of the AdoMetbinding subunit of the human mRNA (N6- Adenosine)-methyltransferase
    • Bokar JA, Shambaugh ME, Polayes D et al. 1997 Purification and cDNA cloning of the AdoMetbinding subunit of the human mRNA (N6- Adenosine)-methyltransferase. RNA 3, 1233-1247.
    • (1997) RNA , vol.3 , pp. 1233-1247
    • Bokar, J.A.1    Shambaugh, M.E.2    Polayes, D.3
  • 46
    • 84897110592 scopus 로고    scopus 로고
    • A METTL3-METTL14 complex mediates mammalian nuclear RNA N6- Adenosine methylation
    • Liu J et al. 2014 A METTL3-METTL14 complex mediates mammalian nuclear RNA N6- Adenosine methylation. Nat. Chem. Biol. 10, 93-95. (doi:10. 1038/nchembio.1432).
    • (2014) Nat. Chem. Biol , vol.10 , pp. 93-95
    • Liu, J.1
  • 47
    • 84893310526 scopus 로고    scopus 로고
    • N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells
    • Wang Y, Li Y, Toth JI, Petroski MD, Zhang Z, Zhao JC. 2014 N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Nat. Cell Biol. 16, 191-198. (doi:10. 1038/ncb2902).
    • (2014) Nat. Cell Biol , vol.16 , pp. 191-198
    • Wang, Y.1    Li, Y.2    Toth, J.I.3    Petroski, M.D.4    Zhang, Z.5    Zhao, J.C.6
  • 48
    • 57749089784 scopus 로고    scopus 로고
    • MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor
    • Zhong S, Li H, Bodi Z, Button J, Vespa L, Herzog M, Fray RG. 2008 MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor. Plant Cell 20, 1278-1288. (doi:10.1105/tpc.108.058883).
    • (2008) Plant Cell , vol.20 , pp. 1278-1288
    • Zhong, S.1    Li, H.2    Bodi, Z.3    Button, J.4    Vespa, L.5    Herzog, M.6    Fray, R.G.7
  • 49
    • 0037109157 scopus 로고    scopus 로고
    • Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: A potential mechanism for the activity of the IME4 gene
    • Clancy MJ. 2002 Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: A potential mechanism for the activity of the IME4 gene. Nucleic Acids Res. 30, 4509-4518. (doi:10.1093/nar/gkf573).
    • (2002) Nucleic Acids Res , vol.30 , pp. 4509-4518
    • Clancy, M.J.1
  • 50
    • 80052601644 scopus 로고    scopus 로고
    • Drosophila inducer of meiosis 4 (IME4) is required for Notch signaling during oogenesis
    • Hongay CF, Orr-Weaver TL. 2011 Drosophila inducer of meiosis 4 (IME4) is required for Notch signaling during oogenesis. Proc. Natl Acad. Sci. USA 108, 14 855-14 860. (doi:10.1073/pnas.1111577108).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 14855-14860
    • Hongay, C.F.1    Orr-Weaver, T.L.2
  • 51
    • 0025084945 scopus 로고
    • Sequence specificity of the human mRNA N6- Adenosine methylase in vitro
    • Harper JE, Miceli SM, Roberts RJ, Manley JL. 1990 Sequence specificity of the human mRNA N6- Adenosine methylase in vitro. Nucleic Acids Res. 18, 5735-5741. (doi:10.1093/nar/18.19.5735).
    • (1990) Nucleic Acids Res , vol.18 , pp. 5735-5741
    • Harper, J.E.1    Miceli, S.M.2    Roberts, R.J.3    Manley, J.L.4
  • 52
    • 0036788427 scopus 로고    scopus 로고
    • Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m6A methyltransferase
    • Bujnicki JM, Feder M, Radlinska M, Blumenthal RM. 2002 Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m6A methyltransferase. J. Mol. Evol. 55, 431-444. (doi:10.1007/s00239-002- 2339-8).
    • (2002) J. Mol. Evol , vol.55 , pp. 431-444
    • Bujnicki, J.M.1    Feder, M.2    Radlinska, M.3    Blumenthal, R.M.4
  • 53
    • 0034703394 scopus 로고    scopus 로고
    • Identification of WTAP, a novel Wilms' tumour 1- Associating protein
    • Little NA, Hastie ND, Davies RC. 2000 Identification of WTAP, a novel Wilms' tumour 1- Associating protein. Hum. Mol. Genet. 9, 2231-2239. (doi:10. 1093/oxfordjournals.hmg.a018914).
    • (2000) Hum. Mol. Genet , vol.9 , pp. 2231-2239
    • Little, N.A.1    Hastie, N.D.2    Davies, R.C.3
  • 54
    • 84864037029 scopus 로고    scopus 로고
    • RNA methylation by the MIS complex regulates a cell fate decision in yeast
    • Agarwala SD, Blitzblau HG, Hochwagen A, Fink GR. 2012 RNA methylation by the MIS complex regulates a cell fate decision in yeast. PLoS Genet. 8, e1002732. (doi:10.1371/journal.pgen.1002732).
    • (2012) PLoS Genet , vol.8 , pp. e1002732
    • Agarwala, S.D.1    Blitzblau, H.G.2    Hochwagen, A.3    Fink, G.R.4
  • 55
    • 84893746230 scopus 로고    scopus 로고
    • Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
    • Ping XL et al. 2014 Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Res. 24, 177-189. (doi:10. 1038/cr.2014.3).
    • (2014) Cell Res , vol.24 , pp. 177-189
    • Ping, X.L.1
  • 56
    • 84904035764 scopus 로고    scopus 로고
    • Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 50 sites
    • Schwartz S et al. 2014 Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 50 sites. Cell Rep. 8, 284-296. (doi:10. 1016/j.celrep.2014.05.048).
    • (2014) Cell Rep , vol.8 , pp. 284-296
    • Schwartz, S.1
  • 57
    • 84877750692 scopus 로고    scopus 로고
    • FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA
    • Fu Y et al. 2013 FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA. Nat. Commun. 4, 1798. (doi:10.1038/ncomms2822).
    • (2013) Nat. Commun , vol.4 , pp. 1798
    • Fu, Y.1
  • 58
    • 34249777814 scopus 로고    scopus 로고
    • Variation in FTO contributes to childhood obesity and severe adult obesity
    • Dina C et al. 2007 Variation in FTO contributes to childhood obesity and severe adult obesity. Nat. Genet. 39, 724-726. (doi:10.1038/ng2048).
    • (2007) Nat. Genet , vol.39 , pp. 724-726
    • Dina, C.1
  • 59
    • 34248594090 scopus 로고    scopus 로고
    • A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    • Frayling TM et al. 2007 A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889-894. (doi:10.1126/science.1141634).
    • (2007) Science , vol.316 , pp. 889-894
    • Frayling, T.M.1
  • 60
    • 34547625955 scopus 로고    scopus 로고
    • Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
    • Scuteri A et al. 2007 Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 3, e115. (doi:10.1371/journal.pgen.0030115).
    • (2007) PLoS Genet , vol.3 , pp. e115
    • Scuteri, A.1
  • 61
    • 84872274463 scopus 로고    scopus 로고
    • ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility
    • Zheng G et al. 2013 ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol. Cell 49, 18-29. (doi:10.1016/j. molcel.2012.10.015).
    • (2013) Mol. Cell , vol.49 , pp. 18-29
    • Zheng, G.1
  • 62
    • 84894599601 scopus 로고    scopus 로고
    • Sprouts of RNA epigenetics: The discovery of mammalian RNA demethylases
    • Zheng G, Dahl JA, Niu Y, Fu Ye, Klungland A, Yang Y-G, He C. 2013 Sprouts of RNA epigenetics: The discovery of mammalian RNA demethylases. RNA Biol. 10, 915-918. (doi:10.4161/rna.24711).
    • (2013) RNA Biol , vol.10 , pp. 915-918
    • Zheng, G.1    Dahl, J.A.2    Niu, Y.3    Fu, Y.4    Klungland, A.5    Yang, Y.-G.6    He, C.7
  • 63
    • 84925777836 scopus 로고    scopus 로고
    • Structural imprints in vivo decode RNA regulatory mechanisms
    • Spitale RC. 2015 Structural imprints in vivo decode RNA regulatory mechanisms. Nature 519, 486-490. (doi:10.1038/nature14263).
    • (2015) Nature , vol.519 , pp. 486-490
    • Spitale, R.C.1
  • 64
    • 84941712451 scopus 로고    scopus 로고
    • N-methyladenosine modification in a long noncoding RNA hairpin predisposes its conformation to protein binding
    • Zhou KI et al. 2015 N-methyladenosine modification in a long noncoding RNA hairpin predisposes its conformation to protein binding. J. Mol. Biol. 428, 822-833. (doi:10.1016/j.jmb.2015.08.021).
    • (2015) J. Mol. Biol , vol.428 , pp. 822-833
    • Zhou, K.I.1
  • 66
    • 84859115602 scopus 로고    scopus 로고
    • HnRNP C tetramer measures RNA length to classify RNA polymerase II transcripts for export
    • McCloskey A, Taniguchi I, Shinmyozu K, Ohno M. 2012 hnRNP C tetramer measures RNA length to classify RNA polymerase II transcripts for export. Science 335, 1643-1646. (doi:10.1126/science. 1218469).
    • (2012) Science , vol.335 , pp. 1643-1646
    • McCloskey, A.1    Taniguchi, I.2    Shinmyozu, K.3    Ohno, M.4
  • 67
    • 0032528304 scopus 로고    scopus 로고
    • HnRNP C increases amyloid precursor protein (APP) production by stabilizing APP mRNA
    • Rajagopalan LE, Westmark CJ, Jarzembowski JA, Malter JS. 1998 hnRNP C increases amyloid precursor protein (APP) production by stabilizing APP mRNA. Nucleic Acids Res. 26, 3418-3423. (doi:10.1093/nar/26.14.3418).
    • (1998) Nucleic Acids Res , vol.26 , pp. 3418-3423
    • Rajagopalan, L.E.1    Westmark, C.J.2    Jarzembowski, J.A.3    Malter, J.S.4
  • 68
    • 84873323035 scopus 로고    scopus 로고
    • Direct competition between hnRNP C and U2AF65 protects the transcriptome from the exonization of Alu elements
    • Zarnack K et al. 2013 Direct competition between hnRNP C and U2AF65 protects the transcriptome from the exonization of Alu elements. Cell 152, 453-466. (doi:10.1016/j.cell.2012.12.023).
    • (2013) Cell , vol.152 , pp. 453-466
    • Zarnack, K.1
  • 69
    • 84908389502 scopus 로고    scopus 로고
    • Structural and mechanistic insights into poly(uridine) tract recognition by the hnRNP C RNA recognition motif
    • Cienikova Z, Damberger FF, Hall J, Allain FHT, Maris C. 2014 Structural and mechanistic insights into poly(uridine) tract recognition by the hnRNP C RNA recognition motif. J. Am. Chem. Soc. 136, 14 536- 14 544. (doi:10.1021/ja507690d).
    • (2014) J. Am. Chem. Soc , vol.136 , pp. 14536-14544
    • Cienikova, Z.1    Damberger, F.F.2    Hall, J.3    Allain, F.H.T.4    Maris, C.5
  • 70
    • 84941424170 scopus 로고    scopus 로고
    • HNRNPA2B1 is a mediator of m6A-dependent nuclear RNA processing events
    • Alarcon CR, Goodarzi H, Lee H, Liu X, Tavazoie S, Tavazoie SF. 2015 HNRNPA2B1 is a mediator of m6A-dependent nuclear RNA processing events. Cell 162, 1299-1308. (doi:10.1016/j.cell.2015. 08.011).
    • (2015) Cell , vol.162 , pp. 1299-1308
    • Alarcon, C.R.1    Goodarzi, H.2    Lee, H.3    Liu, X.4    Tavazoie, S.5    Tavazoie, S.F.6
  • 71
    • 84892372347 scopus 로고    scopus 로고
    • N6-methyladenosine-dependent regulation of messenger RNA stability
    • Wang X et al. 2014 N6-methyladenosine-dependent regulation of messenger RNA stability. Nature 505, 117-120. (doi:10.1038/nature12730).
    • (2014) Nature , vol.505 , pp. 117-120
    • Wang, X.1
  • 72
    • 84945288814 scopus 로고    scopus 로고
    • Dynamic m6A mRNA methylation directs translational control of heat shock response
    • Zhou J et al. 2015 Dynamic m6A mRNA methylation directs translational control of heat shock response. Nature 526, 591-594. (doi:10.1038/nature15377).
    • (2015) Nature , vol.526 , pp. 591-594
    • Zhou, J.1
  • 73
    • 84930621650 scopus 로고    scopus 로고
    • N6-methyladenosine modulates messenger RNA translation efficiency
    • Wang X et al. 2015 N6-methyladenosine modulates messenger RNA translation efficiency. Cell 161, 1388-1399. (doi:10.1016/j.cell.2015.05.014).
    • (2015) Cell , vol.161 , pp. 1388-1399
    • Wang, X.1
  • 75
    • 84902011435 scopus 로고    scopus 로고
    • Human nuclear Dicer restricts the deleterious accumulation of endogenous double-stranded RNA
    • White E, Schlackow M, Kamieniarz-Gdula K, Proudfoot NJ, Gullerova M. 2014 Human nuclear Dicer restricts the deleterious accumulation of endogenous double-stranded RNA. Nat. Struct. Mol. Biol. 21, 552-559. (doi:10.1038/nsmb.2827).
    • (2014) Nat. Struct. Mol. Biol , vol.21 , pp. 552-559
    • White, E.1    Schlackow, M.2    Kamieniarz-Gdula, K.3    Proudfoot, N.J.4    Gullerova, M.5
  • 76
    • 84925796024 scopus 로고    scopus 로고
    • N6-methyladenosine marks primary microRNAs for processing
    • Alarcon CR, Lee H, Goodarzi H, Halberg N, Tavazoie SF. 2015 N6-methyladenosine marks primary microRNAs for processing. Nature 519, 482-485. (doi:10.1038/nature14281).
    • (2015) Nature , vol.519 , pp. 482-485
    • Alarcon, C.R.1    Lee, H.2    Goodarzi, H.3    Halberg, N.4    Tavazoie, S.F.5
  • 77
    • 0027613753 scopus 로고
    • Nuclear organization of pre-mRNA processing
    • Spector DL. 1993 Nuclear organization of pre-mRNA processing. Curr. Opin. Cell Biol. 5, 442-447. (doi:10.1016/0955-0674(93)90009-F).
    • (1993) Curr. Opin. Cell Biol , vol.5 , pp. 442-447
    • Spector, D.L.1
  • 78
    • 0041669439 scopus 로고    scopus 로고
    • Nuclear speckles: A model for nuclear organelles
    • Lamond AI, Spector DL. 2003 Nuclear speckles: A model for nuclear organelles. Nat. Rev. Mol. Cell Biol. 4, 605-612. (doi:10.1038/nrm1172).
    • (2003) Nat. Rev. Mol. Cell Biol. , vol.4 , pp. 605-612
    • Lamond, A.I.1    Spector, D.L.2
  • 79
    • 84897474790 scopus 로고    scopus 로고
    • Nuclear bodies: New insights into assembly/dynamics and disease relevance
    • Sleeman JE, Trinkle-Mulcahy L. 2014 Nuclear bodies: new insights into assembly/dynamics and disease relevance. Curr. Opin. Cell Biol. 28, 76-83. (doi:10.1016/j.ceb.2014.03.004).
    • (2014) Curr. Opin. Cell Biol , vol.28 , pp. 76-83
    • Sleeman, J.E.1    Trinkle-Mulcahy, L.2
  • 80
    • 79960622503 scopus 로고    scopus 로고
    • Biogenesis and function of nuclear bodies
    • Mao YS, Zhang B, Spector DL. 2011 Biogenesis and function of nuclear bodies. Trends Genet. 27, 295-306. (doi:10.1016/j.tig.2011.05.006).
    • (2011) Trends Genet , vol.27 , pp. 295-306
    • Mao, Y.S.1    Zhang, B.2    Spector, D.L.3
  • 81
    • 65349090225 scopus 로고    scopus 로고
    • Nuclear neighborhoods and gene expression
    • Zhao R, Bodnar MS, Spector DL. 2009 Nuclear neighborhoods and gene expression. Curr. Opin. Genet. Dev. 19, 172-179. (doi:10.1016/j.gde.2009. 02.007).
    • (2009) Curr. Opin. Genet. Dev , vol.19 , pp. 172-179
    • Zhao, R.1    Bodnar, M.S.2    Spector, D.L.3
  • 82
    • 84952638781 scopus 로고    scopus 로고
    • Coordination of m6A mRNA methylation and gene transcription by ZFP217 regulates pluripotency and reprogramming
    • Aguilo F et al. 2015 Coordination of m6A mRNA methylation and gene transcription by ZFP217 regulates pluripotency and reprogramming. Cell Stem Cell 17, 689-704. (doi:10.1016/j.stem.2015. 09.005).
    • (2015) Cell Stem Cell , vol.17 , pp. 689-704
    • Aguilo, F.1
  • 83
    • 84891485596 scopus 로고    scopus 로고
    • Adenosine methylation in Arabidopsis mRNA is associated with the 30 end and reduced levels cause developmental defects
    • Bodi Z, Zhong S, Mehra S, Song Jie, Graham N, Li H, May S, Fray RG. 2012 Adenosine methylation in Arabidopsis mRNA is associated with the 30 end and reduced levels cause developmental defects. Front. Plant Sci. 3, 48. (doi:10.3389/fpls. 2012.00048).
    • (2012) Front. Plant Sci , vol.3 , pp. 48
    • Bodi, Z.1    Zhong, S.2    Mehra, S.3    Song, J.4    Graham, N.5    Li, H.6    May, S.7    Fray, R.G.8
  • 85
    • 78649459183 scopus 로고    scopus 로고
    • Overexpression of Fto leads to increased food intake and results in obesity
    • Church C et al. 2010 Overexpression of Fto leads to increased food intake and results in obesity. Nat. Genet. 42, 1086-1092. (doi:10.1038/ng.713).
    • (2010) Nat. Genet , vol.42 , pp. 1086-1092
    • Church, C.1
  • 86
    • 84880916638 scopus 로고    scopus 로고
    • The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry
    • Hess ME et al. 2013 The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nat. Neurosci. 16, 1042-1048. (doi:10.1038/nn.3449).
    • (2013) Nat. Neurosci , vol.16 , pp. 1042-1048
    • Hess, M.E.1
  • 87
    • 84873735640 scopus 로고    scopus 로고
    • Role for the obesity-related FTO gene in the cellular sensing of amino acids
    • Gulati P et al. 2013 Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proc. Natl Acad. Sci. USA 110, 2557-2562. (doi:10.1073/pnas.1222796110).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 2557-2562
    • Gulati, P.1
  • 88
    • 36749041363 scopus 로고    scopus 로고
    • The obesity- Associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
    • Gerken T et al. 2007 The obesity- Associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318, 1469-1472. (doi:10.1126/science.1151710).
    • (2007) Science , vol.318 , pp. 1469-1472
    • Gerken, T.1
  • 89
    • 84897855294 scopus 로고    scopus 로고
    • Obesity- Associated variants within FTO form long-range functional connections with IRX3
    • Smemo S et al. 2014 Obesity- Associated variants within FTO form long-range functional connections with IRX3. Nature 507, 371-375. (doi:10.1038/nature13138).
    • (2014) Nature , vol.507 , pp. 371-375
    • Smemo, S.1
  • 90
    • 76249098866 scopus 로고    scopus 로고
    • Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3
    • Ragvin A et al. 2010 Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. Proc. Natl Acad. Sci. USA 107, 775-780. (doi:10.1073/pnas. 0911591107).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 775-780
    • Ragvin, A.1
  • 91
    • 84898814417 scopus 로고    scopus 로고
    • Gene expression regulation mediated through reversible m6A RNA methylation
    • Fu Y, Dominissini D, Rechavi G, He C. 2014 Gene expression regulation mediated through reversible m6A RNA methylation. Nat. Rev. Genet. 15, 293-306. (doi:10.1038/nrg3724).
    • (2014) Nat. Rev. Genet , vol.15 , pp. 293-306
    • Fu, Y.1    Dominissini, D.2    Rechavi, G.3    He, C.4
  • 92
    • 84899586607 scopus 로고    scopus 로고
    • The dynamic epitranscriptome: N6-methyladenosine and gene expression control
    • Meyer KD, Jaffrey SR. 2014 The dynamic epitranscriptome: N6-methyladenosine and gene expression control. Nat. Rev. Mol. Cell Biol. 15, 313-326. (doi:10.1038/nrm3785).
    • (2014) Nat. Rev. Mol. Cell Biol , vol.15 , pp. 313-326
    • Meyer, K.D.1    Jaffrey, S.R.2
  • 93
    • 84906938693 scopus 로고    scopus 로고
    • Interactions between innate and adaptive lymphocytes
    • Gasteiger G, Rudensky AY. 2014 Interactions between innate and adaptive lymphocytes. Nat. Rev. Immunol. 14, 631-639. (doi:10.1038/nri3726).
    • (2014) Nat. Rev. Immunol , vol.14 , pp. 631-639
    • Gasteiger, G.1    Rudensky, A.Y.2
  • 94
    • 84925441813 scopus 로고    scopus 로고
    • Control of adaptive immunity by the innate immune system
    • Iwasaki A, Medzhitov R. 2015 Control of adaptive immunity by the innate immune system. Nat. Immunol. 16, 343-353. (doi:10.1038/ni.3123).
    • (2015) Nat. Immunol , vol.16 , pp. 343-353
    • Iwasaki, A.1    Medzhitov, R.2
  • 95
    • 84922607138 scopus 로고    scopus 로고
    • The biology of innate lymphoid cells
    • Artis D, Spits H. 2015 The biology of innate lymphoid cells. Nature 517, 293-301. (doi:10. 1038/nature14189).
    • (2015) Nature , vol.517 , pp. 293-301
    • Artis, D.1    Spits, H.2
  • 96
    • 23844464444 scopus 로고    scopus 로고
    • Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA
    • Kariko K, Buckstein M, Ni H, Weissman D. 2005 Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23, 165-175. (doi:10.1016/j.immuni.2005.06.008).
    • (2005) Immunity , vol.23 , pp. 165-175
    • Kariko, K.1    Buckstein, M.2    Ni, H.3    Weissman, D.4
  • 97
    • 56549116047 scopus 로고    scopus 로고
    • Toll-like receptor and RIG-Ilike receptor signaling
    • Kawai T, Akira S. 2008 Toll-like receptor and RIG-Ilike receptor signaling. Ann. N.Y. Acad. Sci. 1143, 1-20. (doi:10.1196/annals.1443.020).
    • (2008) Ann. N.Y. Acad. Sci , vol.1143 , pp. 1-20
    • Kawai, T.1    Akira, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.