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Volumn 4, Issue 8, 2003, Pages 605-612

Nuclear speckles: A model for nuclear organelles

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN T1; DNA; MESSENGER RNA PRECURSOR; NUCLEAR RNA; PHOSPHOLIPID; POLYADENYLATED RNA; RNA POLYMERASE II; TRANSACTIVATOR PROTEIN;

EID: 0041669439     PISSN: 14710072     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrm1172     Document Type: Review
Times cited : (824)

References (97)
  • 1
    • 0035793376 scopus 로고    scopus 로고
    • Protein dynamics: Implications for nuclear architecture and gene expression
    • Misteli, T. Protein dynamics: implications for nuclear architecture and gene expression. Science 291, 843-847 (2001).
    • (2001) Science , vol.291 , pp. 843-847
    • Misteli, T.1
  • 2
    • 0034851781 scopus 로고    scopus 로고
    • Nuclear bodies
    • Spector, D. L. Nuclear bodies. J. Cell Sci. 114, 2891-2893 (2001).
    • (2001) J. Cell Sci. , vol.114 , pp. 2891-2893
    • Spector, D.L.1
  • 3
    • 0032562608 scopus 로고    scopus 로고
    • Structure and function in the nucleus
    • Lamond, A. I. & Earnshaw, W. C. Structure and function in the nucleus, Science 280, 547-553 (1998).
    • (1998) Science , vol.280 , pp. 547-553
    • Lamond, A.I.1    Earnshaw, W.C.2
  • 4
    • 0027305616 scopus 로고
    • Fluorescent labeling of nascent RNA reveals transcription by RNA polymerase II in domains scattered throughout the nucleus
    • Wansink, D. G. et al. Fluorescent labeling of nascent RNA reveals transcription by RNA polymerase II in domains scattered throughout the nucleus. J. Cell Biol. 122, 283-293 (1993).
    • (1993) J. Cell Biol. , vol.122 , pp. 283-293
    • Wansink, D.G.1
  • 5
    • 0034611785 scopus 로고    scopus 로고
    • High mobility of proteins in the mammalian cell nucleus
    • Phair, R. D. & Misteli, T. High mobility of proteins in the mammalian cell nucleus. Nature 404, 604-609 (2000). Photobleaching techniques show that many classes of proteins can move rapidly within the nucleus and that they can rapidly associate and dissociate with nuclear compartments.
    • (2000) Nature , vol.404 , pp. 604-609
    • Phair, R.D.1    Misteli, T.2
  • 6
    • 50549173206 scopus 로고
    • Variations in the morphological patterns of "autoimmune" nuclear fluorescence
    • Beck, J. S. Variations in the morphological patterns of "autoimmune" nuclear fluorescence. Lancet 1, 1203-1205 (1961).
    • (1961) Lancet , vol.1 , pp. 1203-1205
    • Beck, J.S.1
  • 7
    • 0012044768 scopus 로고
    • Studies on nuclear fine structure
    • Swift, H. Studies on nuclear fine structure. Brookhaven Symp. Biol. 12, 134-152 (1959).
    • (1959) Brookhaven Symp. Biol. , vol.12 , pp. 134-152
    • Swift, H.1
  • 8
    • 0018604613 scopus 로고
    • Intranuclear structures of monkey kidney cells recognised by immunofluorescence and immuno-electron microscopy using anti-ribonucleoprotein antibodies
    • in French
    • Perraud, M., Gioud, M. & Monier, J. C. Intranuclear structures of monkey kidney cells recognised by immunofluorescence and immuno-electron microscopy using anti-ribonucleoprotein antibodies. Ann. Immunol. 130, 635-647 (1979) (in French).
    • (1979) Ann. Immunol. , vol.130 , pp. 635-647
    • Perraud, M.1    Gioud, M.2    Monier, J.C.3
  • 9
    • 0019570066 scopus 로고
    • A Monoclonal antibodies to nucleic acid-containing cellular constituents: Probes for molecular biology and autoimmune disease
    • Lerner, E. A., Lerner, M. R., Janeway, C. A. & Steitz, J. A Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease. Proc. Natl Acad. Sci. USA 78, 2737-2741 (1981).
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 2737-2741
    • Lerner, E.A.1    Lerner, M.R.2    Janeway, C.A.3    Steitz, J.4
  • 10
    • 0021082681 scopus 로고
    • Immunoelectron microscopic localization of snRNPs
    • Spector, D. L., Schrier, W. H. & Busch, H. Immunoelectron microscopic localization of snRNPs. Biol. Cell 49, 1-10 (1983).
    • (1983) Biol. Cell , vol.49 , pp. 1-10
    • Spector, D.L.1    Schrier, W.H.2    Busch, H.3
  • 11
    • 0028845611 scopus 로고
    • The interchromatin granules
    • Thiry M. The interchromatin granules. Histol. Histopathol. 10, 1035-1045 (1995).
    • (1995) Histol. Histopathol. , vol.10 , pp. 1035-1045
    • Thiry, M.1
  • 12
    • 0033538831 scopus 로고    scopus 로고
    • Three-dimensional visualization of transcription sites and their association with splicing factor-rich nuclear speckles
    • Wei, X., Somanathan, S., Samarabandu, J. & Berezney, R. Three-dimensional visualization of transcription sites and their association with splicing factor-rich nuclear speckles. J. Cell Biol. 146, 543-558 (1999).
    • (1999) J. Cell Biol. , vol.146 , pp. 543-558
    • Wei, X.1    Somanathan, S.2    Samarabandu, J.3    Berezney, R.4
  • 13
    • 0027318312 scopus 로고
    • Intranuclear distribution of U1 and U2 snRNAs visualized by high resolution in situ hybridization: Revelation of a novel compartment containing U1 but not U2 snRNA in HeLa cells
    • Visa, N., Puvion-Dutilleul, F., Bachellerie, J. P. & Puvion, E. Intranuclear distribution of U1 and U2 snRNAs visualized by high resolution in situ hybridization: revelation of a novel compartment containing U1 but not U2 snRNA in HeLa cells. Eur. J. Cell Biol. 60, 308-321 (1993).
    • (1993) Eur. J. Cell Biol. , vol.60 , pp. 308-321
    • Visa, N.1    Puvion-Dutilleul, F.2    Bachellerie, J.P.3    Puvion, E.4
  • 14
    • 0027135889 scopus 로고
    • Macromolecular domains within the cell nucleus
    • Spector, D. L. Macromolecular domains within the cell nucleus. Annu. Rev. Cell Biol. 9, 265-315 (1993).
    • (1993) Annu. Rev. Cell Biol. , vol.9 , pp. 265-315
    • Spector, D.L.1
  • 15
    • 0028158279 scopus 로고
    • Perichromatin fibrils are in situ forms of nascent transcripts
    • Fakan, S. Perichromatin fibrils are in situ forms of nascent transcripts. Trends Cell Biol. 4, 86-90 (1994).
    • (1994) Trends Cell Biol. , vol.4 , pp. 86-90
    • Fakan, S.1
  • 16
    • 0026058877 scopus 로고
    • Arginine/serine-rich domains of the su(wa) and tra RNA processing regulators target proteins to a subnuclear compartment implicated in splicing
    • Li, H. & Bingham, P. M. Arginine/serine-rich domains of the su(wa) and tra RNA processing regulators target proteins to a subnuclear compartment implicated in splicing. Cell 67, 335-342 (1991).
    • (1991) Cell , vol.67 , pp. 335-342
    • Li, H.1    Bingham, P.M.2
  • 17
    • 0029618696 scopus 로고
    • An amino acid sequence motif sufficient for subnuclear localization of an arginine/serine rich splicing factor
    • Hedley, M. L., Amrein, H. & Maniatis, T. An amino acid sequence motif sufficient for subnuclear localization of an arginine/serine rich splicing factor. Proc. Natl Acad. Sci. USA 92, 11524-11528 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 11524-11528
    • Hedley, M.L.1    Amrein, H.2    Maniatis, T.3
  • 18
    • 0038401969 scopus 로고    scopus 로고
    • Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity
    • Caceres, J. F., Misteli, T., Screaton, G. R., Spector, D. L. & Krainer, A. R. Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity J. Cell Biol. 138, 225-238 (1997).
    • (1997) J. Cell Biol. , vol.138 , pp. 225-238
    • Caceres, J.F.1    Misteli, T.2    Screaton, G.R.3    Spector, D.L.4    Krainer, A.R.5
  • 19
    • 0032740248 scopus 로고    scopus 로고
    • Assembly of the nuclear transcription and processing machinery: Cajal bodies (coiled bodies) and transcriptosomes
    • Gall, J. G., Bellini, M., Wu, Z. & Murphy, C. Assembly of the nuclear transcription and processing machinery: Cajal bodies (coiled bodies) and transcriptosomes. Mol. Biol. Cell 10, 4385-4402 (1999).
    • (1999) Mol. Biol. Cell , vol.10 , pp. 4385-4402
    • Gall, J.G.1    Bellini, M.2    Wu, Z.3    Murphy, C.4
  • 20
    • 0026460769 scopus 로고
    • Spatial distribution of the Sm antigen in Drosophila early embryos
    • Segalat, L. & Lepesant, J. A. Spatial distribution of the Sm antigen in Drosophila early embryos. Biol. Cell 75, 181-185 (1992).
    • (1992) Biol. Cell , vol.75 , pp. 181-185
    • Segalat, L.1    Lepesant, J.A.2
  • 21
    • 0025368854 scopus 로고
    • Differential distribution of factors involved in pre-mRNA processing in the yeast cell nucleus
    • Potashkin, J. A., Derby, R. J. & Spector, D. L. Differential distribution of factors involved in pre-mRNA processing in the yeast cell nucleus. Mol. Cell Biochem. 10, 3524-3534 (1990).
    • (1990) Mol. Cell Biochem. , vol.10 , pp. 3524-3534
    • Potashkin, J.A.1    Derby, R.J.2    Spector, D.L.3
  • 22
    • 0037039475 scopus 로고    scopus 로고
    • Paraspeckles: A novel nuclear domain
    • Fox, A. H. et al. Paraspeckles: a novel nuclear domain. Curr. Biol. 12, 13-25 (2002).
    • (2002) Curr. Biol. , vol.12 , pp. 13-25
    • Fox, A.H.1
  • 23
    • 0025719396 scopus 로고
    • Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors
    • Huang, S. & Spector, D. L. Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors. Genes Dev. 5, 2288-2302 (1991).
    • (1991) Genes Dev. , vol.5 , pp. 2288-2302
    • Huang, S.1    Spector, D.L.2
  • 24
    • 0027418252 scopus 로고
    • Higher level organization of individual gene transcription and RNA splicing
    • Xing, Y., Johnson, C. V., Dobner, P. R. & Lawrence, J. B. Higher level organization of individual gene transcription and RNA splicing. Science 259, 1326-1330 (1993).
    • (1993) Science , vol.259 , pp. 1326-1330
    • Xing, Y.1    Johnson, C.V.2    Dobner, P.R.3    Lawrence, J.B.4
  • 25
    • 0029615378 scopus 로고
    • Nonrandom gene organization: Structural arrangements of specific pre-mRNA transcription and splicing with SC35 domains
    • Xing, Y., Johnson, C. V., Moen, P. T., McNeil, J. A. & Lawrence, J. B. Nonrandom gene organization: structural arrangements of specific pre-mRNA transcription and splicing with SC35 domains. J. Cell Biol. 131, 1635-1647 (1995).
    • (1995) J. Cell Biol. , vol.131 , pp. 1635-1647
    • Xing, Y.1    Johnson, C.V.2    Moen, P.T.3    McNeil, J.A.4    Lawrence, J.B.5
  • 26
    • 0033593806 scopus 로고    scopus 로고
    • Processing of endogenous pre-mRNAs in association with SC-35 domains is gene specific
    • Smith, K. P., Moen, P. T., Wydner, K. L., Coleman, J. R. & Lawrence, J. B. Processing of endogenous pre-mRNAs in association with SC-35 domains is gene specific J. Cell Biol. 144, 617-629 (1999).
    • (1999) J. Cell Biol. , vol.144 , pp. 617-629
    • Smith, K.P.1    Moen, P.T.2    Wydner, K.L.3    Coleman, J.R.4    Lawrence, J.B.5
  • 27
    • 0034618038 scopus 로고    scopus 로고
    • Tracking COL1A1 RNA in osteogenesis imperfecta. Splice-defective transcripts initiate transport from the gene but are retained within the SC35 domain
    • Johnson, C. et al. Tracking COL1A1 RNA in osteogenesis imperfecta. Splice-defective transcripts initiate transport from the gene but are retained within the SC35 domain. J. Cell Biol. 150, 417-432 (2000).
    • (2000) J. Cell Biol. , vol.150 , pp. 417-432
    • Johnson, C.1
  • 28
    • 1842376906 scopus 로고    scopus 로고
    • The dynamics of a pre-mRNA splicing factor in living cells
    • Misteli, T., Caceres, J. F. & Spector, D. L. The dynamics of a pre-mRNA splicing factor in living cells. Nature 387, 523-527 (1997). The first study to show that speckles are dynamic structures that respond to activation of nearby genes, by using live imaging of cells expressing a fluorescent-protein-tagged splicing factor.
    • (1997) Nature , vol.387 , pp. 523-527
    • Misteli, T.1    Caceres, J.F.2    Spector, D.L.3
  • 29
    • 0027953244 scopus 로고
    • Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors
    • O'Keefe, R. T., Mayeda, A., Sadowski, C. L., Krainer, A. R. & Spector, D. L. Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors. J. Cell Biol. 124, 249-260 (1994).
    • (1994) J. Cell Biol. , vol.124 , pp. 249-260
    • O'Keefe, R.T.1    Mayeda, A.2    Sadowski, C.L.3    Krainer, A.R.4    Spector, D.L.5
  • 30
    • 0014510121 scopus 로고
    • Fine structural organization of the interphase nucleus in some mammalian cells
    • Monneron, A. & Bernhard, W. Fine structural organization of the interphase nucleus in some mammalian cells. J. Ultrastruct. Res. 27, 266-288 (1969).
    • (1969) J. Ultrastruct. Res. , vol.27 , pp. 266-288
    • Monneron, A.1    Bernhard, W.2
  • 31
    • 0015091214 scopus 로고
    • Localisation of rapidly and slowly labelled nuclear RNA as visualized by high resolution autoradiography
    • Fakan, S. & Bernhard, W. Localisation of rapidly and slowly labelled nuclear RNA as visualized by high resolution autoradiography. Exp. Cell Res. 67, 129-141 (1971).
    • (1971) Exp. Cell Res. , vol.67 , pp. 129-141
    • Fakan, S.1    Bernhard, W.2
  • 32
    • 0017864664 scopus 로고
    • Ultrastructural localization of transcription sites and of RNA distribution during the cell cycle of synchronized CHO cells
    • Fakan, S. & Nobis, P. Ultrastructural localization of transcription sites and of RNA distribution during the cell cycle of synchronized CHO cells. Exp. Cell Res. 113, 327-337 (1978).
    • (1978) Exp. Cell Res. , vol.113 , pp. 327-337
    • Fakan, S.1    Nobis, P.2
  • 33
    • 0032917782 scopus 로고    scopus 로고
    • Ultrastructural analysis of transcription and splicing in the cell nucleus after bromo-UTP microinjection
    • Cmarko, D. et al. Ultrastructural analysis of transcription and splicing in the cell nucleus after bromo-UTP microinjection. Mol. Biol. Cell. 10, 211-223 (1999). This study showed that transcription is associated with perichromatin fibrils and not with nuclear speckles (IGCs).
    • (1999) Mol. Biol. Cell , vol.10 , pp. 211-223
    • Cmarko, D.1
  • 34
    • 0029952583 scopus 로고    scopus 로고
    • Intron-dependent recruitment of pre-mRNA splicing factors to sites of transcription
    • Huang, S. & Spector, D. L. Intron-dependent recruitment of pre-mRNA splicing factors to sites of transcription. J. Cell Biol. 131, 719-732 (1996).
    • (1996) J. Cell Biol. , vol.131 , pp. 719-732
    • Huang, S.1    Spector, D.L.2
  • 35
    • 0343593691 scopus 로고    scopus 로고
    • Nuclear pre-mRNA compartmentalization: Trafficking of released transcripts to splicing factor reservoirs
    • Melcak, I. et al. Nuclear pre-mRNA compartmentalization: trafficking of released transcripts to splicing factor reservoirs. Mol. Biol. Cell 11, 497-510 (2000).
    • (2000) Mol. Biol. Cell , vol.11 , pp. 497-510
    • Melcak, I.1
  • 36
    • 0036971524 scopus 로고    scopus 로고
    • Evidence that all SC35 domains contain mRNAs and that transcripts can be structurally constrained within these domains
    • Shopland, L. S., Johnson, C. V. & Lawrence, J. B. Evidence that all SC35 domains contain mRNAs and that transcripts can be structurally constrained within these domains. J. Struct. Biol. 140, 131-139 (2002).
    • (2002) J. Struct. Biol. , vol.140 , pp. 131-139
    • Shopland, L.S.1    Johnson, C.V.2    Lawrence, J.B.3
  • 37
    • 0029372979 scopus 로고
    • The superfamily of arginine/serine-rich splicing factors
    • Fu, X.-D. The superfamily of arginine/serine-rich splicing factors. RNA 1, 663-680 (1995).
    • (1995) RNA , vol.1 , pp. 663-680
    • Fu, X.-D.1
  • 38
    • 0002659935 scopus 로고    scopus 로고
    • (ed. Krainer, A. R.) (Oxford Univ. Press, New York
    • Huang, S. & Spector, D. L. in Eukaryotic mRNA Processing (ed. Krainer, A. R.) 37-67 (Oxford Univ. Press, New York, 1997).
    • (1997) Eukaryotic mRNA Processing , pp. 37-67
    • Huang, S.1    Spector, D.L.2
  • 39
    • 0030028882 scopus 로고    scopus 로고
    • The Clk/Sty protein kinase phosphorylates splicing factors and regulates their intranuclear distribution
    • Colwill, K. et al. The Clk/Sty protein kinase phosphorylates splicing factors and regulates their intranuclear distribution. EMBO J. 15, 265-275 (1996).
    • (1996) EMBO J. , vol.15 , pp. 265-275
    • Colwill, K.1
  • 40
    • 0034896206 scopus 로고    scopus 로고
    • CrkRS: A novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles
    • Ko, T. K., Kelly, E. & Pines, J. CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles. J. Cell Sci. 114, 2591-2603 (2001).
    • (2001) J. Cell Sci. , vol.114 , pp. 2591-2603
    • Ko, T.K.1    Kelly, E.2    Pines, J.3
  • 41
    • 0035943711 scopus 로고    scopus 로고
    • Cloning of human PRP4 reveals interaction with Clk1
    • Kojima, T., Zama, T., Wada, K., Onogi, H. & Hagiwara, M. Cloning of human PRP4 reveals interaction with Clk1 J. Biol. Chem. 276, 32247-32256 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 32247-32256
    • Kojima, T.1    Zama, T.2    Wada, K.3    Onogi, H.4    Hagiwara, M.5
  • 42
    • 0037017406 scopus 로고    scopus 로고
    • Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing
    • Sacco-Bubulya, P. & Spector, D. L. Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing. J. Cell Biol. 156, 425-436 (2002).
    • (2002) J. Cell Biol. , vol.156 , pp. 425-436
    • Sacco-Bubulya, P.1    Spector, D.L.2
  • 43
    • 0036920468 scopus 로고    scopus 로고
    • PSKH1, a novel splice factor compartment-associated serine kinase
    • Brede, G., Solheim, J. & Prydz, H. PSKH1, a novel splice factor compartment-associated serine kinase. Nucleic Acids Res. 30, 5301-5309 (2002).
    • (2002) Nucleic Acids Res. , vol.30 , pp. 5301-5309
    • Brede, G.1    Solheim, J.2    Prydz, H.3
  • 44
    • 0032994412 scopus 로고    scopus 로고
    • Nuclear organisation of NIPP1, a regulatory subunit of protein phosphatase 1 that associates with pre-mRNA splicing factors
    • Trinkle-Mulcahy, L. et al. Nuclear organisation of NIPP1, a regulatory subunit of protein phosphatase 1 that associates with pre-mRNA splicing factors. J. Cell Sci. 112, 157-168 (1999).
    • (1999) J. Cell Sci. , vol.112 , pp. 157-168
    • Trinkle-Mulcahy, L.1
  • 45
    • 0035207924 scopus 로고    scopus 로고
    • Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells
    • Trinkle-Mulcahy, L., Sleeman, J. E. & Lamond, A. I. Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells. J. Cell Sci. 114, 4219-4228 (2001).
    • (2001) J. Cell Sci. , vol.114 , pp. 4219-4228
    • Trinkle-Mulcahy, L.1    Sleeman, J.E.2    Lamond, A.I.3
  • 46
    • 0031128181 scopus 로고    scopus 로고
    • Protein phosphorylation and the nuclear organization of pre-mRNA splicing
    • Misteli, T. & Spector, D. L. Protein phosphorylation and the nuclear organization of pre-mRNA splicing. Trends Cell Biol. 7, 135-138 (1997).
    • (1997) Trends Cell Biol. , vol.7 , pp. 135-138
    • Misteli, T.1    Spector, D.L.2
  • 47
    • 0033517103 scopus 로고    scopus 로고
    • Purification and biochemical characterization of interchromatin granule clusters
    • Mintz, P. J., Patterson, S. D., Neuwald, A. F., Spahr, C. S. & Spector, D. L. Purification and biochemical characterization of interchromatin granule clusters. EMBO J. 18, 4308-4320 (1999). The first systematic proteomic study of the protein components of nuclear speckles (IGCs), which were isolated from mouse liver nuclei.
    • (1999) EMBO J. , vol.18 , pp. 4308-4320
    • Mintz, P.J.1    Patterson, S.D.2    Neuwald, A.F.3    Spahr, C.S.4    Spector, D.L.5
  • 48
    • 0029071508 scopus 로고
    • Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing
    • Larsson, S. H. et al. Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing. Cell 81, 391-401 (1995).
    • (1995) Cell , vol.81 , pp. 391-401
    • Larsson, S.H.1
  • 49
    • 0029775622 scopus 로고    scopus 로고
    • A hyperphosphorylated form of the large subunit of RNA polymerase II is associated with splicing complexes and the nuclear matrix
    • Mortillaro, M.J. et al. A hyperphosphorylated form of the large subunit of RNA polymerase II is associated with splicing complexes and the nuclear matrix. Proc. Natl Acad. Sci. USA 93, 8253-8257 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 8253-8257
    • Mortillaro, M.J.1
  • 50
    • 0030909002 scopus 로고    scopus 로고
    • Dynamic relocation of transcription and splicing factors dependent upon transcriptional activity
    • Zeng, C., Kim, E., Warren, S. L. & Berget, S. M. Dynamic relocation of transcription and splicing factors dependent upon transcriptional activity. EMBO J. 16, 1401-1412 (1997).
    • (1997) EMBO J. , vol.16 , pp. 1401-1412
    • Zeng, C.1    Kim, E.2    Warren, S.L.3    Berget, S.M.4
  • 51
    • 0028015909 scopus 로고
    • Immunodetection of poly(A) binding protein II in the cell nucleus
    • Krause, S., Fakan, S., Weis, K. & Wahle, E. Immunodetection of poly(A) binding protein II in the cell nucleus. Exp. Cell Res. 214, 75-82 (1994).
    • (1994) Exp. Cell Res. , vol.214 , pp. 75-82
    • Krause, S.1    Fakan, S.2    Weis, K.3    Wahle, E.4
  • 52
    • 0031815767 scopus 로고    scopus 로고
    • A subset of poly(A) polymerase is concentrated at sites of RNA synthesis and is associated with domains enriched in splicing factors and poly(A) RNA
    • Schul, W., van Driel, R. & de Jong, L. A subset of poly(A) polymerase is concentrated at sites of RNA synthesis and is associated with domains enriched in splicing factors and poly(A) RNA. Exp. Cell Res. 236, 1-12 (1998).
    • (1998) Exp. Cell Res. , vol.236 , pp. 1-12
    • Schul, W.1    Van Driel, R.2    De Jong, L.3
  • 53
    • 0034707668 scopus 로고    scopus 로고
    • Nuclear eukaryotic initiation factor 4E (eIF4E) colocalizes with splicing factors in speckles
    • Dostie, J., Leibkowicz, F. & Sonenberg, N. Nuclear eukaryotic initiation factor 4E (eIF4E) colocalizes with splicing factors in speckles. J. Cell Biol. 148, 239-247 (2000).
    • (2000) J. Cell Biol. , vol.148 , pp. 239-247
    • Dostie, J.1    Leibkowicz, F.2    Sonenberg, N.3
  • 54
    • 0032696240 scopus 로고    scopus 로고
    • Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF 4AI and eIF4AII
    • Li, Q. et al. Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII. Mol. Cell. Biol. 19, 7336-7346 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 7336-7346
    • Li, Q.1
  • 55
    • 0021710701 scopus 로고
    • Small nuclear RNA-protein complex anchors on the actin filaments in bovine lymphocyte nuclear matrix
    • Nakayasu, H. & Ueda, K. Small nuclear RNA-protein complex anchors on the actin filaments in bovine lymphocyte nuclear matrix. Cell Struct. Funct. 9, 317-325 (1984).
    • (1984) Cell Struct. Funct. , vol.9 , pp. 317-325
    • Nakayasu, H.1    Ueda, K.2
  • 56
    • 0033401971 scopus 로고    scopus 로고
    • Colocalization of intranuclear lamin foci with RNA splicing factors
    • Jagatheesan, G. et al. Colocalization of intranuclear lamin foci with RNA splicing factors. J. Cell Sci. 112, 4651-4661 (1999).
    • (1999) J. Cell Sci. , vol.112 , pp. 4651-4661
    • Jagatheesan, G.1
  • 57
    • 0036674269 scopus 로고    scopus 로고
    • Large-scale proteomic analysis of the human spliceosome
    • Rappsilber, J., Ryder, U., Lamond, A. I. & Mann, M. Large-scale proteomic analysis of the human spliceosome. Genome Res 12, 1231-1245 (2002).
    • (2002) Genome Res , vol.12 , pp. 1231-1245
    • Rappsilber, J.1    Ryder, U.2    Lamond, A.I.3    Mann, M.4
  • 58
    • 0037068447 scopus 로고    scopus 로고
    • Comprehensive proteomic analysis of the human spliceosome
    • Zhou, Z., Licklider, L. J., Gygi, S. P. & Reed, R. Comprehensive proteomic analysis of the human spliceosome. Nature 419, 182-185 (2002).
    • (2002) Nature , vol.419 , pp. 182-185
    • Zhou, Z.1    Licklider, L.J.2    Gygi, S.P.3    Reed, R.4
  • 59
    • 0028900584 scopus 로고
    • Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains
    • Bregman, D. B., Du, L., van der Zee, S. & Warren, S. L. Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains. J. Cell Biol. 129, 287-298 (1995).
    • (1995) J. Cell Biol. , vol.129 , pp. 287-298
    • Bregman, D.B.1    Du, L.2    Van der Zee, S.3    Warren, S.L.4
  • 60
    • 0343683416 scopus 로고    scopus 로고
    • Nuclear distribution of transcription factors in relation to sites of transcription and RNA polymerase 11
    • Grande, M. A., van der Kraan, I., de Jong, L. & van Driel, R. Nuclear distribution of transcription factors in relation to sites of transcription and RNA polymerase 11. J. Cell Sci. 110, 1781-1791 (1997).
    • (1997) J. Cell Sci. , vol.110 , pp. 1781-1791
    • Grande, M.A.1    Van der Kraan, I.2    De Jong, L.3    Van Driel, R.4
  • 61
    • 0037049641 scopus 로고    scopus 로고
    • The transcription cycle of RNA polymerase II in living cells
    • Kimura, H., Sugaya, K. & Cook, P. R. The transcription cycle of RNA polymerase II in living cells. J. Cell Biol. 159, 777-782 (2002).
    • (2002) J. Cell Biol. , vol.159 , pp. 777-782
    • Kimura, H.1    Sugaya, K.2    Cook, P.R.3
  • 62
    • 12244297083 scopus 로고    scopus 로고
    • The distribution of RNA polymerase 11 largest subunit (RPB1) in the Xenopus germinal vesicle
    • Doyle, O., Corden, J. L., Murphy, C. & Gall, J. G. The distribution of RNA polymerase 11 largest subunit (RPB1) in the Xenopus germinal vesicle. J. Struct. Biol. 140, 154-166 (2002).
    • (2002) J. Struct. Biol. , vol.140 , pp. 154-166
    • Doyle, O.1    Corden, J.L.2    Murphy, C.3    Gall, J.G.4
  • 63
    • 0034111019 scopus 로고    scopus 로고
    • P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II
    • Price, D. H. P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II. Mol. Cell. Biol. 20, 2629-2634 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 2629-2634
    • Price, D.H.1
  • 64
    • 0035022568 scopus 로고    scopus 로고
    • The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions
    • Herrmann, C. H. & Mancini, M. A. The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions. J. Cell Sci. 114, 1491-1503 (2001).
    • (2001) J. Cell Sci. , vol.114 , pp. 1491-1503
    • Herrmann, C.H.1    Mancini, M.A.2
  • 65
    • 0027294645 scopus 로고
    • Nucleoplasmic organization of small nuclear ribonucleoproteins in cultured human cells
    • Matera, A. G. & Ward, D. C. Nucleoplasmic organization of small nuclear ribonucleoproteins in cultured human cells. J. Cell Biol. 121, 715-727 (1993).
    • (1993) J. Cell Biol. , vol.121 , pp. 715-727
    • Matera, A.G.1    Ward, D.C.2
  • 66
    • 0030927823 scopus 로고    scopus 로고
    • Purification and characterization of FBI-1, a cellular factor that binds to the human immunodeficiency virus type 1 inducer of short transcripts
    • Pessler, F., Pendergrast, P. S. & Hernandez, N. Purification and characterization of FBI-1, a cellular factor that binds to the human immunodeficiency virus type 1 inducer of short transcripts. Mol. Cell. Biol. 17, 3786-3798 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 3786-3798
    • Pessler, F.1    Pendergrast, P.S.2    Hernandez, N.3
  • 67
    • 0036196574 scopus 로고    scopus 로고
    • FBI-1 can stimulate HIV-1 Tat activity and is targeted to a novel subnuclear domain that includes the Tat-P-TEFb-containing nuclear speckles
    • Pendergrast, P. S., Wang, C., Hernandez, N. & Huang, S. FBI-1 can stimulate HIV-1 Tat activity and is targeted to a novel subnuclear domain that includes the Tat-P-TEFb-containing nuclear speckles. Mol. Biol. Cell 13, 915-929 (2002).
    • (2002) Mol. Biol. Cell , vol.13 , pp. 915-929
    • Pendergrast, P.S.1    Wang, C.2    Hernandez, N.3    Huang, S.4
  • 68
    • 0032401763 scopus 로고    scopus 로고
    • Dynamic relocation of chromosomal protein HMG-17 in the nucleus is dependent on transcriptional activity
    • Hook, R., Wilde, F., Scheer, U. & Bustin, M. Dynamic relocation of chromosomal protein HMG-17 in the nucleus is dependent on transcriptional activity. EMBO J. 17, 6992-7001 (1998).
    • (1998) EMBO J. , vol.17 , pp. 6992-7001
    • Hook, R.1    Wilde, F.2    Scheer, U.3    Bustin, M.4
  • 69
    • 0025786160 scopus 로고
    • Discrete nuclear domains of poly(A) RNA and their relationship to the functional organization of the nucleus
    • Carter, K. C., Taneja, K. L. & Lawrence, J. B. Discrete nuclear domains of poly(A) RNA and their relationship to the functional organization of the nucleus. J. Cell Biol. 115, 1191-1202 (1991).
    • (1991) J. Cell Biol. , vol.115 , pp. 1191-1202
    • Carter, K.C.1    Taneja, K.L.2    Lawrence, J.B.3
  • 70
    • 0027320766 scopus 로고
    • Intranuclear distribution of poly A RNA determined by electron microscope in situ hybridization
    • Visa, N., Puvion-Dutilleul, F., Harper, F., Bachellerie, J.-P. & Puvion, E. Intranuclear distribution of poly A RNA determined by electron microscope in situ hybridization. Exp. Cell. Res. 208, 19-34 (1993).
    • (1993) Exp. Cell. Res. , vol.208 , pp. 19-34
    • Visa, N.1    Puvion-Dutilleul, F.2    Harper, F.3    Bachellerie, J.-P.4    Puvion, E.5
  • 71
    • 0027930199 scopus 로고
    • In vivo analysis of the stability and transport of nuclear poly(A)+ RNA
    • Huang, S., Deerinck, M. H., Ellisman, M. H. & Spector, D. L. In vivo analysis of the stability and transport of nuclear poly(A)+ RNA. J. Cell Biol. 126, 877-899 (1994).
    • (1994) J. Cell Biol. , vol.126 , pp. 877-899
    • Huang, S.1    Deerinck, M.H.2    Ellisman, M.H.3    Spector, D.L.4
  • 73
    • 0017261391 scopus 로고
    • Message and non-message sequences adjacent to poly(A) in steady state heterogeneous nuclear RNA of HeLa cells
    • Herman, R. C., Williams, J. G. & Penman, S. Message and non-message sequences adjacent to poly(A) in steady state heterogeneous nuclear RNA of HeLa cells Cell 7, 429-437 (1976).
    • (1976) Cell , vol.7 , pp. 429-437
    • Herman, R.C.1    Williams, J.G.2    Penman, S.3
  • 74
    • 0032567080 scopus 로고    scopus 로고
    • Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling
    • Zhao, K. et al. Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell 95, 625-636 (1998).
    • (1998) Cell , vol.95 , pp. 625-636
    • Zhao, K.1
  • 75
    • 0031771547 scopus 로고    scopus 로고
    • Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors
    • Boronenkov, I. V., Loijens, J. C., Umeda, M. & Anderson, R. A. Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors. Mol. Biol. Cell 9, 3547-3560 (1998).
    • (1998) Mol. Biol. Cell , vol.9 , pp. 3547-3560
    • Boronenkov, I.V.1    Loijens, J.C.2    Umeda, M.3    Anderson, R.A.4
  • 76
    • 0037128211 scopus 로고    scopus 로고
    • Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription
    • Spann, T. P., Goldman, A. E., Wang, C., Huang, S. & Goldman, R. D. Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription. J. Cell Biol. 156, 603-608 (2002).
    • (2002) J. Cell Biol. , vol.156 , pp. 603-608
    • Spann, T.P.1    Goldman, A.E.2    Wang, C.3    Huang, S.4    Goldman, R.D.5
  • 77
    • 0025936626 scopus 로고
    • Associations between distinct pre-mRNA splicing components and the cell nucleus
    • Spector D. L., Fu, X.-D. & Maniatis, T. Associations between distinct pre-mRNA splicing components and the cell nucleus. EMBO J. 10, 3467-3481 (1991).
    • (1991) EMBO J. , vol.10 , pp. 3467-3481
    • Spector, D.L.1    Fu, X.-D.2    Maniatis, T.3
  • 78
    • 0027478001 scopus 로고
    • In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism
    • Jiménez-García, L. F. & Spector, D. L. In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism. Cell 73, 47-59 (1993). This work showed that factors are recruited from nuclear speckles to sites of transcription.
    • (1993) Cell , vol.73 , pp. 47-59
    • Jiménez-García, L.F.1    Spector, D.L.2
  • 79
    • 0028970384 scopus 로고
    • Dynamic organization of splicing factors in adenovirus-infected cells
    • Bridge, E. et al. Dynamic organization of splicing factors in adenovirus-infected cells. J. Virol. 69, 281-290 (1995).
    • (1995) J. Virol. , vol.69 , pp. 281-290
    • Bridge, E.1
  • 80
    • 0034631851 scopus 로고    scopus 로고
    • Reduced mobility of the alternate splicing factor (ASF) through the nucleoplasm and steady state speckle compartments
    • Kruhlak, M. J. et al. Reduced mobility of the alternate splicing factor (ASF) through the nucleoplasm and steady state speckle compartments. J. Cell Biol. 150, 41-51 (2000). This study showed that the dynamics of splicing factor SF2/ASF are consistent with frequent but transient interactions with relatively immobile nuclear binding sites.
    • (2000) J. Cell Biol. , vol.150 , pp. 41-51
    • Kruhlak, M.J.1
  • 81
    • 0022452844 scopus 로고
    • Redistribution of U-snRNPs during mitosis
    • Spector, D. L. & Smith, H. C. Redistribution of U-snRNPs during mitosis. Exp. Cell Res. 163, 87-94 (1986).
    • (1986) Exp. Cell Res. , vol.163 , pp. 87-94
    • Spector, D.L.1    Smith, H.C.2
  • 82
    • 0022358273 scopus 로고
    • Localization and structure of snRNPs during mitosis. Immunofluorescent and biochemical studies
    • Reuter, R., Appel, B., Rinke, J. & Lahrmann, R. Localization and structure of snRNPs during mitosis. Immunofluorescent and biochemical studies. Exp. Cell. Res. 159, 63-79 (1985).
    • (1985) Exp. Cell. Res. , vol.159 , pp. 63-79
    • Reuter, R.1    Appel, B.2    Rinke, J.3    Lahrmann, R.4
  • 83
    • 0028337641 scopus 로고
    • Differential interaction of splicing snRNPs with coiled bodies and interchromatin granules during mitosis and assembly of daughter cell nuclei
    • Ferreira, J. A., Carmo-Fonseca, M. & Lamond, A. I. Differential interaction of splicing snRNPs with coiled bodies and interchromatin granules during mitosis and assembly of daughter cell nuclei. J. Cell Biol. 126, 11-23 (1994). This study identified MIGs as mitotic forms of speckles containing splicing factors and showed that interphase speckles can reform after mitosis, even in the absence of transcription.
    • (1994) J. Cell Biol. , vol.126 , pp. 11-23
    • Ferreira, J.A.1    Carmo-Fonseca, M.2    Lamond, A.I.3
  • 84
    • 0029148239 scopus 로고
    • Behavior of interchromatin granules during the cell cycle
    • Thiry, M. Behavior of interchromatin granules during the cell cycle. Eur. J. Cell Biol. 68, 14-24 (1995). Analysis of the organization of IGCs through the cell cycle at the electron-microscope level.
    • (1995) Eur. J. Cell Biol. , vol.68 , pp. 14-24
    • Thiry, M.1
  • 85
    • 0024817995 scopus 로고
    • Ultrastructural distribution of ribonucleoprotein complexes during mitosis. snRNP antigens are contained in mitotic granule clusters
    • Leser, G. P., Fakan, S. & Martin, T. E. Ultrastructural distribution of ribonucleoprotein complexes during mitosis. snRNP antigens are contained in mitotic granule clusters. Eur. J. Cell Biol. 50, 376-389 (1989).
    • (1989) Eur. J. Cell Biol. , vol.50 , pp. 376-389
    • Leser, G.P.1    Fakan, S.2    Martin, T.E.3
  • 86
    • 0022924515 scopus 로고
    • Distribution of the 70K U1 RNA-associated protein during interphase and mitosis. Correlation with other U RNP particles and proteins of the nuclear matrix
    • Verheijen, R., Kuijpers, H., Vooijs, R., Van Venrooij, W. & Ramaekers, F. Distribution of the 70K U1 RNA-associated protein during interphase and mitosis. Correlation with other U RNP particles and proteins of the nuclear matrix. J. Cell Sci. 86, 173-190 (1986).
    • (1986) J. Cell Sci. , vol.86 , pp. 173-190
    • Verheijen, R.1    Kuijpers, H.2    Vooijs, R.3    Van Venrooij, W.4    Ramaekers, F.5
  • 87
    • 0037339967 scopus 로고    scopus 로고
    • Sequential entry of components of gene expression machinery into daughter nuclei
    • Prasanth, K. V., Sacco-Bubulya, P., Prasanth, S. G. & Spector, D. L. Sequential entry of components of gene expression machinery into daughter nuclei. Mol. Biol. Cell 14, 1043-1057 (2003). This study shows the differential timing of the re-entry of separate components of the gene-expression machinery into newly assembled daughter nuclei after mitosis. This re-entry occurs in a sequential and ordered manner.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 1043-1057
    • Prasanth, K.V.1    Sacco-Bubulya, P.2    Prasanth, S.G.3    Spector, D.L.4
  • 88
    • 0027753943 scopus 로고
    • Differential location of nuclei acids within interchromatin granule clusters
    • Thiry, M. Differential location of nuclei acids within interchromatin granule clusters. Eur. J. Cell Biol. 62, 259-269 (1993).
    • (1993) Eur. J. Cell Biol. , vol.62 , pp. 259-269
    • Thiry, M.1
  • 89
    • 0029798802 scopus 로고    scopus 로고
    • Serine/threonine phosphatase 1 modulates the subnuclear distribution of pre-mRNA splicing factors
    • Misteli, T. & Spector, D. L. Serine/threonine phosphatase 1 modulates the subnuclear distribution of pre-mRNA splicing factors. Mol. Biol. Cell 7, 1559-1572 (1996).
    • (1996) Mol. Biol. Cell , vol.7 , pp. 1559-1572
    • Misteli, T.1    Spector, D.L.2
  • 90
    • 0027056909 scopus 로고
    • Differences in snRNP localization between transformed and nontransformed cells
    • Spector, D. L., Lark, G & Huang, S. Differences in snRNP localization between transformed and nontransformed cells. Mol. Biol. Cell 3, 555-569 (1992).
    • (1992) Mol. Biol. Cell , vol.3 , pp. 555-569
    • Spector, D.L.1    Lark, G.2    Huang, S.3
  • 92
    • 0028286596 scopus 로고
    • A serine kinase regulates intracellular localization of splicing factors in the cell cycle
    • Gui, J. F., Lane, W. S. & Fu, X.-D. A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature 369, 678-682 (1994). Identifies and characterizes the role of a serine kinase, SRPK1, which phosphorylates SR proteins and modulates their localization during the cell cycle.
    • (1994) Nature , vol.369 , pp. 678-682
    • Gui, J.F.1    Lane, W.S.2    Fu, X.-D.3
  • 93
    • 0027962510 scopus 로고
    • Purification and characterization of a kinase specific for the serine- and arginine-rich pre-mRNA splicing factors
    • Gui, J. F., Tronchere, H., Chandler, S. D. & Fu, S. D. Purification and characterization of a kinase specific for the serine- and arginine-rich pre-mRNA splicing factors. Proc. Natl Acad. Sci. USA 91, 10824-10828 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 10824-10828
    • Gui, J.F.1    Tronchere, H.2    Chandler, S.D.3    Fu, S.D.4
  • 94
    • 0032547829 scopus 로고    scopus 로고
    • Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo
    • Misteli, T. et al. Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo. J. Cell Biol. 143, 297-307 (1998).
    • (1998) J. Cell Biol. , vol.143 , pp. 297-307
    • Misteli, T.1
  • 95
    • 0028043718 scopus 로고
    • Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism
    • Mermoud, J. E., Cohen, P. T. W., & Lamond, A. I. Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism. EMBO J. 13, 5679-5688 (1994).
    • (1994) EMBO J. , vol.13 , pp. 5679-5688
    • Mermoud, J.E.1    Cohen, P.T.W.2    Lamond, A.I.3
  • 96
    • 0023091745 scopus 로고
    • Identification of protein antigens associated with the nuclear matrix and with clusters of interchromatin granules in both interphase and mitotic cells
    • Turner, B. M. & Franchi, L. Identification of protein antigens associated with the nuclear matrix and with clusters of interchromatin granules in both interphase and mitotic cells. J. Cell Sci. 87, 269-282 (1987).
    • (1987) J. Cell Sci. , vol.87 , pp. 269-282
    • Turner, B.M.1    Franchi, L.2


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