Pivotal role of extended linker 2 in the activation of Gα by G protein-coupled receptor

Journal of Biological Chemistry

Volumn 290, Issue 1, 2015, Pages 272-283

  Huang, Jianyun ^a   Sun, Yutong ^a,b   Jillian Zhang, J ^a   Huang, Xin Yun ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CHEMICAL ACTIVATION; ENZYME ACTIVITY;

BETA ADRENERGIC RECEPTOR; EXTRACELLULAR SIGNALS; G PROTEIN ACTIVATION; G PROTEIN COUPLED RECEPTORS; GUANINE NUCLEOTIDES; HETEROTRIMERIC G PROTEINS; INTRACELLULAR LOOP 2; NATURAL PRODUCT INHIBITORS;

PROTEINS;

ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; PROTEIN BINDING; RECOMBINANT PROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; EMBRYO; ENZYME ACTIVATION; EXTENDED LINKER 2; IN VITRO STUDY; INTRACELLULAR SIGNALING; MOLECULAR DYNAMICS; MOUSE; MUTAGENESIS; NONHUMAN; NUCLEIC ACID STRUCTURE, METABOLISM AND FUNCTION; NUCLEOTIDE EXCHANGE; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; RAS LIKE GTPASE DOMAIN; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; WILD TYPE; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL PHENOMENA; CHEMISTRY; ESCHERICHIA COLI; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MOLECULAR GENETICS; MOLECULAR MODEL; MUTATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; BINDING SITES; ESCHERICHIA COLI; GENE EXPRESSION; GENE EXPRESSION REGULATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; HEK293 CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ADRENERGIC, BETA; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 84920517379     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.608661     Document Type: Article

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