Common and distinct mechanisms of activation of rhodopsin and other G protein-coupled receptors

Scientific Reports

Volumn 3, Issue , 2013, Pages

  Nakamura, Sumire ^a   Itabashi, Takeshi ^a   Ogawa, Daisuke ^a   Okada, Tetsuji ^a  

^a GAKUSHUIN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A2A RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; LIGAND; RHODOPSIN;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; CYTOPLASM; HUMAN; METABOLISM; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE;

CYTOPLASM; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, ADENOSINE A2A; RECEPTORS, ADRENERGIC, BETA-2; RHODOPSIN;

EID: 84878714296     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep01844     Document Type: Article

References (26)

1. Kobilka, B. K. & Deupi, X. Conformational complexity of G-protein-coupled receptors. Trends Pharmacol. Sci. 28, 397-406 (2007). (Pubitemid 47087966)
2. Farrens, D. L., Altenbach, C., Yang, K., Hubbell, W. L. & Khorana, H. G. Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin. Science 274, 768-770 (1996). (Pubitemid 26398253)
3. Park, J. H., Scheerer, P., Hofmann, K. P., Choe, H. W. & Ernst, O. P. Crystal structure of the ligand-free G-protein-coupled receptor opsin. Nature 454, 183-187 (2008). (Pubitemid 351969893)
4. Rasmussen, S. G. et al. Structure of a nanobody-stabilized active state of the b(2) adrenoceptor. Nature 469, 175-180 (2011).
5. Xu, F. et al. Structure of an agonist-bound human A2A adenosine receptor. Science 332, 322-327 (2011).
6. Hirai, T., Subramaniam, S. & Lanyi, J. K. Structural snapshots of conformational changes in a seven-helix membrane protein: lessons from bacteriorhodopsin. Curr Opin Struct Biol. 19, 433-439 (2009).
7. Choe, H.-W. et al. Crystal structure of metarhodopsin II. Nature 471, 651-655 (2011).
8. Standfuss, J. et al. The structural basis of agonist-induced activation in constitutively active rhodopsin. Nature 471, 656-660 (2011).
9. Deupi, X. et al. Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II. Proc Natl Acad Sci USA 109, 119-124 (2012).
10. Warne, T. et al. The structural basis for agonist and partial agonist action on a b(1)-adrenergic receptor. Nature 469, 241-244 (2011).
11. Søren, G. F. et al. Crystal structure of the b2 adrenergic receptor-Gs protein complex. Nature 477, 549-555 (2011).
12. Lebon, G. et al. Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation. Nature 474, 521-525 (2011).
13. White, J. F. et al. Structure of the agonist-bound neurotensin receptor. Nature 490, 508-513 (2012).
14. Hulme, E. C. GPCR activation: amutagenic spotlight on crystal structures. Trends Pharmacol Sci. 34, 67-84 (2013).
15. Lebon, G., Warne, T. &Tate, C. G. Agonist-bound structures ofGprotein-coupled receptors. Curr Opin Struct Biol. 22, 482-490 (2012).
16. Unal, H. & Karnik, S. S. Domain coupling in GPCRs: the engine for induced conformational changes. Trends Pharmacol Sci. 33, 79-88 (2012).
17. Okada, T. Comparative analysis of the heptahelical transmembrane bundles of G protein-coupled receptors. PLoS One 7, e35802 (2012).
18. Krissinel, E. & Henrick, K. Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. Acta Crystallogr D60, 2256-2268 (2004). (Pubitemid 41742778)
19. Ballesteros, J. A. & Weinstein, H. Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors. Methods Neurosci 25, 366-428 (1995).
20. Bansal, M., Kumar, S. & Velavan, R. HELANAL: a program to characterize helix geometry in proteins. J Biomol Struct Dyn 17, 811-819 (2000). (Pubitemid 30227198)
21. Kabsch, W. & Sander, C. Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. Biopolymers 22, 2577-2637 (1983).
22. Kenakin, T. Ligand-selective receptor conformations revisited: the promise and the problem. Trends Pharmacol Sci. 24, 346-54 (2003). (Pubitemid 37315526)
23. Pettersen, E. F. et al. UCSF Chimera-a visualization system for exploratory research and analysis. J Comput Chem 25, 1605-1612 (2004).
24. McNicholas, S., Potterton, E., Wilson, K. S. & Noble, M. E. M. Presenting your structures: the CCP4mg molecular-graphics software. Acta Cryst D67, 386-394 (2011).
25. Wang, C. et al. Structural basis for molecular recognition at serotonin receptors. Science 340, 610-614 (2013).
26. Wacker, D. et al. Structural Features for Functional Selectivity at Serotonin Receptors. Science 340, 615-619 (2013).