Complementary and alternative medicine use among cancer patients in Palestine with special reference to safety-related concerns

Journal of Ethnopharmacology

Volumn 187, Issue , 2016, Pages 104-122

  Ali Shtayeh, Mohammed S ^a   Jamous, Rana M ^a   Salameh, Nihaya M Y ^a,b   Jamous, Rania M ^a,b   Hamadeh, Amneh M A ^a  

^a West Bank   (Palestine)

^b Palestinian Military Services   (Palestine)

Author keywords

Cancer patient; Complementary and alternative medicine; Herbal drug interaction; Palestine Safety related concern

Indexed keywords

ADVERSE EFFECTS; AGED; ALTERNATIVE MEDICINE; FEMALE; HERB DRUG INTERACTION; HUMAN; MALE; MIDDLE EAST; NEOPLASMS; QUESTIONNAIRE;

AGED; COMPLEMENTARY THERAPIES; FEMALE; HERB-DRUG INTERACTIONS; HUMANS; MALE; MIDDLE EAST; NEOPLASMS; SURVEYS AND QUESTIONNAIRES;

EID: 84964674929     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2016.04.038     Document Type: Article

References (158)

1. M. Wazaify, M. Jabr, and E. Treish The use of herbal preparations as complementary and alternative medicine (CAM) in a sample of patients with cancer in Jordan Complement. Ther. Clin. Pract. 16 4 2010 208 212
2. L.M. Akhu-Zaheya, and E.M. Alkhasawneh Complementary alternative medicine use among a sample of Muslim Jordanian oncology patients Complement. Ther. Clin. Pract. 18 2 2012 121 126
3. A.D. Akyol, and B. Öz The use of complementary and alternative medicine by patients with cancer in Turkey Complement. Ther. Clin. Pract. 2011 10.1016/j.ctcp.2010.12.003
4. M. Al-Fatimi, M. Wurster, G. Schroder, and U. Lindequist Antioxidant, antimicrobial and cytotoxic activities of selected medicinal plants from Yemen J. Ethnopharmacol. 111 2007 657 666
5. L.A Algier, Z. Hanoglu, G. Ozden, and F. Kara The use of complementary and alternative (non-conventional) medicine in cancer patients in Turkey Eur. J. Oncol. Nurs. 9 2005 138 146
6. M.S. Ali-Shtayeh, Z. Yaniv, and J. Mahajna Ethnobotanical survey in the Palestinian area: a classification of the healing potential of medicinal plants J. Ethnopharmacol. 73 2000 221 232
7. Ali-Shtayeh, M.S., Jamous, R.ana M., 2008. Traditional Arabic Palestinian Herbal Medicine, TAPHM. Til, Nablus, Palestine, Biodiversity and Environmental Research Center, BERC. ISBN 978-9950-324-04-6.
8. Ali-Shtayeh, M.S., Jamous, R.M., Abu-Zeitoun, S.Y., 2014. BERC 2014 «National list of Medicinal Plants in Palestine - West Bank and Gaza Strip». Til, Nablus: Biodiversity and Environmental Research Center (BERC).
9. M.S. Ali-Shtayeh, and R.M. Jamous Ethnobotany of Palestinian herbal medicine in the northern West Bank and Gaza Strip: review and comprehensive field study Biodivers. Environ. Sci. Stud. Ser. 4 2006 1 122 (in Arabic)
10. M.S. Ali-Shtayeh, Jamous, M. Rana, Jamous, and M. Rania Herbal preparation use by patients suffering from cancer in Palestine Complement. Ther. Clin. Pract. 17 4 2011 235 240 10.1016/j.ctcp.2011.06.002
11. M.S. Ali-Shtayeh, Jamous, M. Rana, Jamous, and M. Rania Complementary and alternative medicine use amongst Palestinian diabetic patients Complement. Ther. Clin. Pract. 18 2012 16 21
12. M.S. Ali-Shtayeh, Jamous, M. Rana, Jamous, M. Rania, and N.M.Y. Salameh Complementary and alternative medicine (CAM) use among hypertensive patients in Palestine Complement. Ther. Clin. Pract. 19 2013 256 263
13. A. Alsemari, F. Alkhodairy, A. Aldakan, M. Al-Mohanna, E. Bahoush, Z. Shinwari, and A. Alaiya The selective cytotoxic anti-cancer properties and proteomic analysis of Trigonella foenum-graecum BMC Complement. Altern. Med. 14 2014 114 10.1186/1472-6882-14-114
14. R. Appiah-Opong, J.N. Commandeur, B. Vugt-Lussenburg, and N.P. Vermeulen Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products Toxicology 235 2007 83 91
15. P.V.A. Babu, and D. Liu Green tea catechins and cardiovascular health: an update Curr. Med. Chem. 15 18 2008 1840 1850
16. N. Banerjee, S. Talcott, S. Safe, and S.U. Mertens-Talcott Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: Potential role of miRNA-27a and miRNA-155 in cell survival and inflammation Breast Cancer Res. Treat. 136 1 2012 21 34 10.1007/s10549-012-2224-0
17. S. Banerjee, A.O. Kaseb, Z. Wang, D. Kong, M. Mohammad, S. Padhye, F.H. Sarkar, and R.M. Mohammad Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer Cancer Res. 69 2009 5575 5583
18. E. Basch, S. Bent, J. Collins, C. Dacey, P. Hammerness, M. Harrison, M. Smith, P. Szapary, C. Ulbricht, M. Vora, and W. Weissner Flaxseed and flaxseed oil (Linum usitatissimum): a review by the Natural Standards Collaboration J. Soc. Integr. Oncol. 5 3 2007 92 105
19. Basch, E., Dacey, C., Ernst, E., Foppa, I., Grimes Serrano, J.M., Hammerness, P., Kerbel, B., Nummy, K., Seamon, E., Shaffer, M., Tanguay-Colucci, S., Vora, M., Ulbricht, C., Weissner, W., 2012. Hawthorn (Crataegus laevigata, C. oxyacantha, C.monogyna, C. pentagyna). Natural Standard Professional Monograph. Available at (http://www.naturalstandard). com/databases/herbssupplements/all/crataegus.asp (last accessed 21.01.12.).
20. J.H. Beijnen, and J.H. Schellens Drug interactions in oncology Lancet Oncol. 5 2004 489 496
21. Beikang, G., Zhen, Z., Zhong, Z., 2014. Updates on the Clinical Evidenced Herb-Warfarin Interactions. eCAM 2014, Article ID 957362.
22. J. Bekir, M. Mars, P. Vicendo, A. Fterrich, and J. Bouajila Chemical composition and antioxidant, anti-inflammatory, and antiproliferation activities of pomegranate (Punica granatum) flowers J. Med. Food 16 6 2013 544 550 10.1089/jmf.2012.0275
23. Sh. Birdsall, J. Glen, and G. Weiss Assessing potential herb-drug interactions: a clinical decision-making guideline to mitigate patient risk Integr. Cancer Sci. Therap. 1 2 2014 30 34
24. A. Bordia, S.K. Verma, and K.C. Srivastava Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease Prostaglandins Leukot. Essent. Fat Acids 56 1997 379 384
25. Z. Bouallagui, J. Han, H. Isoda, and S. Sayadi Hydroxytyrosol rich extract from olive leaves modulates cell cycle progression in MCF-7 human breast cancer cells Food Chem. Toxicol. 49 1 2011 179 184 10.1016/j.fct.2010.10.014
26. S.A. Brahmi, F.Z. El M'Rabet, Z. Benbrahim, and et al. Complementary medicine use among Moroccan patients with cancer: a descriptive study Pan Afr. Med. J. 10 2011 36
27. B.A. Busnena, A.I. Foudah, T. Melancon, and K.A. El Sayed Olive secoiridoids and semisynthetic bioisostere analogues for the control of metastatic breast cancer Bioorg. Med. Chem. 21 7 2013 2117 2127 10.1016/j.bmc.2012.12.050
28. G. Can, O. Erol, A. Aydiner, and E. Topuz Quality of life and complementary and alternative medicine use among cancer patients in Turkey Eur. J. Oncol. Nurs. 13 2009 287 294
29. H.Y. Chang, M. Wallis, and E. Tiralongo Use of complementary and alternative medicine among people living with diabetes: literature review J. Adv. Nurs. 58 2007 307 319
30. M.L. Chavez, M.A. Jordan, and P.I. Chavez Evidence-based drug herbal interactions Life Sci. 78 2006 2146 2157
31. N. Chehl, G. Chipitsyna, Q. Gong, C.J. Yeo, and H.A. Arafat Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells 11 2009 HPB (Oxford) 373 381
32. P. Chen, J. Li, H.G. Jiang, T. Lan, and Y.C. Chen Curcumin reverses cisplatin resistance in cisplatin-resistant lung cancer cells by inhibiting FA/BRCA pathway Tumour Biol. 36 2015 3591 3599
33. G. Corea, E. Fattorusso, and V. Lanzotti Jatrophane diterpenes as modulators of multidrug resistance. advances of structure-activity relationships and discovery of the potent lead pepluanin Arab J. Med. Chem. 47 2004 2004 988 992
34. D.P. Cronin-Fenton, P. Damkier, and T.L. Lash Metabolism and transport of tamoxifen in relation to its effectiveness: new perspectives on an ongoing controversy Future Oncol. 10 1 2014 107 122
35. E.L. Davis, B. Oh, P.N. Butow, B.A. Mullan, and S. Clarke Cancer patient disclosure and patient-doctor communication of complementary and alternative medicine use: a systematic review Oncologist 17 2012 1475 1481
36. P.A. De Smet Health risks of herbal remedies: an update Clin. Pharmacol. Ther. 76 2004 1 17
37. F. Dehghani, and M.R. Panjehshahin The toxic effect of alcoholic extract of citrullus colocynthis on rat liver Iran. J. Pharmacol. Ther. 5 2006 117 119
38. L.D. DeLeve Alterations in Hepatic Metabolism of Drugs D.W. Kufe, R.E. Pollock, R.R. Weichselbaum, In: Holland-Frei Cancer Medicine 6th ed. 2003 BC Decker Hamilton (ON)
39. K. Effenberger, S. Breyer, and R. Schobert Terpene conjugates of the Nigella sativa seed-oil constituent thymoquinone with enhanced efficacy in cancer cells Chem. Biodivers. 7 2010 129 139
40. E. Ernst Possible interactions between synthetic and herbal medicinal products. Part I: a systemic review of the indirect evidence Perfusion 13 2000 4 6
41. E. Ernst, M.H. Pittler, B. Wider, and K. Boddy The Desktop Guide to Complementary and Alternative Medicine 2nd ed. 2006 Elsevier Mosby Edinburgh
42. E. Ernst, and B.R. Cassileth The prevalence of complementary/alternative medicine in cancer: a systematic review Cancer 83 4 1998 777 782
43. E.R. Ezeome, and A.N. Anarado Use of complementary and alternative medicine by cancer patients at the university of Nigeria Teaching Hospital, Enugu, Nigeria BMC Complement. Altern. Med. 7 2007 28 36
44. E. Ezzeldin, Y.A. Asiri, and M. Iqbal Effects of green tea extracts on the pharmacokinetics of quetiapine in rats Evid. Based Complement. Altern. Med. 2015 615285 2015 4
45. M.M. Farid, S.R. Hussein, L.F. Ibrahim, M.A. El Desouky, A.M. Elsayed, A.A. El Oqlah, and M.M. Saker Cytotoxic activity and phytochemical analysis of Arum palaestinum Boiss Asian Pac. J. Trop. Biomed. 5 11 2015 944 947
46. M. Farooqui, M.A. Hassali, A.K. Abdul Shatar, M.A. Muhammad Aslam Farooqui, F. Saleem, N. ul Haq, and Ch. N. Othman Use of complementary and alternative medicines among Malaysian cancer patients: a descriptive study J. Tradit. Complement. Med. 2015 http://dx.doi.org/10.1016/j.jtcme.2014.12.008
47. N.N. Farshori, E.S. Al-Sheddi, M.M. Al-Oqail, J. Musarrat, A.A. Al-Khedhairy, and M.A. Siddiqui Cytotoxicity assessments of Portulaca oleracea and Petroselinum sativum seed extracts on human hepatocellular carcinoma cells (HepG2) Asian Pac. J. Cancer Prev. 15 16 2014 6633 6638
48. P.S. Fasinu, P.J. Bouic, and B. Rosenkranz An overview of the evidence and mechanisms of herb-drug interactions Front Pharm. 3 2012 69
49. D. Fau, M. Lekeha, G. Farrell, and et al. Diterpenoids from germander, an herbal medicine, induce apoptosis in isolated rat hepatocytes Gastroenterology 113 1997 1334 1346
50. J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D.M. Parkin, D. Forman, and F. Bray Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 Int. J. Cancer 136 2015 E359 E386
51. A. Fugh-Berman Herb-drug interactions Lancet 355 9198 2000 p134 p138
52. S. Fulda Betulinic acid for cancer treatment and prevention Int. J. Mol. Sci. 9 2008 1096 1107
53. M. Ganzera, P. Schneider, and H. Stuppner Inhibitory effects of the essential oil of chamomile (Matricaria recutita L.) and its major con- stituents on human cytochrome P450 enzymes Life Sci. 78 2006 856 861
54. B. Ge, Z. Zhang, and Z. Zuo Updates on the clinical evidenced herb-warfarin interactions Evid. Based Complement. Altern. Med. 957362 2014 18 Article ID 957362
55. G.D. Geromichalos, T. Papadopoulos, D. Sahpazidou, and Z Sinakos Safranal, a Crocus sativus L constituent suppresses the growth of K-562 cells of chronic myelogenous leukemia. In silico and in vitro study Food Chem. Toxicol. 74 2014 45 50 10.1016/j.fct. 2014.09.001
56. E.B. Golden, P.Y. Lam, A. Kardosh, and et al. Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors Blood 113 2009 5927 5937
57. C. Gratus, S. Wilson, S.M. Greenfield, S.L. Damery, S.A. Warmington, R. Grieve, and et al. The use of herbal medicines by people with cancer: a qualitative study BMC Complement. Altern. Med. 9 2009 14 21
58. J.K. Grover, S. Yadav, and V. Vats Medicinal plants of India with anti-diabetic potential J. Ethnopharmacol. 81 2002 81 100
59. M.L. Hardy Dietary supplement use in cancer: help or harm Oncol. Clin. N. Am 22 2008 581 617
60. S.S. Hasan, S.I. Ahmed, N.I. Bukhari, and W.C.W. Loon Use of complementary and alternative medicine among patients with chronic diseases at outpatient clinics Complement. Ther. Clin. Pract. 15 2009 152 157
61. A.M. Heck, B.A. DeWitt, and A.L. Lukes Potential interactions between alternative therapies and warfarin Am. J. Health Syst. Pharm. 57 2000 1221 1227
62. C. Hirobe, Z.S. Qiao, K. Takeya, and H. Itokawa Cytotoxic principles from Majorana syriaca Nat. Med. 52 1998 74 77
63. Z. Hu, X. Yang, P.C.L. Ho, S.Y. Chan, P.W.S. Heng, E. Chan, H.L. Koh, and S. Zhou Herb-drug interactions. Review article Drugs 65 9 2005 1239 1282
64. A.I. Husein, M.S. Ali-Shtayeh, W.J. Jondi, N.A.-A. Zatar, I.M. Abu-Reidah, and R.M. Jamous In vitro antioxidant and antitumor activities of six selected plants used in the Traditional Arabic Palestinian herbal medicine Pharm. Biol. 53 10 2014 1249 1255
65. D. Isha, and P. Milind Imli: a craze lovely Int. Res. J. Pharm. 3 18 2012 110 115
66. O. Ishurd, F. Zgheel, A. Kermagi, M. Flefla, and M. Elmabruk Antitumor activity of beta-D-glucan from Libyan adates J. Med. Food 7 2004 252 255
67. A.A. Izzo, and E. Ernst Interactions between herbal medicines and prescribed drugs an updated systematic review Drugs 69 2009 1777 1798
68. A.A. Izzo, G. Di Carlo, F. Borrelli, and E. Ernst Cardiovascular pharmacotherapy and herbal medicines: the risk of drug interaction Int. J. Cardiol. 98 2005 1 14
69. N.A. Jaradat, R. Shawahna, A.M. Eid, R. Al-Ramahi, M.K. Asma, and A.N. Zaid Herbal remedies use by breast cancer patients in the West Bank of Palestine J. Ethnopharmacol. 178 2016 1 8
70. S. Jayakumar, S. Haridass, and V. Krishnamurthy Anticancer activity of Punica Granatum rind extracts against human lung cancer cell line Asian J. Pharmaceut. Clin. Res. 5 2 2012 S204 S210
71. A.R. Jazieh, R. Al Sudairy, O. Abulkhair, and et al. Use of complementary and.alternative medicine by patients with cancer in Saudi Arabia J. Altern. Complement. Med. 18 11 2012 1045 1049
72. M.A.L. Jeune, J. Kumi-Diaka, and J. Brown Anticancer activities of pomegranate extracts and genistein in human breast cancer cells J. Med. Food 8 4 2005 469 475 PMID: 16379557
73. R. Johansen, and E.L. Toverud Norwegian cancer patients and the health food market-what is used and why? Tidsskr. Nor. Laege. 126 2006 773 775
74. M.M. Joseph, S.R. Aravind, S.K. George, S. Varghese, and T.T. Sreelekha A galactomannan apolysaccharide from Punica granatum imparts in vitro and in vivo anticancer activity Carbohydr. Polym. 98 2 2013 1466 1475 10.1016/j.carbpol.2013.07.023
75. M.M. Joseph, S.R. Aravind, S. Varghese, S. Mini, and T.T. Sreelekha Evaluation of antioxidant, antitumor and immunomodulatory properties of polysaccharide isolated from fruit rind of Punica granatum Mol. Med. Rep. 5 2 2012 489 496 10.3892/mmr. 2011.638
76. M.M. Joseph, S.R. Aravind, S.K. George, R.K. Pillai, S. Mini, and T.T. Sreelekha Co-encapsulation of doxorubicin with galactoxyloglucan nanoparticles for intracellular tumor-targeted delivery in murine ascites and solid tumors Transl. Oncol. 7 5 2014 525 536
77. M.E. Juan, U. Wenzel, H. Daniel, and J.M. Planas Erythrodiol, a natural triterpenoid from olives, has antiproliferative and apoptotic activity in HT-29 human adenocarcinoma cells Mol. Nutr. Food Res. 52 5 2008 595 599 10.1002/mnfr.200700300
78. K.H. Kim, H.J. Lee, S.J. Jeong, H.J. Lee, E.O. Lee, H.S. Kim, Y. Zhang, S.Y. Ryu, M.H. Lee, J. Lü, and S.H. Kim Galbanic acid isolated from Ferula assafoetida exerts in vivo anti-tumor activity in association with anti-angiogenesis and anti-proliferation Pharm. Res. 28 3 2011 597 609 10.1007/s11095-010-0311-7
79. S.H. Kim, J.M. Lee, S.C. Kim, C.B. Park, and P.C. Lee Proposed cytotoxic mechanisms of the saffron carotenoids crocin and crocetin on cancer cell lines Biochem. Cell Biol. 92 2 2014 105 111 10.1139/bcb-2013-0091
80. A. Kmail, B. Lyoussi, H. Zaid, and B. Saad In vitro assessments of cytotoxic and cytostatic effects of Asparagus aphyllus, Crataegus aronia, and Ephedra alata in monocultures and co-cultures of Hepg2 and THP-1-derived macrophages Pharmacog. Communication 5 2015 165 172
81. J. Knop, S. Misaka, K. Singer, E. Hoier, F. Müller, H. Glaeser, J. König, and M.F. Fromm Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein PLoS One 10 10 2015 10.1371/journal.pone.0139370 e0139370
82. M. Krstic, M. Marija Stojadinovic, K. Smiljanic, D. Stanic- Vucinic, and T.C. Velickovic The anti-cancer activity of green tea, coffee and cocoa extracts on human cervical adenocarcinoma HeLa cells depends on both pro-oxidant and anti-proliferative activities of polyphenols RSC Adv. 5 2015 3260 3268 10.1039/C4RA13230K
83. D.K. Kumar, M.A. Rathi, P. Meenakshi, L. Thirumoorthi, M. Sunitha, and V.K. Gopalakrishnan Anticancer activity of Cassia senna (L) against prostate carcinogenesis J. Pharm. Res. 3 12 2010 3028
84. R. Kuttan, P. Bhanumathy, K. Nirmala, and M.C. George Potential anticancer activity of turmeric (Curcuma longa) Cancer lett. 29 2 1985 197 202
85. C. Lau, K.D. Mooiman, R.F. Maas-Bakker, J.H. Beijnen, J.H. Schellens, and I. Meijerman Effect of Chinese herbs on CYP3A4 activity and expression in vitro J. Ethnopharmacol. 149 2013 543 549
86. W.S. Lee, S.M. Yi, J.W. Yun, J.H. Jung, D.H. Kim, H.J. Kim, S.H. Chang, G. Kim, C.H. Ryu, S.C. Shin, S.C. Hong, Y.H. Choi, and J.M. Jung Polyphenols isolated from Allium cepa L. induces apoptosis by induction of p53 and suppression of Bcl-2 through inhibiting PI3K/Akt signaling pathway in AGS human cancer cells J. Cancer Prev. 19 1 2014 14 22
87. M.R. Lee The history of Ephedra (ma-huang) J. R. Coll. Physicians Edinb. 41 1 2011 78 84
88. M. Lekehal, D. Pessayre, J.M. Lereau, C. Moulis, I. Fouraste, and D. Fau Hepatotoxicity of the herbal medicine germander: metabolic activation of its furano diterpenoids by cytochrome P450 3A depletes cytoskeleton associated protein thiols and forms plasma membrane blebs in rat hepatocytes Hepatology 24 1996 212 218
89. J.C. Leng, and F. Gany Traditional Chinese medicine use among Chinese immigrant cancer patients J. Cancer Educ. 29 2014 56 61
90. A.Y. Leung, and S. Foster Encyclopedia of Common Natural Ingredients Used in Food Drugs and Cosmetics 2nd ed. 1996 John Wiley & Sons, New York, NY
91. C.Y. Li, H.J. Du, X.H. Su, Y.J. Zhong, Z.P. Yuan, Y.F. Li, and et al. Juglanones A and B: two novel tetralone dimers from walnut pericarp (Juglans regia) Helvetica Chim. Acta 96 6 2013 1031 1035
92. Y.-P. Lim, C.-Y. Ma, C.-L. Liu, Y.-H. Lin, M.-L. Hu, J.-J. Chen, D.-Z. Hung, W.-T. Hsieh, and J.-D. Huang Sesamin: a naturally occurring lignan inhibits CYP3A4 by antagonizing the pregnane X receptor activation Evid. Based Complement. Altern. Med. 2012 2012 242810
93. L.C. Lin, M.N. Wang, and T.H. Tsai Food-drug interaction of (-)-epigallo- catechin-3-gallate on the pharmacokinetics of irinotecan and the metabolite SN-38 Chem. Biol. Interact. 174 2008 177 182
94. J. Loeper V. Descatoire, and P. Letteron Hepatotoxicity of germander in mice Gastroenterology 106 1994 464 472 86
95. J.A. MacDonald, M.E. Marchand, and R.F. Langler Improving upon the in vitro biological activity of antithrombotic disulfides Blood Coagul. Fibrinolysis 15 6 2004 447 450
96. B. Malaekeh-Nikouei, S.H. Mousavi, S. Shahsavand, S. Mehri, H. Nassirli, and S.A. Moallem Assessment of cytotoxic properties of safranal and nanoliposomal safranal in various cancer cell lines Phytother. Res. 27 12 2013 1868 1873 10.1002/ptr.4945
97. M. Mannel Drug interactions with St John's wort: mechanisms and clinical implications Drug. Saf. 27 2004 773 797
98. J.K. Mason, J. Chen, and L.U. Thompson Flaxseed oil-trastuzumab interaction in breast cancer Food Chem. Toxicol. 48 2010 2223 2226
99. Medenica, R., Janssens, J., Tarsenko, A., Lazovic, G., Corbitt, W., Powell, D., Jocic, D., 1997. Anti-angiogenic activity of Nigella sativa plant extract in cancer therapy. In: Proceedings of the Annual Meeting American Association for Cancer Research. 38, A1377
100. I. Meijerman, J.H. Beijnen, and J.H. Schellens Herb-drug interactions in oncology: focus on mechanisms of induction Oncologist 11 2006 742 752
101. T. Melchardt, T. Magnes, L. Weiss, M. Grundbichler, M. Strasser, and et al. Liver toxicity during temozolomide chemotherapy caused by Chinese herbs BMC Complement. Altern. Med. 14 2014 115
102. M. Michaelis, J. Vogel, and J. Cinatl Cytotoxicity of aphidicolin and its derivatives against neuroblastoma cells in vitro: synergism with doxorubicin and vincristine Anticancer Drugs 11 2000 479 485
103. A. Molassiotis, V. Panteli, E. Patiraki, G. Ozden, N. Platin, E. Madsen, and et al. Complementary and alternative medicine use in lung cancer patients in eight European countries Complement. Ther. Clin. Pract. 12 2006 34 39
104. A. Montazeri, A. Sajadian, M. Ebrahimi, and et al. Factors predicting the use of complementary and alternative therapies among cancer patients in Iran Eur. J. Cancer Care (Engl.) 16 2 2007 144 149
105. A. Munshi, L.H. Ni, and M.S. Tiwana Complementary and alternative medicine in present day oncology care: promises and pitfalls Jpn. J. Clin. Oncol. 38 2008 512 520
106. Natural Medicines Comprehensive Database. Home page. (http://naturaldatabase.therapeuticresearch.com/home.aspx?cs=&s=ND&AspxAutoDetectCookieSupport=1). (accessed 17.12.15).
107. S.K. Noureini, and M. Wink Antiproliferative effects of crocin in HepG2 cells by telomerase inhibition and hTERT down-regulation Asian Pac. J. Cancer Prev. 13 5 2012 2305 2309 PMID: 22901211
108. E.A. Offord, K. Macé, O. Avanti, and A.M. Pfeifer Mechanisms involved in the chemoprotective effects of rosemary extract studied in human liver and bronchial cells Cancer Lett. 114 1997 275 281
109. Palestinian Health Information Center, Ministry of Health, 2015. Health status in Palestine 2010-2014. Nablus: Ministry of Health.
110. O. Paltiel, M. Avitzour, T. Peretz, and et al. Determinants of the use of complementary therapies by patients with cancer J. Clin. Oncol. 19 9 2001 2439 2448
111. G.H. Park, J.H. Park, H.M. Song, H.J. Eo, M.K. Kim, J.W. Lee, Lee M.H., K.H. Cho, J.R. Lee, H.J. Cho, and J.B. Jeong Anti-cancer activity of Ginger (Zingiber officinale) leaf through the expression of activating transcription factor 3 in human colorectal cancer cells BMC Complement. Altern. Med. 14 2014 408 10.1186/1472-6882-14-408
112. N.J. Pearson, and M.A. Chesney The CAM education program of the national center for complementary and alternative medicine: an overview. Acad. Med. J. Assoc. Am. Med. Coll. 82 2007 921 926
113. A. Petroni, M. Blasevich, M. Salami, and et al. Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil Thromb. Res. 78 1995 151 160
114. S.C. Piscitelli, A.H. Burstein, N. Welden, and et al. The effect of garlic supplements on the pharmacokinetics of saquinavir Clin. Infect. Dis. 34 2002 234 238
115. C.A. Plouzek, H.P. Ciolino, R. Clarke, and G.C. Yeh Inhibition of P-glycoprotein activity and reversal of multidrug resistance in vitro by rosemary extract Eur. J. Cancer 35 10 1999 1541 1545
116. M. Pradhan, S. Sribhuwaneswari, D. Karthikeyan, and et al. In-vitro cytoprotection activity of Foeniculum vulgare and Helicteres isora in cultured human blood lymphocytes and antitumour activity against B16F10 melanoma cell line Res. J. Pharm. Technol. 1 4 2008 450 452
117. E. Prakash, and D.K. Gupta Cytotoxic activity of ethanolic extract of Cuminum cyminum Linn against seven human cancer cell line Uni. J. Agri. Res. 2 1 2014 27 30 10.13189/ujar.2014.020104
118. S. Raimondo, F. Naselli, S. Fontana, F. Monteleone, A. Lo Dico, L. Saieva, G. Zito, A. Flugy, M. Manno, M.A. Di Bella, G. De Leo, and R. Alessandro Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death Oncotarget 6 23 2015 19514 19527
119. M. Rastgoo, H. Hosseinzadeh, H. Alavizadeh, A. Abbasi, Z. Ayati, and M.R. Jaafari Antitumor activity of PEGylated nanoliposomes containing crocin in mice bearing C26 colon carcinoma Planta Med. 79 6 2013 447 451 10.1055/s-0032-1328363
120. J.L. Raucy Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products Drug. Metab. Dispos. 31 2003 533 539
121. F.J. Reyes-Zurita, G. Pachón-Peña, D. Lizárraga, E.E. Rufino-Palomares, M. Cascante, and J.A. Lupiáñez The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism BMC Cancer 11 2011 10.1186/1471-2407-11-154
122. R. Rezaee, K. Jamialahmadi, B.R. Zanjani, M. Mahmoudi, K. Abnous, S.Z.T. Rabe, and et al. Crocin effects on human myeloma cells regarding intracellular redox state, DNA fragmentation, and apoptosis or necrosis profile Jundishapur J. Nat. Pharma. Prod. 9 4 2014 PMID: 25625054
123. M. Roth, B.N. Timmermann, and B. Hagenbuch Interactions of green tea catechins with organic anion-transporting polypeptides Drug. Metab. Dispos. 39 2011 920 926
124. S.M. Sacco, K.A. Power, J. Chen, W.E. Ward, and L.U. Thompson Interaction of sesame seed and tamoxifen on tumor growth and bone health in athymic mice Exp. Biol. Med. 232 6 2007 754 761
125. E.M. Saleh, R.A. El-awady, N.A. Eissa, and W.M. Abdel-Rahman Antagonism between curcumin and the topoisomerase II inhibitor etopo- side: a study of DNA damage, cell cycle regulation and death pathways Cancer Biol. Ther. 13 2012 1058 1071
126. E.I. Salim, and S. Fukushima Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis Nutr. Cancer 45 2003 195 202
127. M. Salimi, M.H. Ardestaniyan, K.H. Mostafapour, S. Saeidnia, A.R. Gohari, A. Amanzadeh, and et al. Anti-proliferative and apoptotic activities of constituents of chloroform extract of Juglans regia leaves Cell Prolif. 47 2 2014 172 179
128. M. Salimi, A. Majd, Z. Sepahdar, K. Azadmanesh, S. Irian, M.H. Ardestaniyan, and et al. Cytotoxicity effects of various Juglans regia (walnut) leaf extracts in human cancer cell lines Pharm. Biol 50 11 2012 1416 1422 10.3109/13880209.2012.682118
129. S. Samarghandian, M.H. Boskabady, and S. Davoodi Use of in vitro assays to assess the potential antiproliferative and cytotoxic effects of saffron (Crocus sativus L.) in human lung cancer cell line Pharmacogn. Mag. 6 24 2010 309 314 10.4103/0973-1296.71799
130. S. Samarghandian, and M.M. Shabestari DNA fragmentation and apoptosis induced by safranal in human prostate cancer cell line Indian J. Urol. 29 3 2013 177 183
131. R. Segal, and L. Pilote Research warfarin interaction with Matricaria chamomilla Can. Med. Assoc. J. 174 9 2006 1281 1282
132. M.J. Sewitch, and Y.A. Rajput Literature review of complementary and alternative medicine use by colorectal cancer patients Complement. Ther. Clin. Pract. 16 2010 52 56
133. W.N. Shebaby, M. Mroueh, K. Bodman-Smith, A. Mansour, R.I. Taleb, C.F. Daher, and M. El-Sibai Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells BMC Complement. Altern. Med 14 2014 387
134. S.E. Singletary, G.L. Robb, and G.N. Hortobagy Advanced Therapy of Breast Disease 2004 BC Decker Inc Hamilton
135. H.B. Sowbhagya Chemistry, technology, and nutraceutical functions of cumin (Cuminum cyminum L): an overview Crit. Rev. Food Sci. Nutr. 53 1 2013 1 10
136. K.C. Srivastava Extracts from two frequently consumed spices: cumin (Cuminum cyminum) and turmeric (Curcuma longa) inhibit platelet aggregation and alter eicosanoid biosynthesis in human blood platelets Prostaglandins Leukot. Essent. Fat Acids 37 1989 57 64
137. M.B. Stargrove, J. Treasure, and D.L. McKee Herb Nutrient, and Drug Interactions: Clinical Implications and Therapeutic Strategies 2007 Elsevier, USA
138. S. Subehan, S.F. Zaidi, S. Kadota, and Y. Tezuka Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanism-based inactivator J. Agric. Food Chem. 55 25 2008 10162 10167
139. M. Szewczyk, S. Abarzua, A. Schlichting, B. Nebe, B. Piechulla, V. Briese, and D.U. Richter Effects of extracts from Linum usitatissimum on cell vitality, proliferation and cytotoxicity in human breast cancer cell lines J. Med. Plants Res. 8 5 2014 237 245
140. A. Tachjian, M. Viqar, and J. Arshad Use of Herbal Products and Potential Interactions in Patients with Cardiovascular Diseases J. Am. Coll. Cardiol. 55 2010 515 525
141. M. Tascilar, F.A. de Jong, J. Verweij, and R.H. Mathijssen Complementary and alternative medicine during cancer treatment: beyond innocence Oncologist 11 2006 732 741 10.1634/theoncologist.11-7-732
142. M. Tognolini, V. Ballabeni, S. Bertoni, R. Bruni, M. Impicciatore, and E. Barocelli Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis Pharmacol. Res. 56 2007 254 260
143. A. Trimborn, B. Senf, K. Muenstedt, and et al. Working group prevention and Integrative Oncology of the German Cancer Society. Attitude of employees of a university clinic to complementary and alternative medicine in oncology Ann. Oncol. 24 2013 2641 2645
144. S. Tuna, O. Dizdar, and M. Calis The prevalence of usage of herbal medicines among cancer patients J. Buon. 18 2013 1048 1051
145. M. Walia, T.S. Mann, D. Kumar, V. Agnihotri, and B. Singh Chemical composition and in vitro cytotoxic activity of essential oil of leaves of Malus domestica growing in Western Himalaya (India) Evid. Based Complement. Altern. Med. 2012 2012 649 727
146. M. Wazaify, F.U. Afifi, M. El-Khateeb, and K. Ajlouni Complementary and alternative medicine use among Jordanian patients with diabetes Complement. Ther. Clin. Pract. 17 2011 71 75
147. M. Wazaify, I. Alawwa, N. Yasein, A. Al-Saleh, and F.U. Afifi Complementary and alternative medicine (CAM) use among Jordanian patients with chronic diseases Complement. Ther. Clin. Pract. 2013 10.1016/ j.ctcp.2013.03.001
148. U. Werneke, J. Earl, C. Seydel, O. Horn, P. Crichton, and D. Fannon Potential health risks of complementary and alternative medicine in cancer patients Br. J. Cancer 90 2004 408 413
149. U. Werneke, T. Turner, and S. Priebe Complementary medicines in psychiatry: review of effectiveness and safety Br. J. Psychiatry 188 2006 109 121
150. J.H. Wirth, J.C. Hudgins, and J.A. Paice Use of herbal therapies to relieve pain: a review of ef?cacy and adverse effects Pain Manag. Nurs. 4 2005 145 167
151. A.D. Woolf, W.A. Watson, S. Smolinske, and T. Litovitz The severity of toxic reactions to ephedra: comparisons to other botanical products and national trends from 1993-2002 Clin. Toxicol. (Phila.) 43 5 2005 347 355
152. C.P.R. Xavier, C.F. Lima, M. Fernandes-Ferreira, and C. Pereira-Wilson Salvia fruticosa, Salvia officinalis, and rosmarinic acid induce apoptosis and inhibit proliferation of human colorectal cell lines: the role in MAPK/ERK pathway Nutr. Cancer 61 4 2009 564 571 10.1080/01635580802710733
153. O. Yesil-Celiktas, C. Sevimli, E. Bedir, and F. Vardar-Sukan Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines Plant Foods Hum. Nutr. 65 2010 158 163
154. I. Yildiz, M. Ozguroglu, T. Toptas, and et al. Patterns of complementary and alternative medicine use among Turkish cancer patients J. Palliat. Med. 16 4 2013 383 390
155. G.G. Yue, S.W. Cheng, H. Yu, and et al. The role of turmerones on curcumin transportation and P-glycoprotein activities in intestinal Caco-2 cells J. Med. Food 15 2012 242 252
156. R. Zaini, S.L. Haywood-Small, N.A. Cross, and C.L. Le Maitre Differential interactions of falcarinol combined with anti-tumour agents on cellular proliferation and apoptosis in human lymphoid leukaemia cell lines J. Blood Disord. Transf. 6 2 2015 1 9
157. A. Zaoui, Y. Cherrah, N. Mahassini, K. Alaoui, H. Amarouch, and M. Hassar Acute and chronictoxicity of Nigella sativafixedoil Phytomed 9 2002 69 74
158. L. Zhang, Y.D. Zhang, P. Zhao, and S.M. Huang Predicting drug-drug interactions: an FDA perspective AAPS J. 11 2009 300 306