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Volumn 13, Issue 5, 2012, Pages 2305-2309

Antiproliferative effects of crocin in HepG2 cells by telomerase inhibition and hTERT down-regulation

Author keywords

Crocin; Hepatocarcinoma; hTERT; Telomerase

Indexed keywords

CAROTENOID; CROCIN; TELOMERASE; TERT PROTEIN, HUMAN;

EID: 84872686984     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2012.13.5.2305     Document Type: Article
Times cited : (99)

References (46)
  • 1
    • 9644268896 scopus 로고    scopus 로고
    • Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials
    • Abdullaev FI, Espinosa-Aguirre JJ (2004). Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. Cancer Detect Prev, 28, 426-32.
    • (2004) Cancer Detect Prev , vol.28 , pp. 426-432
    • Abdullaev, F.I.1    Espinosa-Aguirre, J.J.2
  • 2
    • 0242266951 scopus 로고    scopus 로고
    • Use of in vitro assays to assess the potential antigenotoxic and cytotoxic effects of saffron (Crocus sativus L
    • 3n-Negrete L, Caballero-Ortega H, et al (2003). Use of in vitro assays to assess the potential antigenotoxic and cytotoxic effects of saffron (Crocus sativus L.). Toxicol In Vitro, 17, 731-6.
    • (2003) Toxicol In Vitro , vol.17 , pp. 731-736
    • Abdullaev, F.I.1    Riverān-Negrete, L.2    Caballero-Ortega, H.3
  • 4
    • 10444231865 scopus 로고    scopus 로고
    • Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression, A pilot double-blind randomized trial
    • Akhondzadeh S, Fallah-Pour H, Afkham K, et al (2004). Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression, A pilot double-blind randomized trial. BMC Complementary Alternative Med, 4, 12,
    • (2004) BMC Complementary Alternative Med , vol.4 , pp. 12
    • Akhondzadeh, S.1    Fallah-Pour, H.2    Afkham, K.3
  • 5
    • 36749043785 scopus 로고    scopus 로고
    • Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells
    • Aung HH, Wang CZ, Ni M, et al (2007). Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells. Exp Oncol, 29, 175-80.
    • (2007) Exp Oncol , vol.29 , pp. 175-180
    • Aung, H.H.1    Wang, C.Z.2    Ni, M.3
  • 6
    • 78650715139 scopus 로고    scopus 로고
    • DNA fragmentation and cell cycle arrest, A Hallmark of apoptosis induced by crocin from Kashmiri saffron in a human pancreatic cancer cell line
    • Bakshi H, Sam S, Rozati R, et al (2010). DNA fragmentation and cell cycle arrest, A Hallmark of apoptosis induced by crocin from Kashmiri saffron in a human pancreatic cancer cell line. Asian Pacific J Cancer Prev, 11, 675-9.
    • (2010) Asian Pacific J Cancer Prev , vol.11 , pp. 675-679
    • Bakshi, H.1    Sam, S.2    Rozati, R.3
  • 7
    • 77952317000 scopus 로고    scopus 로고
    • Crocin from Kashmiri saffron (Crocus sativus) induces in vitro and in vivo xenograft growth inhibition of Dalton's lymphoma (DLA) in mice
    • Bakshi HA, Sam S, Feroz A, et al (2009). Crocin from Kashmiri saffron (Crocus sativus) induces in vitro and in vivo xenograft growth inhibition of Dalton's lymphoma (DLA) in mice. Asian Pac J Cancer Prev, 10, 887-90.
    • (2009) Asian Pac J Cancer Prev , vol.10 , pp. 887-890
    • Bakshi, H.A.1    Sam, S.2    Feroz, A.3
  • 8
    • 0003893137 scopus 로고
    • Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
    • Blackburn E, Greider C (1995). Telomeres. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
    • (1995) Telomeres
    • Blackburn, E.1    Greider, C.2
  • 9
    • 0035929353 scopus 로고    scopus 로고
    • Switching and signaling at the telomere
    • Blackburn EH (2001). Switching and signaling at the telomere. Cell, 106, 661-73.
    • (2001) Cell , vol.106 , pp. 661-673
    • Blackburn, E.H.1
  • 10
    • 0025685414 scopus 로고
    • Rapid chemosensitivity assay with human normal and tumor cells in vitro
    • Borenfreund E, Bbich H, Martin-Alguacil N, (1990). Rapid chemosensitivity assay with human normal and tumor cells in vitro. In Vitro Cell Dev Biol, 26, 1030-4.
    • (1990) In Vitro Cell Dev Biol , vol.26 , pp. 1030-1034
    • Borenfreund, E.1    Bbich, H.2    Martin-Alguacil, N.3
  • 11
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem, 72, 248-54.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 12
    • 33847666566 scopus 로고    scopus 로고
    • Inhibition of breast cancer cell proliferation by style constituents of different Crocus species
    • Chryssanthi DG, Lamari FN, Iatrou G, et al (2007). Inhibition of breast cancer cell proliferation by style constituents of different Crocus species. Anticancer Res, 27, 357-62.
    • (2007) Anticancer Res , vol.27 , pp. 357-362
    • Chryssanthi, D.G.1    Lamari, F.N.2    Iatrou, G.3
  • 13
    • 4243937106 scopus 로고    scopus 로고
    • A highly selective telomerase inhibitor limiting human cancer cell proliferation
    • Damm K, Hemmann U, Garin-Chesa P, et al (2001). A highly selective telomerase inhibitor limiting human cancer cell proliferation. The EMBO J, 20, 6958-68.
    • (2001) The EMBO J , vol.20 , pp. 6958-6968
    • Damm, K.1    Hemmann, U.2    Garin-Chesa, P.3
  • 14
    • 77956152672 scopus 로고    scopus 로고
    • ibrillation of alpha-lactalbumin: effect of crocin and safranal, two natural small molecules from Crocus sativus
    • Ebrahim-Habibi MB, Amininasab M, Ebrahim-Habibi A, et al. (2010) Fibrillation of alpha-lactalbumin: effect of crocin and safranal, two natural small molecules from Crocus sativus. Biopolymers. 93, 854-65.
    • (2010) Biopolymers , vol.93 , pp. 854-865
    • Ebrahim-Habibi, M.B.1    Amininasab, M.2    Ebrahim-Habibi, A.3    et, al..4
  • 16
    • 80052035361 scopus 로고    scopus 로고
    • rotective effects of saffron extract and its active constituent crocin against oxidative stress and spatial learning andmemory deficits induced by chronic stress in rats
    • Ghadrdoost B, Vafaei AA, Rashidy-Pour A, et al (2011) Protective effects of saffron extract and its active constituent crocin against oxidative stress and spatial learning andmemory deficits induced by chronic stress in rats. Eur J Pharmacol, 667, 222-9.
    • (2011) Eur J Pharmacol , vol.667 , pp. 222-229
    • Ghadrdoost, B.1    Vafaei, A.A.2    Rashidy-Pour, A.3
  • 17
    • 0343673898 scopus 로고    scopus 로고
    • Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1
    • Gunes C, Lichtsteiner S, Vasserot AP, et al (2000). Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1. Cancer Res, 60, 2116-21.
    • (2000) Cancer Res , vol.60 , pp. 2116-2121
    • Gunes, C.1    Lichtsteiner, S.2    Vasserot, A.P.3
  • 18
    • 0032828652 scopus 로고    scopus 로고
    • Inhibition of telomerase limits the growth of human cancer cells
    • Hahn WC, Stewart SA, Brooks MW, et al (1999). Inhibition of telomerase limits the growth of human cancer cells. Nature Med, 5, 1164-70.
    • (1999) Nature Med , vol.5 , pp. 1164-1170
    • Hahn, W.C.1    Stewart, S.A.2    Brooks, M.W.3
  • 19
    • 79954996502 scopus 로고    scopus 로고
    • The effect of crocin and safranal, constituents of saffron, against subacute effect of diazinon on hematological and genotoxicity indices in rats
    • Hariri AT, Moallem SA, Mahmoudi M, et al (2011). The effect of crocin and safranal, constituents of saffron, against subacute effect of diazinon on hematological and genotoxicity indices in rats. Phytomedicine, 18, 499-504.
    • (2011) Phytomedicine , vol.18 , pp. 499-504
    • Hariri, A.T.1    Moallem, S.A.2    Mahmoudi, M.3
  • 20
    • 0029131243 scopus 로고
    • Telomerase activity in gastric cancer
    • Hiyama E, Yokoyama T, Tatsumoto N, et al (1995). Telomerase activity in gastric cancer. Cancer Res, 55, 3258-62.
    • (1995) Cancer Res , vol.55 , pp. 3258-3262
    • Hiyama, E.1    Yokoyama, T.2    Tatsumoto, N.3
  • 21
    • 84858005351 scopus 로고    scopus 로고
    • Effects of saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats
    • Hosseinzadeh H, Sadeghnia HR, Ghaeni FA, et al (2012) Effects of saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats. Phytother Res, 26, 381-6.
    • (2012) Phytother Res , vol.26 , pp. 381-386
    • Hosseinzadeh, H.1    Sadeghnia, H.R.2    Ghaeni, F.A.3
  • 22
    • 0035104256 scopus 로고    scopus 로고
    • Real-time quantitative telomeric repeat amplification protocol assay for the detection of telomerase activity
    • Hou M, Dawei X, Bjorkholm M, et al (2001). Real-time quantitative telomeric repeat amplification protocol assay for the detection of telomerase activity. Clin Chem, 47, 519-24
    • (2001) Clin Chem , vol.47 , pp. 519-524
    • Hou, M.1    Dawei, X.2    Bjorkholm, M.3
  • 23
    • 0034733606 scopus 로고    scopus 로고
    • Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhang
    • Huffman KE, Levene SD, Tesmer VM, et al (2000). Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhang. J Biol Chem, 26, 19719-22.
    • (2000) J Biol Chem , vol.26 , pp. 19719-19722
    • Huffman, K.E.1    Levene, S.D.2    Tesmer, V.M.3
  • 24
    • 84874089673 scopus 로고    scopus 로고
    • Telomerase activity in Iranian patients with esophageal squamous cell carcinoma
    • Kazemi Noureini S, Ziaee AA, Rastegar-Jazii F, et al (2004). Telomerase activity in Iranian patients with esophageal squamous cell carcinoma. Med J Islamic Republic Iran, 2, 147-52.
    • (2004) Med J Islamic Republic Iran , vol.2 , pp. 147-152
    • Noureini, S.K.1    Ziaee, A.A.2    Rastegar-Jazii, F.3
  • 25
    • 70349579537 scopus 로고    scopus 로고
    • Transcriptional down regulation of hTERT and induction of senescence in HepG2 cells by the benzophenanthridine alkaloid chelidonine
    • Kazemi Noureini S, Wink M (2009). Transcriptional down regulation of hTERT and induction of senescence in HepG2 cells by the benzophenanthridine alkaloid chelidonine. World J Gastroenterol, 15, 3603-10.
    • (2009) World J Gastroenterol , vol.15 , pp. 3603-3610
    • Noureini, S.K.1    Wink, M.2
  • 26
    • 0032566005 scopus 로고    scopus 로고
    • Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA
    • Kondo S, Kondo Y, Li G, et al (1998). Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA. Oncogene, 16, 3323-30.
    • (1998) Oncogene , vol.16 , pp. 3323-3230
    • Kondo, S.1    Kondo, Y.2    Li, G.3
  • 27
    • 40049097782 scopus 로고    scopus 로고
    • Anti-carcinogenic activities of natural pigments from beet root and saffron
    • Konoshima T, Takasaki M (2003). Anti-carcinogenic activities of natural pigments from beet root and saffron. Foods Food Ingredients J, 208, 615-22.
    • (2003) Foods Food Ingredients J , vol.208 , pp. 615-622
    • Konoshima, T.1    Takasaki, M.2
  • 28
    • 3142661809 scopus 로고    scopus 로고
    • Inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA
    • Li S, Rosenberg J, Donjacour A, et al (2004). Inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA. Cancer Res, 64, 4833-40.
    • (2004) Cancer Res , vol.64 , pp. 4833-4840
    • Li, S.1    Rosenberg, J.2    Donjacour, A.3
  • 29
    • 0035300424 scopus 로고    scopus 로고
    • Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase
    • Ludwig A, Saretzki G, Holm PS, et al (2001). Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase. Cancer Res, 61, 3053-61.
    • (2001) Cancer Res , vol.61 , pp. 3053-3061
    • Ludwig, A.1    Saretzki, G.2    Holm, P.S.3
  • 30
    • 84864649588 scopus 로고    scopus 로고
    • europrotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells
    • Mehri S, Abnous K, Mousavi SH, et al (2012) Neuroprotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells. Cell Mol Neurobiol, 32, 227-35.
    • (2012) Cell Mol Neurobiol , vol.32 , pp. 227-235
    • Mehri, S.1    Abnous, K.2    Mousavi, S.H.3
  • 31
    • 0035853164 scopus 로고    scopus 로고
    • Telomerase inhibitors based on quadruplex ligands selected by a fluorescent assay
    • Mergny JL, Lacroix L, Teulade-Fichou MP, et al (2001). Telomerase inhibitors based on quadruplex ligands selected by a fluorescent assay. Proc Natl Acad Sci USA, 98, 3062-7.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3062-3067
    • Mergny, J.L.1    Lacroix, L.2    Teulade-Fichou, M.P.3
  • 32
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival, application to proliferation and cytotoxicity assays
    • Mosmann T (1983). Rapid colorimetric assay for cellular growth and survival, application to proliferation and cytotoxicity assays. J Immunol Methods, 65, 55-63.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 33
    • 80053057926 scopus 로고    scopus 로고
    • mprovement of cytotoxic and apoptogenic properties of crocin in cancer cell lines by its nanoliposomal form
    • Mousavi SH, Moallem SA, Mehri S, et al (2011) Improvement of cytotoxic and apoptogenic properties of crocin in cancer cell lines by its nanoliposomal form. Pharm Biol, 49, 1039-45.
    • (2011) Pharm Biol , vol.49 , pp. 1039-1045
    • Mousavi, S.H.1    Moallem, S.A.2    Mehri, S.3
  • 34
    • 0028834324 scopus 로고
    • Saffron chemoprevention in biology and medicine, a review
    • Nair SC, Kurumboor SK, Hasegawa JH (1995). Saffron chemoprevention in biology and medicine, a review. Cancer Biother, 10, 257-64.
    • (1995) Cancer Biother , vol.10 , pp. 257-264
    • Nair, S.C.1    Kurumboor, S.K.2    Hasegawa, J.H.3
  • 35
    • 4143124424 scopus 로고    scopus 로고
    • Antitumor activity of systemically delivered ribozymes targeting murine telomerase RNA
    • Nosrati M, Li S, Bagheri S, et al (2004). Antitumor activity of systemically delivered ribozymes targeting murine telomerase RNA. Clinical Cancer Res, 10, 4983-90.
    • (2004) Clinical Cancer Res , vol.10 , pp. 4983-4990
    • Nosrati, M.1    Li, S.2    Bagheri, S.3
  • 36
    • 33847151661 scopus 로고    scopus 로고
    • Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo
    • Ochiai T, Shimeno H, Mishima K, et al (2006). Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo. Biochim Biophys Acta, 1770, 578-84.
    • (2006) Biochim Biophys Acta , vol.1770 , pp. 578-584
    • Ochiai, T.1    Shimeno, H.2    Mishima, K.3
  • 37
    • 33751305217 scopus 로고    scopus 로고
    • Inhibitory activity on amyloid-beta aggregation and antioxidant properties of Crocus sativus stigmas extract and its crocin constituents
    • Papandreou MA, Kanakis CD, Polissiou MG, et al (2006). Inhibitory activity on amyloid-beta aggregation and antioxidant properties of Crocus sativus stigmas extract and its crocin constituents. J Agric Food Chem, 54, 8762-8.
    • (2006) J Agric Food Chem , vol.54 , pp. 8762-8768
    • Papandreou, M.A.1    Kanakis, C.D.2    Polissiou, M.G.3
  • 38
    • 0005377589 scopus 로고    scopus 로고
    • Antioxidant properties of crocin from Gardenia jasminoides Ellis and study of the reactions of crocin with linoleic acid and crocin with oxygen
    • Pham TQ, Cormier F, Farnworth E, et al (2000). Antioxidant properties of crocin from Gardenia jasminoides Ellis and study of the reactions of crocin with linoleic acid and crocin with oxygen. J Agric Food Chem, 48, 1455-61.
    • (2000) J Agric Food Chem , vol.48 , pp. 1455-1461
    • Pham, T.Q.1    Cormier, F.2    Farnworth, E.3
  • 39
    • 34548445132 scopus 로고    scopus 로고
    • Saffron in phytotherapy, pharmacology and clinical uses
    • Schmidt M, Betti G, Hensel A (2007). Saffron in phytotherapy, pharmacology and clinical uses. Wien Med Wochenschr, 157, 315-9.
    • (2007) Wien Med Wochenschr , vol.157 , pp. 315-319
    • Schmidt, M.1    Betti, G.2    Hensel, A.3
  • 40
    • 0036782884 scopus 로고    scopus 로고
    • Telomerase, a target for cancer therapeutics
    • Shay JW, Wright WE (2002). Telomerase, a target for cancer therapeutics. Cancer Cell, 2, 257-65.
    • (2002) Cancer Cell , vol.2 , pp. 257-265
    • Shay, J.W.1    Wright, W.E.2
  • 41
    • 0038056347 scopus 로고    scopus 로고
    • Telomerase modulates expression of growth-controlling genes and enhances cell proliferation
    • Smith LL, Coller HA, Roberts JM (2003). Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat Cell Biol, 5, 474-9.
    • (2003) Nat Cell Biol , vol.5 , pp. 474-479
    • Smith, L.L.1    Coller, H.A.2    Roberts, J.M.3
  • 42
    • 0014370790 scopus 로고
    • Broadening by acridine orange of the thermal transition of DNA
    • Stewart CR (1968). Broadening by acridine orange of the thermal transition of DNA. Biopolymers, 6, 1737-43.
    • (1968) Biopolymers , vol.6 , pp. 1737-1743
    • Stewart, C.R.1
  • 43
    • 84863231369 scopus 로고    scopus 로고
    • Crocin inhibits proliferation and nucleic acid synthesis and induces apoptosis in the human tongue squamous cell carcinoma cell line Tca8113
    • Sun J, Xu X, Ni C, et al (2011). Crocin inhibits proliferation and nucleic acid synthesis and induces apoptosis in the human tongue squamous cell carcinoma cell line Tca8113. Asian Pac J Cancer Prev, 12, 2679-83.
    • (2011) Asian Pac J Cancer Prev , vol.12 , pp. 2679-2683
    • Sun, J.1    Xu, X.2    Ni, C.3
  • 44
    • 62949154770 scopus 로고    scopus 로고
    • Mind-Altering and Poisonous Plants of the World
    • Briza Publications, Pretoria, Medpharm Publishers, Germany, Timber Press, USA
    • Wink M, Van Wyk BE (2008). Mind-Altering and Poisonous Plants of the World, Briza Publications, Pretoria, Medpharm Publishers, Germany, Timber Press, USA.
    • (2008)
    • Wink, M.1    Van Wyk, B.E.2
  • 45
    • 18744386160 scopus 로고    scopus 로고
    • Telomere and telomerase as targets for anti-cancer and regeneration therapies
    • Yi-hsin HSU, Jing-jer LIN (2005). Telomere and telomerase as targets for anti-cancer and regeneration therapies. Acta Pharmacologica Sinica, 26, 513-8
    • (2005) Acta Pharmacologica Sinica , vol.26 , pp. 513-518
    • Yi-hsin, H.S.U.1    Jing-jer, L.I.N.2
  • 46
    • 33847190347 scopus 로고    scopus 로고
    • Effects of crocin on reperfusion-induced oxidative/nitrative injury to cerebral microvessels after global cerebral ischemia
    • Zheng YQ, Liu JX, Wang JN, et al (2006). Effects of crocin on reperfusion-induced oxidative/nitrative injury to cerebral microvessels after global cerebral ischemia. Brain Res, 1138, 86-94.
    • (2006) Brain Res , vol.1138 , pp. 86-94
    • Zheng, Y.Q.1    Liu, J.X.2    Wang, J.N.3


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