The toxic effect of alcoholic extract of Citrullus colocynthis on rat liver

Iranian Journal of Pharmacology and Therapeutics

Volumn 5, Issue 2, 2006, Pages 117-119

  Dehghani, Farzaneh ^a   Panjehshahin, Mohammad Reza ^b  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Citrullus colocynthis; Liver; Necrosis

Indexed keywords

COLOCYNTH; RETICULINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MEGADOSE; LIVER; LIVER CELL; LIVER FIBROSIS; LIVER PARENCHYMA; LIVER TOXICITY; LYMPHOCYTIC INFILTRATION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; RAT; WATERMELON;

EID: 40149101679     PISSN: 17352657     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Diwan FH, Abdel-Hassan IA, Mohammed ST. Effect of Saponin on mortality and histopathological changes in mice. Eastern Mediterranean Health Journal. 2000;6(2-3):345-351.
2. Nmila R, Gross R, Rchid H, Roye M, Manteghetti M, Petit P, Tijane Ribes G, Sauvaire Y. Insulinotropic effet of Citrullus colocynthis fruit extracts. Planta Med. 2000;66(5):418-23.
3. Bendeddou D, Lalaoui K, Satta D. Immunostimulating activity of the hot water-soluble polysaccharide extracts of Anacyclus Pyrethrum, Alpinia galanga and Citrullus colocynthis. J Ethnopharmacol. 2003;88(2-3):155-60.
4. el-Naggar ME, Abdel-Sattar MM, Mosallam SS. Toxicity of colocynithin and hydrated colocynithin from alcoholic extract of Citrullus colocynthis pulp. J Egypt Soc Parasitol. 1989;19(1):179-85.
5. Elawad AA, Abdel Bari EM, Mahmoud OM, Adam SE. The effect of Citrullus colocynthis on sheep. Vet Hum Toxicol. 1984;26(6):481-5.
6. Barri ME, Onsa TO, Elawad AA, Elsayed NY, Wasfi IA, Abdel Bari EM, Adam SE.Toxicity of five Sudanese plants to young ruminants. J Comp Pathol. 1983;93(4):559-675.
7. Golfain D, Lavergne A, Galian A, Chauveinc L, Prudhomme F. Peculiar acute colitis after ingestion of colocynth: a clinicopathological study of three cases. Gut. 1989;30(10):1412-8.
8. Chaturvedi M, Mali PC, Ansari AS. Induction of reversible antifertility with a crude ethanol extract of Citrullus colocynthis schrad fruit in male rats. Pharmacology. 2003;68(1):38-48.
9. Barth A, Muller D, Durrling K. In vitro investigation of a standardized dried extract of Citrullus colocynthis on liver toxicity in adult rats. Exp Toxicol Pathol. 2002;54(3):223-30.
10. Knodell RG, Ishak KG, Black WC, Chen TS, Graig R, Kaplowitz N, Kiernan TW, Wollman J. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. J Hepatol. 2003;38(4):382-6.
11. Larry D. Hepatotxicity of herbal remedies. Hepatol. 1997;26(1):47-51.
12. Chitturi S, Farrell GC.Hebal hepatotoxicity: An expanding but poorly defined problem. J Gastroenterol Hepatol. 2000;15:1093-1099.
13. Adam SE,Al Yahya MA, Al Farhan AH. Combined toxicity of Cassia senna and Citrullus colocynthis in rats. Ven Hum Toxicol. 2001;43(2):70-2
14. Itzhaki O, Skutelsky E, Kaptzan T, Sinai , Michowitz M, Huszar M, Leibovici J. Ageing-apoptosis relation in murine spleen. Mech Ageing Dev. 2003;124(10- 12):999-1012.
15. Israeli BA, Bogin E. Biochemical changes in liver, kidney and blood associated with common bile duct ligation. Clin Chim Acta. 1986;160(2):211-21.
16. Ryvniak VV. Acid phosphatase distribution in the liver in cirrhosis. Bull Eksp Biol Med. 1986;101(3):363-5
17. Chaturvedi M, Mali PC, Ansari AS. Induction of reversible antifertility with a crude ethanol extract of Citrullus colocynthis schrad fruit in male rats. Pharmacology. 2003;68(1):38-48.
18. Shivakumar Chitturi, Geoffrey C Farrell. Herbal hepatotoxicity : An expanding but poorly defined problem . J Gastroenterol Hepatol. 2000:15;1093-1099.