Antitumor activity of PEGylated nanoliposomes containing crocin in mice bearing C26 colon carcinoma

Planta Medica

Volumn 79, Issue 6, 2013, Pages 447-451

  Rastgoo, Marziyeh ^a   Hosseinzadeh, Hossein ^b   Alavizadeh, Hoda ^a   Abbasi, Azam ^a   Ayati, Zahra ^a   Jaafari, Mahmoud R ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

antitumor activity; C26 colon carcinoma; cancer; crocin; Crocus sativus; Iridaceae; PEGylated nanoliposome; saffron

Indexed keywords

CHOLESTEROL; CROCIN; DISTEAROYLPHOSPHATIDYLCHOLINE; DOXORUBICIN; EBEDOXO; MACROGOL; METHOXY POLYETHYLENE GLYCOL; PHOSPHATIDYLCHOLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CHEMICAL MODIFICATION; COLON CARCINOMA; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG FORMULATION; EVAPORATION; HYDROGENATION; IN VITRO STUDY; LIPOSOMAL DELIVERY; MOUSE; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; ZETA POTENTIAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA; CAROTENOIDS; COLON; COLONIC NEOPLASMS; CROCUS; FEMALE; LIPOSOMES; MICE; MICE, INBRED BALB C; POLYETHYLENE GLYCOLS; TUMOR CELLS, CULTURED;

CROCUS SATIVUS; IRIDACEAE; MUS;

EID: 84876694588     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0032-1328363     Document Type: Article

References (30)

1. Gutheil W., Reed G., Ray A., Anant S., Dhar A. Crocetin: an agent derived from saffron for prevention and therapy for cancer. Curr Pharm Biotechnol: 2012; 13 173 179
2. Abdullaev F. I. Biological effects of saffron. Biofactors: 1993; 4 83 86 (Pubitemid 23218839)
3. Abdullaev F. I. Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.). Exp Biol Med: 2002; 227 20 25
4. Behravan J., Hosseinzadeh H., Rastgoo A., Hessani M. Evaluation of the cytotoxic activity of crocin and safranal using potato disc and brine shrimp assays. Physiol Pharmacol: 2010; 13 397 403
5. Escribano J., Alonso G. L., Coca-Prados M., Fernández J. A. Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Lett: 1996; 100 23 30 (Pubitemid 26056388)
6. Garc-Olmo D. C., Riese H. H., Escribano J., Onta J., Fernandez J. A., Atiénzar M., Garcí-Olmo D. Effects of long-term treatment of colon adenocarcinoma with crocin, a carotenoid from saffron (Crocus sativus L.): an experimental study in the rat. Nutr Cancer: 1999; 35 120 126 (Pubitemid 30115121)
7. Torchilin V. P. Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discov: 2005; 4 145 160 (Pubitemid 40282557)
8. Maeda H., Wu J., Sawa T., Matsumura Y., Hori K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release: 2000; 65 271 284 (Pubitemid 30122932)
9. Hadizadeh F., Mohajeri S., Seifi M. Extraction and purification of crocin from saffron stigmas employing a simple and efficient crystallization method. Pakistan J Biol Sci: 2010; 13 691 698
10. Malaekeh-Nikouei B., Jaafari M. R., Tabassi S. AS, Samiei A. The enhancement of immunosuppressive effects of cyclosporine A on human T-cells using fusogenic liposomes. Colloids Surf B Biointerfaces: 2008; 67 238 244
11. Huang Z., Jaafari M. R., Szoka F. C. Jr. Disterolphospholipids: nonexchangeable lipids and their application to liposomal drug delivery. Angew Chem Int Ed Engl: 2009; 121 4210 4213
12. Baselga J., Norton L., Albanell J., Kim Y. M., Mendelsohn J. Recombinant humanized anti-HER2 antibody (Herceptin™) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts. Cancer Res: 1998; 58 2825
13. Nair S. C., Pannikar B., Panikkar K. R. Antitumour activity of saffron (Crocus sativus). Cancer Lett: 1991; 57 109 114
14. Nair S. C., Kurumboor S. K., Hasegawa J. H. Saffron chemoprevention in biology and medicine: a review. Cancer Biother: 1995; 10 257 264
15. Smith T. Carotenoids and cancer: prevention and potential therapy. Br J Biomed Sci: 1998; 55 268
16. Escribano J., Ríos I., Fernández J. A. Isolation and cytotoxic properties of a novel glycoconjugate from corms of saffron plant (Crocus sativus L.). BBA General Subjects: 1999; 1426 217 222 (Pubitemid 29027885)
17. Tavakkol-Afshari J., Brook A., Mousavi S. H. Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines. Food Chem Toxicol: 2008; 46 3443 3447
18. Mousavi S. H., Moallem S. A., Mehri S., Shahsavand S., Nassirli H., Malaekeh-Nikouei B. Improvement of cytotoxic and apoptogenic properties of crocin in cancer cell lines by its nanoliposomal form. Pharm Biol: 2011; 49 1039 1045
19. Hatakeyama H., Akita H., Harashima H. A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma. Adv Drug Deliv Rev: 2011; 63 152 160
20. Drummond D. C., Noble C. O., Hayes M. E., Park J. W., Kirpotin D. B. Pharmacokinetics and in vivo drug release rates in liposomal nanocarrier development. J Pharm Sci: 2008; 97 4696 4740
21. Papahadjopoulos D., Nir S., Ohki S. Permeability properties of phospholipid membranes: effect of cholesterol and temperature. BBA Biomembranes: 1972; 266 561 583
22. Abdullaev F., Espinosa-Aguirre J. Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. Cancer Detect Prev: 2004; 28 426 432 (Pubitemid 39568938)
23. Premkumar K., Thirunavukkarasu C., Abraham S., Santhiya S., Ramesh A. Protective effect of saffron (Crocus sativus L.) aqueous extract against genetic damage induced by anti-tumor agents in mice. Hum Exp Toxicol: 2006; 25 79 84 (Pubitemid 43345342)
24. Nair S., Salomi M., Varghese C., Panikkar B., Panikkar K. Effect of saffron on thymocyte proliferation, intracellular glutathione levels and its antitumor activity. BioFactors (Oxford, England): 1992; 4 51
25. Raina B. L., Agarwal S. G., Bhatia A. K., Gaur G. S. Changes in pigments and volatiles of saffron (Crocus sativus L.) during processing and storage. J Sci Food Agric: 1996; 71 27 32 (Pubitemid 126548576)
26. Selim K., Tsimidou M., Biliaderis C. Kinetic studies of degradation of saffron carotenoids encapsulated in amorphous polymer matrices. Food Chem: 2000; 71 199 206
27. Hosseinzadeh H., Shariaty V. M., Sameni A. K., Vahabzadeh M. Acute ad sub-acute toxicity of crocin, a constituent of Crocus sativus L. (saffron), in mice and rats. Pharmacologyonline: 2010; 2 943 951
28. Paola P. Carotenoids and modulation of cancer: molecular targets. Curr Pharmacogen: 2004; 2 35 45
29. Melnyk J. P., Wang S., Marcone M. F. Chemical and biological properties of the worlds most expensive spice: Saffron. Food Res Int: 2010; 43 1981 1989
30. Aung H. H., Wang C. Z., Ni M., Fishbein A., Mehendale S. R., Xie J. T., Shoyama C. Y., Yuan C. S. Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells. Exp Oncol: 2007; 29 175 180 (Pubitemid 350206742)