Interaction of sesame seed and tamoxifen on tumor growth and bone health in athymic mice

Experimental Biology and Medicine

Volumn 232, Issue 6, 2007, Pages 754-761

  Sacco, Sandra M ^a   Power, Krista A ^a   Chen, Jianmin ^a   Ward, Wendy E ^a   Thompson, Lilian U ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Athymic mice; Bone; Breast cancer; Lignans; Sesame seed

Indexed keywords

ESTROGEN; LIGNAN; TAMOXIFEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; BONE DENSITY; BONE MINERAL; BONE STRENGTH; BREAST CANCER; CANCER GROWTH; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG INHIBITION; DRUG POTENTIATION; FEMALE; FEMUR; HUMAN; HUMAN CELL; LUMBAR VERTEBRA; MOUSE; NONHUMAN; NUDE MOUSE; OVARIECTOMY; PREMENOPAUSE; SEED; SESAME;

ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; APOPTOSIS; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; COMBINED MODALITY THERAPY; FEMALE; FEMUR; HUMANS; LUMBAR VERTEBRAE; MICE; MICE, NUDE; OVARIECTOMY; PREMENOPAUSE; SEEDS; SESAMUM; TAMOXIFEN; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS; SESAMUM INDICUM;

EID: 34249738546     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Adlercreutz H, Mazur W. Phyto-estrogens and Western diseases. Ann Med 29:95-120, 1997.
2. Dai Q, Franke A, Jin F, Shu X, Hebert J, Custer L, Cheng J, Gao Y, Zheng W. Urinary excretion of phytoestrogens and risk of breast cancer among Chinese women in Shanghai. Cancer Epidemiol Biomarkers Prev 11:815-821, 2002.
3. Linseisen J, Piller R, Hermann S, Chang-Claude J. Dietary phytoestrogen intake and premenopausal breast cancer risk in a German case-control study. Int J Cancer 110:284-290, 2004.
4. McCann S, Muti P, Vitp D, Edge S, Trefisan M, Freudenheim J. Dietary lignan intakes and risk of pre- and postmenopausal breast cancer. Int J Cancer 111:440-443, 2004.
5. Pietinen P, Stumpf K, Mannisto S, Kataja V, Uusitupa M, Adlercreutz H. Serum enterolactone and risk of breast cancer: a case-control study in eastern Finland. Cancer Epidemiol Biomarkers Prev 10:339-344, 2001.
6. Thompson LU, Boucher BA, Liu Z, Cotterchio M, Kreiger N. Phytoestrogen content of foods consumed in Canada, including isoflavones, lignans, and coumestan. Nutr Cancer 54:184-201, 2006.
7. Thompson LU, Robb P, Serraino M, Cheung F. Mammalian lignan production from various foods. Nutr Cancer 16:43-52, 1991.
8. Coulman KD, Liu Z, Hum WQ, Michaelides J, Thompson LU. Whole sesame seed is a rich source of mammalian lignan precursors as whole flaxseed. Nutr Cancer 52:156-165, 2005.
9. Liu Z, Saarinen NM, Thompson LU. Sesamin is one of the major precursors of mammalian lignans in sesame seed (Sesamum indicum) as observed in vitro and in rats. J Nutr 136:906-912, 2006.
10. Rowland I, Faughnan M, Hoey L, Wahala K, Williamson G, Cassidy A. Bioavailability of phyto-oestrogens. Br J Nutr 89(Suppl 1):S45-S58, 2003.
11. Power KA, Thompson LU. Flaxseed and lignans: Effects on breast cancer. In: Awad AB, Bradford PG, Eds. Nutrition and Cancer Prevention. Boca Raton, FL: Taylor & Francis Group, pp385, 2006.
12. Phipps WR, Martini MC, Lampe JW, Slavin JL, Kurzer MS. Effect of flax seed ingestion on the menstrual cycle. J Clin Endocrinol Metab 77:1215-1219, 1993.
13. Wilcox G, Wahglvist ML, Burger HG, Medley G. Oestrogenic effects of plant foods in postmenopausal women. Br Med J 301:905-906, 1990.
14. Chen J, Hui E, Ip T, Thompson LU. Dietary flaxseed enhances the inhibitory effect of tamoxifen on the growth of estrogen dependent human breast cancer (MCF-7) in nude mice. Clin Cancer Res 10:7703-7711, 2004.
15. Chen J, Thompson LU. Lignans and tamoxifen, alone or in combination, reduce human breast cancer cell adhesion, invasion and migration in vitro. Breast Cancer Res Treat 80:163-170, 2003.
16. Chen J, Wang L, Thompson LU. Flaxseed and its components reduce metastasis after surgical excision of solid human breast tumor in nude mice. Cancer Lett 234:168-175, 2006.
17. Dabrosin C, Chen J, Wang L, Thompson LU. Flaxseed inhibits metastasis and decreases extracellular vascular endothelial growth factor in human breast cancer xenografts. Cancer Lett 185:31-37, 2002.
18. Power KA, Saarinen NM, Chen JM, Thompson LU. Mammalian lignans enterolactone and enterodiol, alone and in combination with the isoflavone genistein, do not promote the growth of MCF-7 xenografts in ovariectomized athymic nude mice. Int J Cancer 118:1316-1320, 2006.
19. Bergman Jungeström M, Thompson LU, Dabrosin C. Flaxseed and its lignans inhibit estradiol-induced growth, angiogenesis and secretion of VEGF in human breast cancer xenografts in vivo. Clin Cancer Res 13:1061-1067, 2007.
20. Power KA, Ward WE, Chen JM, Saarinen NM, Thompson LU. Genistein alone and in combination with the mammalian lignans enterolactone and enterodiol induce estrogenic effects on bone and uterus in a postmenopausal breast cancer mouse model. Bone 39:117-124, 2006.
21. Duffy C, Cyr M. Phytoestrogens: potential benefits and implications for breast cancer survivors. J Womens Health 12:617-631, 2003.
22. Penalvo JL, Heinonen SM, Aura AM, Adlercreutz H. Dietary sesamin is converted to enterolactone in humans. J Nutr 135:1056-1062, 2005.
23. Olfert ED, Cross BM, McWilliam AA, Eds. Guide to the Care and Use of Experimental Animals, (2nd ed.). Ottawa: Canadian Council on Animal Care, Vol 1, 1993.
24. Reeves PG, Nielsen FH, Fahey GC Jr. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformation of the AIN-76A rodent diet. J Nutr 123:1939-1951, 1993.
25. Fonseca D, Ward WE. Daidzein together with high calcium preserve bone mass and biomechanical strength at multiple sites in ovariectomized mice. Bone 35:489-497, 2004.
26. Asarian L, Geary N. Modulation of appetite by gonadal steroid hormones. Philos Trans R Soc Lond B Biol Sci 361:1251-1263, 2006.
27. Geary N, Asarian L, Korach KS, Pfaff DW, Ogawa S. Deficits in estrogen-dependent control of feeding, weight gain, and cholecystokinin satiation in ER-alpha null mice. Endocrinology 142:4751-4757, 2001.
28. Jordan VC, Phelps E, Lindgren JU. Effects of anti-estrogens on bone in castrated and intake female rats. Breast Cancer Res Treat 10:31-35, 1987.
29. Wallen JW, Belanger MP, Wittnich C. Sex hormones and the selective estrogen receptor modulator tamoxifen modulate weekly body weights and food intakes in adolescent and adult rats. J Nutr 131:2351-2357, 2001.
30. Hirose N, Doi F, Ueki T, Akazawa K, Chijiiwa K, Sugano M, Akimoto K, Shimizu S, Yamada H. Suppressive effect of sesamin against 7, 12-dimethylbenz[a]-anthracene induced rat mammary carcinogenesis. Anticancer Res 12:1259-1265, 1992.
31. Sheng H, Hirose Y, Hata K, Zheng O, Kuno T, Asano N, Yamada Y, Hara A, Osawa T, Mori H. Modifying effect of dietary sesaminol glucosides on the formation of azoxymethane-induced premalignant lesions of rat colon. Cancer Lett 246:63-68, 2007.
32. Sirato-Yasumoto S, Katsuta M, Okuyama Y, Takahashi Y, Ide T. Effect of sesame seed rich in sesamin and sesamolin on fatty acid oxidation in rat liver. J Agric Food Chem 49:2647-2651, 2001.
33. Wu WH, Kang YP, Wang NH, Jou HJ, Wang TA. Sesame ingestion affects sex hormones, antioxidant status, and blood lipids in postmenopausal women. J Nutr 136:1270-1275, 2006.
34. Phillips KM, Ruggio DM, Ashraf-Khorassani M. Phytosterol composition of nuts and seeds commonly consumed in the United States. J Agric Food Chem 53:9436-9445, 2005.
35. USDA: Nutrient Data Laboratory. Available at: www.nal.usda.gov/fnic/ foodcomp/search. Accessed March 20, 2007.
36. Jordan VC. Selective estrogen receptor modulation: concept and consequences in cancer. Cancer Cell 5:207-213, 2004.
37. Gottardis MM, Jordan VC. Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration. Cancer Res 48:5183-5187, 1988.
38. MacGregor JI, Jordan VC. Basic guide to the mechanisms of antiestrogen action. Pharmacol Rev 50:151-196, 1998.
39. Early Breast Cancer Trialists' Collaborative Group. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365:1687-1717, 2005.
40. Osborne KC, Hobbs K, Clark GM. Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice. Cancer Res 45:584-590, 1985.
41. Lewis JS, Jordan VC. Selective estrogen receptor modulators (SERMs): mechanisms of anticarcinogenesis and drug resistance. Mutat Res 591:247-263, 2005.
42. Mandlekar S, Kong AN. Mechanisms of tamoxifen-induced apoptosis. Apoptosis 6:469-477, 2001.
43. Nakano D, Kwak CJ, Fujii K, Ikemura K, Satake A, Ohkita M, Takaoka M, Ono Y, Nakai M, Tomimori N, Kiso Y, Matsumura Y. Sesamin metabolites induce an endothelial nitric oxide-dependent vasorelaxation through their antioxidative property-independent mechanisms: possible involvement of the metabolites in the antihypertensive effect of sesamin. J Pharmacol Exp Ther 318:328-335, 2006.
44. Khan A. Management of low bone mineral density in premenopausal women. J Obstet Gynaecol Can 27:345-349, 2005.
45. Mackey JR, Joy AA. Skeletal health in postmenopausal survivors of early breast cancer. Int J Cancer 114:1010-1015, 2005.
46. Vehmanen L, Elomaa I, Blomqvist C, Saarto T. Tamoxifen treatment after adjuvant chemotherapy has opposite effects on bone mineral density in premenopausal patients depending on menstrual status. J Clin Oncol 24:675-680, 2006.
47. Lee SK, Kadono Y, Okada F, Jacquin C. Koczon-Jaremko B, Gronowicz G, Adams DJ, Aquila HL, Choi Y, Lorenzo JA. T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy. J Bone Miner Res 21:1704-1712, 2006.
48. Reed CA, Berndtson AK, Nephew KP. Dose-dependent effects of 4-hydroxytamoxifen, the active metabolite of tamoxifen, on estrogen receptor-alpha expression in the rat uterus. Anticancer Drugs 16:559-567, 2005.