Sensitive NMR Approach for Determining the Binding Mode of Tightly Binding Ligand Molecules to Protein Targets

Journal of the American Chemical Society

Volumn 138, Issue 13, 2016, Pages 4539-4546

  Chen, Wan Na ^a   Nitsche, Christoph ^a,b   Pilla, Kala Bharath ^a   Graham, Bim ^c   Huber, Thomas ^a   Klein, Christian D ^b   Otting, Gottfried ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BINS; COMPLEXATION; ISOMERS; LIGANDS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS; VIRUSES;

HIGH AFFINITY LIGANDS; MEASUREMENTS OF; NUCLEAR MAGNETIC RESONANCE(NMR); PROTEIN-LIGAND COMPLEXES; RESONANCE ASSIGNMENTS; STABLE-ISOTOPE LABELING; STRUCTURAL KNOWLEDGE; TERT-BUTYL GROUP;

NUCLEAR MAGNETIC RESONANCE;

LANTHANIDE; NONSTRUCTURAL PROTEIN 2B; NONSTRUCTURAL PROTEIN 3; STABLE ISOTOPE; UNCLASSIFIED DRUG; VIRUS PROTEIN; BUTANOL; LIGAND; NS3 PROTEASE, DENGUE VIRUS; PROTEIN; SERINE PROTEINASE;

ARTICLE; BINDING SITE; CONFORMATION; CRYSTAL STRUCTURE; DENGUE VIRUS; DRUG PROTEIN BINDING; ISOTOPE LABELING; LIGAND BINDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; PROTEIN STRUCTURE; PROTEIN TARGETING; STRUCTURAL MODEL; CHEMICAL MODEL; CHEMISTRY; METABOLISM; MOLECULAR MODEL; PROTEIN CONFORMATION;

BUTANOLS; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; PROTEINS; SERINE ENDOPEPTIDASES;

EID: 84964575922     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.6b00416     Document Type: Article

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