An NMR strategy for fragment-based ligand screening utilizing a paramagnetic lanthanide probe

Journal of Biomolecular NMR

Volumn 51, Issue 3, 2011, Pages 395-408

  Saio, Tomohide ^a   Ogura, Kenji ^a   Shimizu, Kazumi ^a   Yokochi, Masashi ^a   Burke Jr , Terrence R ^b   Inagaki, Fuyuhiko ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Fragment based drug design (FBDD); Lanthanide binding peptide tag (LBT); Ligand screening; Paramagnetic relaxation enhancement (PRE); Protein ligand structure; Pseudo contact shift (PCS)

Indexed keywords

GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; LANTHANIDE; LIGAND; PROTEIN SH2;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; FRAGMENTATION REACTION; LIGAND BINDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PARAMAGNETIC RELAXATION ENHANCEMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; PROTEIN TARGETING; PSEUDO CONTACT SHIFT; RADIOLOGICAL PARAMETERS; SRC HOMOLOGY DOMAIN;

BINDING SITES; GRB2 ADAPTOR PROTEIN; LANTHANOID SERIES ELEMENTS; LIGANDS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; SRC HOMOLOGY DOMAINS;

EID: 80755153749     PISSN: 09252738     EISSN: 15735001     Source Type: Journal    
DOI: 10.1007/s10858-011-9566-5     Document Type: Article

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