Different modes of inhibitor binding to prolyl hydroxylase by combined use of X-ray crystallography and NMR spectroscopy of paramagnetic complexes

Journal of the American Chemical Society

Volumn 131, Issue 46, 2009, Pages 16654-16655

  Poppe, Leszek ^a   Tegley, Christopher M ^a   Li, Vivian ^a   Lewis, Jeffrey ^a   Zondlo, James ^a   Yang, Evelyn ^a   Kurzeja, Robert J M ^a   Syed, Rashid ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AQUEOUS SOLUTIONS; CRYSTALLOGRAPHIC STRUCTURE; DIFFERENT MODES; METAL BINDING PROPERTIES; NMR SPECTROSCOPY; PARAMAGNETIC COMPLEXES; PROLYL HYDROXYLASE; PROLYL-4-HYDROXYLASE;

BINDING ENERGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

X RAY CRYSTALLOGRAPHY;

METAL ION; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CRYSTALLOGRAPHY; MAGNETISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN EXPRESSION; STOICHIOMETRY; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; NAPHTHYRIDINES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROCOLLAGEN-PROLINE DIOXYGENASE;

EID: 70450183810     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja907933p     Document Type: Article

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