NMR second site screening for structure determination of ligands bound inthe hydrophobie pocket of HIV-1 gp41

Journal of the American Chemical Society

Volumn 131, Issue 8, 2009, Pages 2821-2823

  Balogh, Edina ^a   Wu, Dong ^a   Zhou, Guangyan ^a   Gochin, Miriam ^a,b  

^a Touro University California   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COILED COIL; DRUG DESIGN; FUSION INHIBITORS; HYDROPHOBIC POCKETS; LIGAND BINDING; MULTIPLE MEASUREMENTS; NEW APPROACHES; NONPEPTIDE; ORIENTATION DEPENDENT; PARAMAGNETIC EFFECT; PARAMAGNETIC PROBES; PARAMAGNETIC RELAXATION; SITE SCREENING; SMALL MOLECULES; STRUCTURAL DATA; STRUCTURAL INFORMATION; STRUCTURE DETERMINATION; STRUCTURE-BASED;

DRUG INTERACTIONS; HYDROPHOBICITY; NUCLEAR MAGNETIC RESONANCE; PARAMAGNETIC MATERIALS; PEPTIDES; PROBES; VIRUSES;

LIGANDS;

C PEPTIDE; GLYCOPROTEIN 41; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN; 2,2' BIPYRIDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; GLYCOPROTEIN GP 41; GP41 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; LIGAND; PEPTIDE;

ACCURACY; ARTICLE; BINDING AFFINITY; CHEMICAL LABELING; CHEMICAL STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROPHOBICITY; LIGAND BINDING; MAGNETISM; NUCLEAR MAGNETIC RESONANCE; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SCREENING; SPIN LABELING; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; METHODOLOGY; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

2,2'-DIPYRIDYL; AMINO ACID SEQUENCE; ANTI-HIV AGENTS; BINDING SITES; DRUG DESIGN; HIV ENVELOPE PROTEIN GP41; HYDROPHOBICITY; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; SPIN LABELS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 68049108497     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja8094558     Document Type: Article

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