Sulforaphane protects against acetaminophen-induced hepatotoxicity

Food and Chemical Toxicology

Volumn 80, Issue , 2015, Pages 193-200

  Noh, Jung Ran ^a   Kim, Yong Hoon ^a   Hwang, Jung Hwan ^a   Choi, Dong Hee ^a   Kim, Kyoung Shim ^a   Oh, Won Keun ^b   Lee, Chul Ho ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Acetaminophen; Heme oxygenase 1; Hepatotoxicity; Oxidative stress; Sulforaphane

Indexed keywords

4 HYDROXYNONENAL; ALANINE AMINOTRANSFERASE; ANALGESIC AGENT; ANTINEOPLASTIC AGENT; ASPARTATE AMINOTRANSFERASE; DRUG TOXICITY; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE 1; ISOTHIOCYANIC ACID DERIVATIVE; MALONALDEHYDE; MESSENGER RNA; NFE2L2 PROTEIN, MOUSE; PARACETAMOL; PHARMACOLOGY; REACTIVE OXYGEN METABOLITE; SULFORAFAN; SULFORAPHANE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2;

ACETAMINOPHEN INDUCED HEPATOTOXICITY; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; C57BL MOUSE; CELL CULTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; ENZYME INDUCTION; GCLC GENE; GENE; GENE EXPRESSION REGULATION; GENETICS; HO1 GENE; IN VITRO STUDY; IN VIVO STUDY; LIPID PEROXIDATION; LIVER; LIVER CELL; LIVER PROTECTION; LIVER TOXICITY; MALE; METABOLISM; MOUSE; NONHUMAN; NQO1 GENE; OXIDATIVE STRESS; PATHOLOGY; PREVENTION; PROTEIN DEPLETION; PROTEIN EXPRESSION; SOD GENE; UPREGULATION;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTICARCINOGENIC AGENTS; CELLS, CULTURED; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETICS; GLUTATHIONE; HEME OXYGENASE-1; HEPATOCYTES; ISOTHIOCYANATES; LIVER; MALE; METABOLISM; MICE; MICE, INBRED C57BL; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PATHOLOGY; PHARMACOLOGY; PREVENTION AND CONTROL; TOXICITY;

MUS;

EID: 84964294854     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2015.03.020     Document Type: Article

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