Sulforaphane protects liver injury induced by intestinal ischemia reperfusion through Nrf2-ARE pathway

World Journal of Gastroenterology

Volumn 16, Issue 24, 2010, Pages 3002-3010

  Zhao, Hai Dong ^a   Zhang, Feng ^a   Shen, Gang ^a   Li, Yu Bing ^a   Li, Ying Hua ^a   Jing, Hui Rong ^a   Ma, Ling Fei ^a   Yao, Ji Hong ^a   Tian, Xiao Feng ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Antioxidant response element; Intestinal ischemia reperfusion; Liver injury; NF E2 related factor 2; Sulforaphane

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HEME OXYGENASE 1; MYELOPEROXIDASE; SULFORAPHANE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; ANTINEOPLASTIC AGENT; ANTIOXIDANT; ISOTHIOCYANIC ACID DERIVATIVE; SULFORAFAN; THIOCYANIC ACID DERIVATIVE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; INTESTINE ISCHEMIA; LIVER INJURY; LIVER PROTECTION; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SUPERIOR MESENTERIC ARTERY OBSTRUCTION; WESTERN BLOTTING; ANIMAL; DNA RESPONSIVE ELEMENT; DRUG EFFECTS; INTESTINE; LIVER; METABOLISM; PATHOLOGY; RANDOMIZATION; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; VASCULARIZATION;

ANIMALS; ANTICARCINOGENIC AGENTS; ANTIOXIDANTS; HEME OXYGENASE-1; INTESTINES; ISOTHIOCYANATES; LIVER; MALE; NF-E2-RELATED FACTOR 2; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; THIOCYANATES;

EID: 77954560109     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v16.i24.3002     Document Type: Article

References (42)

1. Kubes P, Hunter J, Granger DN. Ischemia/reperfusioninduced feline intestinal dysfunction: importance of granulocyte recruitment. Gastroenterology 1992; 103: 807-812
2. Hassoun HT, Kone BC, Mercer DW, Moody FG, Weisbrodt NW, Moore FA. Post-injury multiple organ failure: the role of the gut. Shock 2001; 15: 1-10
3. Pierro A, Eaton S. Intestinal ischemia reperfusion injury and multisystem organ failure. Semin Pediatr Surg 2004; 13: 11-17
4. Li JY, Yin HZ, Gu X, Zhou Y, Zhang WH, Qin YM. Melatonin protects liver from intestine ischemia reperfusion injury in rats. World J Gastroenterol 2008; 14: 7392-7396
5. Homer-Vanniasinkam S, Crinnion JN, Gough MJ. Postischaemic organ dysfunction: a review. Eur J Vasc Endovasc Surg 1997; 14: 195-203
6. Radhakrishnan RS, Radhakrishnan GL, Radhakrishnan HR, Xue H, Adams SD, Moore-Olufemi SD, Harting MT, Cox CS Jr, Kone BC. Pretreatment with bone morphogenetic protein-7 (BMP-7) mimics ischemia preconditioning following intestinal ischemia/reperfusion injury in the intestine and liver. Shock 2008; 30: 532-536
7. Yao JH, Zhang XS, Zheng SS, Li YH, Wang LM, Wang ZZ, Chu L, Hu XW, Liu KX, Tian XF. Prophylaxis with carnosol attenuates liver injury induced by intestinal ischemia/reperfusion. World J Gastroenterol 2009; 15: 3240-3245
8. Yao JH, Li YH, Wang ZZ, Zhang XS, Wang YZ, Yuan JC, Zhou Q, Liu KX, Tian XF. Proteasome inhibitor lactacystin ablates liver injury induced by intestinal ischaemia-reperfusion. Clin Exp Pharmacol Physiol 2007; 34: 1102-1108
9. Tomita M, Kishimoto H, Takizawa Y, Hayashi M. Effects of intestinal ischemia/reperfusion on P-glycoprotein mediated biliary and renal excretion of rhodamine123 in rat. Drug Metab Pharmacokinet 2009; 24: 428-437
10. Yildiz F, Terzi A, Coban S, Celik H, Aksoy N, Bitiren M, Cakir H, Ozdogan MK. Protective effects of resveratrol on small intestines against intestinal ischemia-reperfusion injury in rats. J Gastroenterol Hepatol 2009; 24: 1781-1785
11. Deitch EA, Rutan R, Waymack JP. Trauma, shock, and gut translocation. New Horiz 1996; 4: 289-299
12. Sun Z, Olanders K, Lasson A, Dib M, Annborn M, Andersson K, Wang X, Andersson R. Effective treatment of gut barrier dysfunction using an antioxidant, a PAF inhibitor, and monoclonal antibodies against the adhesion molecule PECAM-1. J Surg Res 2002; 105: 220-233
13. Brooks HJ, McConnell MA, Corbett J, Buchan GS, Fitzpatrick CE, Broadbent RS. Potential prophylactic value of bovine colostrum in necrotizing enterocolitis in neonates: an in vitro study on bacterial attachment, antibody levels and cytokine production. FEMS Immunol Med Microbiol 2006; 48: 347-354
14. Guven A, Tunc T, Topal T, Kul M, Korkmaz A, Gundogdu G, Onguru O, Ozturk H. Alpha-lipoic acid and ebselen prevent ischemia/reperfusion injury in the rat intestine. Surg Today 2008; 38: 1029-1035
15. Li C, Jackson RM. Reactive species mechanisms of cellular hypoxia-reoxygenation injury. Am J Physiol Cell Physiol 2002; 282: C227-C241
16. Nitescu N, Ricksten SE, Marcussen N, Haraldsson B, Nilsson U, Basu S, Guron G. N-acetylcysteine attenuates kidney injury in rats subjected to renal ischaemia-reperfusion. Nephrol Dial Transplant 2006; 21: 1240-1247
17. Yu D, Sekine-Suzuki E, Xue L, Fujimori A, Kubota N, Okayasu R. Chemopreventive agent sulforaphane enhances radiosensitivity in human tumor cells. Int J Cancer 2009; 125: 1205-1211
18. de Vries HE, Witte M, Hondius D, Rozemuller AJ, Drukarch B, Hoozemans J, van Horssen J. Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease? Free Radic Biol Med 2008; 45: 1375-1383
19. Kwak MK, Wakabayashi N, Kensler TW. Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers. Mutat Res 2004; 555: 133-148
20. Kobayashi M, Yamamoto M. Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid Redox Signal 2005; 7: 385-394
21. Shah ZA, Li RC, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, Doré S. Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury. Neuroscience 2007; 147: 53-59
22. Leonard MO, Kieran NE, Howell K, Burne MJ, Varadarajan R, Dhakshinamoorthy S, Porter AG, O'Farrelly C, Rabb H, Taylor CT. Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury. FASEB J 2006; 20: 2624-2626
23. Lee JM, Johnson JA. An important role of Nrf2-ARE pathway in the cellular defense mechanism. J Biochem Mol Biol 2004; 37: 139-143
24. Juge N, Mithen RF, Traka M. Molecular basis for chemoprevention by sulforaphane: a comprehensive review. Cell Mol Life Sci 2007; 64: 1105-1127
25. Shen G, Khor TO, Hu R, Yu S, Nair S, Ho CT, Reddy BS, Huang MT, Newmark HL, Kong AN. Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse. Cancer Res 2007; 67: 9937-9944
26. Yoon HY, Kang NI, Lee HK, Jang KY, Park JW, Park BH. Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme. Biochem Pharmacol 2008; 75: 2214-2223
27. Megison SM, Horton JW, Chao H, Walker PB. A new model for intestinal ischemia in the rat. J Surg Res 1990; 49: 168-173
28. Song M, Xia B, Li J. Effects of topical treatment of sodium butyrate and 5-aminosalicylic acid on expression of trefoil factor 3, interleukin 1beta, and nuclear factor kappaB in trinitrobenzene sulphonic acid induced colitis in rats. Postgrad Med J 2006; 82: 130-135
29. Turnage RH, Bagnasco J, Berger J, Guice KS, Oldham KT, Hinshaw DB. Hepatocellular oxidant stress following intestinal ischemia-reperfusion injury. J Surg Res 1991; 51: 467-471
30. Leister I, Mbachu EM, Post S, Samel ST, Stojanovic T, Gutt CN, Becker H, Markus PM. Vasoactive intestinal polypeptide and gastrin-releasing peptide attenuate hepatic microvasculatory disturbances following intestinal ischemia and reperfusion. Digestion 2002; 66: 186-192
31. Kaplan N, Yagmurdur H, Kilinc K, Baltaci B, Tezel S. The protective effects of intravenous anesthetics and verapamil in gut ischemia/reperfusion-induced liver injury. Anesth Analg 2007; 105: 1371-1378, table of contents
32. Horie Y, Wolf R, Anderson DC, Granger DN. Hepatic leukostasis and hypoxic stress in adhesion molecule-deficient mice after gut ischemia/reperfusion. J Clin Invest 1997; 99: 781-788
33. Itoh M, Guth PH. Role of oxygen-derived free radicals in hemorrhagic shock-induced gastric lesions in the rat. Gastroenterology 1985; 88: 1162-1167
34. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 1985; 312: 159-163
35. Johnson JA, Johnson DA, Kraft AD, Calkins MJ, Jakel RJ, Vargas MR, Chen PC. The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration. Ann N Y Acad Sci 2008; 1147: 61-69
36. Nguyen T, Nioi P, Pickett CB. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem 2009; 284: 13291-13295
37. Jeong WS, Jun M, Kong AN. Nrf2: a potential molecular target for cancer chemoprevention by natural compounds. Antioxid Redox Signal 2006; 8: 99-106
38. Calvert JW, Jha S, Gundewar S, Elrod JW, Ramachandran A, Pattillo CB, Kevil CG, Lefer DJ. Hydrogen sulfide mediates cardioprotection through Nrf2 signaling. Circ Res 2009; 105: 365-374
39. Satoh T, Kosaka K, Itoh K, Kobayashi A, Yamamoto M, Shimojo Y, Kitajima C, Cui J, Kamins J, Okamoto S, Izumi M, Shirasawa T, Lipton SA. Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. J Neurochem 2008; 104: 1116-1131
40. Surh YJ, Kundu JK, Na HK. Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Med 2008; 74: 1526-1539
41. Dragun D, Hoff U, Park JK, Qun Y, Schneider W, Luft FC, Haller H. Prolonged cold preservation augments vascular injury independent of renal transplant immunogenicity and function. Kidney Int 2001; 60: 1173-1181
42. Fujita T, Toda K, Karimova A, Yan SF, Naka Y, Yet SF, Pinsky DJ. Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis. Nat Med 2001; 7: 598-604