Inverse thio effects in the hepatitis delta virus ribozyme reveal that the reaction pathway is controlled by metal ion charge density

Biochemistry

Volumn 54, Issue 12, 2015, Pages 2160-2175

  Thaplyal, Pallavi ^a,c   Ganguly, Abir ^b,d   Hammes Schiffer, Sharon ^b   Bevilacqua, Philip C ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d MAX PLANCK INSTITUT FÜR KOHLENFORSCHUNG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHARGE DENSITY; FREE ENERGY; METALS; MOLECULAR MODELING; POSITIVE IONS; QUANTUM THEORY; SUBSTRATES; VIRUSES;

DIVALENT CATION; EXPERIMENTAL CONDITIONS; FREE ENERGY SIMULATIONS; HEPATITIS DELTA VIRUS; NON-BRIDGING OXYGEN; QUANTUM MECHANICAL/MOLECULAR MECHANICAL; REACTION PATHWAYS; THEORETICAL STUDY;

METAL IONS;

AMMONIA; BARIUM ION; CALCIUM; HAMMERHEAD RIBOZYME; HEPATITIS DELTA VIRUS RIBOZYME; LITHIUM ION; MAGNESIUM; METAL ION; PHOSPHOROTHIOIC ACID; POTASSIUM; PROTON; SODIUM; STRONTIUM; UNCLASSIFIED DRUG; VIRUS RNA;

ARTICLE; DENSITY; HEPATITIS DELTA VIRUS; HYDROGEN BOND; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; PROTON TRANSPORT; QUANTUM MECHANICS; REACTION ANALYSIS; STEREOSPECIFICITY;

HEPATITIS DELTA VIRUS;

EID: 84964253416     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b00190     Document Type: Article

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