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Volumn 48, Issue 50, 2009, Pages 11961-11970

Competition between Co(NH3)63+ and inner sphere Mg2+ ions in the HDV ribozyme

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CLEAVAGE REACTION; COMPETITIVE BINDING; DATA SUPPORT; DIVALENT CATION; HEPATITIS DELTA VIRUS; MAGNESIUM IONS; MICROSCOPIC ANALYSIS; MOLAR CONCENTRATION; MONOVALENT CATIONS; PHOSPHODIESTER GROUPS; PHOSPHODIESTERS; PHYSIOLOGICAL CONDITION; RIBOZYMES; RING MODES; SELF-CLEAVAGE; SOLUTION STUDY;

EID: 74249091547     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901091v     Document Type: Article
Times cited : (32)

References (47)
  • 1
    • 0027305803 scopus 로고
    • Self-cleavage activity of the genomic HDV ribozyme in the presence of various divalent metal ions
    • Suh, Y. A., Kumar, P. K., Taira, K., and Nishikawa, S. (1993) Self-cleavage activity of the genomic HDV ribozyme in the presence of various divalent metal ions. Nucleic Acids Res. 21, 3277-3280. (Pubitemid 23230500)
    • (1993) Nucleic Acids Research , vol.21 , Issue.14 , pp. 3277-3280
    • Suh, Y.-A.1    Kumar, P.K.R.2    Taira, K.3    Nishikawa, S.4
  • 2
    • 0032832044 scopus 로고    scopus 로고
    • Ribozyme cleavage of a 2,5-phosphodiester linkage: Mechanism and a restricted divalent metal-ion requirement
    • Shih, I. H., and Been, M. D. (1999) Ribozyme cleavage of a 2,5-phosphodiester linkage: mechanism and a restricted divalent metal-ion requirement. RNA 5, 1140-1148.
    • (1999) RNA , vol.5 , pp. 1140-1148
    • Shih, I.H.1    Been, M.D.2
  • 3
    • 0034712097 scopus 로고    scopus 로고
    • General acid-base catalysis in the mechanism of a hepatitis delta virus ribozyme
    • DOI 10.1126/science.287.5457.1493
    • Nakano, S., Chadalavada, D. M., and Bevilacqua, P. C. (2000) General acid-base catalysis in the mechanism of a hepatitis delta virus ribozyme. Science 287, 1493-1497. (Pubitemid 30127144)
    • (2000) Science , vol.287 , Issue.5457 , pp. 1493-1497
    • Nakano, S.-I.1    Chadalavada, D.M.2    Bevilacqua, P.C.3
  • 4
    • 0035833978 scopus 로고    scopus 로고
    • Mechanistic characterization of the HDV genomic ribozyme: Assessing the catalytic and structural contributions of divalent metal ions within a multichannel reaction mechanism
    • DOI 10.1021/bi011253n
    • Nakano, S., Proctor, D. J., and Bevilacqua, P. C. (2001) Mechanistic characterization of the HDV genomic ribozyme: assessing the catalytic and structural contributions of divalent metal ions within a multichannel reaction mechanism. Biochemistry 40, 12022-12038. (Pubitemid 32946544)
    • (2001) Biochemistry , vol.40 , Issue.40 , pp. 12022-12038
    • Nakano, S.1    Proctor, D.J.2    Bevilacqua, P.C.3
  • 5
    • 0037452909 scopus 로고    scopus 로고
    • Mechanistic characterization of the HDV genomic ribozyme: Classifying the catalytic and structural metal ion sites within a multichannel reaction mechanism
    • DOI 10.1021/bi026815x
    • Nakano, S., Cerrone, A. L., and Bevilacqua, P. C. (2003) Mechanistic characterization of the HDV genomic ribozyme: classifying the catalytic and structural metal ion sites within a multichannel reaction mechanism. Biochemistry 42, 2982-2994. (Pubitemid 36331542)
    • (2003) Biochemistry , vol.42 , Issue.10 , pp. 2982-2994
    • Nakano, S.-I.1    Cerrone, A.L.2    Bevilacqua, P.C.3
  • 6
    • 33749016245 scopus 로고    scopus 로고
    • HDV ribozyme activity in monovalent cations
    • Perrotta, A. T., and Been, M. D. (2006) HDV ribozyme activity in monovalent cations. Biochemistry 45, 11357-11365.
    • (2006) Biochemistry , vol.45 , pp. 11357-11365
    • Perrotta, A.T.1    Been, M.D.2
  • 7
    • 33847691104 scopus 로고    scopus 로고
    • Structural Roles of Monovalent Cations in the HDV Ribozyme
    • DOI 10.1016/j.str.2007.01.017, PII S0969212607000731
    • Ke, A., Ding, F., Batchelor, J. D., and Doudna, J. A. (2007) Structural roles of monovalent cations in the HDV ribozyme. Structure 15, 281-287. (Pubitemid 46366724)
    • (2007) Structure , vol.15 , Issue.3 , pp. 281-287
    • Ke, A.1    Ding, F.2    Batchelor, J.D.3    Doudna, J.A.4
  • 9
    • 61749093844 scopus 로고    scopus 로고
    • A catalytic metal ion interacts with the cleavage site G·U wobble in the HDV ribozyme
    • Chen, J. H., Gong, B., Bevilacqua, P. C., Carey, P. R., and Golden, B. L. (2009) A catalytic metal ion interacts with the cleavage site G·U wobble in the HDV ribozyme. Biochemistry 48, 1498-1507.
    • (2009) Biochemistry , vol.48 , pp. 1498-1507
    • Chen, J.H.1    Gong, B.2    Bevilacqua, P.C.3    Carey, P.R.4    Golden, B.L.5
  • 10
    • 0035793217 scopus 로고    scopus 로고
    • A pH-sensitive RNA tertiary interaction affects self-cleavage activity of the HDV ribozymes in the absence of added divalent metal ion
    • Wadkins, T. S., Shih, I., Perrotta, A. T., and Been, M. D. (2001) A pH-sensitive RNA tertiary interaction affects self-cleavage activity of the HDV ribozymes in the absence of added divalent metal ion. J. Mol. Biol. 305, 1045-1055.
    • (2001) J. Mol. Biol. , vol.305 , pp. 1045-1055
    • Wadkins, T.S.1    Shih, I.2    Perrotta, A.T.3    Been, M.D.4
  • 11
    • 55549085243 scopus 로고    scopus 로고
    • Mechanistic characterization of the HDV genomic ribozyme: Solvent isotope effects and proton inventories in the absence of divalent metal ions support C75 as the general acid
    • Cerrone-Szakal, A. L., Siegfried, N. A., and Bevilacqua, P. C. (2008) Mechanistic characterization of the HDV genomic ribozyme: solvent isotope effects and proton inventories in the absence of divalent metal ions support C75 as the general acid. J. Am. Chem. Soc. 130, 14504-14520.
    • (2008) J. Am. Chem. Soc. , vol.130 , pp. 14504-14520
    • Cerrone-Szakal, A.L.1    Siegfried, N.A.2    Bevilacqua, P.C.3
  • 12
    • 0031194873 scopus 로고    scopus 로고
    • A unique mechanism for RNA catalysis: The role of metal cofactors in hairpin ribozyme cleavage
    • Hampel, A., and Cowan, J. A. (1997) A unique mechanism for RNA catalysis: the role of metal cofactors in hairpin ribozyme cleavage. Chem. Biol. 4, 513-517.
    • (1997) Chem. Biol. , vol.4 , pp. 513-517
    • Hampel, A.1    Cowan, J.A.2
  • 13
    • 0031215134 scopus 로고    scopus 로고
    • An unusual pH-independent and metal-ion-independent mechanism for hairpin ribozyme catalysis
    • Nesbitt, S., Hegg, L. A., and Fedor, M. J. (1997) An unusual pH-independent and metal-ion-independent mechanism for hairpin ribozyme catalysis. Chem. Biol. 4, 619-630.
    • (1997) Chem. Biol. , vol.4 , pp. 619-630
    • Nesbitt, S.1    Hegg, L.A.2    Fedor, M.J.3
  • 14
    • 0030967825 scopus 로고    scopus 로고
    • Metal ions play a passive role in the hairpin ribozyme catalysed reaction
    • DOI 10.1093/nar/25.19.3760
    • Young, K. J., Gill, F., and Grasby, J. A. (1997) Metal ions play a passive role in the hairpin ribozyme catalysed reaction. Nucleic Acids Res. 25, 3760-3766. (Pubitemid 27420480)
    • (1997) Nucleic Acids Research , vol.25 , Issue.19 , pp. 3760-3766
    • Young, K.J.1    Gill, F.2    Grasby, J.A.3
  • 15
    • 0027365639 scopus 로고
    • Raman spectroscopy of DNA-metal complexes. I. Interactions and conformational effects of the divalent cations: Mg, Ca, Sr, Ba, Mn, Co, Ni, Cu, Pd, and Cd
    • Duguid, J., Bloomfield, V. A., Benevides, J., and Thomas, G. J., Jr. (1993) Raman spectroscopy of DNA-metal complexes. I. Interactions and conformational effects of the divalent cations: Mg, Ca, Sr, Ba, Mn, Co, Ni, Cu, Pd, and Cd. Biophys. J. 65, 1916-1928.
    • (1993) Biophys. J. , vol.65 , pp. 1916-1928
    • Duguid, J.1    Bloomfield, V.A.2    Benevides, J.3    Thomas Jr., G.J.4
  • 17
    • 0031604810 scopus 로고    scopus 로고
    • Vibrational study of phosphate modes in GDP and GTP and their interaction with magnesium in aqueous solution
    • Wang, J. H., Xiao, D. G., Deng, H., Callender, R., and Webb, M. R. (1998) Vibrational study of phosphate modes in GDP and GTP and their interaction with magnesium in aqueous solution. Biospectroscopy 4, 219-227.
    • (1998) Biospectroscopy , vol.4 , pp. 219-227
    • Wang, J.H.1    Xiao, D.G.2    Deng, H.3    Callender, R.4    Webb, M.R.5
  • 18
  • 19
    • 0037381880 scopus 로고    scopus 로고
    • A comparative study of DNA complexation with Mg(II) and Ca(II) in aqueous solution: Major and minor grooves bindings
    • Ahmad, R., Arakawa, H., and Tajmir-Riahi, H. A. (2003) A comparative study of DNA complexation with Mg(II) and Ca(II) in aqueous solution: major and minor grooves bindings. Biophys. J. 84, 2460-2466. (Pubitemid 36373567)
    • (2003) Biophysical Journal , vol.84 , Issue.4 , pp. 2460-2466
    • Ahmad, R.1    Arakawa, H.2    Tajmir-Riahi, H.A.3
  • 20
    • 0019210870 scopus 로고
    • Heavy metal -nucleotide interactions. 14. Raman difference spectrophotometric studies of competitive reactions in mixtures of four nucleotides with electrophiles. Factors governing selectivity in the binding reactions
    • Moller, M. R., Bruck, M. A., O'Connor, T., Armatis, F. J., Knolinski, E. A., Kottmair, N., and Tobias, R. S. (1980) Heavy metal -nucleotide interactions. 14. Raman difference spectrophotometric studies of competitive reactions in mixtures of four nucleotides with electrophiles. Factors governing selectivity in the binding reactions. J. Am. Chem. Soc. 102, 4589-4598.
    • (1980) J. Am. Chem. Soc. , vol.102 , pp. 4589-4598
    • Moller, M.R.1    Bruck, M.A.2    O'Connor, T.3    Armatis, F.J.4    Knolinski, E.A.5    Kottmair, N.6    Tobias, R.S.7
  • 21
    • 0019963739 scopus 로고
    • Heavy metal-nucleotide interactions. 15. Reactions of calf thymus DNA with the electrophiles methylmercury(II) nitrate, cis- dichlorodiammineplatinum(II), and trans-dichlorodiammineplatinum(II) studied using Raman difference spectroscopy. Evidence for the formation of C-DNA upon metalation
    • O'Connor, T., Bina, M., McMillin, D. R., Haley, M. R., and Tobias, R. S. (1982) Heavy metal-nucleotide interactions. 15. Reactions of calf thymus DNA with the electrophiles methylmercury(II) nitrate, cis- dichlorodiammineplatinum(II), and trans-dichlorodiammineplatinum(II) studied using Raman difference spectroscopy. Evidence for the formation of C-DNA upon metalation. Biophys. Chem. 15, 223-234.
    • (1982) Biophys. Chem. , vol.15 , pp. 223-234
    • O'Connor, T.1    Bina, M.2    McMillin, D.R.3    Haley, M.R.4    Tobias, R.S.5
  • 22
    • 0028290484 scopus 로고
    • Nonresonance Raman difference spectroscopy: A general probe of protein structure, ligand binding, enzymatic catalysis, and the structures of other biomacromolecules
    • Callender, R., and Deng, H. (1994) Nonresonance Raman difference spectroscopy: a general probe of protein structure, ligand binding, enzymatic catalysis, and the structures of other biomacromolecules. Annu. Rev. Biophys. Biomol. Struct. 23, 215-245.
    • (1994) Annu. Rev. Biophys. Biomol. Struct. , vol.23 , pp. 215-245
    • Callender, R.1    Deng, H.2
  • 23
    • 33646727439 scopus 로고    scopus 로고
    • Raman crystallography and other biochemical applications of Raman microscopy
    • Carey, P. R. (2006) Raman crystallography and other biochemical applications of Raman microscopy. Annu. Rev. Phys. Chem. 57, 527-554.
    • (2006) Annu. Rev. Phys. Chem. , vol.57 , pp. 527-554
    • Carey, P.R.1
  • 24
    • 35848964370 scopus 로고    scopus 로고
    • Direct measurement of a pK(a) near neutrality for the catalytic cytosine in the genomic HDV ribozyme using Raman crystallography
    • Gong, B., Chen, J. H., Chase, E., Chadalavada, D. M., Yajima, R., Golden, B. L., Bevilacqua, P. C., and Carey, P. R. (2007) Direct measurement of a pK(a) near neutrality for the catalytic cytosine in the genomic HDV ribozyme using Raman crystallography. J. Am. Chem. Soc. 129, 13335-13342.
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 13335-13342
    • Gong, B.1    Chen, J.H.2    Chase, E.3    Chadalavada, D.M.4    Yajima, R.5    Golden, B.L.6    Bevilacqua, P.C.7    Carey, P.R.8
  • 26
    • 35848964370 scopus 로고    scopus 로고
    • Direct measurement of a pK(a) near neutrality for the catalytic cytosine in the genomic HDV ribozyme using Raman crystallography
    • Gong, B., Chen, J. H., Chase, E., Chadalavada, D. M., Yajima, R., Golden, B. L., Bevilacqua, P. C., and Carey, P. R. (2007) Direct measurement of a pK(a) near neutrality for the catalytic cytosine in the genomic HDV ribozyme using Raman crystallography. J. Am. Chem. Soc. 129, 13335-13342.
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 13335-13342
    • Gong, B.1    Chen, J.H.2    Chase, E.3    Chadalavada, D.M.4    Yajima, R.5    Golden, B.L.6    Bevilacqua, P.C.7    Carey, P.R.8
  • 29
    • 0015462829 scopus 로고
    • Raman studies of nucleic acids. VII. Poly A-poly U and poly G-poly C
    • Lafleur, L., Rice, J., and Thomas, G. J., Jr. (1972) Raman studies of nucleic acids. VII. Poly A-poly U and poly G-poly C. Biopolymers 11, 2423-2437.
    • (1972) Biopolymers , vol.11 , pp. 2423-2437
    • Lafleur, L.1    Rice, J.2    Thomas Jr., G.J.3
  • 30
    • 0019840664 scopus 로고
    • Structural studies of tobacco mosaic virus and its components by laser Raman spectroscopy
    • Fish, S. R., Hartman, K. A., Stubbs, G. J., and Thomas, G. J., Jr. (1981) Structural studies of tobacco mosaic virus and its components by laser Raman spectroscopy. Biochemistry 20, 7449-7457.
    • (1981) Biochemistry , vol.20 , pp. 7449-7457
    • Fish, S.R.1    Hartman, K.A.2    Stubbs, G.J.3    Thomas Jr., G.J.4
  • 31
    • 0014995585 scopus 로고
    • Conformational dependence of the Raman scattering intensities from polynucleotides. 3. Order-disorder changes in helical structures
    • Small, E. W., and Peticolas, W. L. (1971) Conformational dependence of the Raman scattering intensities from polynucleotides. 3. Order-disorder changes in helical structures. Biopolymers 10, 1377-1418.
    • (1971) Biopolymers , vol.10 , pp. 1377-1418
    • Small, E.W.1    Peticolas, W.L.2
  • 32
    • 0000457596 scopus 로고
    • Vibrational spectra of guanine. A noral coordinate analysis
    • Majoube, M. (1984) Vibrational spectra of guanine. A noral coordinate analysis. J. Chim. Phys. 81, 303-315.
    • (1984) J. Chim. Phys. , vol.81 , pp. 303-315
    • Majoube, M.1
  • 33
    • 0019210870 scopus 로고
    • Heavy metal-nucleotide interactions. 14. Raman difference spectrophotometric studies of competitive reactions in mixtures of four nucleotides with the electrophiles methylmercury(II) perchlorate, cis dimethylgold(III) perchlorate, dichloroethylene-diamine-palladium(II), trans-dichlorodiaminepalladium(II), and aquopentaaminecobalt(III) perchlorate.
    • Moller, M. R., Bruck, M. A., O'Connor, T., Armatis, F. J., Jr., Knolinski, E. A., Kottmair, N., and Tobias, R. S. (1980) Heavy metal-nucleotide interactions. 14. Raman difference spectrophotometric studies of competitive reactions in mixtures of four nucleotides with the electrophiles methylmercury(II) perchlorate, cis dimethylgold(III) perchlorate, dichloroethylene-diamine-palladium(II), trans-dichlorodiaminepalladium(II), and aquopentaaminecobalt(III) perchlorate. Factors governing selectivity in the binding reactions. J. Am. Chem. Soc. 102, 4589-4598.
    • (1980) J. Am. Chem. Soc. , vol.102 , pp. 4589-4598
    • Moller, M.R.1    Bruck, M.A.2    O'Connor, T.3    Armatis Jr., F.J.4    Knolinski, E.A.5    Kottmair, N.6    Tobias, R.S.7
  • 34
    • 33749530512 scopus 로고    scopus 로고
    • Structural characterization of the 5′ untranslated RNA of hepatitis C virus by vibrational spectroscopy
    • Rodriguez-Casado, A., Bartolome, J., Carreno, V., Molina, M., and Carmona, P. (2006) Structural characterization of the 5′ untranslated RNA of hepatitis C virus by vibrational spectroscopy. Biophys. Chem. 124, 73-79.
    • (2006) Biophys. Chem. , vol.124 , pp. 73-79
    • Rodriguez-Casado, A.1    Bartolome, J.2    Carreno, V.3    Molina, M.4    Carmona, P.5
  • 35
    • 34047159425 scopus 로고    scopus 로고
    • Raman and Raman optical activity (ROA) analysis of RNA structural motifs in Domain I of the EMCV IRES
    • DOI 10.1093/nar/gkm012
    • Hobro, A. J., Rouhi, M., Blanch, E. W., and Conn, G. L. (2007) Raman and Raman optical activity (ROA) analysis of RNA structural motifs in domain I of the EMCV IRES. Nucleic Acids Res. 35, 1169-1177. (Pubitemid 46522970)
    • (2007) Nucleic Acids Research , vol.35 , Issue.4 , pp. 1169-1177
    • Hobro, A.J.1    Rouhi, M.2    Blanch, E.W.3    Conn, G.L.4
  • 36
    • 0032497521 scopus 로고    scopus 로고
    • Crystal structure of a hepatitis delta virus ribozyme
    • DOI 10.1038/26912
    • Ferre-D'Amare, A. R., Zhou, K., and Doudna, J. A. (1998) Crystal structure of a hepatitis delta virus ribozyme. Nature 395, 567-574. (Pubitemid 28475703)
    • (1998) Nature , vol.395 , Issue.6702 , pp. 567-574
    • Ferre-D'Amare, A.R.1    Zhou, K.2    Doudna, J.A.3
  • 37
    • 2442641641 scopus 로고    scopus 로고
    • A conformational switch controls hepatitis delta virus ribozyme catalysis
    • DOI 10.1038/nature02522
    • Ke, A., Zhou, K., Ding, F., Cate, J. H., and Doudna, J. A. (2004) A conformational switch controls hepatitis delta virus ribozyme catalysis. Nature 429, 201-205. (Pubitemid 38656198)
    • (2004) Nature , vol.429 , Issue.6988 , pp. 201-205
    • Ke, A.1    Zhou, K.2    Ding, F.3    Cate, J.H.D.4    Doudna, J.A.5
  • 38
    • 0000604820 scopus 로고
    • Ribonuclease H activation by inert transition-metal complexes. Mechanistic probes for metallocofactors: Insights on the metallobiochemistry of divalent magnesium ion
    • Jou, R., and Cowan, J. A. (1991) Ribonuclease H activation by inert transition-metal complexes. Mechanistic probes for metallocofactors: insights on the metallobiochemistry of divalent magnesium ion. J. Am. Chem. Soc. 113, 6685-6686.
    • (1991) J. Am. Chem. Soc. , vol.113 , pp. 6685-6686
    • Jou, R.1    Cowan, J.A.2
  • 39
    • 0021893691 scopus 로고
    • 31P relaxation rate studies of the interaction of phosphoenolpyruvate and its analogues with avian phosphoenolpyruvate carboxykinase
    • 31P relaxation rate studies of the interaction of phosphoenolpyruvate and its analogues with avian phosphoenolpyruvate carboxykinase. Biochemistry 24, 1152-1160.
    • (1985) Biochemistry , vol.24 , pp. 1152-1160
    • Duffy, T.H.1    Nowak, T.2
  • 40
    • 1242274330 scopus 로고    scopus 로고
    • A guide to ions and RNA structure
    • Draper, D. E. (2004) A guide to ions and RNA structure. RNA 10, 335-343.
    • (2004) RNA , vol.10 , pp. 335-343
    • Draper, D.E.1
  • 41
    • 58749105663 scopus 로고    scopus 로고
    • RNA folding: Thermodynamic and molecular descriptions of the roles of ions
    • Draper, D. E. (2008) RNA folding: thermodynamic and molecular descriptions of the roles of ions. Biophys. J. 95, 5489-5495.
    • (2008) Biophys. J. , vol.95 , pp. 5489-5495
    • Draper, D.E.1
  • 42
    • 74249117899 scopus 로고    scopus 로고
    • http://www-lbit.iro.umontreal.ca/mcannotate-simple.
  • 43
    • 33947356675 scopus 로고    scopus 로고
    • Mechanistic characterization of the HDV genomic ribozyme: A mutant of the C41 motif provides insight into the positioning and thermodynamic linkage of metal ions and protons
    • DOI 10.1021/bi061732s
    • Nakano, S., and Bevilacqua, P. C. (2007) Mechanistic characterization of the HDV genomic ribozyme: a mutant of the C41 motif provides insight into the positioning and thermodynamic linkage of metal ions and protons. Biochemistry 46, 3001-3012. (Pubitemid 46449124)
    • (2007) Biochemistry , vol.46 , Issue.11 , pp. 3001-3012
    • Nakano, S.-I.1    Bevilacqua, P.C.2
  • 44
    • 0034695419 scopus 로고    scopus 로고
    • Crystallization and structure determination of a hepatitis delta virus ribozyme: Use of the RNA-binding protein U1A as a crystallization module
    • Ferre-D'Amare, A. R., and Doudna, J. A. (2000) Crystallization and structure determination of a hepatitis delta virus ribozyme: use of the RNA-binding protein U1A as a crystallization module. J. Mol. Biol. 295, 541-556.
    • (2000) J. Mol. Biol. , vol.295 , pp. 541-556
    • Ferre-D'Amare, A.R.1    Doudna, J.A.2
  • 45
    • 0030768931 scopus 로고    scopus 로고
    • The Hill equation revisited: Uses and misuses
    • Weiss, J. N. (1997) The Hill equation revisited: uses and misuses. FASEB J. 11, 835-841.
    • (1997) FASEB J. , vol.11 , pp. 835-841
    • Weiss, J.N.1
  • 46
    • 0035997396 scopus 로고    scopus 로고
    • Catalytic strategies of the hepatitis delta virus ribozymes
    • Shih, I. H., and Been, M. D. (2002) Catalytic strategies of the hepatitis delta virus ribozymes. Annu. Rev. Biochem. 71, 887-917.
    • (2002) Annu. Rev. Biochem. , vol.71 , pp. 887-917
    • Shih, I.H.1    Been, M.D.2
  • 47
    • 0032472205 scopus 로고    scopus 로고
    • Inhibition of the hammerhead ribozyme cleavage reaction by site-specific binding of Tb
    • Feig, A. L., Scott, W. G., and Uhlenbeck, O. C. (1998) Inhibition of the hammerhead ribozyme cleavage reaction by site-specific binding of Tb. Science 279, 81-84.
    • (1998) Science , vol.279 , pp. 81-84
    • Feig, A.L.1    Scott, W.G.2    Uhlenbeck, O.C.3


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