Evidence for the role of active site residues in the hairpin ribozyme from molecular simulations along the reaction path

Journal of the American Chemical Society

Volumn 136, Issue 22, 2014, Pages 7789-7792

  Heldenbrand, Hugh ^a   Janowski, Pawel A ^b   Giambaşu, George ^b   Giese, Timothy J ^b   Wedekind, Joseph E ^c   York, Darrin M ^b  

^a University of Minnesota   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; MOLECULAR DYNAMICS; NUCLEOPHILES;

ACTIVE SITE RESIDUES; DIVALENT METAL ION; HYDROGEN BOND INTERACTION; MOLECULAR DYNAMICS SIMULATIONS; MOLECULAR SIMULATIONS; NON-BRIDGING OXYGEN; PHOSPHORYL TRANSFER REACTIONS; STRUCTURE AND DYNAMICS;

HYDROGEN BONDS;

ACID; BASE; HAIRPIN RIBOZYME; METAL ION; NUCLEOPHILE; RIBOZYME; UNCLASSIFIED DRUG; OXYGEN;

ARTICLE; CATALYSIS; CONFORMATION; CRYSTAL STRUCTURE; HYDROGEN BOND; MOLECULAR DYNAMICS; PHOSPHORYLATION; PROTON TRANSPORT; REACTION ANALYSIS; CHEMISTRY; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; PROTEIN CONFORMATION;

CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY; HYDROGEN BONDING; MOLECULAR DYNAMICS SIMULATION; OXYGEN; PHOSPHORYLATION; PROTEIN CONFORMATION; RNA, CATALYTIC;

EID: 84901921779     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja500180q     Document Type: Article

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