The glmS Ribozyme Tunes the Catalytically Critical p K a of Its Coenzyme Glucosamine-6-phosphate

Journal of the American Chemical Society

Volumn 133, Issue 36, 2011, Pages 14188-14191

  Gong, Bo ^a   Klein, Daniel J ^b   Ferré D'Amaré, Adrian R ^c   Carey, Paul R ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID-BASE CATALYSTS; ACTIVE SITE; BINDING AFFINITIES; CATALYTIC RNA; COFACTORS; RIBOSWITCHES; RIBOZYMES; SELF-CLEAVAGE; SMALL MOLECULES;

BINDING ENERGY; CRYSTALLOGRAPHY; FUNCTIONAL GROUPS; RNA;

GLUCOSAMINE;

AMINE; GLMS PROTEIN; GLUCOSAMINE PHOSPHATE ACETYLTRANSFERASE; GUANINE; PHOSPHATE; RIBOZYME; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; PH; PKA; RAMAN SPECTROMETRY; RNA BINDING; WILD TYPE;

BACTERIAL PROTEINS; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; GLUCOSAMINE; GLUCOSE-6-PHOSPHATE; RNA, CATALYTIC;

EID: 80052557910     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja205185g     Document Type: Article

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