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Volumn 6, Issue , 2016, Pages

Therapeutic hypothermia attenuates tissue damage and cytokine expression after traumatic brain injury by inhibiting necroptosis in the rat

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; BIOLOGICAL MARKER; CYTOKINE; MESSENGER RNA;

EID: 84964199296     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep24547     Document Type: Article
Times cited : (72)

References (57)
  • 1
    • 84926319950 scopus 로고    scopus 로고
    • Inflammation and neuroprotection in traumatic brain injury
    • Corps, K. N., Roth, T. L. & McGavern, D. B. Inflammation and neuroprotection in traumatic brain injury. JAMA Neurol. 72, 355-362 (2015).
    • (2015) JAMA Neurol. , vol.72 , pp. 355-362
    • Corps, K.N.1    Roth, T.L.2    McGavern, D.B.3
  • 2
    • 85027934703 scopus 로고    scopus 로고
    • N-arachidonoyl-L-serine is neuroprotective after traumatic brain injury by reducing apoptosis
    • Cohen-Yeshurun, A. et al. N-arachidonoyl-L-serine is neuroprotective after traumatic brain injury by reducing apoptosis. J Cereb Blood Flow Metab. 31, 1768-1777 (2011).
    • (2011) J Cereb Blood Flow Metab. , vol.31 , pp. 1768-1777
    • Cohen-Yeshurun, A.1
  • 3
    • 39749103417 scopus 로고    scopus 로고
    • Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gammaglutamylcysteinyl ethyl ester
    • Lai, Y. et al. Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gammaglutamylcysteinyl ethyl ester. J Cereb Blood Flow Metab. 28, 540-550 (2008).
    • (2008) J Cereb Blood Flow Metab. , vol.28 , pp. 540-550
    • Lai, Y.1
  • 4
    • 33644840693 scopus 로고    scopus 로고
    • Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
    • Degterev, A. et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol. 1, 112-119 (2005).
    • (2005) Nat Chem Biol. , vol.1 , pp. 112-119
    • Degterev, A.1
  • 5
    • 84922602504 scopus 로고    scopus 로고
    • Necroptosis and its role in inflammation
    • Pasparakis, M. & Vandenabeele, P. Necroptosis and its role in inflammation. Nature. 517, 311-320 (2015).
    • (2015) Nature , vol.517 , pp. 311-320
    • Pasparakis, M.1    Vandenabeele, P.2
  • 6
    • 84881190695 scopus 로고    scopus 로고
    • Tumor necrosis factor in traumatic brain injury: Effects of genetic deletion of p55 or p75 receptor
    • Longhi, L. et al. Tumor necrosis factor in traumatic brain injury: effects of genetic deletion of p55 or p75 receptor. J Cereb Blood Flow Metab. 33, 1182-1189 (2013).
    • (2013) J Cereb Blood Flow Metab. , vol.33 , pp. 1182-1189
    • Longhi, L.1
  • 7
    • 79551631617 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha and fas receptor contribute to cognitive deficits independent of cell death after concussive traumatic brain injury in mice
    • Khuman, J. et al. Tumor necrosis factor alpha and Fas receptor contribute to cognitive deficits independent of cell death after concussive traumatic brain injury in mice. J Cereb Blood Flow Metab. 31, 778-789 (2011).
    • (2011) J Cereb Blood Flow Metab. , vol.31 , pp. 778-789
    • Khuman, J.1
  • 8
    • 1342285692 scopus 로고    scopus 로고
    • Tumor necrosis factor: An apoptosis JuNKie?
    • Varfolomeev, E. E. & Ashkenazi, A. Tumor necrosis factor: an apoptosis JuNKie? Cell. 116, 491-497 (2004).
    • (2004) Cell , vol.116 , pp. 491-497
    • Varfolomeev, E.E.1    Ashkenazi, A.2
  • 10
    • 84864240409 scopus 로고    scopus 로고
    • The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis
    • Li, J. et al. The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell. 150, 339-350 (2012).
    • (2012) Cell , vol.150 , pp. 339-350
    • Li, J.1
  • 11
    • 67650812332 scopus 로고    scopus 로고
    • RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis
    • Zhang, D. W. et al. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science. 325, 332-336 (2009).
    • (2009) Science , vol.325 , pp. 332-336
    • Zhang, D.W.1
  • 12
    • 84961291582 scopus 로고    scopus 로고
    • RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis
    • Orozco, S. et al. RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis. Cell Death Differ. 21, 1511-1521 (2014).
    • (2014) Cell Death Differ. , vol.21 , pp. 1511-1521
    • Orozco, S.1
  • 13
    • 84932095487 scopus 로고    scopus 로고
    • Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis
    • Wu, X. N. et al. Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis. Cell Death Differ. 21, 1709-1720 (2014).
    • (2014) Cell Death Differ. , vol.21 , pp. 1709-1720
    • Wu, X.N.1
  • 14
    • 84884308522 scopus 로고    scopus 로고
    • The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism
    • Murphy, J. M. et al. The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity. 39, 443-453 (2013).
    • (2013) Immunity , vol.39 , pp. 443-453
    • Murphy, J.M.1
  • 15
    • 84893728596 scopus 로고    scopus 로고
    • MLKL regulates necrotic plasma membrane permeabilization
    • Galluzzi, L., Kepp, O. & Kroemer, G. MLKL regulates necrotic plasma membrane permeabilization. Cell Res. 24, 139-140 (2014).
    • (2014) Cell Res. , vol.24 , pp. 139-140
    • Galluzzi, L.1    Kepp, O.2    Kroemer, G.3
  • 16
    • 84856160569 scopus 로고    scopus 로고
    • Caspase 8 inhibits programmed necrosis by processing CYLD
    • O'Donnell, M. A. et al. Caspase 8 inhibits programmed necrosis by processing CYLD. Nat Cell Biol. 13, 1437-1442 (2011).
    • (2011) Nat Cell Biol. , vol.13 , pp. 1437-1442
    • O'Donnell, M.A.1
  • 17
    • 78650718758 scopus 로고    scopus 로고
    • Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis
    • Trichonas, G. et al. Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis. Proc. Natl. Acad. Sci. USA 107, 21695-21700 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 21695-21700
    • Trichonas, G.1
  • 18
    • 50249132439 scopus 로고    scopus 로고
    • Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice
    • You, Z. et al. Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab. 28, 1564-1573 (2008).
    • (2008) J Cereb Blood Flow Metab. , vol.28 , pp. 1564-1573
    • You, Z.1
  • 19
    • 84866742588 scopus 로고    scopus 로고
    • Necrostatin-1 suppresses autophagy and apoptosis in mice traumatic brain injury model
    • Wang, Y. Q. et al. Necrostatin-1 suppresses autophagy and apoptosis in mice traumatic brain injury model. Neurochem Res. 37, 1849-1858 (2012).
    • (2012) Neurochem Res. , vol.37 , pp. 1849-1858
    • Wang, Y.Q.1
  • 20
    • 84908703873 scopus 로고    scopus 로고
    • Necroptosis, in vivo detection in experimental disease models
    • Jouan-Lanhouet, S. et al. Necroptosis, in vivo detection in experimental disease models. Semin Cell Dev Biol. 35, 2-13 (2014).
    • (2014) Semin Cell Dev Biol. , vol.35 , pp. 2-13
    • Jouan-Lanhouet, S.1
  • 21
    • 84904322380 scopus 로고    scopus 로고
    • RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction
    • Luedde, M. et al. RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction. Cardiovasc Res. 103, 206-216 (2014).
    • (2014) Cardiovasc Res. , vol.103 , pp. 206-216
    • Luedde, M.1
  • 22
    • 80755132824 scopus 로고    scopus 로고
    • The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation
    • Bonnet, M. C. et al. The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity 35, 572-582 (2011).
    • (2011) Immunity , vol.35 , pp. 572-582
    • Bonnet, M.C.1
  • 23
    • 72949098569 scopus 로고    scopus 로고
    • The evidence for hypothermia as a neuroprotectant in traumatic brain injury
    • Dietrich, W. D. & Bramlett, H. M. The evidence for hypothermia as a neuroprotectant in traumatic brain injury. Neurotherapeutics 7, 43-50 (2010).
    • (2010) Neurotherapeutics , vol.7 , pp. 43-50
    • Dietrich, W.D.1    Bramlett, H.M.2
  • 24
    • 0027979691 scopus 로고
    • Post-traumatic brain hypothermia reduces histopathological damage following concussive brain injury in the rat
    • Dietrich, W. D. et al. Post-traumatic brain hypothermia reduces histopathological damage following concussive brain injury in the rat. Acta Neuropathol. 87, 250-258 (1994).
    • (1994) Acta Neuropathol. , vol.87 , pp. 250-258
    • Dietrich, W.D.1
  • 25
    • 0031933403 scopus 로고    scopus 로고
    • Protective effects of moderate hypothermia on behavioral deficits but not necrotic cavitation following cortical impact injury in the rat
    • Dixon, C. E. et al. Protective effects of moderate hypothermia on behavioral deficits but not necrotic cavitation following cortical impact injury in the rat. J Neurotrauma 15, 95-103 (1998).
    • (1998) J Neurotrauma , vol.15 , pp. 95-103
    • Dixon, C.E.1
  • 26
    • 0026625096 scopus 로고
    • Systemic hypothermia in treatment of brain injury
    • Clifton, G. L., Allen, S., Berry, J. & Koch, S. M. Systemic hypothermia in treatment of brain injury. J Neurotrauma 9, Suppl 2, S487-495 (1992).
    • (1992) J Neurotrauma , vol.9 , pp. S487-495
    • Clifton, G.L.1    Allen, S.2    Berry, J.3    Koch, S.M.4
  • 27
    • 84876728859 scopus 로고    scopus 로고
    • Effects of therapeutic hypothermia on the glial proteome and phenotype
    • Kim, J. H., Seo, M. & Suk, K. Effects of therapeutic hypothermia on the glial proteome and phenotype. Curr Protein Pept Sci. 14, 51-60 (2013).
    • (2013) Curr Protein Pept Sci. , vol.14 , pp. 51-60
    • Kim, J.H.1    Seo, M.2    Suk, K.3
  • 28
    • 84858706456 scopus 로고    scopus 로고
    • Neuroprotective mechanisms of hypothermia in brain ischaemia
    • Yenari, M. A. & Han, H. S. Neuroprotective mechanisms of hypothermia in brain ischaemia. Nat Rev Neurosci. 13, 267-278 (2012).
    • (2012) Nat Rev Neurosci. , vol.13 , pp. 267-278
    • Yenari, M.A.1    Han, H.S.2
  • 29
    • 0020525719 scopus 로고
    • Ethical guidelines for investigations of experimental pain in conscious animals
    • Zimmermann, M. Ethical Guidelines for investigations of Experimental Pain in Conscious Animals. Pain. 16, 109-110 (1983).
    • (1983) Pain , vol.16 , pp. 109-110
    • Zimmermann, M.1
  • 30
    • 77953931898 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 expression and protein levels after fluid percussion injury in rats: The effect of injury severity and brain temperature
    • Jia, F. et al. Matrix metalloproteinase-9 expression and protein levels after fluid percussion injury in rats: the effect of injury severity and brain temperature. J Neurotrauma. 27, 1059-1068 (2010).
    • (2010) J Neurotrauma. , vol.27 , pp. 1059-1068
    • Jia, F.1
  • 31
    • 78651372342 scopus 로고    scopus 로고
    • Post-traumatic seizures exacerbate histopathological damage after fluid-percussion brain injury
    • Bao, Y. H. et al. Post-traumatic seizures exacerbate histopathological damage after fluid-percussion brain injury. J Neurotrauma. 28, 35-42 (2011).
    • (2011) J Neurotrauma. , vol.28 , pp. 35-42
    • Bao, Y.H.1
  • 32
    • 84933036444 scopus 로고    scopus 로고
    • Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion
    • Yin, B. et al. Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion. Brain Res. doi: 10.1016/j. brainres.2015.03.024 (2015).
    • (2015) Brain Res.
    • Yin, B.1
  • 34
    • 84873462599 scopus 로고    scopus 로고
    • The tangled circuitry of metabolism and apoptosis
    • Andersen, J. L. & Kornbluth, S. The tangled circuitry of metabolism and apoptosis. Mol Cell. 49, 399-410 (2013).
    • (2013) Mol Cell. , vol.49 , pp. 399-410
    • Andersen, J.L.1    Kornbluth, S.2
  • 35
    • 43049152912 scopus 로고    scopus 로고
    • TNF-alpha induces two distinct caspase-8 activation pathways
    • Wang, L., Du, F. & Wang, X. TNF-alpha induces two distinct caspase-8 activation pathways. Cell. 133, 693-703 (2008).
    • (2008) Cell , vol.133 , pp. 693-703
    • Wang, L.1    Du, F.2    Wang, X.3
  • 36
    • 5944233768 scopus 로고    scopus 로고
    • Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
    • Holler, N. et al. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol. 1, 489-495 (2000).
    • (2000) Nat Immunol. , vol.1 , pp. 489-495
    • Holler, N.1
  • 37
    • 0027201877 scopus 로고
    • Unilateral cortical contusion injury in the rat: Vascular disruption and temporal development of cortical necrosis
    • Sutton, R. L., Lescaudron, L. & Stein, D. G. Unilateral cortical contusion injury in the rat: vascular disruption and temporal development of cortical necrosis. J Neurotrauma. 10, 135-149 (1993).
    • (1993) J Neurotrauma. , vol.10 , pp. 135-149
    • Sutton, R.L.1    Lescaudron, L.2    Stein, D.G.3
  • 38
    • 84899850247 scopus 로고    scopus 로고
    • Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3
    • Vieira, M. et al. Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3. Neurobiol Dis. 68, 26-36 (2014).
    • (2014) Neurobiol Dis. , vol.68 , pp. 26-36
    • Vieira, M.1
  • 39
    • 84859299752 scopus 로고    scopus 로고
    • Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury
    • Linkermann, A. et al. Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury. Kidney Int. 81, 751-761 (2012).
    • (2012) Kidney Int. , vol.81 , pp. 751-761
    • Linkermann, A.1
  • 40
    • 60749117577 scopus 로고    scopus 로고
    • Effect of post-traumatic mild hypothermia on hippocampal cell death after traumatic brain injury in rats
    • Jia, F., Mao, Q., Liang, Y. M. & Jiang, J. Y. Effect of post-traumatic mild hypothermia on hippocampal cell death after traumatic brain injury in rats. J Neurotrauma. 26, 243-252 (2009).
    • (2009) J Neurotrauma. , vol.26 , pp. 243-252
    • Jia, F.1    Mao, Q.2    Liang, Y.M.3    Jiang, J.Y.4
  • 41
    • 84907164146 scopus 로고    scopus 로고
    • Protective effects of necrostatin-1 on glucocorticoid-induced osteoporosis in rats
    • Feng, M. et al. Protective effects of necrostatin-1 on glucocorticoid-induced osteoporosis in rats. J Steroid Biochem Mol Biol. 144, Pt B, 455-462 (2014).
    • (2014) J Steroid Biochem Mol Biol. , vol.144 , pp. 455-462
    • Feng, M.1
  • 42
    • 84868531636 scopus 로고    scopus 로고
    • Fueling the flames: Mammalian programmed necrosis in inflammatory diseases
    • Chan, F. K. Fueling the flames: Mammalian programmed necrosis in inflammatory diseases. Cold Spring Harb Perspect Biol. doi: 10.1101/cshperspect.a008805 (2012).
    • (2012) Cold Spring Harb Perspect Biol.
    • Chan, F.K.1
  • 43
    • 84878964122 scopus 로고    scopus 로고
    • TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1
    • Moujalled, D. M. et al. TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1. Cell Death Dis. 4, e465 (2013).
    • (2013) Cell Death Dis. , vol.4 , pp. e465
    • Moujalled, D.M.1
  • 44
    • 84897088275 scopus 로고    scopus 로고
    • Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis
    • Newton, K. et al. Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis. Science. 343, 1357-1360 (2014).
    • (2014) Science , vol.343 , pp. 1357-1360
    • Newton, K.1
  • 45
    • 84912106351 scopus 로고    scopus 로고
    • RIP3 induces apoptosis independent of pronecrotic kinase activity
    • Mandal, P. et al. RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity. Mol Cell. 56, 481-495 (2014).
    • (2014) Mol Cell. , vol.56 , pp. 481-495
    • Mandal, P.1
  • 46
    • 84862907788 scopus 로고    scopus 로고
    • Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase
    • Sun, L. et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell. 148, 213-227 (2012).
    • (2012) Cell , vol.148 , pp. 213-227
    • Sun, L.1
  • 47
    • 84870501216 scopus 로고    scopus 로고
    • Therapeutic hypothermia for traumatic brain injury
    • Urbano, L. A. & Oddo, M. Therapeutic hypothermia for traumatic brain injury. Curr Neurol Neurosci Rep. 12, 580-591 (2012).
    • (2012) Curr Neurol Neurosci Rep. , vol.12 , pp. 580-591
    • Urbano, L.A.1    Oddo, M.2
  • 48
    • 33750349217 scopus 로고    scopus 로고
    • Therapeutic hypothermia modulates TNFR1 signaling in the traumatized brain via early transient activation of the JNK pathway and suppression of XIAP cleavage
    • Lotocki, G. et al. Therapeutic hypothermia modulates TNFR1 signaling in the traumatized brain via early transient activation of the JNK pathway and suppression of XIAP cleavage. Eur J Neurosci. 24, 2283-2290 (2006).
    • (2006) Eur J Neurosci. , vol.24 , pp. 2283-2290
    • Lotocki, G.1
  • 49
    • 8444242969 scopus 로고    scopus 로고
    • Traumatic injury in the developing brain-effects of hypothermia
    • Fritz, H. G. & Bauer, R. Traumatic injury in the developing brain-effects of hypothermia. Exp Toxicol Pathol. 56, 91-102 (2004).
    • (2004) Exp Toxicol Pathol. , vol.56 , pp. 91-102
    • Fritz, H.G.1    Bauer, R.2
  • 50
    • 84892439582 scopus 로고    scopus 로고
    • Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration
    • Murakami, Y. et al. Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration. Cell Death Differ 21, 270-277 (2014).
    • (2014) Cell Death Differ , vol.21 , pp. 270-277
    • Murakami, Y.1
  • 51
    • 66749183275 scopus 로고    scopus 로고
    • Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha
    • He, S. et al. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell. 137, 1100-1111 (2009).
    • (2009) Cell , vol.137 , pp. 1100-1111
    • He, S.1
  • 52
    • 84881184694 scopus 로고    scopus 로고
    • Mlkl knockout mice demonstrate the indispensable role of mlkl in necroptosis
    • Wu, J. et al. Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Cell Res. 23, 994-1006 (2013).
    • (2013) Cell Res. , vol.23 , pp. 994-1006
    • Wu, J.1
  • 53
    • 84893808994 scopus 로고    scopus 로고
    • RIPK3 as a potential therapeutic target for gaucher's disease
    • Vitner, E. B. et al. RIPK3 as a potential therapeutic target for Gaucher's disease. Nat Med. 20, 204-208 (2014).
    • (2014) Nat Med. , vol.20 , pp. 204-208
    • Vitner, E.B.1
  • 54
    • 84880357849 scopus 로고    scopus 로고
    • Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury
    • Linkermann, A. et al. Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury. Proc Natl Acad Sci USA 110, 12024-12029 (2013).
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 12024-12029
    • Linkermann, A.1
  • 55
    • 34547868894 scopus 로고    scopus 로고
    • The antiinflammatory effects of propofol in endotoxemic rats during moderate and mild hypothermia
    • Kanakura, H. & Taniguchi, T. The antiinflammatory effects of propofol in endotoxemic rats during moderate and mild hypothermia. J Anesth. 21, 354-360 (2007).
    • (2007) J Anesth. , vol.21 , pp. 354-360
    • Kanakura, H.1    Taniguchi, T.2
  • 56
    • 84867101159 scopus 로고    scopus 로고
    • Anti-high mobility group box-1 antibody therapy for traumatic brain injury
    • Okuma, Y. et al. Anti-high mobility group box-1 antibody therapy for traumatic brain injury. Ann Neurol. 72, 373-384 (2012).
    • (2012) Ann Neurol. , vol.72 , pp. 373-384
    • Okuma, Y.1
  • 57
    • 0036326050 scopus 로고    scopus 로고
    • Elevated intracranial IL-18 in humans and mice after traumatic brain injury and evidence of neuroprotective effects of IL-18-binding protein after experimental closed head injury
    • Yatsiv, I. et al. Elevated intracranial IL-18 in humans and mice after traumatic brain injury and evidence of neuroprotective effects of IL-18-binding protein after experimental closed head injury. J Cereb Blood Flow Metab. 22, 971-978 (2002).
    • (2002) J Cereb Blood Flow Metab. , vol.22 , pp. 971-978
    • Yatsiv, I.1


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