Therapeutic hypothermia modulates TNFR1 signaling in the traumatized brain via early transient activation of the JNK pathway and suppression of XIAP cleavage

European Journal of Neuroscience

Volumn 24, Issue 8, 2006, Pages 2283-2290

  Lotocki, George ^a   De Rivero Vaccari, Juan Pablo ^a   Perez, Enrique R ^a   Alonso, Ofelia F ^a   Curbelo, Karell ^a   Keane, Robert W ^a   Dietrich, W Dalton ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Inflammation; Intracellular signaling; Preconditioning; Traumatic brain injury; Tumor necrosis factor

Indexed keywords

CASPASE 3; HEAT SHOCK PROTEIN 70; I KAPPA B KINASE BETA; MITOGEN ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR RECEPTOR 1; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; CRYOTHERAPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRAUMATIC BRAIN INJURY;

ANIMALS; ANTIBODIES; BODY TEMPERATURE; BRAIN INJURIES; CASPASES; CELL SURVIVAL; ENZYME ACTIVATION; HSP70 HEAT-SHOCK PROTEINS; HYPOTHERMIA, INDUCED; I-KAPPA B PROTEINS; IMMUNOBLOTTING; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; RATS; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SIGNAL TRANSDUCTION; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 33750349217     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2006.05123.x     Document Type: Article

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