RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling aftermyocardial infarction

Cardiovascular Research

Volumn 103, Issue 2, 2014, Pages 206-216

  Luedde, Mark ^a   Lutz, Matthias ^a   Carter, Natalie ^a   Sosna, Justyna ^a   Jacoby, Christoph ^b   Vucur, Mihael ^c   Gautheron, Jérémie ^c   Roderburg, Christoph ^c   Borg, Nadine ^b   Reisinger, Florian ^d   Hippe, Hans Joerg ^a   Linkermann, Andreas ^a   Wolf, Monika J ^e   Rose John, Stefan ^a   Lüllmann Rauch, Renate ^a   Adam, Dieter ^a   Flögel, Ulrich ^b   Heikenwalder, Mathias ^a   Luedde, Tom ^c   Frey, Norbert ^a,f  

^a UNIVERSITY OF KIEL   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e UNIVERSITY OF ZURICH   (Switzerland)

^f DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

Inflammation; Myocardial infarction; Programmed necrosis; Receptor interacting protein 3; Remodelling

Indexed keywords

PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; RECEPTOR INTERACTING PROTEIN KINASE 1; RECEPTOR INTERACTING PROTEIN KINASE 3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RECEPTOR-INTERACTING PROTEIN 3, RAT; RIPK3 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CORONARY ARTERY LIGATION; EXPERIMENTAL MYOCARDIAL INFARCTION; GENE OVEREXPRESSION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; IMMUNOBLOTTING; IN VIVO STUDY; INFLAMMATION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MOUSE; NECROPTOSIS; NEWBORN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; UPREGULATION; ANIMAL; C57BL MOUSE; CELL DEATH; HEART INFARCTION; HEART MUSCLE; METABOLISM; MITOCHONDRION; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; WISTAR RAT;

ANIMALS; CELL DEATH; MICE, INBRED C57BL; MITOCHONDRIA; MYOCARDIAL INFARCTION; MYOCARDIUM; MYOCYTES, CARDIAC; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84904322380     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvu146     Document Type: Article

References (36)

1. World Health Organization. The top 10 causes of death. Fact sheet N° 310, 2014
2. Sugano M, Koyanagi M, Tsuchida K, Hata T, Makino N. In vivo gene transfer of soluble TNF-alpha receptor 1 alleviates myocardial infarction. FASEB J 2002;16:1421-1422
3. Wollert KC, Heineke J, Westermann J, Ludde M, Fiedler B, Zierhut W, Laurent D, Bauer MK, Schulze-Osthoff K, Drexler H. The cardiac Fas (APO-1/CD95) Receptor/ Fas ligand system: relation to diastolic wall stress in volume-overload hypertrophy in vivo and activation of the transcription factor AP-1 in cardiac myocytes. Circulation 2000;101:1172-1178 (Pubitemid 30146620)
4. Bialik S, Geenen DL, Sasson IE, Cheng R, Horner JW, Evans SM, Lord EM, Koch CJ, Kitsis RN. Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53. J Clin Invest 1997;100:1363-1372 (Pubitemid 27425760)
5. Sun M, DawoodF,WenWH,Chen M, Dixon I, KirshenbaumLA, Liu PP. Excessive tumor necrosis factor activation after infarction contributes to susceptibility of myocardial rupture and left ventricular dysfunction. Circulation 2004;110:3221-3228 (Pubitemid 39525069)
6. Kung G, Konstantinidis K, Kitsis RN. Programmed necrosis, not apoptosis, in the heart. Circ Res 2011;108:1017-1036
7. Dorn GW II. Apoptotic and non-apoptotic programmed cardiomyocyte death in ventricular remodelling. Cardiovasc Res 2009;81:465-473
8. Declercq W, Vanden Berghe T, Vandenabeele P. RIP kinases at the crossroads of cell death and survival. Cell 2009;138:229-232
9. He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 2009;137: 1100-1111
10. Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 2009;325:332-336
11. Christofferson DE, Yuan J. Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol 2010;22:263-268
12. Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK. Phosphorylationdriven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 2009;137:1112-1123
13. Welz PS, Wullaert A, Vlantis K, Kondylis V, Fernandez-Majada V, Ermolaeva M, Kirsch P, Sterner-Kock A, van Loo G, Pasparakis M. FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature 2011;477:330-334
14. Lim SY, Davidson SM, Mocanu MM, YellonDM, Smith CC. The cardioprotective effect of necrostatin requires the cyclophilin-D component of the mitochondrial permeability transition pore. Cardiovasc Drugs Ther 2007;21:467-469 (Pubitemid 350231514)
15. Oerlemans MI, Liu J, Arslan F, den Ouden K, van Middelaar BJ, Doevendans PA, Sluijter JP. Inhibition of RIP1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia-reperfusion in vivo. Basic Res Cardiol 2012;107:270
16. Smith CC, Davidson SM, Lim SY, Simpkin JC, Hothersall JS, Yellon DM. Necrostatin: A potentially novel cardioprotective agent. Cardiovasc Drugs Ther 2007;21:227-233 (Pubitemid 47387468)
17. Hippe HJ, Luedde M, Lutz S, Koehler H, Eschenhagen T, Frey N, Katus HA, Wieland T, Niroomand F. Regulation of cardiac cAMP synthesis and contractility by nucleoside diphosphate kinase B/G protein beta gamma dimer complexes. Circ Res 2007;100: 1191-1199 (Pubitemid 46684132)
18. Newton K, Sun X, Dixit VM. Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4. Mol Cell Biol 2004;24:1464-1469 (Pubitemid 38167070)
19. Flogel U, Ding Z, Hardung H, Jander S, Reichmann G, Jacoby C, Schubert R, Schrader J. In vivo monitoring of inflammation after cardiac and cerebral ischemia by fluorine magnetic resonance imaging. Circulation 2008;118:140-148
20. Wang Z, Jiang H, Chen S, Du F,Wang X. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 2012;148: 228-243
21. Galluzzi L, Kepp O, KroemerG. Mitochondria: master regulators of danger signalling. Nat Rev Mol Cell Biol 2012;13:780-788
22. Kaiser WJ, Upton JW, Long AB, Livingston-Rosanoff D, Daley-Bauer LP, Hakem R, Caspary T, Mocarski ES. RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 2011;471:368-372
23. Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C, Hakem R, Salvesen GS, Green DR. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 2011;471:363-367
24. Vanlangenakker N, Bertrand MJ, Bogaert P, Vandenabeele P, Vanden Berghe T. TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members. Cell Death Dis 2011;2:e230
25. Han J, Zhong CQ, Zhang DW. Programmed necrosis: backup to and competitor with apoptosis in the immune system. Nat Immunol 2011;12:1143-1149
26. Frantz S, Bauersachs J, Ertl G. Post-infarct remodelling: contribution of wound healing and inflammation. Cardiovasc Res 2009;81:474-481
27. Whelan RS, Kaplinskiy V, Kitsis RN. Cell death in the pathogenesis of heart disease: mechanisms and significance. Annu Rev Physiol 2010;72:19-44
28. Takimoto E, Kass DA. Role of oxidative stress in cardiac hypertrophy and remodeling. Hypertension 2007;49:241-248 (Pubitemid 46142995)
29. Hori M, Nishida K. Oxidative stress and left ventricular remodelling after myocardial infarction. Cardiovasc Res 2009;81:457-464
30. Chan FK, Baehrecke EH. RIP3 finds partners in crime. Cell 2012;148:17-18
31. Sun L,Wang H,Wang Z,HeS, ChenS, Liao D,Wang L, YanJ, LiuW, Lei X,Wang X. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 2012;148:213-227
32. Vanden Berghe T, Vanlangenakker N, Parthoens E, Deckers W, Devos M, Festjens N, Guerin CJ, Brunk UT, DeclercqW, Vandenabeele P. Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features. Cell Death Differ 2010; 17:922-930
33. Vanlangenakker N, Vanden Berghe T, Bogaert P, Laukens B, Zobel K, Deshayes K, Vucic D, Fulda S, Vandenabeele P, Bertrand MJ. cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Cell Death Differ 2011;18:656-665
34. Li Q, Spencer NY, Oakley FD, Buettner GR, Engelhardt JF. Endosomal Nox2 facilitates redox-dependent induction of NF-kappaB by TNF-alpha. Antioxid Redox Signal 2009; 11:1249-1263
35. Fliegner D, Westermann D, Riad A, Schubert C, Becher E, Fielitz J, Tschope C, Regitz-Zagrosek V. Up-regulation of PPARgamma in myocardial infarction. Eur J Heart Fail 2008;10:30-38
36. TaitSW, Oberst A, Quarato G, Milasta S, Haller M,Wang R, Karvela M, Ichim G, Yatim N, Albert ML, Kidd G,Wakefield R, Frase S, Krautwald S, Linkermann A, Green DR. Widespread mitochondrial depletion via mitophagy does not compromise necroptosis. Cell Rep 2013;5:878-885