Tumor necrosis factor alpha and Fas receptor contribute to cognitive deficits independent of cell death after concussive traumatic brain injury in mice

Journal of Cerebral Blood Flow and Metabolism

Volumn 31, Issue 2, 2011, Pages 778-789

  Khuman, Jugta ^a   Meehan, William P ^a,b   Zhu, Xiaoxia ^a,c   Qiu, Jianhua ^a   Hoffmann, Ulrike ^a   Zhang, Jimmy ^a   Giovannone, Eric ^a   Lo, Eng H ^a   Whalen, Michael J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c FUDAN UNIVERSITY   (China)

Author keywords

cognition; concussion; inflammation; mice; traumatic brain injury; tumor necrosis factor

Indexed keywords

FAS ANTIGEN; MESSENGER RNA; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN NERVE CELL; CELL ACTIVATION; COGNITIVE DEFECT; CONCUSSION; CONTROLLED STUDY; FUNCTION TEST; HEAD INJURY; HEAD MOVEMENT; MALE; MAZE TEST; MICROGLIA; MOUSE; NERVE CELL NECROSIS; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRAUMATIC BRAIN INJURY; WILD TYPE; WIRE GRIP TEST;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIGENS, CD95; ASTROCYTES; BLOOD-BRAIN BARRIER; BRAIN CONCUSSION; BRAIN EDEMA; BRAIN INJURIES; CELL COUNT; CELL DEATH; COGNITION DISORDERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HAND STRENGTH; HEAD INJURIES, CLOSED; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MAZE LEARNING; MICE; MICROGLIA; NEUTROPHILS; NF-KAPPA B; PERMEABILITY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79551631617     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2010.172     Document Type: Article

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