Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 4, 2016, Pages 1026-1031

  Youm, Yun Hee ^a   Horvath, Tamas L ^a   Mangelsdorf, David J ^b,c   Kliewer, Steven A ^b,c   Dixit, Vishwa Deep ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Aging; FGF21; Inflammation; Metabolism; Thymus

Indexed keywords

FIBROBLAST GROWTH FACTOR 21; FIBROBLAST GROWTH FACTOR RECEPTOR; KLOTHO PROTEIN; LIPID; FIBROBLAST GROWTH FACTOR; LYMPHOCYTE ANTIGEN RECEPTOR;

ADULT; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BROWN ADIPOSE TISSUE; CALORIC RESTRICTION; CONTROLLED STUDY; EPITHELIUM CELL; GENE OVEREXPRESSION; GENETIC GAIN; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNE SYSTEM; INVOLUTION; LETHALITY; MIDDLE AGED; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SENESCENCE; STEM CELL; STROMA CELL; T LYMPHOCYTE; THYMOCYTE; THYMUS; ANIMAL; C57BL MOUSE; IMMUNOLOGY; IMMUNOSENESCENCE; PHYSIOLOGY;

AGING; ANIMALS; FIBROBLAST GROWTH FACTORS; IMMUNOSENESCENCE; MICE; MICE, INBRED C57BL; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; THYMUS GLAND;

EID: 84955481171     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1514511113     Document Type: Article

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