Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver

Toxicological Sciences

Volumn 150, Issue 1, 2016, Pages 204-215

  Hu, Jiangting ^a,b   Ramshesh, Venkat K ^a,b   McGill, Mitchell R ^c   Jaeschke, Hartmut ^c   Lemasters, John J ^a,b,d  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^d INSTITUTE OF THEORETICAL AND EXPERIMENTAL BIOPHYSICS   (Russian Federation)

Author keywords

APAP; Hepatocytes; Mitochondria; Multiphoton microscopy; Nontoxic dose

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BENZOQUINONE DERIVATIVE; CYCLOSPORIN DERIVATIVE; FAT DROPLET; N ACETYL 4 -BENZOQUINONE IMINE; N METHYL 4 ISOLEUCINE CYCLOSPORIN; PARACETAMOL; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; (MELLE-4)CYCLOSPORIN; CYCLOSPORIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL VIABILITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; IN VIVO STUDY; LIVER; LIVER CELL; LIVER INJURY; LOW DRUG DOSE; MALE; MITOCHONDRIAL PERMEABILITY; MOUSE; NECROSIS; NONHUMAN; PROTON TRANSPORT; STEATOSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; C57BL MOUSE; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER MITOCHONDRION; METABOLISM; MULTIPHOTON MICROSCOPY; PATHOLOGY; TOXIC HEPATITIS;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANIMALS; CHEMICAL AND DRUG INDUCED LIVER INJURY; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; INJECTIONS, INTRAPERITONEAL; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER; MALE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; MITOCHONDRIA, LIVER;

EID: 84963799629     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv319     Document Type: Article

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