Linkers having a crucial role in antibody–drug conjugates

International Journal of Molecular Sciences

Volumn 17, Issue 4, 2016, Pages

  Lu, Jun ^a   Jiang, Feng ^a   Lu, Aiping ^a   Zhang, Ge ^a  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

Antibody drug conjugates; Attachment site; Cytotoxic drug; Linker; Monoclonal antibody; Tumor

Indexed keywords

ANETUMAB RAVTANSINE; BRENTUXIMAB VEDOTIN; CALICHEAMICIN; CANTUZUMAB RAVTANSINE; COLTUXIMAB RAVTANSINE; CYTOTOXIC AGENT; DOXORUBICIN; ENFORTUMAB VEDOTIN; GEMTUZUMAB OZOGAMICIN; GLEMBATUMUMAB VEDOTIN; HUMAN IMMUNOGLOBULIN; INDATUXIMAB RAVTANSINE; INOTUZUMAB OZOGAMICIN; LORVOTUZUMAB MERTANSINE; MAYTANSINE; MILATUZUMAB; MONOCLONAL ANTIBODY; SOBLIDOTIN; TRASTUZUMAB EMTANSINE; VORSETUZUMAB MAFODOTIN; ANTIBODY CONJUGATE; ANTINEOPLASTIC AGENT; CROSS LINKING REAGENT;

ACUTE MYELOBLASTIC LEUKEMIA; ANTIGEN ANTIBODY REACTION; B CELL LYMPHOMA; BREAST CANCER; BREAST METASTASIS; CANCER THERAPY; CROSS LINKING; CYTOTOXICITY; DRUG CONJUGATION; DRUG RELEASE; DRUG STABILITY; GLIOBLASTOMA; HUMAN; IMMUNOGENICITY; INTERNALIZATION; KIDNEY CARCINOMA; LYMPHOMA; LYSOSOME; MULTIPLE MYELOMA; NONHODGKIN LYMPHOMA; PHARMACODYNAMICS; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); REVIEW; SOLID TUMOR; STRUCTURE ACTIVITY RELATION; THERAPEUTIC INDEX; ANIMAL; CHEMISTRY; MOLECULAR MODEL; NEOPLASMS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CROSS-LINKING REAGENTS; HUMANS; IMMUNOCONJUGATES; MODELS, MOLECULAR; NEOPLASMS;

EID: 84963737665     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms17040561     Document Type: Review

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