Conjugation site heterogeneity causes variable electrostatic properties in Fc conjugates

Bioconjugate Chemistry

Volumn 24, Issue 6, 2013, Pages 1008-1016

  Boylan, Nicholas J ^a   Zhou, Wen ^a,c   Proos, Robert J ^a   Tolbert, Thomas J ^b   Wolfe, Janet L ^a   Laurence, Jennifer S ^b  

^a Wolfe Laboratories Inc   (United States)

^b UNIVERSITY OF KANSAS   (United States)

^c BAXTER HEALTHCARE CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBODIES; DRUG PRODUCTS; ELECTROSTATICS; ION CHROMATOGRAPHY; ION EXCHANGE;

ANTIBODY-DRUG CONJUGATES; CHARGE PROPERTIES; CHARGE VARIANTS; CLINICAL DEVELOPMENT; DEVELOPMENT PROCESS; ELECTROSTATIC PROPERTIES; IMMUNOCONJUGATE; ION EXCHANGE CHROMATOGRAPHY; ISOELECTRIC FOCUSING; SITE HETEROGENEITY;

CHROMATOGRAPHIC ANALYSIS;

ANTIBODY CONJUGATE; IMMUNOGLOBULIN G1; LYSINE;

ANION EXCHANGE; ARTICLE; CONJUGATION; DEAMINATION; ION EXCHANGE CHROMATOGRAPHY; ISOELECTRIC FOCUSING; ISOLATION PROCEDURE; MASS SPECTROMETRY; PROTEIN ANALYSIS; PROTEIN PURIFICATION; STATIC ELECTRICITY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ALEXA;

EID: 84879376486     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc4000564     Document Type: Article

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