-
1
-
-
0025753852
-
The molecular pathology of Alzheimer’s disease
-
CrossRef
-
Selkoe, D.J. The molecular pathology of Alzheimer’s disease. Neuron 1991, 6, 487-498. [CrossRef]
-
(1991)
Neuron
, vol.6
, pp. 487-498
-
-
Selkoe, D.J.1
-
2
-
-
3943092621
-
Pathway towards and away from Alzheimer’s disease
-
CrossRefPubMed
-
Mattson, M.P. Pathway towards and away from Alzheimer’s disease. Nature 2004, 430, 631-639. [CrossRef] [PubMed]
-
(2004)
Nature
, vol.430
, pp. 631-639
-
-
Mattson, M.P.1
-
3
-
-
75149142375
-
The molecular biology of senile plaques and neurofibrillary tangles in Alzheimer’s disease
-
PubMed
-
Armstrong, R.A. The molecular biology of senile plaques and neurofibrillary tangles in Alzheimer’s disease. Folia Neuropathol. 2009, 47, 289-299. [PubMed]
-
(2009)
Folia Neuropathol
, vol.47
, pp. 289-299
-
-
Armstrong, R.A.1
-
4
-
-
0037135111
-
The amyloid hypothesis of Alzheimer’s disease: Progress and problems on the road to therapeutics
-
CrossRefPubMed
-
Hardy, J.; Selkoe, D.J. The amyloid hypothesis of Alzheimer’s disease: Progress and problems on the road to therapeutics. Science 2002, 297, 353-356. [CrossRef] [PubMed]
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
5
-
-
0027173094
-
A tau-like protein interacts with stress fibers and microtubules in human and rodent cultured cell lines
-
PubMed
-
Cross, D.; Vial, C.; Maccioni, R.B. A tau-like protein interacts with stress fibers and microtubules in human and rodent cultured cell lines. J. Cell Sci. 1993, 105, 51-60. [PubMed]
-
(1993)
J. Cell Sci
, vol.105
, pp. 51-60
-
-
Cross, D.1
Vial, C.2
MacCioni, R.B.3
-
6
-
-
0009364134
-
Microtubule-associated protein tau is a major antigenic component of paired helical filaments in Alzheimer disease
-
CrossRefPubMed
-
Kosik, K.S.; Joachim, C.L.; Selkoe, D.J. Microtubule-associated protein tau is a major antigenic component of paired helical filaments in Alzheimer disease. PNAS 1986, 83, 4044-4048. [CrossRef] [PubMed]
-
(1986)
PNAS
, vol.83
, pp. 4044-4048
-
-
Kosik, K.S.1
Joachim, C.L.2
Selkoe, D.J.3
-
7
-
-
0028845388
-
Role of microtubule-associated proteins in the control of microtubule assembly
-
PubMed
-
Maccioni, R.B.; Cambiazo, V. Role of microtubule-associated proteins in the control of microtubule assembly. Physiol. Rev. 1995, 75, 835-864. [PubMed]
-
(1995)
Physiol. Rev
, vol.75
, pp. 835-864
-
-
MacCioni, R.B.1
Cambiazo, V.2
-
8
-
-
0029034870
-
Tau domains, phosphorylation, and interactions with microtubules
-
CrossRef
-
Mandelkow, E.M.; Biernat, J.; Drewes, G.; Gustke, N.; Trinczek, B.; Mandelkow, E. Tau domains, phosphorylation, and interactions with microtubules. Neurobiol. Aging 1995, 16, 355-363. [CrossRef]
-
(1995)
Neurobiol. Aging
, vol.16
, pp. 355-363
-
-
Mandelkow, E.M.1
Biernat, J.2
Drewes, G.3
Gustke, N.4
Trinczek, B.5
Mandelkow, E.6
-
9
-
-
0026040907
-
Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats
-
CrossRefPubMed
-
Kraegen, E.W.; Clark, P.W.; Jenkins, A.B.; Daley, E.A.; Chisholm, D.J.; Storlien, L.H. Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Diabetes 1991, 40, 1397-1403. [CrossRef] [PubMed]
-
(1991)
Diabetes
, vol.40
, pp. 1397-1403
-
-
Kraegen, E.W.1
Clark, P.W.2
Jenkins, A.B.3
Daley, E.A.4
Chisholm, D.J.5
Storlien, L.H.6
-
10
-
-
0027010404
-
Hypertension, hyperlipidemia, insulin resistance and obesity: Parts of a metabolic syndrome
-
PubMed
-
Lind, L.; Lithell, H. Hypertension, hyperlipidemia, insulin resistance and obesity: Parts of a metabolic syndrome. Blood Press. Suppl. 1992, 4, 49-54. [PubMed]
-
(1992)
Blood Press
, vol.4
, pp. 49-54
-
-
Lind, L.1
Lithell, H.2
-
11
-
-
0034669345
-
Invited commentary: Insulin resistance syndrome? Syndrome X? Multiple metabolic syndrom? A syndrome at all? Factor analysis reveals patterns in the fabric of correlated metabolic risk factors
-
CrossRefPubMed
-
Meigs, J.B. Invited commentary: Insulin resistance syndrome? Syndrome X? Multiple metabolic syndrom? A syndrome at all? Factor analysis reveals patterns in the fabric of correlated metabolic risk factors. Am. J. Epidemiol. 2000, 152, 908-911. [CrossRef] [PubMed]
-
(2000)
Am. J. Epidemiol
, vol.152
, pp. 908-911
-
-
Meigs, J.B.1
-
12
-
-
0031050268
-
Risk of dementia among persons with diabetes mellitus: A population-based cohort study
-
CrossRefPubMed
-
Leibson, C.L.; Rocca, W.A.; Hanson, V.A.; Cha, R.; Kokmen, E.; O’Brien, P.C.; Palumbo, P.J. Risk of dementia among persons with diabetes mellitus: A population-based cohort study. Am. J. Epidemiol. 1997, 145, 301-308. [CrossRef] [PubMed]
-
(1997)
Am. J. Epidemiol
, vol.145
, pp. 301-308
-
-
Leibson, C.L.1
Rocca, W.A.2
Hanson, V.A.3
Cha, R.4
Kokmen, E.5
O’Brien, P.C.6
Palumbo, P.J.7
-
13
-
-
2442424380
-
Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function
-
CrossRefPubMed
-
Arvanitakis, Z.; Wilson, R.S.; Bienias, J.L.; Evans, D.A.; Bennett, D.A. Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch. Neurol. 2004, 61, 661-666. [CrossRef] [PubMed]
-
(2004)
Arch. Neurol
, vol.61
, pp. 661-666
-
-
Arvanitakis, Z.1
Wilson, R.S.2
Bienias, J.L.3
Evans, D.A.4
Bennett, D.A.5
-
14
-
-
78650122129
-
Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer’s disease
-
CrossRefPubMed
-
Frisardi, V.; Solfrizzi, V.; Seripa, D.; Capurso, C.; Santamato, A.; Sancarlo, D.; Vendemiale, G.; Pilotto, A.; Panza, F. Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer’s disease. Ageing Res. Rev. 2010, 9, 399-417. [CrossRef] [PubMed]
-
(2010)
Ageing Res. Rev
, vol.9
, pp. 399-417
-
-
Frisardi, V.1
Solfrizzi, V.2
Seripa, D.3
Capurso, C.4
Santamato, A.5
Sancarlo, D.6
Vendemiale, G.7
Pilotto, A.8
Panza, F.9
-
15
-
-
80052059865
-
Risk factors and preventive interventions for Alzheimer disease: State of the science
-
CrossRefPubMed
-
Daviglus, M.L.; Plassman, B.L.; Pirzada, A.; Bell, C.C.; Bowen, P.E.; Burke, J.R.; Connolly, E.S., Jr.; Dunbar-Jacob, J.M.; Granieri, E.C.; McGarry, K.; et al. Risk factors and preventive interventions for Alzheimer disease: State of the science. Arch. Neurol. 2011, 68, 1185-1190. [CrossRef] [PubMed]
-
(2011)
Arch. Neurol
, vol.68
, pp. 1185-1190
-
-
Daviglus, M.L.1
Plassman, B.L.2
Pirzada, A.3
Bell, C.C.4
Bowen, P.E.5
Burke, J.R.6
Connolly, E.S.7
Dunbar-Jacob, J.M.8
Granieri, E.C.9
McGarry, K.10
-
16
-
-
84881221053
-
Glucose levels and risk of dementia
-
CrossRefPubMed
-
Crane, P.K.; Walker, R.; Hubbard, R.A.; Li, G.; Nathan, D.M.; Zheng, H.; Haneuse, S.; Craft, S.; Montine, T.J.; Kahn, S.E.; et al. Glucose levels and risk of dementia. N. Engl. J. Med. 2013, 369, 540-548. [CrossRef] [PubMed]
-
(2013)
N. Engl. J. Med
, vol.369
, pp. 540-548
-
-
Crane, P.K.1
Walker, R.2
Hubbard, R.A.3
Li, G.4
Nathan, D.M.5
Zheng, H.6
Haneuse, S.7
Craft, S.8
Montine, T.J.9
Kahn, S.E.10
-
17
-
-
0032764016
-
Diabetes mellitus and the risk of dementia: The Rotterdam Study
-
CrossRefPubMed
-
Ott, A.; Stolk, R.P.; van Harskamp, F.; Pols, H.A.P.; Hofman, A.; Breteler, M.M.B. Diabetes mellitus and the risk of dementia: The Rotterdam Study. Neurology 1999, 53, 1937-1942. [CrossRef] [PubMed]
-
(1999)
Neurology
, vol.53
, pp. 1937-1942
-
-
Ott, A.1
Stolk, R.P.2
Van Harskamp, F.3
Pols, H.4
Hofman, A.5
Breteler, M.6
-
18
-
-
0037452760
-
Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly
-
CrossRefPubMed
-
Convit, A.; Wolf, O.T.; Tarshish, C.; de Leon, M.J. Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly. PNAS 2003, 100, 2019-2022. [CrossRef] [PubMed]
-
(2003)
PNAS
, vol.100
, pp. 2019-2022
-
-
Convit, A.1
Wolf, O.T.2
Tarshish, C.3
De Leon, M.J.4
-
19
-
-
15244351255
-
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer’s disease—Is this type 3 diabetes?
-
PubMed
-
Steen, E.; Terry, B.M.; Rivera, E.J.; Cannon, J.L.; Neely, T.R.; Tavares, R.; Xu, X.J.; Wands, J.R.; de la Monte, S.M. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer’s disease—Is this type 3 diabetes? J. Alzheimers Dis. 2005, 7, 63-80. [PubMed]
-
(2005)
J. Alzheimers Dis
, vol.7
, pp. 63-80
-
-
Steen, E.1
Terry, B.M.2
Rivera, E.J.3
Cannon, J.L.4
Neely, T.R.5
Tavares, R.6
Xu, X.J.7
Wands, J.R.8
De La Monte, S.M.9
-
20
-
-
54549127447
-
Impaired insulin secretion increases the risk of Alzheimer disease
-
CrossRefPubMed
-
Rönnemaa, E.; Zethelius, B.; Sundelöf, J.; Sundström, J.; Degerman-Gunnarsson, M.; Berne, C.; Lannfelt, L.; Kilander, L. Impaired insulin secretion increases the risk of Alzheimer disease. Neurology 2008, 71, 1065-1071. [CrossRef] [PubMed]
-
(2008)
Neurology
, vol.71
, pp. 1065-1071
-
-
Rönnemaa, E.1
Zethelius, B.2
Sundelöf, J.3
Sundström, J.4
Degerman-Gunnarsson, M.5
Berne, C.6
Lannfelt, L.7
Kilander, L.8
-
21
-
-
77957289008
-
Metabolic syndrome and cognitive impairment: Current epidemiology and possible underlying mechanisms
-
PubMed
-
Panza, F.; Frisardi, V.; Capurso, C.; Imbimbo, B.P.; Vendemiale, G.; Santamato, A.; D’Onofrio, G.; Seripa, D.; Sancarlo, D.; Pilotto, A.; et al. Metabolic syndrome and cognitive impairment: Current epidemiology and possible underlying mechanisms. J. Alzheimers Dis. 2010, 21, 691-724. [PubMed]
-
(2010)
J. Alzheimers Dis
, vol.21
, pp. 691-724
-
-
Panza, F.1
Frisardi, V.2
Capurso, C.3
Imbimbo, B.P.4
Vendemiale, G.5
Santamato, A.6
D’Onofrio, G.7
Seripa, D.8
Sancarlo, D.9
Pilotto, A.10
-
22
-
-
80555157642
-
Glucose tolerance status and risk of dementia in the community: The Hisayama study
-
CrossRefPubMed
-
Ohara, T.; Doi, Y.; Ninomiya, T.; Hirakawa, Y.; Hata, J.; Iwaki, T.; Kanba, S.; Kiyohara, Y. Glucose tolerance status and risk of dementia in the community: The Hisayama study. Neurology 2011, 77, 1126-1134. [CrossRef] [PubMed]
-
(2011)
Neurology
, vol.77
, pp. 1126-1134
-
-
Ohara, T.1
Doi, Y.2
Ninomiya, T.3
Hirakawa, Y.4
Hata, J.5
Iwaki, T.6
Kanba, S.7
Kiyohara, Y.8
-
23
-
-
84903136322
-
Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease
-
CrossRefPubMed
-
De Felice, F.G.; Ferreira, S.T. Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease. Diabetes 2014, 63, 2262-2272. [CrossRef] [PubMed]
-
(2014)
Diabetes
, vol.63
, pp. 2262-2272
-
-
De Felice, F.G.1
Ferreira, S.T.2
-
24
-
-
51549110571
-
Expression of insulin system in the olfactory epithelium: First approaches to its role and regulation
-
CrossRefPubMed
-
Lacroix, M.C.; Badonnel, K.; Meunier, N.; Tan, F.; Schlegel-Le Poupon, C.; Durieux, D.; Monnerie, R.; Baly, C.; Congar, P.; Salesse, R. et al. Expression of insulin system in the olfactory epithelium: First approaches to its role and regulation. J. Neuroendocrinol. 2008, 20, 1176-1190. [CrossRef] [PubMed]
-
(2008)
J. Neuroendocrinol
, vol.20
, pp. 1176-1190
-
-
Lacroix, M.C.1
Badonnel, K.2
Meunier, N.3
Tan, F.4
Schlegel-Le Poupon, C.5
Durieux, D.6
Monnerie, R.7
Baly, C.8
Congar, P.9
Salesse, R.10
-
25
-
-
82955181280
-
Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb
-
CrossRefPubMed
-
Kuwabara, T.; Kagalwala, M.N.; Onuma, Y.; Ito, Y.; Warashina, M.; Terashima, K.; Sanosaka, T.; Nakashima, K.; Gage, F.H.; Asashima, M. Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb. EMBO Mol. Med. 2011, 3, 742-754. [CrossRef] [PubMed]
-
(2011)
EMBO Mol. Med
, vol.3
, pp. 742-754
-
-
Kuwabara, T.1
Kagalwala, M.N.2
Onuma, Y.3
Ito, Y.4
Warashina, M.5
Terashima, K.6
Sanosaka, T.7
Nakashima, K.8
Gage, F.H.9
Asashima, M.10
-
26
-
-
0036895563
-
The role of insulin in human brain glucose metabolism: An 18 fluoro-deoxyglucose positron emission tomography study
-
CrossRefPubMed
-
Bingham, E.M.; Hopkins, D.; Smith, D.; Pernet, A.; Hallett, W.; Reed, L.; Marsden, P.K.; Amiel, S.A. The role of insulin in human brain glucose metabolism: An 18 fluoro-deoxyglucose positron emission tomography study. Diabetes 2002, 51, 3384-3390. [CrossRef] [PubMed]
-
(2002)
Diabetes
, vol.51
, pp. 3384-3390
-
-
Bingham, E.M.1
Hopkins, D.2
Smith, D.3
Pernet, A.4
Hallett, W.5
Reed, L.6
Marsden, P.K.7
Amiel, S.A.8
-
27
-
-
1842633872
-
Insulin and the insulin receptor in experimental models of learning and memory
-
CrossRefPubMed
-
Zhao, W.Q.; Chen, H.; Quon, M.J.; Alkon, D.L. Insulin and the insulin receptor in experimental models of learning and memory. Eur. J. Pharmacol. 2004, 490, 71-81. [CrossRef] [PubMed]
-
(2004)
Eur. J. Pharmacol
, vol.490
, pp. 71-81
-
-
Zhao, W.Q.1
Chen, H.2
Quon, M.J.3
Alkon, D.L.4
-
28
-
-
10644221251
-
Insulin enhances mitochondrial inner membrane potential and increases ATP levels through phosphoinositide 3-kinase in adult sensory neurons
-
CrossRefPubMed
-
Huang, T.J.; Verkhratsky, A.; Fernyhough, P. Insulin enhances mitochondrial inner membrane potential and increases ATP levels through phosphoinositide 3-kinase in adult sensory neurons. Mol. Cell. Neurosci. 2005, 28, 42-54. [CrossRef] [PubMed]
-
(2005)
Mol. Cell. Neurosci
, vol.28
, pp. 42-54
-
-
Huang, T.J.1
Verkhratsky, A.2
Fernyhough, P.3
-
29
-
-
33750882488
-
Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress
-
CrossRefPubMed
-
Duarte, A.I.; Proença, T.; Oliveira, C.R.; Santos, M.S.; Rego, A.C. Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress. Diabetes 2006, 55, 2863-2870. [CrossRef] [PubMed]
-
(2006)
Diabetes
, vol.55
, pp. 2863-2870
-
-
Duarte, A.I.1
Proença, T.2
Oliveira, C.R.3
Santos, M.S.4
Rego, A.C.5
-
30
-
-
33645100144
-
Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway
-
CrossRefPubMed
-
Salkovic-Petrisic, M.; Tribl, F.; Schmidt, M.; Hoyer, S.; Riederer, P. Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway. J. Neurochem. 2006, 96, 1005-1015. [CrossRef] [PubMed]
-
(2006)
J. Neurochem
, vol.96
, pp. 1005-1015
-
-
Salkovic-Petrisic, M.1
Tribl, F.2
Schmidt, M.3
Hoyer, S.4
Riederer, P.5
-
31
-
-
78651274000
-
Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes
-
CrossRefPubMed
-
Baker, L.D.; Cross, D.J.; Minoshima, S.; Belongia, D.; Watson, G.S.; Craft, S. Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes. Arch. Neurol. 2010, 68, 51-57. [CrossRef] [PubMed]
-
(2010)
Arch. Neurol
, vol.68
, pp. 51-57
-
-
Baker, L.D.1
Cross, D.J.2
Minoshima, S.3
Belongia, D.4
Watson, G.S.5
Craft, S.6
-
32
-
-
4644286910
-
Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer’s disease
-
CrossRefPubMed
-
Ho, L.; Qin, W.; Pompl, P.N.; Xiang, Z.; Wang, J.; Zhao, Z.; Peng, Y.; Cambareri, G.; Rocher, A.; Mobbs, C.V. et al. Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer’s disease. FASEB J. 2004, 18, 902-904. [CrossRef] [PubMed]
-
(2004)
FASEB J
, vol.18
, pp. 902-904
-
-
Ho, L.1
Qin, W.2
Pompl, P.N.3
Xiang, Z.4
Wang, J.5
Zhao, Z.6
Peng, Y.7
Cambareri, G.8
Rocher, A.9
Mobbs, C.V.10
-
33
-
-
77950352189
-
GLP-1 receptor stimulation reduces amyloid-β peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer’s disease
-
PubMed
-
Li, Y.; Duffy, K.B.; Ottinger, M.A.; Ray, B.; Bailey, J.A.; Holloway, H.W.; Tweedie, D.; Perry, T.; Mattson, M.P.; Kapogiannis, D. et al. GLP-1 receptor stimulation reduces amyloid-β peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer’s disease. J. Alzheimers Dis. 2010, 19, 1205-1219. [PubMed]
-
(2010)
J. Alzheimers Dis
, vol.19
, pp. 1205-1219
-
-
Li, Y.1
Duffy, K.B.2
Ottinger, M.A.3
Ray, B.4
Bailey, J.A.5
Holloway, H.W.6
Tweedie, D.7
Perry, T.8
Mattson, M.P.9
Kapogiannis, D.10
-
34
-
-
77049100748
-
Insulin-resistant brain state after intracerebroventricular streptozotocin injection exacerbates Alzheimer-like changes in Tg2576 AβPP-overexpressing mice
-
PubMed
-
Plaschke, K.; Kopitz, J.; Siegelin, M.; Schliebs, R.; Salkovic-Petrisic, M.; Riederer, P.; Hoyer, S. Insulin-resistant brain state after intracerebroventricular streptozotocin injection exacerbates Alzheimer-like changes in Tg2576 AβPP-overexpressing mice. J. Alzheimers Dis. 2010, 19, 691-704. [PubMed]
-
(2010)
J. Alzheimers Dis
, vol.19
, pp. 691-704
-
-
Plaschke, K.1
Kopitz, J.2
Siegelin, M.3
Schliebs, R.4
Salkovic-Petrisic, M.5
Riederer, P.6
Hoyer, S.7
-
35
-
-
77951028451
-
Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβdeposition in an Alzheimer mouse model with diabetes
-
CrossRefPubMed
-
Takeda, S.; Sato, N.; Uchio-Yamada, K.; Sawada, K.; Kunieda, T.; Takeuchi, D.; Kurinami, H.; Shinohara, M.; Rakugi, H.; Morishita, R. Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβdeposition in an Alzheimer mouse model with diabetes. PNAS 2010, 107, 7036-7041. [CrossRef] [PubMed]
-
(2010)
PNAS
, vol.107
, pp. 7036-7041
-
-
Takeda, S.1
Sato, N.2
Uchio-Yamada, K.3
Sawada, K.4
Kunieda, T.5
Takeuchi, D.6
Kurinami, H.7
Shinohara, M.8
Rakugi, H.9
Morishita, R.10
-
36
-
-
84867537762
-
Amyloid- β and Tau Pathology of Alzheimer’s Disease Induced by Diabetes in a Rabbit Animal Model
-
Bitela, C.L.; Kasinathanb, C.; Kaswalab, R.H.; Klein, W.L.; Frederiksea, P.H. Amyloid- β and Tau Pathology of Alzheimer’s Disease Induced by Diabetes in a Rabbit Animal Model. J. Alzheimers Dis. 2012, 32, 291-305.
-
(2012)
J. Alzheimers Dis
, vol.32
, pp. 291-305
-
-
Bitela, C.L.1
Kasinathanb, C.2
Kaswalab, R.H.3
Klein, W.L.4
Frederiksea, P.H.5
-
37
-
-
84869179307
-
Diabetes exacerbates amyloid and neurovascular pathology in aging-accelerated mice
-
CrossRefPubMed
-
Currais, A.; Prior, M.; Lo, D.; Jolivalt, C.; Schubert, D.; Maher, P. Diabetes exacerbates amyloid and neurovascular pathology in aging-accelerated mice. Aging Cell 2012, 11, 1017-1026. [CrossRef] [PubMed]
-
(2012)
Aging Cell
, vol.11
, pp. 1017-1026
-
-
Currais, A.1
Prior, M.2
Lo, D.3
Jolivalt, C.4
Schubert, D.5
Maher, P.6
-
38
-
-
85058205901
-
Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice
-
CrossRefPubMed
-
Maesako, M.; Uemura, K.; Kubota, M.; Kuzuya, A.; Sasaki, K.; Asada, M.; Watanabe, K.; Hayashida, N.; Ihara, M.; Ito, H. et al. Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice. Neurobiol. Aging 2012, 33, 1011.e11-1011.e23. [CrossRef] [PubMed]
-
(2012)
Neurobiol. Aging
, vol.33
-
-
Maesako, M.1
Uemura, K.2
Kubota, M.3
Kuzuya, A.4
Sasaki, K.5
Asada, M.6
Watanabe, K.7
Hayashida, N.8
Ihara, M.9
Ito, H.10
-
39
-
-
84870895663
-
Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditions
-
CrossRefPubMed
-
Son, S.M.; Song, H.; Byun, J.; Park, K.S.; Jang, H.C.; Park, Y.J.; Mook-Jung, I. Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditions. Autophagy 2012, 8, 1842-1844. [CrossRef] [PubMed]
-
(2012)
Autophagy
, vol.8
, pp. 1842-1844
-
-
Son, S.M.1
Song, H.2
Byun, J.3
Park, K.S.4
Jang, H.C.5
Park, Y.J.6
Mook-Jung, I.7
-
40
-
-
84859757164
-
Brain insulin resistance accelerates Aβ fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes
-
CrossRefPubMed
-
Yamamoto, N.; Matsubara, T.; Sobue, K.; Tanida, M.; Kasahara, R.; Naruse, K.; Taniura, H.; Sato, T.; Suzuki, K. Brain insulin resistance accelerates Aβ fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes. J. Neurochem. 2012, 121, 619-628. [CrossRef] [PubMed]
-
(2012)
J. Neurochem
, vol.121
, pp. 619-628
-
-
Yamamoto, N.1
Matsubara, T.2
Sobue, K.3
Tanida, M.4
Kasahara, R.5
Naruse, K.6
Taniura, H.7
Sato, T.8
Suzuki, K.9
-
41
-
-
84889263487
-
A. non-transgenic mouse model (Icv-STZ mouse) of Alzheimer’s disease: Similarities to and differences from the transgenic model (3xTg-AD mouse)
-
CrossRefPubMed
-
Chen, Y.; Liang, Z.; Blanchard, J.; Dai, C.L.; Sun, S.; Lee, M.H.; Grundke-Iqbal, I.; Iqbal, K.; Liu, F.; Gong, C.X. A non-transgenic mouse model (icv-STZ mouse) of Alzheimer’s disease: Similarities to and differences from the transgenic model (3xTg-AD mouse). Mol. Neurobiol. 2013, 47, 711-725. [CrossRef] [PubMed]
-
(2013)
Mol. Neurobiol
, vol.47
, pp. 711-725
-
-
Chen, Y.1
Liang, Z.2
Blanchard, J.3
Dai, C.L.4
Sun, S.5
Lee, M.H.6
Grundke-Iqbal, I.7
Iqbal, K.8
Liu, F.9
Gong, C.X.10
-
42
-
-
84880715461
-
High glucose promotes Aβ production by inhibiting APP degradation
-
CrossRefPubMed
-
Yang, Y.; Wu, Y.; Zhang, S.; Song, W. High glucose promotes Aβ production by inhibiting APP degradation. PLoS ONE 2013, 8, e69824. [CrossRef] [PubMed]
-
(2013)
Plos ONE
, vol.8
-
-
Yang, Y.1
Wu, Y.2
Zhang, S.3
Song, W.4
-
43
-
-
84892771543
-
Experimental Induction of Type 2 Diabetes in Aging-Accelerated Mice Triggered Alzheimer-Like Pathology and Memory Deficits
-
Mehlaa, J.; Chauhanc, B.C.; Chauhana, N.B. Experimental Induction of Type 2 Diabetes in Aging-Accelerated Mice Triggered Alzheimer-Like Pathology and Memory Deficits. J. Alzheimers Dis. 2014, 39, 145-162.
-
(2014)
J. Alzheimers Dis
, vol.39
, pp. 145-162
-
-
Mehlaa, J.1
Chauhanc, B.C.2
Chauhana, N.B.3
-
44
-
-
0033595706
-
β -Secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE
-
CrossRefPubMed
-
Vassar, R.; Bennett, B.D.; Babu-Khan, S.; Kahn, S.; Mendiaz, E.A.; Denis, P.; Teplow, D.B.; Ross, S.; Amarante, P.; Loeloffs, R. et al. β -Secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999, 286, 735-741. [CrossRef] [PubMed]
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloffs, R.10
-
45
-
-
0036548070
-
Gamma-Secretase, Notch, Aβ and Alzheimer’s disease: Where do the presenilins fit in?
-
CrossRefPubMed
-
Sisodia, S.S.; St George-Hyslop, P.H. Gamma-Secretase, Notch, Aβ and Alzheimer’s disease: Where do the presenilins fit in? Nat. Rev. Neurosci. 2002, 3, 281-290. [CrossRef] [PubMed]
-
(2002)
Nat. Rev. Neurosci
, vol.3
, pp. 281-290
-
-
Sisodia, S.S.1
St George-Hyslop, P.H.2
-
46
-
-
0343819757
-
Presenilin 1 is linked with-secretase activity in the detergent solubilized state
-
CrossRefPubMed
-
Li, Y.M.; Lai, M.T.; Xu, M.; Huang, Q.; DiMuzio-Mower, J.; Sardana, M.K.; Shi, X.P.; Yin, K.C.; Shafer, J.A.; Gardell, S.J. Presenilin 1 is linked with-secretase activity in the detergent solubilized state. PNAS 2000, 97, 6138-6143. [CrossRef] [PubMed]
-
(2000)
PNAS
, vol.97
, pp. 6138-6143
-
-
Li, Y.M.1
Lai, M.T.2
Xu, M.3
Huang, Q.4
Dimuzio-Mower, J.5
Sardana, M.K.6
Shi, X.P.7
Yin, K.C.8
Shafer, J.A.9
Gardell, S.J.10
-
47
-
-
0034618715
-
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing
-
PubMed
-
Yu, G.; Nishimura, M.; Arakawa, S.; Levitan, D.; Zhang, L.; Tandon, A.; Song, Y.Q.; Rogaeva, E.; Chen, F.; Kawarai, T. et al. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing. Nature 2000, 407, 48-54. [PubMed]
-
(2000)
Nature
, vol.407
, pp. 48-54
-
-
Yu, G.1
Nishimura, M.2
Arakawa, S.3
Levitan, D.4
Zhang, L.5
Tandon, A.6
Song, Y.Q.7
Rogaeva, E.8
Chen, F.9
Kawarai, T.10
-
48
-
-
18444417998
-
Aph-1 and pen-2 are required for Notch pathway signaling,-secretase cleavage of βAPP, and presenilin protein accumulation
-
CrossRef
-
Francis, R.; McGrath, G.; Zhang, J.; Ruddy, D.A.; Sym, M.; Apfeld, J.; Nicoll, M.; Maxwell, M.; Hai, B.; Ellis, M.C. et al. Aph-1 and pen-2 are required for Notch pathway signaling,-secretase cleavage of βAPP, and presenilin protein accumulation. Dev. Cell 2000, 3, 85-97. [CrossRef]
-
(2000)
Dev. Cell
, vol.3
, pp. 85-97
-
-
Francis, R.1
McGrath, G.2
Zhang, J.3
Ruddy, D.A.4
Sym, M.5
Apfeld, J.6
Nicoll, M.7
Maxwell, M.8
Hai, B.9
Ellis, M.C.10
-
49
-
-
0037154158
-
APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
-
CrossRefPubMed
-
Goutte, C.; Tsunozaki, M.; Hale, V.A.; Priess, J.R. APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. PNAS 2002, 99, 775-779. [CrossRef] [PubMed]
-
(2002)
PNAS
, vol.99
, pp. 775-779
-
-
Goutte, C.1
Tsunozaki, M.2
Hale, V.A.3
Priess, J.R.4
-
50
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer’s disease
-
CrossRefPubMed
-
Sherrington, R.; Rogaev, E.I.; Liang, Y.; Rogaeva, E.A.; Levesque, G.; Ikeda, M.; Chi, H.; Lin, C.; Li, G.; Holman, K. et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer’s disease. Nature 1995, 375, 754-760. [CrossRef] [PubMed]
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
Ikeda, M.6
Chi, H.7
Lin, C.8
Li, G.9
Holman, K.10
-
51
-
-
0031052381
-
Amyloid, the presenilins and Alzheimer’s disease
-
CrossRef
-
Hardy, J. Amyloid, the presenilins and Alzheimer’s disease. Trends Neurosci. 1997, 20, 154-159. [CrossRef]
-
(1997)
Trends Neurosci
, vol.20
, pp. 154-159
-
-
Hardy, J.1
-
52
-
-
0030293676
-
Familial Alzheimer’s disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo
-
CrossRef
-
Borchelt, D.R.; Thinakaran, G.; Eckman, C.B.; Lee, M.K.; Davenport, F.; Ratovitsky, T.; Prada, C.M.; Kim, G.; Seekins, S.; Yager, D. et al. Familial Alzheimer’s disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron 1996, 17, 1005-1013. [CrossRef]
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
Prada, C.M.7
Kim, G.8
Seekins, S.9
Yager, D.10
-
53
-
-
16044366039
-
Increased amyloid- β42(43) in brains of mice expressing mutant presenilin 1
-
CrossRefPubMed
-
Duff, K.; Eckman, C.B.; Zehr, C.; Yu, X.; Prada, C.M.; Perez-tur, J.; Hutton, M.; Buee, L.; Harigaya, Y.; Yager, D. et al. Increased amyloid- β42(43) in brains of mice expressing mutant presenilin 1. Nature 1996, 383, 710-713. [CrossRef] [PubMed]
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.B.2
Zehr, C.3
Yu, X.4
Prada, C.M.5
Perez-Tur, J.6
Hutton, M.7
Buee, L.8
Harigaya, Y.9
Yager, D.10
-
54
-
-
16044373524
-
Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer’s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer’s disease
-
CrossRefPubMed
-
Scheuner, D.; Eckman, C.B.; Jensen, M.; Song, X.; Citron, M.; Suzuki, N.; Bird, T.D.; Hardy, J.; Hutton, M.; Kukull, W. et al. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer’s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer’s disease. Nat. Med. 1996, 2, 864-870. [CrossRef] [PubMed]
-
(1996)
Nat. Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.B.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
-
55
-
-
77954466407
-
Amyloid- β peptide oligomers disrupt axonal transport through an NMDA receptordependent mechanism that is mediated by glycogen synthase kinase 3β in primary cultured hippocampal neurons
-
CrossRefPubMed
-
Decker, H.; Lo, K.Y.; Unger, S.M.; Ferreira, S.T.; Silverman, M.A. Amyloid- β peptide oligomers disrupt axonal transport through an NMDA receptordependent mechanism that is mediated by glycogen synthase kinase 3β in primary cultured hippocampal neurons. J. Neurosci. 2010, 30, 9166-9171. [CrossRef] [PubMed]
-
(2010)
J. Neurosci
, vol.30
, pp. 9166-9171
-
-
Decker, H.1
Lo, K.Y.2
Unger, S.M.3
Ferreira, S.T.4
Silverman, M.A.5
-
56
-
-
77957737750
-
Tau reduction prevents Aβ-induced defects in axonal transport
-
CrossRefPubMed
-
Vossel, K.A.; Zhang, K.; Brodbeck, J.; Daub, A.C.; Sharma, P.; Finkbeiner, S.; Cui, B.; Mucke, L. Tau reduction prevents Aβ-induced defects in axonal transport. Science 2010, 330, 198. [CrossRef] [PubMed]
-
(2010)
Science
, vol.330
, pp. 198
-
-
Vossel, K.A.1
Zhang, K.2
Brodbeck, J.3
Daub, A.C.4
Sharma, P.5
Finkbeiner, S.6
Cui, B.7
Mucke, L.8
-
57
-
-
84859577721
-
Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid β-protein oligomers
-
CrossRefPubMed
-
Tang, Y.; Scott, D.A.; Das, U.; Edland, S.D.; Radomski, K.; Koo, E.H.; Roy, S. Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid β-protein oligomers. Traffic 2012, 13, 681-693. [CrossRef] [PubMed]
-
(2012)
Traffic
, vol.13
, pp. 681-693
-
-
Tang, Y.1
Scott, D.A.2
Das, U.3
Edland, S.D.4
Radomski, K.5
Koo, E.H.6
Roy, S.7
-
58
-
-
10944269186
-
The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
-
CrossRefPubMed
-
Li, Z.; Okamoto, K.; Hayashi, Y.; Sheng, M. The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Cell 2004, 119, 873-887. [CrossRef] [PubMed]
-
(2004)
Cell
, vol.119
, pp. 873-887
-
-
Li, Z.1
Okamoto, K.2
Hayashi, Y.3
Sheng, M.4
-
59
-
-
84856056846
-
Mitochondrial transport in neurons: Impact on synaptic homeostasis and neurodegeneration
-
CrossRefPubMed
-
Sheng, Z.H.; Cai, Q. Mitochondrial transport in neurons: Impact on synaptic homeostasis and neurodegeneration. Nat. Rev. Neurosci. 2012, 13, 77-93. [CrossRef] [PubMed]
-
(2012)
Nat. Rev. Neurosci
, vol.13
, pp. 77-93
-
-
Sheng, Z.H.1
Cai, Q.2
-
60
-
-
84897567836
-
Mitochondrial trafficking and anchoring in neurons: New insight and implications
-
CrossRefPubMed
-
Sheng, Z.H. Mitochondrial trafficking and anchoring in neurons: New insight and implications. J. Cell Biol. 2014, 204, 1087-1098. [CrossRef] [PubMed]
-
(2014)
J. Cell Biol
, vol.204
, pp. 1087-1098
-
-
Sheng, Z.H.1
-
61
-
-
84876072089
-
Interactions between estradiol, BDNF and dendritic spines in promoting memory
-
CrossRefPubMed
-
Luine, V.; Frankfurt, M. Interactions between estradiol, BDNF and dendritic spines in promoting memory. Neuroscience 2012, 239, 34-45. [CrossRef] [PubMed]
-
(2012)
Neuroscience
, vol.239
, pp. 34-45
-
-
Luine, V.1
Frankfurt, M.2
-
62
-
-
84904735929
-
The BDNF effects on dendritic spines of mature hippocampal neurons depend on neuronal activity. Front
-
CrossRefPubMed
-
Kellner, Y.; Gödecke, N.; Dierkes, T.; Thieme, N.; Zagrebelsky, M.; Korte, M. The BDNF effects on dendritic spines of mature hippocampal neurons depend on neuronal activity. Front. Synaptic Neurosci. 2014, 6, 5. [CrossRef] [PubMed]
-
(2014)
Synaptic Neurosci
, vol.6
, pp. 5
-
-
Kellner, Y.1
Gödecke, N.2
Dierkes, T.3
Thieme, N.4
Zagrebelsky, M.5
Korte, M.6
-
63
-
-
84888135844
-
The entorhinal cortex and neurotrophin signaling in Alzheimer’s disease and other disorders
-
CrossRefPubMed
-
Scharfman, H.E.; Chao, M.V. The entorhinal cortex and neurotrophin signaling in Alzheimer’s disease and other disorders. Cogn. Neurosci. 2013, 4, 123-135. [CrossRef] [PubMed]
-
(2013)
Cogn. Neurosci
, vol.4
, pp. 123-135
-
-
Scharfman, H.E.1
Chao, M.V.2
-
64
-
-
84891657378
-
Synaptic activity and bioenergy homeostasis: Implications in brain trauma and neurodegenerative diseases
-
CrossRefPubMed
-
Khatri, N.; Man, H.Y. Synaptic activity and bioenergy homeostasis: Implications in brain trauma and neurodegenerative diseases. Front. Neurol. 2013, 4, 199. [CrossRef] [PubMed]
-
(2013)
Front. Neurol
, vol.4
, pp. 199
-
-
Khatri, N.1
Man, H.Y.2
-
65
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins
-
CrossRefPubMed
-
Lambert, M.P.; Barlow, A.K.; Chromy, B.A.; Edwards, C.; Freed, R.; Liosatos, M.; Morgan, T.E.; Rozovsky, I.; Trommer, B.; Viola, K.L. et al. Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins. PNAS 1998, 95, 6448-6453. [CrossRef] [PubMed]
-
(1998)
PNAS
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
Edwards, C.4
Freed, R.5
Liosatos, M.6
Morgan, T.E.7
Rozovsky, I.8
Trommer, B.9
Viola, K.L.10
-
66
-
-
0037041426
-
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
-
CrossRefPubMed
-
Walsh, D.M.; Klyubin, I.; Fadeeva, J.V.; Cullen, W.K.; Anwyl, R.; Wolfe, M.S.; Rowan, M.J.; Selkoe, D.J. Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002, 416, 535-539. [CrossRef] [PubMed]
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
Rowan, M.J.7
Selkoe, D.J.8
-
67
-
-
49149124343
-
Amyloid-β protein dimers isolated directly from Alzheimer’s brains impair synaptic plasticity and memory
-
CrossRefPubMed
-
Shankar, G.M.; Li, S.; Mehta, T.H.; Garcia-Munoz, A.; Shepardson, N.E.; Smith, I.; Brett, F.M.; Farrell, M.A.; Rowan, M.J.; Lemere, C.A. et al. Amyloid-β protein dimers isolated directly from Alzheimer’s brains impair synaptic plasticity and memory. Nat. Med. 2008, 14, 837-842. [CrossRef] [PubMed]
-
(2008)
Nat. Med
, vol.14
, pp. 837-842
-
-
Shankar, G.M.1
Li, S.2
Mehta, T.H.3
Garcia-Munoz, A.4
Shepardson, N.E.5
Smith, I.6
Brett, F.M.7
Farrell, M.A.8
Rowan, M.J.9
Lemere, C.A.10
-
68
-
-
67249087641
-
Soluble oligomers of amyloid β protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake
-
CrossRefPubMed
-
Li, S.; Hong, S.; Shepardson, N.E.; Walsh, D.M.; Shankar, G.M.; Selkoe, D. Soluble oligomers of amyloid β protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron 2009, 62, 788-801. [CrossRef] [PubMed]
-
(2009)
Neuron
, vol.62
, pp. 788-801
-
-
Li, S.1
Hong, S.2
Shepardson, N.E.3
Walsh, D.M.4
Shankar, G.M.5
Selkoe, D.6
-
69
-
-
33846633336
-
Aβ oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer’s disease
-
CrossRefPubMed
-
Lacor, P.N.; Buniel, M.C.; Furlow, P.W.; Clemente, A.S.; Velasco, P.T.; Wood, M.; Viola, K.L.; Klein, W.L. Aβ oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer’s disease. J. Neurosci. 2007, 27, 796-807. [CrossRef] [PubMed]
-
(2007)
J. Neurosci
, vol.27
, pp. 796-807
-
-
Lacor, P.N.1
Buniel, M.C.2
Furlow, P.W.3
Clemente, A.S.4
Velasco, P.T.5
Wood, M.6
Viola, K.L.7
Klein, W.L.8
-
70
-
-
33947314641
-
Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
-
CrossRefPubMed
-
Shankar, G.M.; Bloodgood, B.L.; Townsend, M.; Walsh, D.M.; Selkoe, D.J.; Sabatini, B.L. Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J. Neurosci. 2007, 27, 2866-2875. [CrossRef] [PubMed]
-
(2007)
J. Neurosci
, vol.27
, pp. 2866-2875
-
-
Shankar, G.M.1
Bloodgood, B.L.2
Townsend, M.3
Walsh, D.M.4
Selkoe, D.J.5
Sabatini, B.L.6
-
71
-
-
77952585217
-
Type 1 diabetes exaggerates features of Alzheimer’s disease in APP transgenic mice
-
CrossRefPubMed
-
Jolivalt, C.G.; Hurford, R.; Lee, C.A.; Dumaop, W.; Rockenstein, E.; Masliah, E. Type 1 diabetes exaggerates features of Alzheimer’s disease in APP transgenic mice. Exp. Neurol. 2010, 223, 22-31. [CrossRef] [PubMed]
-
(2010)
Exp. Neurol
, vol.223
, pp. 22-31
-
-
Jolivalt, C.G.1
Hurford, R.2
Lee, C.A.3
Dumaop, W.4
Rockenstein, E.5
Masliah, E.6
-
72
-
-
84857714157
-
Mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer’s disease
-
CrossRefPubMed
-
Devi, L.; Alldred, M.J.; Ginsberg, S.D.; Ohno, M. Mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer’s disease. PLoS ONE 2012, 7, e32792. [CrossRef] [PubMed]
-
(2012)
Plos ONE
, vol.7
-
-
Devi, L.1
Alldred, M.J.2
Ginsberg, S.D.3
Ohno, M.4
-
73
-
-
43049106790
-
Increased amyloid β-peptide (1-40) level in brain of streptozotocin-induced diabetic rats
-
CrossRefPubMed
-
Liu, Y.; Liu, H.; Yang, J.; Liu, X.; Lu, S.; Wen, T.; Xie, L.; Wang, G. Increased amyloid β-peptide (1-40) level in brain of streptozotocin-induced diabetic rats. Neuroscience 2008, 153, 796-802. [CrossRef] [PubMed]
-
(2008)
Neuroscience
, vol.153
, pp. 796-802
-
-
Liu, Y.1
Liu, H.2
Yang, J.3
Liu, X.4
Lu, S.5
Wen, T.6
Xie, L.7
Wang, G.8
-
74
-
-
84907406954
-
Brain aging and AD-like pathology in streptozotocin-induced diabetic rats
-
CrossRefPubMed
-
Wang, J.Q.; Yin, J.; Song, Y.F.; Zhang, L.; Ren, Y.X.; Wang, D.G.; Gao, L.P.; Jing, Y.H. Brain aging and AD-like pathology in streptozotocin-induced diabetic rats. J. Diabetes Res. 2014, 2014, 796840. [CrossRef] [PubMed]
-
(2014)
J. Diabetes Res
, vol.2014
-
-
Wang, J.Q.1
Yin, J.2
Song, Y.F.3
Zhang, L.4
Ren, Y.X.5
Wang, D.G.6
Gao, L.P.7
Jing, Y.H.8
-
75
-
-
0027304893
-
Action of the diabetogenic drug streptozotocin on glycolytic and glycogenolytic metabolism in adult rat brain cortex and hippocampus
-
CrossRef
-
Plaschke, K.; Hoyer, S. Action of the diabetogenic drug streptozotocin on glycolytic and glycogenolytic metabolism in adult rat brain cortex and hippocampus. Int. J. Dev. Neurosci. 1993, 11, 477-483. [CrossRef]
-
(1993)
Int. J. Dev. Neurosci
, vol.11
, pp. 477-483
-
-
Plaschke, K.1
Hoyer, S.2
-
76
-
-
0028598190
-
Intracerebroventricular injection of streptozotocin induces discrete local changes in cerebral glucose utilization in rats
-
CrossRef
-
Duelli, R.; Schröck, H.; Kuschinsky, W.; Hoyer, S. Intracerebroventricular injection of streptozotocin induces discrete local changes in cerebral glucose utilization in rats. Int. J. Dev. Neurosci. 1994, 12, 737-743. [CrossRef]
-
(1994)
Int. J. Dev. Neurosci
, vol.12
, pp. 737-743
-
-
Duelli, R.1
Schröck, H.2
Kuschinsky, W.3
Hoyer, S.4
-
77
-
-
0028170864
-
Desensitization of brain insulin receptor. Effect on glucose/energy and related metabolism
-
PubMed
-
Hoyer, S.; Müller, D.; Plaschke, K. Desensitization of brain insulin receptor. Effect on glucose/energy and related metabolism. J. Neural Transm. Suppl. 1994, 44, 259-268. [PubMed]
-
(1994)
J. Neural Transm. Suppl
, vol.44
, pp. 259-268
-
-
Hoyer, S.1
Müller, D.2
Plaschke, K.3
-
78
-
-
0031797937
-
Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats
-
CrossRefPubMed
-
Lannert, H.; Hoyer, S. Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats. Behav. Neurosci. 1998, 112, 1199-1208. [CrossRef] [PubMed]
-
(1998)
Behav. Neurosci
, vol.112
, pp. 1199-1208
-
-
Lannert, H.1
Hoyer, S.2
-
79
-
-
84918558536
-
Enhancement of β-amyloid oligomer accumulation after intracerebroventricular injection of streptozotocin, which involves central insulin signaling in a transgenic mouse model
-
CrossRefPubMed
-
Lin, F.; Jia, J.; Qin, W. Enhancement of β-amyloid oligomer accumulation after intracerebroventricular injection of streptozotocin, which involves central insulin signaling in a transgenic mouse model. Neuroreport 2014, 25, 1289-1295. [CrossRef] [PubMed]
-
(2014)
Neuroreport
, vol.25
, pp. 1289-1295
-
-
Lin, F.1
Jia, J.2
Qin, W.3
-
80
-
-
0033621739
-
Identification of the major Aβ1-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
-
CrossRefPubMed
-
Iwata, N.; Tsubuki, S.; Takaki, Y.; Watanabe, K.; Sekiguchi, M.; Hosoki, E.; Kawashima-Morishima, M.; Lee, H.J.; Hama, E.; Sekine-Aizawa, Y. et al. Identification of the major Aβ1-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition. Nat. Med. 2000, 6, 143-150. [CrossRef] [PubMed]
-
(2000)
Nat. Med
, vol.6
, pp. 143-150
-
-
Iwata, N.1
Tsubuki, S.2
Takaki, Y.3
Watanabe, K.4
Sekiguchi, M.5
Hosoki, E.6
Kawashima-Morishima, M.7
Lee, H.J.8
Hama, E.9
Sekine-Aizawa, Y.10
-
81
-
-
0035816707
-
Degradation of the Alzheimer’s amyloid β peptide by endothelin-converting enzyme
-
CrossRefPubMed
-
Eckman, E.A.; Reed, D.K.; Eckman, C.B. Degradation of the Alzheimer’s amyloid β peptide by endothelin-converting enzyme. J. Biol. Chem. 2001, 276, 24540-24548. [CrossRef] [PubMed]
-
(2001)
J. Biol. Chem
, vol.276
, pp. 24540-24548
-
-
Eckman, E.A.1
Reed, D.K.2
Eckman, C.B.3
-
82
-
-
0000398342
-
Insulin-degrading enzyme regulates extracellular levels of amyloid β-protein by degradation
-
CrossRefPubMed
-
Qiu, W.Q.; Walsh, D.M.; Ye, Z.; Vekrellis, K.; Zhang, J.; Podlisny, M.B.; Rosner, M.R.; Safavi, A.; Hersh, L.B.; Selkoe, D.J. Insulin-degrading enzyme regulates extracellular levels of amyloid β-protein by degradation. J. Biol. Chem. 1998, 273, 32730-32738. [CrossRef] [PubMed]
-
(1998)
J. Biol. Chem
, vol.273
, pp. 32730-32738
-
-
Qiu, W.Q.1
Walsh, D.M.2
Ye, Z.3
Vekrellis, K.4
Zhang, J.5
Podlisny, M.B.6
Rosner, M.R.7
Safavi, A.8
Hersh, L.B.9
Selkoe, D.J.10
-
83
-
-
79955429140
-
Impaired amyloid β-degrading enzymes in brain of streptozotocin-induced diabetic rats
-
CrossRef
-
Liu, Y.; Liu, L.; Lu, S.; Wang, D.; Liu, X.; Xie, L.; Wang, G. Impaired amyloid β-degrading enzymes in brain of streptozotocin-induced diabetic rats. J. Endocrinol. Investig. 2011, 34, 26-31. [CrossRef]
-
(2011)
J. Endocrinol. Investig
, vol.34
, pp. 26-31
-
-
Liu, Y.1
Liu, L.2
Lu, S.3
Wang, D.4
Liu, X.5
Xie, L.6
Wang, G.7
-
84
-
-
84911895310
-
Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease
-
CrossRefPubMed
-
Vandal, M.; White, P.J.; Tremblay, C.; St-Amour, I.; Chevrier, G.; Emond, V.; Lefrançois, D.; Virgili, J.; Planel, E.; Giguere, Y. et al. Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease. Diabetes 2014, 63, 4291-4301. [CrossRef] [PubMed]
-
(2014)
Diabetes
, vol.63
, pp. 4291-4301
-
-
Vandal, M.1
White, P.J.2
Tremblay, C.3
St-Amour, I.4
Chevrier, G.5
Emond, V.6
Lefrançois, D.7
Virgili, J.8
Planel, E.9
Giguere, Y.10
-
85
-
-
84892771543
-
Experimental induction of type 2 diabetes in aging-accelerated mice triggered Alzheimer-like pathology and memory deficits
-
PubMed
-
Mehla, J.; Chauhan, B.C.; Chauhan, N.B. Experimental induction of type 2 diabetes in aging-accelerated mice triggered Alzheimer-like pathology and memory deficits. J. Alzheimers Dis. 2014, 39, 145-162. [PubMed]
-
(2014)
J. Alzheimers Dis
, vol.39
, pp. 145-162
-
-
Mehla, J.1
Chauhan, B.C.2
Chauhan, N.B.3
-
86
-
-
37549035051
-
Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease
-
CrossRefPubMed
-
Cao, D.; Lu, H.; Lewis, T.L.; Li, L. Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease. J. Biol. Chem. 2007, 282, 36275-36282. [CrossRef] [PubMed]
-
(2007)
J. Biol. Chem
, vol.282
, pp. 36275-36282
-
-
Cao, D.1
Lu, H.2
Lewis, T.L.3
Li, L.4
-
87
-
-
34347377319
-
Alzheimer-like changes in rat models of spontaneous diabetes
-
CrossRefPubMed
-
Li, Z.G.; Zhang, W.; Sima, A.A. Alzheimer-like changes in rat models of spontaneous diabetes. Diabetes 2007, 56, 1817-1824. [CrossRef] [PubMed]
-
(2007)
Diabetes
, vol.56
, pp. 1817-1824
-
-
Li, Z.G.1
Zhang, W.2
Sima, A.A.3
-
88
-
-
84929470878
-
Effect of high glucose levels on amyloid β production in retinas of spontaneous diabetes mellitus Otsuka Long-Evans Tokushima fatty rats
-
CrossRefPubMed
-
Nagai, N.; Ito, Y.; Tanino, T. Effect of high glucose levels on amyloid β production in retinas of spontaneous diabetes mellitus Otsuka Long-Evans Tokushima fatty rats. Biol. Pharm. Bull. 2015, 38, 601-610. [CrossRef] [PubMed]
-
(2015)
Biol. Pharm. Bull
, vol.38
, pp. 601-610
-
-
Nagai, N.1
Ito, Y.2
Tanino, T.3
-
89
-
-
0025195944
-
Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain
-
CrossRefPubMed
-
Cataldo, A.M.; Nixon, R.A. Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain. PNAS 1990, 87, 3861-3865. [CrossRef] [PubMed]
-
(1990)
PNAS
, vol.87
, pp. 3861-3865
-
-
Cataldo, A.M.1
Nixon, R.A.2
-
90
-
-
0030836345
-
Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer’s disease: Neuropathologic evidence for a mechanism of increased β-amyloidogenesis
-
PubMed
-
Cataldo, A.M.; Barnett, J.L.; Pieroni, C.; Nixon, R.A. Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer’s disease: Neuropathologic evidence for a mechanism of increased β-amyloidogenesis. J. Neurosci. 1997, 17, 6142-6151. [PubMed]
-
(1997)
J. Neurosci
, vol.17
, pp. 6142-6151
-
-
Cataldo, A.M.1
Barnett, J.L.2
Pieroni, C.3
Nixon, R.A.4
-
91
-
-
4644319713
-
Aβ localization in abnormal endosomes: Association with earliest Aβ elevations in AD a syndrome. Neurobiol
-
CrossRefPubMed
-
Cataldo, A.M.; Petanceska, S.; Terio, N.B.; Peterhoff, C.M.; Durham, R.; Mercken, M.; Metha, P.D.; Buxbaum, J.; Haroutunian, V.; Nixon, R.A. Aβ localization in abnormal endosomes: Association with earliest Aβ elevations in AD a syndrome. Neurobiol. Aging 2004, 25, 1263-1272. [CrossRef] [PubMed]
-
(2004)
Aging
, vol.25
, pp. 1263-1272
-
-
Cataldo, A.M.1
Petanceska, S.2
Terio, N.B.3
Peterhoff, C.M.4
Durham, R.5
Mercken, M.6
Metha, P.D.7
Buxbaum, J.8
Haroutunian, V.9
Nixon, R.A.10
-
92
-
-
11444267601
-
Endosome function and dysfunction in Alzheimer’s disease and other neurodegenerative diseases
-
CrossRefPubMed
-
Nixon, R.A. Endosome function and dysfunction in Alzheimer’s disease and other neurodegenerative diseases. Neurobiol. Aging 2005, 26, 373-382. [CrossRef] [PubMed]
-
(2005)
Neurobiol. Aging
, vol.26
, pp. 373-382
-
-
Nixon, R.A.1
-
93
-
-
38349046973
-
Autophagy, amyloidogenesis and Alzheimer disease
-
CrossRefPubMed
-
Nixon, R.A. Autophagy, amyloidogenesis and Alzheimer disease. J. Cell Sci. 2007, 120, 4081-4091. [CrossRef] [PubMed]
-
(2007)
J. Cell Sci
, vol.120
, pp. 4081-4091
-
-
Nixon, R.A.1
-
94
-
-
71449086017
-
Dynein dysfunction induces endocytic pathology accompanied by an increase in Rab GTPases: A potential mechanism underlying age-dependent endocytic dysfunction
-
CrossRefPubMed
-
Kimura, N.; Inoue, M.; Okabayashi, S.; Ono, F.; Negishi, T. Dynein dysfunction induces endocytic pathology accompanied by an increase in Rab GTPases: A potential mechanism underlying age-dependent endocytic dysfunction. J. Biol. Chem. 2009, 284, 31291-31302. [CrossRef] [PubMed]
-
(2009)
J. Biol. Chem
, vol.284
, pp. 31291-31302
-
-
Kimura, N.1
Inoue, M.2
Okabayashi, S.3
Ono, F.4
Negishi, T.5
-
95
-
-
84856021939
-
Dynein dysfunction disrupts intracellular vesicle trafficking bidirectionally and perturbs synaptic vesicle docking via endocytic disturbances a potential mechanism underlying age-dependent impairment of cognitive function
-
CrossRefPubMed
-
Kimura, N.; Okabayashi, S.; Ono, F. Dynein dysfunction disrupts intracellular vesicle trafficking bidirectionally and perturbs synaptic vesicle docking via endocytic disturbances a potential mechanism underlying age-dependent impairment of cognitive function. Am. J. Pathol. 2012, 180, 550-561. [CrossRef] [PubMed]
-
(2012)
Am. J. Pathol
, vol.180
, pp. 550-561
-
-
Kimura, N.1
Okabayashi, S.2
Ono, F.3
-
96
-
-
0042733013
-
Rab5-stimulated up-regulation of the endocytic pathway increases intracellular β-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Aβ production
-
CrossRefPubMed
-
Grbovic, O.M.; Mathews, P.M.; Jiang, Y.; Schmidt, S.D.; Dinakar, R.; Summers-Terio, N.B.; Ceresa, B.P.; Nixon, R.A.; Cataldo, A.M. Rab5-stimulated up-regulation of the endocytic pathway increases intracellular β-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Aβ production. J. Biol. Chem. 2003, 278, 31261-31268. [CrossRef] [PubMed]
-
(2003)
J. Biol. Chem
, vol.278
, pp. 31261-31268
-
-
Grbovic, O.M.1
Mathews, P.M.2
Jiang, Y.3
Schmidt, S.D.4
Dinakar, R.5
Summers-Terio, N.B.6
Ceresa, B.P.7
Nixon, R.A.8
Cataldo, A.M.9
-
97
-
-
25444482802
-
BACE is degraded via the lysosomal pathway
-
CrossRefPubMed
-
Koh, Y.H.; von Arnim, C.A.; Hyman, B.T.; Tanzi, R.E.; Tesco, G. BACE is degraded via the lysosomal pathway. J. Biol. Chem. 2005, 280, 32499-32504. [CrossRef] [PubMed]
-
(2005)
J. Biol. Chem
, vol.280
, pp. 32499-32504
-
-
Koh, Y.H.1
Von Arnim, C.A.2
Hyman, B.T.3
Tanzi, R.E.4
Tesco, G.5
-
98
-
-
84864464317
-
Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: Implications for Alzheimer’s disease
-
CrossRefPubMed
-
Lefort, R.; Pozueta, J.; Shelanski, M. Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: Implications for Alzheimer’s disease. J. Neurosci. 2012, 32, 10674-10685. [CrossRef] [PubMed]
-
(2012)
J. Neurosci
, vol.32
, pp. 10674-10685
-
-
Lefort, R.1
Pozueta, J.2
Shelanski, M.3
-
99
-
-
70349558522
-
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease
-
CrossRefPubMed
-
Harold, D.; Abraham, R.; Hollingworth, P.; Sims, R.; Gerrish, A.; Hamshere, M.L.; Pahwa, J.S.; Moskvina, V.; Dowzell, K.; Williams, A. et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease. Nat. Genet. 2009, 41, 1088-1093. [CrossRef] [PubMed]
-
(2009)
Nat. Genet
, vol.41
, pp. 1088-1093
-
-
Harold, D.1
Abraham, R.2
Hollingworth, P.3
Sims, R.4
Gerrish, A.5
Hamshere, M.L.6
Pahwa, J.S.7
Moskvina, V.8
Dowzell, K.9
Williams, A.10
-
100
-
-
77952307991
-
Genome-wide analysis of genetic loci associated with Alzheimer disease
-
CrossRefPubMed
-
Seshadri, S.; Fitzpatrick, A.L.; Ikram, M.A.; DeStefano, A.L.; Gudnason, V.; Boada, M.; Bis, J.C.; Smith, A.V.; Carassquillo, M.M.; Lambert, J.C. et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 2010, 303, 1832-1840. [CrossRef] [PubMed]
-
(2010)
JAMA
, vol.303
, pp. 1832-1840
-
-
Seshadri, S.1
Fitzpatrick, A.L.2
Ikram, M.A.3
Destefano, A.L.4
Gudnason, V.5
Boada, M.6
Bis, J.C.7
Smith, A.V.8
Carassquillo, M.M.9
Lambert, J.C.10
-
101
-
-
84863469061
-
Identification of Alzheimer disease associated variants in genes that regulate retromer function
-
CrossRefPubMed
-
Vardarajan, B.N.; Bruesegem, S.Y.; Harbour, M.E.; St George-Hyslop, P.; Seaman, M.N.; Farrer, L.A. Identification of Alzheimer disease associated variants in genes that regulate retromer function. Neurobiol. Aging 2012, 33, 2231. [CrossRef] [PubMed]
-
(2012)
Neurobiol. Aging
, vol.33
, pp. 2231
-
-
Vardarajan, B.N.1
Bruesegem, S.Y.2
Harbour, M.E.3
St George-Hyslop, P.4
Seaman, M.N.5
Farrer, L.A.6
-
102
-
-
84899053934
-
Genomic convergence and network analysis approach to identify candidate genes in Alzheimer’s disease
-
CrossRefPubMed
-
Talwar, P.; Silla, Y.; Grover, S.; Gupta, M.; Agarwal, R.; Kushwaha, S.; Kukreti, R. Genomic convergence and network analysis approach to identify candidate genes in Alzheimer’s disease. BMC Genom. 2014, 15, 199. [CrossRef] [PubMed]
-
(2014)
BMC Genom
, vol.15
, pp. 199
-
-
Talwar, P.1
Silla, Y.2
Grover, S.3
Gupta, M.4
Agarwal, R.5
Kushwaha, S.6
Kukreti, R.7
-
103
-
-
84908463972
-
Genetics of Alzheimer’s disease
-
PubMed
-
Chouraki, V.; Seshadri, S. Genetics of Alzheimer’s disease. Adv. Genet. 2014, 87, 245-294. [PubMed]
-
(2014)
Adv. Genet
, vol.87
, pp. 245-294
-
-
Chouraki, V.1
Seshadri, S.2
-
104
-
-
84923233738
-
Diabetes mellitus accelerates Aβ pathology in brain accompanied by enhanced GAβ generation in nonhuman primates
-
CrossRefPubMed
-
Okabayashi, S.; Shimozawa, N.; Yasutomi, Y.; Yanagisawa, K.; Kimura, N. Diabetes mellitus accelerates Aβ pathology in brain accompanied by enhanced GAβ generation in nonhuman primates. PLoS ONE 2015, 10, e0117362. [CrossRef] [PubMed]
-
(2015)
Plos ONE
, vol.10
-
-
Okabayashi, S.1
Shimozawa, N.2
Yasutomi, Y.3
Yanagisawa, K.4
Kimura, N.5
-
105
-
-
77957326612
-
Diabetes-associated SorCS1 regulates Alzheimer’s amyloid-β metabolism: Evidence for involvement of SorL1 and the retromer complex
-
CrossRefPubMed
-
Lane, R.F.; Raines, S.M.; Steele, J.W.; Ehrlich, M.E.; Lah, J.A.; Small, S.A.; Tanzi, R.E.; Attie, A.D.; Gandy, S. Diabetes-associated SorCS1 regulates Alzheimer’s amyloid-β metabolism: Evidence for involvement of SorL1 and the retromer complex. J. Neurosci. 2010, 30, 13110-13115. [CrossRef] [PubMed]
-
(2010)
J. Neurosci
, vol.30
, pp. 13110-13115
-
-
Lane, R.F.1
Raines, S.M.2
Steele, J.W.3
Ehrlich, M.E.4
Lah, J.A.5
Small, S.A.6
Tanzi, R.E.7
Attie, A.D.8
Gandy, S.9
-
106
-
-
19944375450
-
Tau pathology in Alzheimer disease and other tauopathies
-
CrossRefPubMed
-
Iqbal, K.; Alonso Adel, C.; Chen, S.; Chohan, M.O.; El-Akkad, E.; Gong, C.X.; Khatoon, S.; Li, B.; Liu, F.; Rahman, A. et al. Tau pathology in Alzheimer disease and other tauopathies. Biochim. Biophys. Acta 2005, 1739, 198-210. [CrossRef] [PubMed]
-
(2005)
Biochim. Biophys. Acta
, vol.1739
, pp. 198-210
-
-
Iqbal, K.1
Alonso Adel, C.2
Chen, S.3
Chohan, M.O.4
El-Akkad, E.5
Gong, C.X.6
Khatoon, S.7
Li, B.8
Liu, F.9
Rahman, A.10
-
107
-
-
0031045216
-
Physiology and pathology of tau protein kinases in relation to Alzheimer’s disease
-
PubMed
-
Imahori, K.; Uchida, T. Physiology and pathology of tau protein kinases in relation to Alzheimer’s disease. J. Biochem. 1997, 121, 179-188. [PubMed]
-
(1997)
J. Biochem
, vol.121
, pp. 179-188
-
-
Imahori, K.1
Uchida, T.2
-
108
-
-
0026619472
-
Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments
-
CrossRef
-
Ishiguro, K.; Omori, A.; Takamatsu, M.; Sato, K.; Arioka, M.; Uchida, T.; Imahori, K. Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments. Neurosci. Lett. 1992, 148, 202-206. [CrossRef]
-
(1992)
Neurosci. Lett
, vol.148
, pp. 202-206
-
-
Ishiguro, K.1
Omori, A.2
Takamatsu, M.3
Sato, K.4
Arioka, M.5
Uchida, T.6
Imahori, K.7
-
109
-
-
0032502829
-
Takashima, A. Characterization of tau phosphorylation in glycogen synthase kinase-3β and cyclin dependent kinase-5 activator (p23) transfected cells
-
CrossRef
-
Michel, G.; Mercken, M.; Murayama, M.; Noguchi, K.; Ishiguro, K.; Imahori, H.; Takashima, A. Characterization of tau phosphorylation in glycogen synthase kinase-3β and cyclin dependent kinase-5 activator (p23) transfected cells. Biochim. Biophys. Acta 1998, 1380, 177-182. [CrossRef]
-
(1998)
Biochim. Biophys. Acta
, vol.1380
, pp. 177-182
-
-
Michel, G.1
Mercken, M.2
Murayama, M.3
Noguchi, K.4
Ishiguro, K.5
Imahori, H.6
-
110
-
-
0032987650
-
Phosphorylation of tau protein by recombinant GSK3β: Pronounced phosphorylation at select Ser/Thr-Pro motif but no phosphorylation at Ser267 in the repeat domain
-
CrossRef
-
Godeman, R.; Biernat, J.; Mandelkow, E.; Mandelkow, E.M. Phosphorylation of tau protein by recombinant GSK3β: Pronounced phosphorylation at select Ser/Thr-Pro motif but no phosphorylation at Ser267 in the repeat domain. FEBS Lett. 1999, 454, 157-164. [CrossRef]
-
(1999)
FEBS Lett
, vol.454
, pp. 157-164
-
-
Godeman, R.1
Biernat, J.2
Mandelkow, E.3
Mandelkow, E.M.4
-
111
-
-
0026487365
-
Glycogen synthase kinase-3 induces Alzheimer’s disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase
-
CrossRef
-
Hanger, D.P.; Hughes, K.; Woodgett, J.R.; Brion, J.P.; Anderton, B.H. Glycogen synthase kinase-3 induces Alzheimer’s disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase. Neurosci. Lett. 1992, 147, 58-62. [CrossRef]
-
(1992)
Neurosci. Lett
, vol.147
, pp. 58-62
-
-
Hanger, D.P.1
Hughes, K.2
Woodgett, J.R.3
Brion, J.P.4
Anderton, B.H.5
-
112
-
-
0021985413
-
Tsubokawa, M. Et al. Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
-
CrossRefPubMed
-
Ullrich, A.; Bell, J.R.; Chen, E.Y.; Herrera, R.; Petruzzelli, L.M.; Dull, T.J.; Gray, A.; Coussens, L.; Liao, Y.C.; Tsubokawa, M. et al. Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature 1985, 313, 756-761. [CrossRef] [PubMed]
-
(1985)
Nature
, vol.313
, pp. 756-761
-
-
Ullrich, A.1
Bell, J.R.2
Chen, E.Y.3
Herrera, R.4
Petruzzelli, L.M.5
Dull, T.J.6
Gray, A.7
Coussens, L.8
Liao, Y.C.9
-
113
-
-
0028287467
-
The IRS-1 signaling system
-
CrossRef
-
Myers, M.G., Jr.; Sun, X.J.; White, M.F. The IRS-1 signaling system. Trends Biochem. Sci. 1994, 19, 289-293. [CrossRef]
-
(1994)
Trends Biochem. Sci
, vol.19
, pp. 289-293
-
-
Myers, M.G.1
Sun, X.J.2
White, M.F.3
-
114
-
-
0025220148
-
Intrinsic kinase activity of the insulin receptor
-
CrossRef
-
O’Hare, T.; Pilch, P.F. Intrinsic kinase activity of the insulin receptor. Int. J. Biochem. 1990, 22, 315-324. [CrossRef]
-
(1990)
Int. J. Biochem
, vol.22
, pp. 315-324
-
-
O’Hare, T.1
Pilch, P.F.2
-
115
-
-
84872501218
-
Insulin in the brain: Sources, localization and functions
-
CrossRefPubMed
-
Ghasemi, R.; Haeri, A.; Dargahi, L.; Mohamed, Z.; Ahmadiani, A. Insulin in the brain: Sources, localization and functions. Mol. Neurobiol. 2013, 47, 145-171. [CrossRef] [PubMed]
-
(2013)
Mol. Neurobiol
, vol.47
, pp. 145-171
-
-
Ghasemi, R.1
Haeri, A.2
Dargahi, L.3
Mohamed, Z.4
Ahmadiani, A.5
-
116
-
-
0027438687
-
Insulin and insulin-like growth factor-I induced phosphorylation in neurally derived cells
-
CrossRefPubMed
-
Adamo, M.L.; Shemer, J.; Roberts, C.T., Jr.; LeRoith, D. Insulin and insulin-like growth factor-I induced phosphorylation in neurally derived cells. Ann. N. Y. Acad. Sci. 1993, 692, 113-125. [CrossRef] [PubMed]
-
(1993)
Ann. N. Y. Acad. Sci
, vol.692
, pp. 113-125
-
-
Adamo, M.L.1
Shemer, J.2
Roberts, C.T.3
Leroith, D.4
-
117
-
-
0033197996
-
The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses
-
PubMed
-
Abbott, M.A.; Wells, D.G.; Fallon, J.R. The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses. J. Neurosci. 1999, 19, 7300-7308. [PubMed]
-
(1999)
J. Neurosci
, vol.19
, pp. 7300-7308
-
-
Abbott, M.A.1
Wells, D.G.2
Fallon, J.R.3
-
118
-
-
0023271871
-
Localization and characterization of insulin receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry
-
CrossRefPubMed
-
Werther, G.A.; Hogg, A.; Oldfield, B.J.; McKinley, M.J.; Figdor, R.; Allen, A.M.; Mendelsohn, F.A. Localization and characterization of insulin receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry. Endocrinology 1987, 121, 1562-1570. [CrossRef] [PubMed]
-
(1987)
Endocrinology
, vol.121
, pp. 1562-1570
-
-
Werther, G.A.1
Hogg, A.2
Oldfield, B.J.3
McKinley, M.J.4
Figdor, R.5
Allen, A.M.6
Mendelsohn, F.A.7
-
119
-
-
2642538349
-
Regulation of glycogen synthase kinase-3β by products of lipid peroxidation in human neuroblastoma cells
-
CrossRefPubMed
-
Dozza, B.; Smith, M.A.; Perry, G.; Tabaton, M.; Strocchi, P. Regulation of glycogen synthase kinase-3β by products of lipid peroxidation in human neuroblastoma cells. J. Neurochem. 2004, 89, 1224-1232. [CrossRef] [PubMed]
-
(2004)
J. Neurochem
, vol.89
, pp. 1224-1232
-
-
Dozza, B.1
Smith, M.A.2
Perry, G.3
Tabaton, M.4
Strocchi, P.5
-
120
-
-
70949084806
-
Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer’s disease
-
CrossRefPubMed
-
Ke, Y.D.; Delerue, F.; Gladbach, A.; Götz, J.; Ittner, L.M. Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer’s disease. PLoS ONE 2009, 4, e7917. [CrossRef] [PubMed]
-
(2009)
Plos ONE
, vol.4
-
-
Ke, Y.D.1
Delerue, F.2
Gladbach, A.3
Götz, J.4
Ittner, L.M.5
-
121
-
-
0027214404
-
Phosphoprotein phosphatase activities in Alzheimer disease brain
-
CrossRefPubMed
-
Gong, C.X.; Singh, T.J.; Grundke-Iqbal, I.; Iqbal, K. Phosphoprotein phosphatase activities in Alzheimer disease brain. J. Neurochem. 1993, 61, 921-927. [CrossRef] [PubMed]
-
(1993)
J. Neurochem
, vol.61
, pp. 921-927
-
-
Gong, C.X.1
Singh, T.J.2
Grundke-Iqbal, I.3
Iqbal, K.4
-
122
-
-
0029113874
-
Phosphatase activity toward abnormally phosphorylated tau: Decrease in Alzheimer disease brain
-
CrossRefPubMed
-
Gong, C.X.; Shaikh, S.; Wang, J.Z.; Zaidi, T.; Grundke-Iqbal, I.; Iqbal, K. Phosphatase activity toward abnormally phosphorylated tau: Decrease in Alzheimer disease brain. J. Neurochem. 1995, 65, 732-738. [CrossRef] [PubMed]
-
(1995)
J. Neurochem
, vol.65
, pp. 732-738
-
-
Gong, C.X.1
Shaikh, S.2
Wang, J.Z.3
Zaidi, T.4
Grundke-Iqbal, I.5
Iqbal, K.6
-
123
-
-
0035075793
-
PP2A mRNA expression is quantitatively decreased in Alzheimer’s disease hippocampus. Exp
-
CrossRefPubMed
-
Vogelsberg-Ragaglia, V.; Schuck, T.; Trojanowski, J.Q.; Lee, V.M. PP2A mRNA expression is quantitatively decreased in Alzheimer’s disease hippocampus. Exp. Neurol. 2001, 168, 402-412. [CrossRef] [PubMed]
-
(2001)
Neurol
, vol.168
, pp. 402-412
-
-
Vogelsberg-Ragaglia, V.1
Schuck, T.2
Trojanowski, J.Q.3
Lee, V.M.4
-
124
-
-
19544362550
-
Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer’s disease
-
CrossRef
-
Tanimukai, H.; Grundke-Iqbal, I.; Iqbal, K. Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer’s disease. Am. J. Pathol. 2005, 166, 1761-1771. [CrossRef]
-
(2005)
Am. J. Pathol
, vol.166
, pp. 1761-1771
-
-
Tanimukai, H.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
125
-
-
37249040432
-
Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms
-
CrossRefPubMed
-
Planel, E.; Tatebayashi, Y.; Miyasaka, T.; Liu, L.; Wang, L.; Herman, M.; Yu, W.H.; Luchsinger, J.A.; Wadzinski, B.; Duff, K.E. et al. Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms. J. Neurosci. 2007, 27, 13635-13648. [CrossRef] [PubMed]
-
(2007)
J. Neurosci
, vol.27
, pp. 13635-13648
-
-
Planel, E.1
Tatebayashi, Y.2
Miyasaka, T.3
Liu, L.4
Wang, L.5
Herman, M.6
Yu, W.H.7
Luchsinger, J.A.8
Wadzinski, B.9
Duff, K.E.10
-
126
-
-
33845515523
-
Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency
-
CrossRefPubMed
-
Clodfelder-Miller, B.J.; Zmijewska, A.A.; Johnson, G.V.; Jope, R.S. Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency. Diabetes 2006, 55, 3320-3325. [CrossRef] [PubMed]
-
(2006)
Diabetes
, vol.55
, pp. 3320-3325
-
-
Clodfelder-Miller, B.J.1
Zmijewska, A.A.2
Johnson, G.V.3
Jope, R.S.4
-
127
-
-
84873035509
-
Deregulation of protein phosphatase 2A and hyperphosphorylation of β protein following onset of diabetes in NOD mice
-
CrossRefPubMed
-
Papon, M.A.; El Khoury, N.B.; Marcouiller, F.; Julien, C.; Morin, F.; Bretteville, A.; Petry, F.R.; Gaudreau, S.; Amrani, A.; Mathews, P.M. et al. Deregulation of protein phosphatase 2A and hyperphosphorylation of β protein following onset of diabetes in NOD mice. Diabetes 2013, 62, 609-617. [CrossRef] [PubMed]
-
(2013)
Diabetes
, vol.62
, pp. 609-617
-
-
Papon, M.A.1
El Khoury, N.B.2
Marcouiller, F.3
Julien, C.4
Morin, F.5
Bretteville, A.6
Petry, F.R.7
Gaudreau, S.8
Amrani, A.9
Mathews, P.M.10
-
128
-
-
84906776296
-
Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice
-
CrossRefPubMed
-
Chen, Y.; Zhao, Y.; Dai, C.L.; Liang, Z.; Run, X.; Iqbal, K.; Liu, F.; Gong, C.X. Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice. Exp. Neurol. 2014, 261, 610-619. [CrossRef] [PubMed]
-
(2014)
Exp. Neurol
, vol.261
, pp. 610-619
-
-
Chen, Y.1
Zhao, Y.2
Dai, C.L.3
Liang, Z.4
Run, X.5
Iqbal, K.6
Liu, F.7
Gong, C.X.8
-
129
-
-
84903702536
-
Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer’s disease
-
CrossRefPubMed
-
Pedrós, I.; Petrov, D.; Allgaier, M.; Sureda, F.; Barroso, E.; Beas-Zarate, C.; Auladell, C.; Pallàs, M.; Vázquez-Carrera, M.; Casadesús, G. et al. Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer’s disease. Biochim. Biophys. Acta 2014, 1842, 1556-1566. [CrossRef] [PubMed]
-
(2014)
Biochim. Biophys. Acta
, vol.1842
, pp. 1556-1566
-
-
Pedrós, I.1
Petrov, D.2
Allgaier, M.3
Sureda, F.4
Barroso, E.5
Beas-Zarate, C.6
Auladell, C.7
Pallàs, M.8
Vázquez-Carrera, M.9
Casadesús, G.10
-
130
-
-
84855613853
-
Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: A pilot clinical trial
-
CrossRefPubMed
-
Craft, S.; Baker, L.D.; Montine, T.J.; Minoshima, S.; Watson, G.S.; Claxton, A.; Arbuckle, M.; Callaghan, M.; Tsai, E.; Plymate, S.R. et al. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: A pilot clinical trial. Arch. Neurol. 2012, 69, 29-38. [CrossRef] [PubMed]
-
(2012)
Arch. Neurol
, vol.69
, pp. 29-38
-
-
Craft, S.1
Baker, L.D.2
Montine, T.J.3
Minoshima, S.4
Watson, G.S.5
Claxton, A.6
Arbuckle, M.7
Callaghan, M.8
Tsai, E.9
Plymate, S.R.10
-
131
-
-
84922666525
-
Longacting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or earlystage Alzheimer’s disease dementia
-
PubMed
-
Claxton, A.; Baker, L.D.; Hanson, A.; Trittschuh, E.H.; Cholerton, B.; Morgan, A.; Callaghan, M.; Arbuckle, M.; Behl, C.; Craft, S. Longacting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or earlystage Alzheimer’s disease dementia. J. Alzheimers Dis. 2015, 44, 897-906. [PubMed]
-
(2015)
J. Alzheimers Dis
, vol.44
, pp. 897-906
-
-
Claxton, A.1
Baker, L.D.2
Hanson, A.3
Trittschuh, E.H.4
Cholerton, B.5
Morgan, A.6
Callaghan, M.7
Arbuckle, M.8
Behl, C.9
Craft, S.10
|